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Items: 40

1.

Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema.

Johansson Å, Rask-Andersen M, Karlsson T, Ek WE.

Hum Mol Genet. 2019 Jul 30. pii: ddz175. doi: 10.1093/hmg/ddz175. [Epub ahead of print]

PMID:
31361310
2.

Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects.

Rask-Andersen M, Karlsson T, Ek WE, Johansson Å.

Nat Commun. 2019 Jan 21;10(1):339. doi: 10.1038/s41467-018-08000-4.

3.

Orphan Drugs and Their Impact on Pharmaceutical Development: (Trends in Pharmacological Sciences 39, 525-535, 2018).

Attwood MM, Rask-Andersen M, Schiöth HB.

Trends Pharmacol Sci. 2018 Dec;39(12):1077. doi: 10.1016/j.tips.2018.09.007. Epub 2018 Oct 13. No abstract available.

PMID:
30327127
4.

Orphan Drugs and Their Impact on Pharmaceutical Development.

Attwood MM, Rask-Andersen M, Schiöth HB.

Trends Pharmacol Sci. 2018 Jun;39(6):525-535. doi: 10.1016/j.tips.2018.03.003. Review. Erratum in: Trends Pharmacol Sci. 2018 Dec;39(12):1077.

PMID:
29779531
5.

Genetic variants influencing phenotypic variance heterogeneity.

Ek WE, Rask-Andersen M, Karlsson T, Enroth S, Gyllensten U, Johansson Å.

Hum Mol Genet. 2018 Mar 1;27(5):799-810. doi: 10.1093/hmg/ddx441.

PMID:
29325024
6.

Breast-feeding and risk of asthma, hay fever, and eczema.

Ek WE, Karlsson T, Hernándes CA, Rask-Andersen M, Johansson Å.

J Allergy Clin Immunol. 2018 Mar;141(3):1157-1159.e9. doi: 10.1016/j.jaci.2017.10.022. Epub 2017 Nov 10. No abstract available.

PMID:
29132959
7.

Trends in GPCR drug discovery: new agents, targets and indications.

Hauser AS, Attwood MM, Rask-Andersen M, Schiöth HB, Gloriam DE.

Nat Rev Drug Discov. 2017 Dec;16(12):829-842. doi: 10.1038/nrd.2017.178. Epub 2017 Oct 27. Review.

PMID:
29075003
8.

The relative contribution of DNA methylation and genetic variants on protein biomarkers for human diseases.

Ahsan M, Ek WE, Rask-Andersen M, Karlsson T, Lind-Thomsen A, Enroth S, Gyllensten U, Johansson Å.

PLoS Genet. 2017 Sep 15;13(9):e1007005. doi: 10.1371/journal.pgen.1007005. eCollection 2017 Sep.

9.

Gene-environment interaction study for BMI reveals interactions between genetic factors and physical activity, alcohol consumption and socioeconomic status.

Rask-Andersen M, Karlsson T, Ek WE, Johansson Å.

PLoS Genet. 2017 Sep 5;13(9):e1006977. doi: 10.1371/journal.pgen.1006977. eCollection 2017 Sep.

10.

Tea and coffee consumption in relation to DNA methylation in four European cohorts.

Ek WE, Tobi EW, Ahsan M, Lampa E, Ponzi E, Kyrtopoulos SA, Georgiadis P, Lumey LH, Heijmans BT, Botsivali M, Bergdahl IA, Karlsson T, Rask-Andersen M, Palli D, Ingelsson E, Hedman ÅK, Nilsson LM, Vineis P, Lind L, Flanagan JM, Johansson Å; Epigenome-Wide Association Study Consortium.

Hum Mol Genet. 2017 Aug 15;26(16):3221-3231. doi: 10.1093/hmg/ddx194.

11.

Epigenome-wide DNA methylation study of IgE concentration in relation to self-reported allergies.

Ek WE, Ahsan M, Rask-Andersen M, Liang L, Moffatt MF, Gyllensten U, Johansson Å.

Epigenomics. 2017 Apr;9(4):407-418. doi: 10.2217/epi-2016-0158. Epub 2017 Mar 21.

PMID:
28322575
12.

A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels.

Wiemerslage L, Islam R, van der Kamp C, Cao H, Olivo G, Ence-Eriksson F, Castillo S, Larsen AL, Bandstein M, Dahlberg LS, Perland E, Gustavsson V, Nilsson J, Vogel H, Schürmann A, Larsson EM, Rask-Andersen M, Benedict C, Schiöth HB.

Int J Obes (Lond). 2017 Jun;41(6):990-994. doi: 10.1038/ijo.2017.43. Epub 2017 Feb 14.

PMID:
28194012
13.

Epigenome-wide association study reveals differential DNA methylation in individuals with a history of myocardial infarction.

Rask-Andersen M, Martinsson D, Ahsan M, Enroth S, Ek WE, Gyllensten U, Johansson Å.

Hum Mol Genet. 2016 Nov 1;25(21):4739-4748. doi: 10.1093/hmg/ddw302.

PMID:
28172975
14.

Adolescents newly diagnosed with eating disorders have structural differences in brain regions linked with eating disorder symptoms.

Solstrand Dahlberg L, Wiemerslage L, Swenne I, Larsen A, Stark J, Rask-Andersen M, Salonen-Ros H, Larsson EM, Schiöth HB, Brooks SJ.

Nord J Psychiatry. 2017 Apr;71(3):188-196. doi: 10.1080/08039488.2016.1250948. Epub 2016 Nov 15.

PMID:
27844498
15.

Postprandial alterations in whole-blood DNA methylation are mediated by changes in white blood cell composition.

Rask-Andersen M, Bringeland N, Nilsson EK, Bandstein M, Olaya Búcaro M, Vogel H, Schürmann A, Hogenkamp PS, Benedict C, Schiöth HB.

Am J Clin Nutr. 2016 Aug;104(2):518-25. doi: 10.3945/ajcn.115.122366. Epub 2016 Jul 6.

PMID:
27385611
16.

Reduced vasopressin receptors activation mediates the anti-depressant effects of fluoxetine and venlafaxine in bulbectomy model of depression.

Poretti MB, Sawant RS, Rask-Andersen M, de Cuneo MF, Schiöth HB, Perez MF, Carlini VP.

Psychopharmacology (Berl). 2016 Mar;233(6):1077-86. doi: 10.1007/s00213-015-4187-4. Epub 2015 Dec 23.

PMID:
26700241
17.

The role of DNA methylation in the pathogenesis of disease: what can epigenome-wide association studies tell?

Ek WE, Rask-Andersen M, Johansson Å.

Epigenomics. 2016 Jan;8(1):5-7. doi: 10.2217/epi.15.99. Epub 2015 Dec 23. No abstract available.

PMID:
26698830
18.

Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers.

Voisin S, Almén MS, Zheleznyakova GY, Lundberg L, Zarei S, Castillo S, Eriksson FE, Nilsson EK, Blüher M, Böttcher Y, Kovacs P, Klovins J, Rask-Andersen M, Schiöth HB.

Genome Med. 2015 Oct 8;7:103. doi: 10.1186/s13073-015-0225-4.

19.

Determination of obesity associated gene variants related to TMEM18 through ultra-deep targeted re-sequencing in a case-control cohort for pediatric obesity.

Rask-Andersen M, Sällman Almén M, Jacobsson JA, Ameur A, Moschonis G, Dedoussis G, Marcus C, Gyllensten U, Fredriksson R, Schiöth HB.

Genet Res (Camb). 2015 Sep 14;97:e16. doi: 10.1017/S0016672315000117.

PMID:
26365393
20.

Scrutinizing the FTO locus: compelling evidence for a complex, long-range regulatory context.

Rask-Andersen M, Almén MS, Schiöth HB.

Hum Genet. 2015 Nov;134(11-12):1183-93. doi: 10.1007/s00439-015-1599-5. Epub 2015 Sep 4.

PMID:
26340902
21.

Association of the LINGO2-related SNP rs10968576 with body mass in a cohort of elderly Swedes.

Rask-Andersen M, Almén MS, Lind L, Schiöth HB.

Mol Genet Genomics. 2015 Aug;290(4):1485-91. doi: 10.1007/s00438-015-1009-7. Epub 2015 Feb 25.

PMID:
25711307
22.

Obsessive-compulsivity and working memory are associated with differential prefrontal cortex and insula activation in adolescents with a recent diagnosis of an eating disorder.

Brooks SJ, Solstrand Dahlberg L, Swenne I, Aronsson M, Zarei S, Lundberg L, Jacobsson JA, Rask-Andersen M, Salonen-Ros H, Rosling A, Larsson EM, Schiöth HB.

Psychiatry Res. 2014 Dec 30;224(3):246-53. doi: 10.1016/j.pscychresns.2014.10.001. Epub 2014 Oct 13.

PMID:
25456522
23.

Advances in kinase targeting: current clinical use and clinical trials.

Rask-Andersen M, Zhang J, Fabbro D, Schiöth HB.

Trends Pharmacol Sci. 2014 Nov;35(11):604-20. doi: 10.1016/j.tips.2014.09.007. Epub 2014 Oct 10. Review.

PMID:
25312588
24.

Ghrelin effects expression of several genes associated with depression-like behavior.

Poretti MB, Rask-Andersen M, Kumar P, Rubiales de Barioglio S, Fiol de Cuneo M, Schiöth HB, Carlini VP.

Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jan 2;56:227-34. doi: 10.1016/j.pnpbp.2014.09.012. Epub 2014 Oct 5.

PMID:
25286107
25.

CDKAL1-related single nucleotide polymorphisms are associated with insulin resistance in a cross-sectional cohort of Greek children.

Rask-Andersen M, Philippot G, Moschonis G, Dedoussis G, Manios Y, Marcus C, Fredriksson R, Schiöth HB.

PLoS One. 2014 Apr 2;9(4):e93193. doi: 10.1371/journal.pone.0093193. eCollection 2014.

26.

Exposure to a high-fat high-sugar diet causes strong up-regulation of proopiomelanocortin and differentially affects dopamine D1 and D2 receptor gene expression in the brainstem of rats.

Alsiö J, Rask-Andersen M, Chavan RA, Olszewski PK, Levine AS, Fredriksson R, Schiöth HB.

Neurosci Lett. 2014 Jan 24;559:18-23. doi: 10.1016/j.neulet.2013.11.008. Epub 2013 Nov 19.

PMID:
24262750
27.

Insulin receptor-like ectodomain genes and splice variants are found in both arthropods and human brain cDNA.

Västermark Å, Rask-Andersen M, Sawant RS, Reiter JL, Schiöth HB, Williams MJ.

J Syst Evol. 2013 Nov;51(6):664-670. Epub 2013 Sep 2.

28.

The druggable genome: Evaluation of drug targets in clinical trials suggests major shifts in molecular class and indication.

Rask-Andersen M, Masuram S, Schiöth HB.

Annu Rev Pharmacol Toxicol. 2014;54:9-26. doi: 10.1146/annurev-pharmtox-011613-135943. Epub 2013 Aug 30. Review.

PMID:
24016212
29.

The STK33-linked SNP rs4929949 is associated with obesity and BMI in two independent cohorts of Swedish and Greek children.

Rask-Andersen M, Moschonis G, Chrousos GP, Marcus C, Dedoussis GV, Fredriksson R, Schiöth HB.

PLoS One. 2013 Aug 15;8(8):e71353. doi: 10.1371/journal.pone.0071353. eCollection 2013.

30.

Solute carriers as drug targets: current use, clinical trials and prospective.

Rask-Andersen M, Masuram S, Fredriksson R, Schiöth HB.

Mol Aspects Med. 2013 Apr-Jun;34(2-3):702-10. doi: 10.1016/j.mam.2012.07.015. Review.

PMID:
23506903
31.

A debate on current eating disorder diagnoses in light of neurobiological findings: is it time for a spectrum model?

Brooks SJ, Rask-Andersen M, Benedict C, Schiöth HB.

BMC Psychiatry. 2012 Jul 6;12:76. doi: 10.1186/1471-244X-12-76.

32.

The MAP2K5-linked SNP rs2241423 is associated with BMI and obesity in two cohorts of Swedish and Greek children.

Rask-Andersen M, Jacobsson JA, Moschonis G, Ek AE, Chrousos GP, Marcus C, Manios Y, Fredriksson R, Schiöth HB.

BMC Med Genet. 2012 May 17;13:36.

33.

Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted sequencing in obese and lean children.

Sällman Almén M, Rask-Andersen M, Jacobsson JA, Ameur A, Kalnina I, Moschonis G, Juhlin S, Bringeland N, Hedberg LA, Ignatovica V, Chrousos GP, Manios Y, Klovins J, Marcus C, Gyllensten U, Fredriksson R, Schiöth HB.

Int J Obes (Lond). 2013 Mar;37(3):424-31. doi: 10.1038/ijo.2012.57. Epub 2012 Apr 24.

34.

Differential effects of fluoxetine and venlafaxine on memory recognition: possible mechanisms of action.

Carlini VP, Poretti MB, Rask-Andersen M, Chavan RA, Ponzio MF, Sawant RS, de Barioglio SR, Schiöth HB, de Cuneo MF.

Prog Neuropsychopharmacol Biol Psychiatry. 2012 Aug 7;38(2):159-67. doi: 10.1016/j.pnpbp.2012.03.004. Epub 2012 Mar 15.

PMID:
22449479
35.

Functional coupling analysis suggests link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway.

Rask-Andersen M, Almén MS, Olausen HR, Olszewski PK, Eriksson J, Chavan RA, Levine AS, Fredriksson R, Schiöth HB.

BMC Neurosci. 2011 Nov 16;12:117. doi: 10.1186/1471-2202-12-117.

36.

Association of TMEM18 variants with BMI and waist circumference in children and correlation of mRNA expression in the PFC with body weight in rats.

Rask-Andersen M, Jacobsson JA, Moschonis G, Chavan RA, Sikder MA, Allzén E, Alsiö J, Chrousos GP, Manios Y, Fredriksson R, Schiöth HB.

Eur J Hum Genet. 2012 Feb;20(2):192-7. doi: 10.1038/ejhg.2011.176. Epub 2011 Sep 28.

37.

Trends in the exploitation of novel drug targets.

Rask-Andersen M, Almén MS, Schiöth HB.

Nat Rev Drug Discov. 2011 Aug 1;10(8):579-90. doi: 10.1038/nrd3478. Review.

PMID:
21804595
38.

Genetic and expression studies of SMN2 gene in Russian patients with spinal muscular atrophy type II and III.

Zheleznyakova GY, Kiselev AV, Vakharlovsky VG, Rask-Andersen M, Chavan R, Egorova AA, Schiöth HB, Baranov VS.

BMC Med Genet. 2011 Jul 15;12:96. doi: 10.1186/1471-2350-12-96.

39.

Genetic variants near the MGAT1 gene are associated with body weight, BMI and fatty acid metabolism among adults and children.

Jacobsson JA, Rask-Andersen M, Risérus U, Moschonis G, Koumpitski A, Chrousos GP, Lannfelt L, Marcus C, Gyllensten U, Schiöth HB, Fredriksson R.

Int J Obes (Lond). 2012 Jan;36(1):119-29. doi: 10.1038/ijo.2011.11. Epub 2011 Feb 8.

40.

Molecular mechanisms underlying anorexia nervosa: focus on human gene association studies and systems controlling food intake.

Rask-Andersen M, Olszewski PK, Levine AS, Schiöth HB.

Brain Res Rev. 2010 Mar;62(2):147-64. doi: 10.1016/j.brainresrev.2009.10.007. Epub 2009 Nov 18. Review.

PMID:
19931559

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