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Items: 1 to 50 of 63

1.

Megakaryocyte polyploidization: role in platelet production.

Vainchenker W, Raslova H.

Platelets. 2019 Sep 22:1-10. doi: 10.1080/09537104.2019.1667497. [Epub ahead of print]

PMID:
31544577
2.

Filamin A: key actor in platelet biology.

Rosa JP, Raslova H, Bryckaert M.

Blood. 2019 Aug 30. pii: blood.2019000014. doi: 10.1182/blood.2019000014. [Epub ahead of print]

PMID:
31471375
3.

Rare type 1-like and type 2-like calreticulin mutants induce similar myeloproliferative neoplasms as prevalent type 1 and 2 mutants in mice.

Toppaldoddi KR, da Costa Cacemiro M, Bluteau O, Panneau-Schmaltz B, Pioch A, Muller D, Villeval JL, Raslova H, Constantinescu SN, Plo I, Vainchenker W, Marty C.

Oncogene. 2019 Mar;38(10):1651-1660. doi: 10.1038/s41388-018-0538-z. Epub 2018 Oct 19.

PMID:
30846848
4.

Disrupted filamin A/αIIbβ3 interaction induces macrothrombocytopenia by increasing RhoA activity.

Donada A, Balayn N, Sliwa D, Lordier L, Ceglia V, Baschieri F, Goizet C, Favier R, Tosca L, Tachdjian G, Denis CV, Plo I, Vainchenker W, Debili N, Rosa JP, Bryckaert M, Raslova H.

Blood. 2019 Apr 18;133(16):1778-1788. doi: 10.1182/blood-2018-07-861427. Epub 2019 Jan 2.

5.

Downregulation of TREM-like transcript-1 and collagen receptor α2 subunit, two novel RUNX1-targets, contributes to platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia.

Glembotsky AC, Sliwa D, Bluteau D, Balayn N, Marin Oyarzún CP, Raimbault A, Bordas M, Droin N, Pirozhkova I, Washington V, Goette NP, Marta RF, Favier R, Raslova H, Heller PG.

Haematologica. 2019 Jun;104(6):1244-1255. doi: 10.3324/haematol.2018.188904. Epub 2018 Dec 13.

6.

Clinic, pathogenic mechanisms and drug testing of two inherited thrombocytopenias, ANKRD26-related Thrombocytopenia and MYH9-related diseases.

Balduini A, Raslova H, Di Buduo CA, Donada A, Ballmaier M, Germeshausen M, Balduini CL.

Eur J Med Genet. 2018 Nov;61(11):715-722. doi: 10.1016/j.ejmg.2018.01.014. Epub 2018 Mar 13. Review.

PMID:
29545013
7.

CK2: a key regulator of thrombopoiesis.

Vainchenker W, Raslova H.

Blood. 2017 Dec 21;130(25):2695-2697. doi: 10.1182/blood-2017-10-808568. No abstract available.

PMID:
29269531
8.

New pathogenic mechanisms induced by germline erythropoietin receptor mutations in primary erythrocytosis.

Pasquier F, Marty C, Balligand T, Verdier F, Grosjean S, Gryshkova V, Raslova H, Constantinescu SN, Casadevall N, Vainchenker W, Bellanné-Chantelot C, Plo I.

Haematologica. 2018 Apr;103(4):575-586. doi: 10.3324/haematol.2017.176370. Epub 2017 Dec 21.

9.

Critical role of the HDAC6-cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect.

Messaoudi K, Ali A, Ishaq R, Palazzo A, Sliwa D, Bluteau O, Souquère S, Muller D, Diop KM, Rameau P, Lapierre V, Marolleau JP, Matthias P, Godin I, Pierron G, Thomas SG, Watson SP, Droin N, Vainchenker W, Plo I, Raslova H, Debili N.

Nat Commun. 2017 Nov 27;8(1):1786. doi: 10.1038/s41467-017-01690-2.

10.

Megakaryocyte and polyploidization.

Mazzi S, Lordier L, Debili N, Raslova H, Vainchenker W.

Exp Hematol. 2018 Jan;57:1-13. doi: 10.1016/j.exphem.2017.10.001. Epub 2017 Oct 27. Review.

PMID:
29111429
11.

Mutations of the integrin αIIb/β3 intracytoplasmic salt bridge cause macrothrombocytopenia and enlarged platelet α-granules.

Favier M, Bordet JC, Favier R, Gkalea V, Pillois X, Rameau P, Debili N, Alessi MC, Nurden P, Raslova H, Nurden A.

Am J Hematol. 2018 Feb;93(2):195-204. doi: 10.1002/ajh.24958. Epub 2017 Nov 17.

12.

A new heterozygous mutation in GP1BA gene responsible for macrothrombocytopenia.

Ghalloussi D, Saut N, Bernot D, Pillois X, Rameau P, Sébahoun G, Alessi MC, Raslova H, Baccini V.

Br J Haematol. 2018 Nov;183(3):503-506. doi: 10.1111/bjh.14986. Epub 2017 Oct 30. No abstract available.

PMID:
29082515
13.

ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.

Thirant C, Ignacimouttou C, Lopez CK, Diop M, Le Mouël L, Thiollier C, Siret A, Dessen P, Aid Z, Rivière J, Rameau P, Lefebvre C, Khaled M, Leverger G, Ballerini P, Petit A, Raslova H, Carmichael CL, Kile BT, Soler E, Crispino JD, Wichmann C, Pflumio F, Schwaller J, Vainchenker W, Lobry C, Droin N, Bernard OA, Malinge S, Mercher T.

Cancer Cell. 2017 Mar 13;31(3):452-465. doi: 10.1016/j.ccell.2017.02.006.

14.

An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L.

Favale F, Messaoudi K, Varghese LN, Boukour S, Pecquet C, Gryshkova V, Defour JP, Albu RI, Bluteau O, Ballerini P, Leverger G, Plo I, Debili N, Raslova H, Favier R, Constantinescu SN, Vainchenker W.

Blood. 2016 Dec 29;128(26):3146-3158. doi: 10.1182/blood-2016-06-722058. Epub 2016 Nov 10.

PMID:
28034873
15.

Acquired TET2 mutation in one patient with familial platelet disorder with predisposition to AML led to the development of pre-leukaemic clone resulting in T2-ALL and AML-M0.

Manchev VT, Bouzid H, Antony-Debré I, Leite B, Meurice G, Droin N, Prebet T, Costello RT, Vainchenker W, Plo I, Diop M, Macintyre E, Asnafi V, Favier R, Baccini V, Raslova H.

J Cell Mol Med. 2017 Jun;21(6):1237-1242. doi: 10.1111/jcmm.13051. Epub 2016 Dec 20.

16.

Eltrombopag, a potent stimulator of megakaryopoiesis.

Raslova H, Vainchenker W, Plo I.

Haematologica. 2016 Dec;101(12):1443-1445. No abstract available.

17.

Activity of nonmuscle myosin II isoforms determines localization at the cleavage furrow of megakaryocytes.

Roy A, Lordier L, Mazzi S, Chang Y, Lapierre V, Larghero J, Debili N, Raslova H, Vainchenker W.

Blood. 2016 Dec 29;128(26):3137-3145. doi: 10.1182/blood-2016-04-711630. Epub 2016 Oct 13.

PMID:
27737892
18.

The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation.

Palazzo A, Bluteau O, Messaoudi K, Marangoni F, Chang Y, Souquere S, Pierron G, Lapierre V, Zheng Y, Vainchenker W, Raslova H, Debili N.

J Thromb Haemost. 2016 Dec;14(12):2524-2535. doi: 10.1111/jth.13519. Epub 2016 Nov 15.

19.

Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors.

Poggi M, Canault M, Favier M, Turro E, Saultier P, Ghalloussi D, Baccini V, Vidal L, Mezzapesa A, Chelghoum N, Mohand-Oumoussa B, Falaise C, Favier R, Ouwehand WH, Fiore M, Peiretti F, Morange PE, Saut N, Bernot D, Greinacher A, BioResource N, Nurden AT, Nurden P, Freson K, Trégouët DA, Raslova H, Alessi MC.

Haematologica. 2017 Feb;102(2):282-294. doi: 10.3324/haematol.2016.147694. Epub 2016 Sep 23.

20.

Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint.

Roy A, Lordier L, Pioche-Durieu C, Souquere S, Roy L, Rameau P, Lapierre V, Le Cam E, Plo I, Debili N, Raslova H, Vainchenker W.

Haematologica. 2016 Dec;101(12):1469-1478. Epub 2016 Aug 11.

21.

P53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis.

Mahfoudhi E, Lordier L, Marty C, Pan J, Roy A, Roy L, Rameau P, Abbes S, Debili N, Raslova H, Chang Y, Debussche L, Vainchenker W, Plo I.

Oncotarget. 2016 May 31;7(22):31980-92. doi: 10.18632/oncotarget.7881.

22.

Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants.

Chachoua I, Pecquet C, El-Khoury M, Nivarthi H, Albu RI, Marty C, Gryshkova V, Defour JP, Vertenoeil G, Ngo A, Koay A, Raslova H, Courtoy PJ, Choong ML, Plo I, Vainchenker W, Kralovics R, Constantinescu SN.

Blood. 2016 Mar 10;127(10):1325-35. doi: 10.1182/blood-2015-11-681932. Epub 2015 Dec 14.

PMID:
26668133
23.

Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis.

Marty C, Pecquet C, Nivarthi H, El-Khoury M, Chachoua I, Tulliez M, Villeval JL, Raslova H, Kralovics R, Constantinescu SN, Plo I, Vainchenker W.

Blood. 2016 Mar 10;127(10):1317-24. doi: 10.1182/blood-2015-11-679571. Epub 2015 Nov 25.

PMID:
26608331
24.

Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients.

Cabagnols X, Favale F, Pasquier F, Messaoudi K, Defour JP, Ianotto JC, Marzac C, Le Couédic JP, Droin N, Chachoua I, Favier R, Diop MK, Ugo V, Casadevall N, Debili N, Raslova H, Bellanné-Chantelot C, Constantinescu SN, Bluteau O, Plo I, Vainchenker W.

Blood. 2016 Jan 21;127(3):333-42. doi: 10.1182/blood-2015-07-661983. Epub 2015 Oct 8.

PMID:
26450985
25.

Somatic mutations associated with leukemic progression of familial platelet disorder with predisposition to acute myeloid leukemia.

Antony-Debré I, Duployez N, Bucci M, Geffroy S, Micol JB, Renneville A, Boissel N, Dhédin N, Réa D, Nelken B, Berthon C, Leblanc T, Mozziconacci MJ, Favier R, Heller PG, Abdel-Wahab O, Raslova H, Latger-Cannard V, Preudhomme C.

Leukemia. 2016 Apr;30(4):999-1002. doi: 10.1038/leu.2015.236. Epub 2015 Aug 28. No abstract available.

PMID:
26316320
26.

Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies.

Saliba J, Saint-Martin C, Di Stefano A, Lenglet G, Marty C, Keren B, Pasquier F, Valle VD, Secardin L, Leroy G, Mahfoudhi E, Grosjean S, Droin N, Diop M, Dessen P, Charrier S, Palazzo A, Merlevede J, Meniane JC, Delaunay-Darivon C, Fuseau P, Isnard F, Casadevall N, Solary E, Debili N, Bernard OA, Raslova H, Najman A, Vainchenker W, Bellanné-Chantelot C, Plo I.

Nat Genet. 2015 Oct;47(10):1131-40. doi: 10.1038/ng.3380. Epub 2015 Aug 17.

PMID:
26280900
27.

Progress in understanding the diagnosis and molecular genetics of macrothrombocytopenias.

Favier R, Raslova H.

Br J Haematol. 2015 Sep;170(5):626-39. doi: 10.1111/bjh.13478. Epub 2015 May 5. Review.

PMID:
25944497
28.

Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.

Antony-Debré I, Manchev VT, Balayn N, Bluteau D, Tomowiak C, Legrand C, Langlois T, Bawa O, Tosca L, Tachdjian G, Leheup B, Debili N, Plo I, Mills JA, French DL, Weiss MJ, Solary E, Favier R, Vainchenker W, Raslova H.

Blood. 2015 Feb 5;125(6):930-40. doi: 10.1182/blood-2014-06-585513. Epub 2014 Dec 9.

29.

p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging.

Hilpert M, Legrand C, Bluteau D, Balayn N, Betems A, Bluteau O, Villeval JL, Louache F, Gonin P, Debili N, Plo I, Vainchenker W, Gilles L, Raslova H.

Stem Cell Reports. 2014 Dec 9;3(6):1085-102. doi: 10.1016/j.stemcr.2014.10.005. Epub 2014 Nov 20.

30.

A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene.

Manchev VT, Hilpert M, Berrou E, Elaib Z, Aouba A, Boukour S, Souquere S, Pierron G, Rameau P, Andrews R, Lanza F, Bobe R, Vainchenker W, Rosa JP, Bryckaert M, Debili N, Favier R, Raslova H.

Blood. 2014 Oct 16;124(16):2554-63. doi: 10.1182/blood-2014-01-551820. Epub 2014 Jul 24.

31.

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding.

Canault M, Ghalloussi D, Grosdidier C, Guinier M, Perret C, Chelghoum N, Germain M, Raslova H, Peiretti F, Morange PE, Saut N, Pillois X, Nurden AT, Cambien F, Pierres A, van den Berg TK, Kuijpers TW, Alessi MC, Tregouet DA.

J Exp Med. 2014 Jun 30;211(7):1349-62. doi: 10.1084/jem.20130477. Epub 2014 Jun 23.

32.

Mechanisms underlying platelet function defect in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia: potential role for candidate RUNX1 targets.

Glembotsky AC, Bluteau D, Espasandin YR, Goette NP, Marta RF, Marin Oyarzun CP, Korin L, Lev PR, Laguens RP, Molinas FC, Raslova H, Heller PG.

J Thromb Haemost. 2014 May;12(5):761-72. doi: 10.1111/jth.12550.

33.

Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation.

Bluteau D, Balduini A, Balayn N, Currao M, Nurden P, Deswarte C, Leverger G, Noris P, Perrotta S, Solary E, Vainchenker W, Debili N, Favier R, Raslova H.

J Clin Invest. 2014 Feb;124(2):580-91. doi: 10.1172/JCI71861. Epub 2014 Jan 16.

34.

The abnormal proplatelet formation in MYH9-related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition.

Chen Y, Boukour S, Milloud R, Favier R, Saposnik B, Schlegel N, Nurden A, Raslova H, Vainchenker W, Balland M, Nurden P, Debili N.

J Thromb Haemost. 2013 Dec;11(12):2163-75. doi: 10.1111/jth.12436.

35.

Heterozygous and homozygous JAK2(V617F) states modeled by induced pluripotent stem cells from myeloproliferative neoplasm patients.

Saliba J, Hamidi S, Lenglet G, Langlois T, Yin J, Cabagnols X, Secardin L, Legrand C, Galy A, Opolon P, Benyahia B, Solary E, Bernard OA, Chen L, Debili N, Raslova H, Norol F, Vainchenker W, Plo I, Di Stefano A.

PLoS One. 2013 Sep 16;8(9):e74257. doi: 10.1371/journal.pone.0074257. eCollection 2013.

36.

Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms.

Ali A, Bluteau O, Messaoudi K, Palazzo A, Boukour S, Lordier L, Lecluse Y, Rameau P, Kraus-Berthier L, Jacquet-Bescond A, Lelièvre H, Depil S, Dessen P, Solary E, Raslova H, Vainchenker W, Plo I, Debili N.

Cell Death Dis. 2013 Jul 25;4:e738. doi: 10.1038/cddis.2013.260.

37.

Developmental changes in human megakaryopoiesis.

Bluteau O, Langlois T, Rivera-Munoz P, Favale F, Rameau P, Meurice G, Dessen P, Solary E, Raslova H, Mercher T, Debili N, Vainchenker W.

J Thromb Haemost. 2013 Sep;11(9):1730-41. doi: 10.1111/jth.12326.

38.

Concomitant germ-line RUNX1 and acquired ASXL1 mutations in a T-cell acute lymphoblastic leukemia.

Prebet T, Carbuccia N, Raslova H, Favier R, Rey J, Arnoulet C, Vey N, Vainchenker W, Birnbaum D, Mozziconacci MJ.

Eur J Haematol. 2013 Sep;91(3):277-9. doi: 10.1111/ejh.12147. Epub 2013 Jun 28. No abstract available.

PMID:
23692290
39.

Dysmegakaryopoiesis of FPD/AML pedigrees with constitutional RUNX1 mutations is linked to myosin II deregulated expression.

Bluteau D, Glembotsky AC, Raimbault A, Balayn N, Gilles L, Rameau P, Nurden P, Alessi MC, Debili N, Vainchenker W, Heller PG, Favier R, Raslova H.

Blood. 2012 Sep 27;120(13):2708-18. Epub 2012 Aug 16.

PMID:
22898599
40.

Primary hematopoietic cells from DBA patients with mutations in RPL11 and RPS19 genes exhibit distinct erythroid phenotype in vitro.

Moniz H, Gastou M, Leblanc T, Hurtaud C, Crétien A, Lécluse Y, Raslova H, Larghero J, Croisille L, Faubladier M, Bluteau O, Lordier L, Tchernia G, Vainchenker W, Mohandas N, Da Costa L; DBA Group of Société d'Hématologie et d'Immunologie Pédiatrique-SHIP.

Cell Death Dis. 2012 Jul 26;3:e356. doi: 10.1038/cddis.2012.88.

41.

MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations.

Antony-Debré I, Bluteau D, Itzykson R, Baccini V, Renneville A, Boehlen F, Morabito M, Droin N, Deswarte C, Chang Y, Leverger G, Solary E, Vainchenker W, Favier R, Raslova H.

Blood. 2012 Sep 27;120(13):2719-22. Epub 2012 Jun 7.

PMID:
22677128
42.

RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization.

Lordier L, Bluteau D, Jalil A, Legrand C, Pan J, Rameau P, Jouni D, Bluteau O, Mercher T, Leon C, Gachet C, Debili N, Vainchenker W, Raslova H, Chang Y.

Nat Commun. 2012 Mar 6;3:717. doi: 10.1038/ncomms1704.

PMID:
22395608
43.

Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia.

Bluteau D, Gilles L, Hilpert M, Antony-Debré I, James C, Debili N, Camara-Clayette V, Wagner-Ballon O, Cordette-Lagarde V, Robert T, Ripoche H, Gonin P, Swierczek S, Prchal J, Vainchenker W, Favier R, Raslova H.

Blood. 2011 Dec 8;118(24):6310-20. doi: 10.1182/blood-2010-12-325555. Epub 2011 Jul 1.

PMID:
21725049
44.

The serum response factor (SRF)/megakaryocytic acute leukemia (MAL) network participates in megakaryocyte development.

Ragu C, Boukour S, Elain G, Wagner-Ballon O, Raslova H, Debili N, Olson EN, Daegelen D, Vainchenker W, Bernard OA, Penard-Lacronique V.

Leukemia. 2010 Jun;24(6):1227-30. doi: 10.1038/leu.2010.80. Epub 2010 Apr 29. No abstract available.

PMID:
20428204
45.

MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9.

Gilles L, Bluteau D, Boukour S, Chang Y, Zhang Y, Robert T, Dessen P, Debili N, Bernard OA, Vainchenker W, Raslova H.

Blood. 2009 Nov 5;114(19):4221-32. doi: 10.1182/blood-2009-03-209932. Epub 2009 Sep 1.

PMID:
19724058
46.

Regulation of megakaryocyte maturation and platelet formation.

Bluteau D, Lordier L, Di Stefano A, Chang Y, Raslova H, Debili N, Vainchenker W.

J Thromb Haemost. 2009 Jul;7 Suppl 1:227-34. doi: 10.1111/j.1538-7836.2009.03398.x. Review.

47.

Occurrence of human papillomavirus 16 and 18 in smears from the two cervix regions of onco-gynecological patients in Slovakia.

Kúdelová M, Krivos V, Raslová H, Valovicová M, Belvoncíková P, Matis J.

Acta Virol. 2008;52(1):17-22.

PMID:
18459831
48.

P19INK4D links endomitotic arrest and megakaryocyte maturation and is regulated by AML-1.

Gilles L, Guièze R, Bluteau D, Cordette-Lagarde V, Lacout C, Favier R, Larbret F, Debili N, Vainchenker W, Raslova H.

Blood. 2008 Apr 15;111(8):4081-91. doi: 10.1182/blood-2007-09-113266. Epub 2008 Feb 14.

PMID:
18276842
49.

p210(BCR-ABL) reprograms transformed and normal human megakaryocytic progenitor cells into erythroid cells and suppresses FLI-1 transcription.

Buet D, Raslova H, Geay JF, Jarrier P, Lazar V, Turhan A, Morlé F, Vainchenker W, Louache F.

Leukemia. 2007 May;21(5):917-25. Epub 2007 Feb 22.

PMID:
17315025
50.

Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approach.

Raslova H, Kauffmann A, Sekkaï D, Ripoche H, Larbret F, Robert T, Tronik Le Roux D, Kroemer G, Debili N, Dessen P, Lazar V, Vainchenker W.

Blood. 2007 Apr 15;109(8):3225-34. Epub 2006 Dec 14.

PMID:
17170127

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