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Antimicrob Agents Chemother. 2002 Apr;46(4):1125-7.

Comparison of oral artesunate and dihydroartemisinin antimalarial bioavailabilities in acute falciparum malaria.

Author information

1
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Abstract

Plasma antimalarial activity following oral artesunate or dihydroartemisinin (DHA) treatment was measured by a bioassay in 18 patients with uncomplicated falciparum malaria. The mean antimalarial activity in terms of the bioavailability of DHA relative to that of artesunate did not differ significantly from 1, suggesting that DHA can be formulated to be an acceptable oral alternative to artesunate.

PMID:
11897605
PMCID:
PMC127101
DOI:
10.1128/aac.46.4.1125-1127.2002
[Indexed for MEDLINE]
Free PMC Article

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