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The DESIGNER Approach Helps Decipher the Hypoglycemic Bioactive Principles of Artemisia dracunculus (Russian Tarragon).

Yu Y, Simmler C, Kuhn P, Poulev A, Raskin I, Ribnicky D, Floyd ZE, Pauli GF.

J Nat Prod. 2019 Dec 27;82(12):3321-3329. doi: 10.1021/acs.jnatprod.9b00548. Epub 2019 Dec 9.


Epigenome and transcriptome study of moringa isothiocyanate in mouse kidney mesangial cells induced by high glucose, a potential model for diabetic-induced nephropathy.

Li S, Li W, Wu R, Yin R, Sargsyan D, Raskin I, Kong AN.

AAPS J. 2019 Dec 5;22(1):8. doi: 10.1208/s12248-019-0393-z.


CpG methyl-seq and RNA-seq epigenomic and transcriptomic studies on the preventive effects of Moringa isothiocyanate in mouse epidermal JB6 cells induced by the tumor promoter TPA.

Wang C, Wu R, Sargsyan D, Zheng M, Li S, Yin R, Su S, Raskin I, Kong AN.

J Nutr Biochem. 2019 Jun;68:69-78. doi: 10.1016/j.jnutbio.2019.03.011. Epub 2019 Mar 28.


A dietary isothiocyanate-enriched moringa (Moringa oleifera) seed extract improves glucose tolerance in a high-fat-diet mouse model and modulates the gut microbiome.

Jaja-Chimedza A, Zhang L, Wolff K, Graf BL, Kuhn P, Moskal K, Carmouche R, Newman S, Salbaum JM, Raskin I.

J Funct Foods. 2018 Aug;47:376-385. doi: 10.1016/j.jff.2018.05.056. Epub 2018 Jun 9.


Distinct Fractions of an Artemisia scoparia Extract Contain Compounds With Novel Adipogenic Bioactivity.

Boudreau A, Poulev A, Ribnicky DM, Raskin I, Rathinasabapathy T, Richard AJ, Stephens JM.

Front Nutr. 2019 Mar 8;6:18. doi: 10.3389/fnut.2019.00018. eCollection 2019.


Genetic and Phytochemical Characterization of Lettuce Flavonoid Biosynthesis Mutants.

Gurdon C, Poulev A, Armas I, Satorov S, Tsai M, Raskin I.

Sci Rep. 2019 Mar 1;9(1):3305. doi: 10.1038/s41598-019-39287-y.


Tricin levels and expression of flavonoid biosynthetic genes in developing grains of purple and brown pericarp rice.

Poulev A, Heckman JR, Raskin I, Belanger FC.

PeerJ. 2019 Feb 18;7:e6477. doi: 10.7717/peerj.6477. eCollection 2019.


Moringa Isothiocyanate Activates Nrf2: Potential Role in Diabetic Nephropathy.

Cheng D, Gao L, Su S, Sargsyan D, Wu R, Raskin I, Kong AN.

AAPS J. 2019 Feb 19;21(2):31. doi: 10.1208/s12248-019-0301-6.


Physicochemical differences between malanga (Xanthosoma sagittifolium) and potato (Solanum tuberosum) tubers are associated with differential effects on the gut microbiome.

Graf BL, Zhang L, Corradini MG, Kuhn P, Newman SS, Salbaum JM, Raskin I.

J Funct Foods. 2018 Jun;45:268-276. doi: 10.1016/j.jff.2018.04.032. Epub 2018 Apr 21.


Grape polyphenols reduce gut-localized reactive oxygen species associated with the development of metabolic syndrome in mice.

Kuhn P, Kalariya HM, Poulev A, Ribnicky DM, Jaja-Chimedza A, Roopchand DE, Raskin I.

PLoS One. 2018 Oct 11;13(10):e0198716. doi: 10.1371/journal.pone.0198716. eCollection 2018.


Rapid, field-deployable method for collecting and preserving plant metabolome for biochemical and functional characterization.

Skubel SA, Dushenkov V, Graf BL, Niu Q, Poulev A, Kalariya HM, Foxcroft LC, Raskin I.

PLoS One. 2018 Sep 6;13(9):e0203569. doi: 10.1371/journal.pone.0203569. eCollection 2018.


A 14-day repeated-dose oral toxicological evaluation of an isothiocyanate-enriched hydro-alcoholic extract from Moringa oleifera Lam. seeds in rats.

Kim Y, Jaja-Chimedza A, Merrill D, Mendes O, Raskin I.

Toxicol Rep. 2018 Mar 6;5:418-426. doi: 10.1016/j.toxrep.2018.02.012. eCollection 2018.


Grape proanthocyanidin-induced intestinal bloom of Akkermansia muciniphila is dependent on its baseline abundance and precedes activation of host genes related to metabolic health.

Zhang L, Carmody RN, Kalariya HM, Duran RM, Moskal K, Poulev A, Kuhn P, Tveter KM, Turnbaugh PJ, Raskin I, Roopchand DE.

J Nutr Biochem. 2018 Jun;56:142-151. doi: 10.1016/j.jnutbio.2018.02.009. Epub 2018 Feb 15.


Bioactive polyphenols in kinkéliba tea (Combretum micranthum) and their glucose-lowering activities.

Welch C, Zhen J, Bassène E, Raskin I, Simon JE, Wu Q.

J Food Drug Anal. 2018 Apr;26(2):487-496. doi: 10.1016/j.jfda.2017.05.009. Epub 2017 Jun 13.


An Extract of Russian Tarragon Prevents Obesity-Related Ectopic Lipid Accumulation.

Yu Y, Mendoza TM, Ribnicky DM, Poulev A, Noland RC, Mynatt RL, Raskin I, Cefalu WT, Floyd ZE.

Mol Nutr Food Res. 2018 Apr;62(8):e1700856. doi: 10.1002/mnfr.201700856. Epub 2018 Apr 3.


Isothiocyanate-enriched moringa seed extract alleviates ulcerative colitis symptoms in mice.

Kim Y, Wu AG, Jaja-Chimedza A, Graf BL, Waterman C, Verzi MP, Raskin I.

PLoS One. 2017 Sep 18;12(9):e0184709. doi: 10.1371/journal.pone.0184709. eCollection 2017.


Biochemical characterization and anti-inflammatory properties of an isothiocyanate-enriched moringa (Moringa oleifera) seed extract.

Jaja-Chimedza A, Graf BL, Simmler C, Kim Y, Kuhn P, Pauli GF, Raskin I.

PLoS One. 2017 Aug 8;12(8):e0182658. doi: 10.1371/journal.pone.0182658. eCollection 2017.


A rapid and efficient in vitro regeneration system for lettuce (Lactuca sativa L.).

Armas I, Pogrebnyak N, Raskin I.

Plant Methods. 2017 Jul 21;13:58. doi: 10.1186/s13007-017-0208-0. eCollection 2017.


High phenolics Rutgers Scarlet Lettuce improves glucose metabolism in high fat diet-induced obese mice.

Cheng DM, Roopchand DE, Poulev A, Kuhn P, Armas I, Johnson WD, Oren A, Ribnicky D, Zelzion E, Bhattacharya D, Raskin I.

Mol Nutr Food Res. 2016 Nov;60(11):2367-2378. doi: 10.1002/mnfr.201600290. Epub 2016 Aug 16.


Innovations in Health Value and Functional Food Development of Quinoa (Chenopodium quinoa Willd.).

Graf BL, Rojas-Silva P, Rojo LE, Delatorre-Herrera J, Baldeón ME, Raskin I.

Compr Rev Food Sci Food Saf. 2015 Jul;14(4):431-445. Epub 2015 Apr 10.


Evaluating the effect of 20-hydroxyecdysone (20HE) on mechanistic target of rapamycin complex 1 (mTORC1) signaling in the skeletal muscle and liver of rats.

Anthony TG, Mirek ET, Bargoud AR, Phillipson-Weiner L, DeOliveira CM, Wetstein B, Graf BL, Kuhn PE, Raskin I.

Appl Physiol Nutr Metab. 2015 Dec;40(12):1324-8. doi: 10.1139/apnm-2015-0301. Epub 2015 Sep 17.


Novel value-added uses for sweet potato juice and flour in polyphenol- and protein-enriched functional food ingredients.

Grace MH, Truong AN, Truong VD, Raskin I, Lila MA.

Food Sci Nutr. 2015 Sep;3(5):415-24. doi: 10.1002/fsn3.234. Epub 2015 Apr 9.


Dietary Polyphenols Promote Growth of the Gut Bacterium Akkermansia muciniphila and Attenuate High-Fat Diet-Induced Metabolic Syndrome.

Roopchand DE, Carmody RN, Kuhn P, Moskal K, Rojas-Silva P, Turnbaugh PJ, Raskin I.

Diabetes. 2015 Aug;64(8):2847-58. doi: 10.2337/db14-1916. Epub 2015 Apr 6.


Phytoecdysteroids and flavonoid glycosides among Chilean and commercial sources of Chenopodium quinoa: variation and correlation to physico-chemical characteristics.

Graf BL, Rojo LE, Delatorre-Herrera J, Poulev A, Calfio C, Raskin I.

J Sci Food Agric. 2016 Jan 30;96(2):633-43. doi: 10.1002/jsfa.7134. Epub 2015 Mar 19.


Isothiocyanate-rich Moringa oleifera extract reduces weight gain, insulin resistance, and hepatic gluconeogenesis in mice.

Waterman C, Rojas-Silva P, Tumer TB, Kuhn P, Richard AJ, Wicks S, Stephens JM, Wang Z, Mynatt R, Cefalu W, Raskin I.

Mol Nutr Food Res. 2015 Jun;59(6):1013-24. doi: 10.1002/mnfr.201400679. Epub 2015 Apr 27.


Direct and indirect antioxidant activity of polyphenol- and isothiocyanate-enriched fractions from Moringa oleifera.

Tumer TB, Rojas-Silva P, Poulev A, Raskin I, Waterman C.

J Agric Food Chem. 2015 Feb 11;63(5):1505-13. doi: 10.1021/jf505014n. Epub 2015 Jan 29.


Novel strategies for capturing health-protective mango phytochemicals in shelf stable food matrices.

Guzman I, Grace MH, Yousef GG, Raskin I, Lila MA.

Int J Food Sci Nutr. 2015 Mar;66(2):175-85. doi: 10.3109/09637486.2014.979315. Epub 2014 Dec 18.


Compounds leached from quinoa seeds inhibit matrix metalloproteinase activity and intracellular reactive oxygen species.

Graf BL, Cheng DM, Esposito D, Shertel T, Poulev A, Plundrich N, Itenberg D, Dayan N, Lila MA, Raskin I.

Int J Cosmet Sci. 2015 Apr;37(2):212-21. doi: 10.1111/ics.12185. Epub 2015 Jan 14.


Bioactive capacity, sensory properties, and nutritional analysis of a shelf stable protein-rich functional ingredient with concentrated fruit and vegetable phytoactives.

Grace MH, Yousef GG, Esposito D, Raskin I, Lila MA.

Plant Foods Hum Nutr. 2014 Dec;69(4):372-8. doi: 10.1007/s11130-014-0444-7.


Concentrating immunoprotective phytoactive compounds from fruits and vegetables into shelf-stable protein-rich ingredients.

Yousef GG, Grace MH, Medina JL, Neff S, Guzman I, Brown AF, Raskin I, Lila MA.

Plant Foods Hum Nutr. 2014 Dec;69(4):317-24. doi: 10.1007/s11130-014-0445-6.


Anti-inflammatory activity of grains of paradise (Aframomum melegueta Schum) extract.

Ilic NM, Dey M, Poulev AA, Logendra S, Kuhn PE, Raskin I.

J Agric Food Chem. 2014 Oct 29;62(43):10452-7. doi: 10.1021/jf5026086. Epub 2014 Oct 20.


Bioactives of Artemisia dracunculus L. enhance insulin sensitivity by modulation of ceramide metabolism in rat skeletal muscle cells.

Obanda DN, Ribnicky DM, Raskin I, Cefalu WT.

Nutrition. 2014 Jul-Aug;30(7-8 Suppl):S59-66. doi: 10.1016/j.nut.2014.03.006. Epub 2014 Mar 19.


Polyphenol-rich Rutgers Scarlet Lettuce improves glucose metabolism and liver lipid accumulation in diet-induced obese C57BL/6 mice.

Cheng DM, Pogrebnyak N, Kuhn P, Poulev A, Waterman C, Rojas-Silva P, Johnson WD, Raskin I.

Nutrition. 2014 Jul-Aug;30(7-8 Suppl):S52-8. doi: 10.1016/j.nut.2014.02.022. Epub 2014 Mar 12.


Artemisia dracunculus L. polyphenols complexed to soy protein show enhanced bioavailability and hypoglycemic activity in C57BL/6 mice.

Ribnicky DM, Roopchand DE, Poulev A, Kuhn P, Oren A, Cefalu WT, Raskin I.

Nutrition. 2014 Jul-Aug;30(7-8 Suppl):S4-10. doi: 10.1016/j.nut.2014.03.009. Epub 2014 Mar 28.


Quinoa seeds leach phytoecdysteroids and other compounds with anti-diabetic properties.

Graf BL, Poulev A, Kuhn P, Grace MH, Lila MA, Raskin I.

Food Chem. 2014 Nov 15;163:178-85. doi: 10.1016/j.foodchem.2014.04.088. Epub 2014 May 4.


Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro.

Waterman C, Cheng DM, Rojas-Silva P, Poulev A, Dreifus J, Lila MA, Raskin I.

Phytochemistry. 2014 Jul;103:114-122. doi: 10.1016/j.phytochem.2014.03.028. Epub 2014 Apr 11.


Development and phytochemical characterization of high polyphenol red lettuce with anti-diabetic properties.

Cheng DM, Pogrebnyak N, Kuhn P, Krueger CG, Johnson WD, Raskin I.

PLoS One. 2014 Mar 17;9(3):e91571. doi: 10.1371/journal.pone.0091571. eCollection 2014.


Concord grape pomace polyphenols complexed to soy protein isolate are stable and hypoglycemic in diabetic mice.

Roopchand DE, Kuhn P, Krueger CG, Moskal K, Lila MA, Raskin I.

J Agric Food Chem. 2013 Nov 27;61(47):11428-33. doi: 10.1021/jf403238e. Epub 2013 Nov 15.


Leishmanicidal activity of a daucane sesquiterpene isolated from Eryngium foetidum.

Rojas-Silva P, Graziose R, Vesely B, Poulev A, Mbeunkui F, Grace MH, Kyle DE, Lila MA, Raskin I.

Pharm Biol. 2014 Mar;52(3):398-401. doi: 10.3109/13880209.2013.837077. Epub 2013 Oct 23.


Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1).

Ribnicky DM, Roopchand DE, Oren A, Grace M, Poulev A, Lila MA, Havenaar R, Raskin I.

Food Chem. 2014 Jan 1;142:349-57. doi: 10.1016/j.foodchem.2013.07.073. Epub 2013 Jul 25.


Food-compatible method for the efficient extraction and stabilization of cranberry pomace polyphenols.

Roopchand DE, Krueger CG, Moskal K, Fridlender B, Lila MA, Raskin I.

Food Chem. 2013 Dec 15;141(4):3664-9. doi: 10.1016/j.foodchem.2013.06.050. Epub 2013 Jun 21.


Acceleration of cutaneous wound healing by brassinosteroids.

Esposito D, Rathinasabapathy T, Schmidt B, Shakarjian MP, Komarnytsky S, Raskin I.

Wound Repair Regen. 2013 Sep-Oct;21(5):688-96. doi: 10.1111/wrr.12075. Epub 2013 Aug 12.


Stable binding of alternative protein-enriched food matrices with concentrated cranberry bioflavonoids for functional food applications.

Grace MH, Guzman I, Roopchand DE, Moskal K, Cheng DM, Pogrebnyak N, Raskin I, Howell A, Lila MA.

J Agric Food Chem. 2013 Jul 17;61(28):6856-64. doi: 10.1021/jf401627m. Epub 2013 Jul 1.


Artemisia scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 pathway.

Wang ZQ, Zhang XH, Yu Y, Tipton RC, Raskin I, Ribnicky D, Johnson W, Cefalu WT.

Metabolism. 2013 Sep;62(9):1239-49. doi: 10.1016/j.metabol.2013.03.004. Epub 2013 May 21.


Bioactive polyphenols from muscadine grape and blackcurrant stably concentrated onto protein-rich matrices for topical applications.

Plundrich N, Grace MH, Raskin I, Ann Lila M.

Int J Cosmet Sci. 2013 Aug;35(4):394-401. doi: 10.1111/ics.12057. Epub 2013 Jun 6.


Effects of pregnane glycosides on food intake depend on stimulation of the melanocortin pathway and BDNF in an animal model.

Komarnytsky S, Esposito D, Rathinasabapathy T, Poulev A, Raskin I.

J Agric Food Chem. 2013 Feb 27;61(8):1841-9. doi: 10.1021/jf3033649. Epub 2013 Feb 17.


Antiplasmodial activity of cucurbitacin glycosides from Datisca glomerata (C. Presl) Baill.

Graziose R, Grace MH, Rathinasabapathy T, Rojas-Silva P, Dekock C, Poulev A, Lila MA, Smith P, Raskin I.

Phytochemistry. 2013 Mar;87:78-85. doi: 10.1016/j.phytochem.2012.11.025. Epub 2012 Dec 25.


Blueberry polyphenol-enriched soybean flour reduces hyperglycemia, body weight gain and serum cholesterol in mice.

Roopchand DE, Kuhn P, Rojo LE, Lila MA, Raskin I.

Pharmacol Res. 2013 Feb;68(1):59-67. doi: 10.1016/j.phrs.2012.11.008. Epub 2012 Dec 4.


Antiplasmodial activity of the ethnobotanical plant Cassia fistula.

Grace MH, Lategan C, Graziose R, Smith PJ, Raskin I, Lila MA.

Nat Prod Commun. 2012 Oct;7(10):1263-6.


Pregnane glycosides interfere with steroidogenic enzymes to down-regulate corticosteroid production in human adrenocortical H295R cells.

Komarnytsky S, Esposito D, Poulev A, Raskin I.

J Cell Physiol. 2013 May;228(5):1120-6. doi: 10.1002/jcp.24262.

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