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Effect of blast-related mTBI on the working memory system: a resting state fMRI study.

Pagulayan KF, Petrie EC, Cook DG, Hendrickson RC, Rau H, Reilly M, Mayer C, Meabon JS, Raskind MA, Peskind ER, Kleinhans N.

Brain Imaging Behav. 2018 Dec 5. doi: 10.1007/s11682-018-9987-9. [Epub ahead of print]


Blast exposure elicits blood-brain barrier disruption and repair mediated by tight junction integrity and nitric oxide dependent processes.

Logsdon AF, Meabon JS, Cline MM, Bullock KM, Raskind MA, Peskind ER, Banks WA, Cook DG.

Sci Rep. 2018 Jul 27;8(1):11344. doi: 10.1038/s41598-018-29341-6.


Evidence for altered brain reactivity to norepinephrine in Veterans with a history of traumatic stress.

Hendrickson RC, Raskind MA, Millard SP, Sikkema C, Terry GE, Pagulayan KF, Li G, Peskind ER.

Neurobiol Stress. 2018 Mar 15;8:103-111. doi: 10.1016/j.ynstr.2018.03.001. eCollection 2018 Feb.


Prazosin for Post-Traumatic Stress Disorder.

Raskind MA, Peskind ER.

N Engl J Med. 2018 Apr 26;378(17):1649-1650. doi: 10.1056/NEJMc1803171. No abstract available.


Associations between CSF cortisol and CSF norepinephrine in cognitively normal controls and patients with amnestic MCI and AD dementia.

Wang LY, Raskind MA, Wilkinson CW, Shofer JB, Sikkema C, Szot P, Quinn JF, Galasko DR, Peskind ER.

Int J Geriatr Psychiatry. 2018 May;33(5):763-768. doi: 10.1002/gps.4856. Epub 2018 Feb 15.


Trial of Prazosin for Post-Traumatic Stress Disorder in Military Veterans.

Raskind MA, Peskind ER, Chow B, Harris C, Davis-Karim A, Holmes HA, Hart KL, McFall M, Mellman TA, Reist C, Romesser J, Rosenheck R, Shih MC, Stein MB, Swift R, Gleason T, Lu Y, Huang GD.

N Engl J Med. 2018 Feb 8;378(6):507-517. doi: 10.1056/NEJMoa1507598.


Effect of dietary palmitic and stearic acids on sucrose motivation and hypothalamic and striatal cell signals in the rat.

Figlewicz DP, Jay J, West CH, Zavosh A, Hampe CS, Radtke JR, Raskind MA, Peskind ER.

Am J Physiol Regul Integr Comp Physiol. 2018 Feb 1;314(2):R191-R200. doi: 10.1152/ajpregu.00340.2017. Epub 2017 Nov 1.


Effect of simvastatin on CSF Alzheimer disease biomarkers in cognitively normal adults.

Li G, Mayer CL, Morelli D, Millard SP, Raskind WH, Petrie EC, Cherrier M, Fagan AM, Raskind MA, Peskind ER.

Neurology. 2017 Sep 19;89(12):1251-1255. doi: 10.1212/WNL.0000000000004392. Epub 2017 Aug 18.


Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults.

Li G, Shofer JB, Petrie EC, Yu CE, Wilkinson CW, Figlewicz DP, Shutes-David A, Zhang J, Montine TJ, Raskind MA, Quinn JF, Galasko DR, Peskind ER.

Alzheimers Res Ther. 2017 Jul 3;9(1):48. doi: 10.1186/s13195-017-0271-9.


Multiple lipopolysaccharide (LPS) injections alter interleukin 6 (IL-6), IL-7, IL-10 and IL-6 and IL-7 receptor mRNA in CNS and spleen.

Szot P, Franklin A, Figlewicz DP, Beuca TP, Bullock K, Hansen K, Banks WA, Raskind MA, Peskind ER.

Neuroscience. 2017 Jul 4;355:9-21. doi: 10.1016/j.neuroscience.2017.04.028. Epub 2017 Apr 27.


Higher Pretreatment Blood Pressure Is Associated With Greater Posttraumatic Stress Disorder Symptom Reduction in Soldiers Treated With Prazosin.

Raskind MA, Millard SP, Petrie EC, Peterson K, Williams T, Hoff DJ, Hart K, Holmes H, Hill J, Daniels C, Hendrickson R, Peskind ER.

Biol Psychiatry. 2016 Nov 15;80(10):736-742. doi: 10.1016/j.biopsych.2016.03.2108. Epub 2016 Apr 11.


The phosphatase calcineurin regulates pathological TDP-43 phosphorylation.

Liachko NF, Saxton AD, McMillan PJ, Strovas TJ, Currey HN, Taylor LM, Wheeler JM, Oblak AL, Ghetti B, Montine TJ, Keene CD, Raskind MA, Bird TD, Kraemer BC.

Acta Neuropathol. 2016 Oct;132(4):545-61. doi: 10.1007/s00401-016-1600-y. Epub 2016 Jul 29.


Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients.

Takeda S, Commins C, DeVos SL, Nobuhara CK, Wegmann S, Roe AD, Costantino I, Fan Z, Nicholls SB, Sherman AE, Trisini Lipsanopoulos AT, Scherzer CR, Carlson GA, Pitstick R, Peskind ER, Raskind MA, Li G, Montine TJ, Frosch MP, Hyman BT.

Ann Neurol. 2016 Sep;80(3):355-67. doi: 10.1002/ana.24716. Epub 2016 Aug 3.


Doxazosin XL reduces symptoms of posttraumatic stress disorder in veterans with PTSD: a pilot clinical trial.

Rodgman C, Verrico CD, Holst M, Thompson-Lake D, Haile CN, De La Garza R 2nd, Raskind MA, Newton TF.

J Clin Psychiatry. 2016 May;77(5):e561-5. doi: 10.4088/JCP.14m09681.


Noradrenergic dysregulation in the pathophysiology of PTSD.

Hendrickson RC, Raskind MA.

Exp Neurol. 2016 Oct;284(Pt B):181-195. doi: 10.1016/j.expneurol.2016.05.014. Epub 2016 May 21. Review.


Posttraumatic Stress Disorder and Aging.

Palmer BW, Raskind MA.

Am J Geriatr Psychiatry. 2016 Mar;24(3):177-80. doi: 10.1016/j.jagp.2016.01.133. Epub 2016 Jan 15. No abstract available.


Blast exposure causes dynamic microglial/macrophage responses and microdomains of brain microvessel dysfunction.

Huber BR, Meabon JS, Hoffer ZS, Zhang J, Hoekstra JG, Pagulayan KF, McMillan PJ, Mayer CL, Banks WA, Kraemer BC, Raskind MA, McGavern DB, Peskind ER, Cook DG.

Neuroscience. 2016 Apr 5;319:206-20. doi: 10.1016/j.neuroscience.2016.01.022. Epub 2016 Jan 14.


Repetitive blast exposure in mice and combat veterans causes persistent cerebellar dysfunction.

Meabon JS, Huber BR, Cross DJ, Richards TL, Minoshima S, Pagulayan KF, Li G, Meeker KD, Kraemer BC, Petrie EC, Raskind MA, Peskind ER, Cook DG.

Sci Transl Med. 2016 Jan 13;8(321):321ra6. doi: 10.1126/scitranslmed.aaa9585.


Depressive-like behavior observed with a minimal loss of locus coeruleus (LC) neurons following administration of 6-hydroxydopamine is associated with electrophysiological changes and reversed with precursors of norepinephrine.

Szot P, Franklin A, Miguelez C, Wang Y, Vidaurrazaga I, Ugedo L, Sikkema C, Wilkinson CW, Raskind MA.

Neuropharmacology. 2016 Feb;101:76-86. doi: 10.1016/j.neuropharm.2015.09.003. Epub 2015 Sep 8.


The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.

Liachko NF, McMillan PJ, Strovas TJ, Loomis E, Greenup L, Murrell JR, Ghetti B, Raskind MA, Montine TJ, Bird TD, Leverenz JB, Kraemer BC.

PLoS Genet. 2014 Dec 4;10(12):e1004803. doi: 10.1371/journal.pgen.1004803. eCollection 2014 Dec.


Influence of lifestyle modifications on age-related free radical injury to brain.

Peskind ER, Li G, Shofer JB, Millard SP, Leverenz JB, Yu CE, Raskind MA, Quinn JF, Galasko DR, Montine TJ.

JAMA Neurol. 2014 Sep;71(9):1150-4. doi: 10.1001/jamaneurol.2014.1428.


Violence in war and violence back home.

Raskind MA, McCaslin C, Jakupcak M.

Am J Psychiatry. 2014 Jul;171(7):701-4. doi: 10.1176/appi.ajp.2014.14040528. No abstract available.


Cross-sectional and longitudinal relationships between cerebrospinal fluid biomarkers and cognitive function in people without cognitive impairment from across the adult life span.

Li G, Millard SP, Peskind ER, Zhang J, Yu CE, Leverenz JB, Mayer C, Shofer JS, Raskind MA, Quinn JF, Galasko DR, Montine TJ.

JAMA Neurol. 2014 Jun;71(6):742-51. doi: 10.1001/jamaneurol.2014.445.


Antipsychotic drugs for psychosis and agitation in dementia: efficacy, safety, and a possible noradrenergic mechanism of action.

Raskind MA, Wang LY.

Int Psychogeriatr. 2014 Jun;26(6):879-83. doi: 10.1017/S1041610214000477. Epub 2014 Apr 4. No abstract available.


Neuroimaging, behavioral, and psychological sequelae of repetitive combined blast/impact mild traumatic brain injury in Iraq and Afghanistan war veterans.

Petrie EC, Cross DJ, Yarnykh VL, Richards T, Martin NM, Pagulayan K, Hoff D, Hart K, Mayer C, Tarabochia M, Raskind MA, Minoshima S, Peskind ER.

J Neurotrauma. 2014 Mar 1;31(5):425-36. doi: 10.1089/neu.2013.2952.


A trial of prazosin for combat trauma PTSD with nightmares in active-duty soldiers returned from Iraq and Afghanistan.

Raskind MA, Peterson K, Williams T, Hoff DJ, Hart K, Holmes H, Homas D, Hill J, Daniels C, Calohan J, Millard SP, Rohde K, O'Connell J, Pritzl D, Feiszli K, Petrie EC, Gross C, Mayer CL, Freed MC, Engel C, Peskind ER.

Am J Psychiatry. 2013 Sep;170(9):1003-10. doi: 10.1176/appi.ajp.2013.12081133.


Cerebrospinal fluid norepinephrine and cognition in subjects across the adult age span.

Wang LY, Murphy RR, Hanscom B, Li G, Millard SP, Petrie EC, Galasko DR, Sikkema C, Raskind MA, Wilkinson CW, Peskind ER.

Neurobiol Aging. 2013 Oct;34(10):2287-92. doi: 10.1016/j.neurobiolaging.2013.04.007. Epub 2013 Apr 30.


Sequential Loss of LC Noradrenergic and Dopaminergic Neurons Results in a Correlation of Dopaminergic Neuronal Number to Striatal Dopamine Concentration.

Szot P, Franklin A, Sikkema C, Wilkinson CW, Raskind MA.

Front Pharmacol. 2012 Oct 22;3:184. doi: 10.3389/fphar.2012.00184. eCollection 2012.


Lesioning noradrenergic neurons of the locus coeruleus in C57Bl/6 mice with unilateral 6-hydroxydopamine injection, to assess molecular, electrophysiological and biochemical changes in noradrenergic signaling.

Szot P, Knight L, Franklin A, Sikkema C, Foster S, Wilkinson CW, White SS, Raskind MA.

Neuroscience. 2012 Aug 2;216:143-57. doi: 10.1016/j.neuroscience.2012.04.046. Epub 2012 Apr 25.


The neurobiology of the stress-resistant brain.

Fleshner M, Maier SF, Lyons DM, Raskind MA.

Stress. 2011 Sep;14(5):498-502. doi: 10.3109/10253890.2011.596865. Epub 2011 Jul 26.


The role of norepinephrine in differential response to stress in an animal model of posttraumatic stress disorder.

Olson VG, Rockett HR, Reh RK, Redila VA, Tran PM, Venkov HA, Defino MC, Hague C, Peskind ER, Szot P, Raskind MA.

Biol Psychiatry. 2011 Sep 1;70(5):441-8. doi: 10.1016/j.biopsych.2010.11.029. Epub 2011 Jan 20.


Differential response of the central noradrenergic nervous system to the loss of locus coeruleus neurons in Parkinson's disease and Alzheimer's disease.

McMillan PJ, White SS, Franklin A, Greenup JL, Leverenz JB, Raskind MA, Szot P.

Brain Res. 2011 Feb 10;1373:240-52. doi: 10.1016/j.brainres.2010.12.015. Epub 2010 Dec 11.


Prazosin treatment of trauma nightmares and sleep disturbance in soldiers deployed in Iraq.

Calohan J, Peterson K, Peskind ER, Raskind MA.

J Trauma Stress. 2010 Oct;23(5):645-8. doi: 10.1002/jts.20570.


Cerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war Veterans with persistent post-concussive symptoms.

Peskind ER, Petrie EC, Cross DJ, Pagulayan K, McCraw K, Hoff D, Hart K, Yu CE, Raskind MA, Cook DG, Minoshima S.

Neuroimage. 2011 Jan;54 Suppl 1:S76-82. doi: 10.1016/j.neuroimage.2010.04.008. Epub 2010 Apr 10.


Dosing by side effect threshold: two cases of panic disorder responsive to low-dose venlafaxine.

Orenstein H, Raskind MA.

J Clin Psychiatry. 2010 Jan;71(1):89-91. doi: 10.4088/JCP.09l05016blu. No abstract available.


A comprehensive analysis of the effect of DSP4 on the locus coeruleus noradrenergic system in the rat.

Szot P, Miguelez C, White SS, Franklin A, Sikkema C, Wilkinson CW, Ugedo L, Raskind MA.

Neuroscience. 2010 Mar 10;166(1):279-91. doi: 10.1016/j.neuroscience.2009.12.027. Epub 2010 Jan 4.


Adrenocortical responsiveness to infusions of physiological doses of ACTH is not altered in posttraumatic stress disorder.

Radant AD, Dobie DJ, Peskind ER, Murburg MM, Petrie EC, Kanter ED, Raskind MA, Wilkinson CW.

Front Behav Neurosci. 2009 Oct 30;3:40. doi: 10.3389/neuro.08.040.2009. eCollection 2009.


Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression.

Wang LY, Shofer JB, Rohde K, Hart KL, Hoff DJ, McFall YH, Raskind MA, Peskind ER.

Am J Geriatr Psychiatry. 2009 Sep;17(9):744-51. doi: 10.1097/JGP.0b013e3181ab8c61.


Preclinical evidence of Alzheimer changes: convergent cerebrospinal fluid biomarker and fluorodeoxyglucose positron emission tomography findings.

Petrie EC, Cross DJ, Galasko D, Schellenberg GD, Raskind MA, Peskind ER, Minoshima S.

Arch Neurol. 2009 May;66(5):632-7. doi: 10.1001/archneurol.2009.59.


Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects.

Li G, Peskind ER, Millard SP, Chi P, Sokal I, Yu CE, Bekris LM, Raskind MA, Galasko DR, Montine TJ.

PLoS One. 2009;4(5):e5424. doi: 10.1371/journal.pone.0005424. Epub 2009 May 1.


The alpha1-adrenergic receptor antagonist, prazosin, reduces alcohol drinking in alcohol-preferring (P) rats.

Rasmussen DD, Alexander LL, Raskind MA, Froehlich JC.

Alcohol Clin Exp Res. 2009 Feb;33(2):264-72. doi: 10.1111/j.1530-0277.2008.00829.x. Epub 2008 Nov 19.


Diagnosis and treatment of depression comorbid with neurologic disorders.

Raskind MA.

Am J Med. 2008 Nov;121(11 Suppl 2):S28-37. doi: 10.1016/j.amjmed.2008.09.011.


Nonnightmare distressed awakenings in veterans with posttraumatic stress disorder: response to prazosin.

Thompson CE, Taylor FB, McFall ME, Barnes RF, Raskind MA.

J Trauma Stress. 2008 Aug;21(4):417-20. doi: 10.1002/jts.20351.


alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol.

Walker BM, Rasmussen DD, Raskind MA, Koob GF.

Alcohol. 2008 Mar;42(2):91-7. doi: 10.1016/j.alcohol.2007.12.002.


Prazosin effects on objective sleep measures and clinical symptoms in civilian trauma posttraumatic stress disorder: a placebo-controlled study.

Taylor FB, Martin P, Thompson C, Williams J, Mellman TA, Gross C, Peskind ER, Raskind MA.

Biol Psychiatry. 2008 Mar 15;63(6):629-32. Epub 2007 Sep 14.


Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease.

Li G, Larson EB, Sonnen JA, Shofer JB, Petrie EC, Schantz A, Peskind ER, Raskind MA, Breitner JC, Montine TJ.

Neurology. 2007 Aug 28;69(9):878-85.


CSF tau/Abeta42 ratio for increased risk of mild cognitive impairment: a follow-up study.

Li G, Sokal I, Quinn JF, Leverenz JB, Brodey M, Schellenberg GD, Kaye JA, Raskind MA, Zhang J, Peskind ER, Montine TJ.

Neurology. 2007 Aug 14;69(7):631-9.


Changes in adrenoreceptors in the prefrontal cortex of subjects with dementia: evidence of compensatory changes.

Szot P, White SS, Greenup JL, Leverenz JB, Peskind ER, Raskind MA.

Neuroscience. 2007 Apr 25;146(1):471-80. Epub 2007 Feb 26.


Beneficial effects of prazosin for visual hallucinations associated with chronic cocaine abuse.

Tapp AM, Kennedy A, Peskind ER, Raskind MA.

J Clin Psychiatry. 2006 Nov;67(11):1819-20. No abstract available.


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