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Items: 48

1.

Histoplasma Responses to Nutritional Immunity Imposed by Macrophage Activation.

Brechting PJ, Rappleye CA.

J Fungi (Basel). 2019 Jun 5;5(2). pii: E45. doi: 10.3390/jof5020045. Review.

2.

Macrophage activation by IFN-γ triggers restriction of phagosomal copper from intracellular pathogens.

Shen Q, Beucler MJ, Ray SC, Rappleye CA.

PLoS Pathog. 2018 Nov 19;14(11):e1007444. doi: 10.1371/journal.ppat.1007444. eCollection 2018 Nov.

3.

Characterization of the APSES-family transcriptional regulators of Histoplasma capsulatum.

Longo LVG, Ray SC, Puccia R, Rappleye CA.

FEMS Yeast Res. 2018 Dec 1;18(8). doi: 10.1093/femsyr/foy087.

PMID:
30101348
4.

Synthesis and biological evaluation of aminothiazoles against Histoplasma capsulatum and Cryptococcus neoformans.

Ishita K, Stefanopoulos S, Khalil A, Cheng X, Tjarks W, Rappleye CA.

Bioorg Med Chem. 2018 May 15;26(9):2251-2261. doi: 10.1016/j.bmc.2018.01.024. Epub 2018 Feb 2.

5.

Flying under the radar: Histoplasma capsulatum avoidance of innate immune recognition.

Ray SC, Rappleye CA.

Semin Cell Dev Biol. 2019 May;89:91-98. doi: 10.1016/j.semcdb.2018.03.009. Epub 2018 Mar 21. Review.

PMID:
29551572
6.

O-Mannosylation of Proteins Enables Histoplasma Yeast Survival at Mammalian Body Temperatures.

Garfoot AL, Goughenour KD, Wüthrich M, Rajaram MVS, Schlesinger LS, Klein BS, Rappleye CA.

MBio. 2018 Jan 2;9(1). pii: e02121-17. doi: 10.1128/mBio.02121-17.

7.

Differentiation of the fungus Histoplasma capsulatum into a pathogen of phagocytes.

Shen Q, Rappleye CA.

Curr Opin Microbiol. 2017 Dec;40:1-7. doi: 10.1016/j.mib.2017.10.003. Epub 2017 Oct 27. Review.

8.

Trans-ungual Delivery of AR-12, a Novel Antifungal Drug.

Kushwaha AS, Sharma P, Shivakumar HN, Rappleye C, Zukiwski A, Proniuk S, Murthy SN.

AAPS PharmSciTech. 2017 Oct;18(7):2702-2705. doi: 10.1208/s12249-017-0752-y. Epub 2017 Mar 13.

PMID:
28289970
9.

Eng1 and Exg8 Are the Major β-Glucanases Secreted by the Fungal Pathogen Histoplasma capsulatum.

Garfoot AL, Dearing KL, VanSchoiack AD, Wysocki VH, Rappleye CA.

J Biol Chem. 2017 Mar 24;292(12):4801-4810. doi: 10.1074/jbc.M116.762104. Epub 2017 Feb 2.

10.

Antifungal therapeutics for dimorphic fungal pathogens.

Goughenour KD, Rappleye CA.

Virulence. 2017 Feb 17;8(2):211-221. doi: 10.1080/21505594.2016.1235653. Epub 2016 Sep 19.

11.

Targeting CBLB as a potential therapeutic approach for disseminated candidiasis.

Xiao Y, Tang J, Guo H, Zhao Y, Tang R, Ouyang S, Zeng Q, Rappleye CA, Rajaram MV, Schlesinger LS, Tao L, Brown GD, Langdon WY, Li BT, Zhang J.

Nat Med. 2016 Aug;22(8):906-14. doi: 10.1038/nm.4141. Epub 2016 Jul 18.

12.

The Eng1 β-Glucanase Enhances Histoplasma Virulence by Reducing β-Glucan Exposure.

Garfoot AL, Shen Q, Wüthrich M, Klein BS, Rappleye CA.

MBio. 2016 Apr 19;7(2):e01388-15. doi: 10.1128/mBio.01388-15.

13.

Sutureless Microsurgical Anastomosis Using an Optimized Thermoreversible Intravascular Poloxamer Stent.

Davis CR, Rappleye CT, Than PA, Rodrigues M, Findlay MW, Bishop SN, Whitmore AJ, Maan ZN, McGoldrick RB, Grobbelaar AO, Gurtner GC.

Plast Reconstr Surg. 2016 Feb;137(2):546-56. doi: 10.1097/01.prs.0000475774.37267.3f.

PMID:
26818289
14.

Quantitative Microplate-Based Growth Assay for Determination of Antifungal Susceptibility of Histoplasma capsulatum Yeasts.

Goughenour KD, Balada-Llasat JM, Rappleye CA.

J Clin Microbiol. 2015 Oct;53(10):3286-95. doi: 10.1128/JCM.00795-15. Epub 2015 Aug 5.

15.

Histoplasma capsulatum surmounts obstacles to intracellular pathogenesis.

Garfoot AL, Rappleye CA.

FEBS J. 2016 Feb;283(4):619-33. doi: 10.1111/febs.13389. Epub 2015 Nov 25. Review.

16.

Design, synthesis, and biological evaluation of aminothiazole derivatives against the fungal pathogens Histoplasma capsulatum and Cryptococcus neoformans.

Khalil A, Edwards JA, Rappleye CA, Tjarks W.

Bioorg Med Chem. 2015 Feb 1;23(3):532-47. doi: 10.1016/j.bmc.2014.12.006. Epub 2014 Dec 10.

17.

Transgenic expression of CXCR3 on T cells enhances susceptibility to cutaneous Leishmania major infection by inhibiting monocyte maturation and promoting a Th2 response.

Oghumu S, Stock JC, Varikuti S, Dong R, Terrazas C, Edwards JA, Rappleye CA, Holovatyk A, Sharpe A, Satoskar AR.

Infect Immun. 2015 Jan;83(1):67-76. doi: 10.1128/IAI.02540-14. Epub 2014 Oct 13.

18.

Glycosylation and immunoreactivity of the Histoplasma capsulatum Cfp4 yeast-phase exoantigen.

Holbrook ED, Kemski MM, Richer SM, Wheat LJ, Rappleye CA.

Infect Immun. 2014 Oct;82(10):4414-25. doi: 10.1128/IAI.01893-14. Epub 2014 Aug 11.

19.

Histoplasma capsulatum depends on de novo vitamin biosynthesis for intraphagosomal proliferation.

Garfoot AL, Zemska O, Rappleye CA.

Infect Immun. 2014 Jan;82(1):393-404. doi: 10.1128/IAI.00824-13. Epub 2013 Nov 4.

20.

Histoplasma yeast and mycelial transcriptomes reveal pathogenic-phase and lineage-specific gene expression profiles.

Edwards JA, Chen C, Kemski MM, Hu J, Mitchell TK, Rappleye CA.

BMC Genomics. 2013 Oct 10;14:695. doi: 10.1186/1471-2164-14-695.

21.

Identification of an aminothiazole with antifungal activity against intracellular Histoplasma capsulatum.

Edwards JA, Kemski MM, Rappleye CA.

Antimicrob Agents Chemother. 2013 Sep;57(9):4349-59. doi: 10.1128/AAC.00459-13. Epub 2013 Jul 1.

22.

Redundant catalases detoxify phagocyte reactive oxygen and facilitate Histoplasma capsulatum pathogenesis.

Holbrook ED, Smolnycki KA, Youseff BH, Rappleye CA.

Infect Immun. 2013 Jul;81(7):2334-46. doi: 10.1128/IAI.00173-13. Epub 2013 Apr 15.

23.

Spectrum of T-DNA integrations for insertional mutagenesis of Histoplasma capsulatum.

Kemski MM, Stevens B, Rappleye CA.

Fungal Biol. 2013 Jan;117(1):41-51. doi: 10.1016/j.funbio.2012.11.004. Epub 2012 Dec 2.

24.

Extracellular superoxide dismutase protects Histoplasma yeast cells from host-derived oxidative stress.

Youseff BH, Holbrook ED, Smolnycki KA, Rappleye CA.

PLoS Pathog. 2012;8(5):e1002713. doi: 10.1371/journal.ppat.1002713. Epub 2012 May 17.

25.

RNAi-based gene silencing using a GFP sentinel system in Histoplasma capsulatum.

Youseff BH, Rappleye CA.

Methods Mol Biol. 2012;845:151-64. doi: 10.1007/978-1-61779-539-8_10.

PMID:
22328373
26.

Agrobacterium-mediated insertional mutagenesis in Histoplasma capsulatum.

Zemska O, Rappleye CA.

Methods Mol Biol. 2012;845:51-66. doi: 10.1007/978-1-61779-539-8_4.

PMID:
22328367
27.

Histoplasma mechanisms of pathogenesis--one portfolio doesn't fit all.

Edwards JA, Rappleye CA.

FEMS Microbiol Lett. 2011 Nov;324(1):1-9. doi: 10.1111/j.1574-6968.2011.02363.x. Epub 2011 Aug 9. Review.

28.

Vascular anastomosis using controlled phase transitions in poloxamer gels.

Chang EI, Galvez MG, Glotzbach JP, Hamou CD, El-ftesi S, Rappleye CT, Sommer KM, Rajadas J, Abilez OJ, Fuller GG, Longaker MT, Gurtner GC.

Nat Med. 2011 Aug 28;17(9):1147-52. doi: 10.1038/nm.2424.

PMID:
21873986
29.

Discovery of a role for Hsp82 in Histoplasma virulence through a quantitative screen for macrophage lethality.

Edwards JA, Zemska O, Rappleye CA.

Infect Immun. 2011 Aug;79(8):3348-57. doi: 10.1128/IAI.05124-11. Epub 2011 May 23.

30.

Definition of the extracellular proteome of pathogenic-phase Histoplasma capsulatum.

Holbrook ED, Edwards JA, Youseff BH, Rappleye CA.

J Proteome Res. 2011 Apr 1;10(4):1929-43. doi: 10.1021/pr1011697. Epub 2011 Feb 25.

31.

The yeast-phase virulence requirement for α-glucan synthase differs among Histoplasma capsulatum chemotypes.

Edwards JA, Alore EA, Rappleye CA.

Eukaryot Cell. 2011 Jan;10(1):87-97. doi: 10.1128/EC.00214-10. Epub 2010 Oct 29.

32.

Reverse genetics through random mutagenesis in Histoplasma capsulatum.

Youseff BH, Dougherty JA, Rappleye CA.

BMC Microbiol. 2009 Nov 17;9:236. doi: 10.1186/1471-2180-9-236.

33.

Histoplasma capsulatum pathogenesis: making a lifestyle switch.

Holbrook ED, Rappleye CA.

Curr Opin Microbiol. 2008 Aug;11(4):318-24. doi: 10.1016/j.mib.2008.05.010. Epub 2008 Jun 21. Review.

PMID:
18573684
34.

Fungal stealth technology.

Rappleye CA, Goldman WE.

Trends Immunol. 2008 Jan;29(1):18-24. Epub 2007 Nov 28. Review.

PMID:
18054285
35.

Towards a molecular genetic system for the pathogenic fungus Paracoccidioides brasiliensis.

Almeida AJ, Carmona JA, Cunha C, Carvalho A, Rappleye CA, Goldman WE, Hooykaas PJ, Leão C, Ludovico P, Rodrigues F.

Fungal Genet Biol. 2007 Dec;44(12):1387-98. Epub 2007 Apr 14.

PMID:
17512227
37.

Histoplasma capsulatum alpha-(1,3)-glucan blocks innate immune recognition by the beta-glucan receptor.

Rappleye CA, Eissenberg LG, Goldman WE.

Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1366-70. Epub 2007 Jan 16.

38.

An alpha-(1,4)-amylase is essential for alpha-(1,3)-glucan production and virulence in Histoplasma capsulatum.

Marion CL, Rappleye CA, Engle JT, Goldman WE.

Mol Microbiol. 2006 Nov;62(4):970-83. Epub 2006 Oct 13.

39.

Defining virulence genes in the dimorphic fungi.

Rappleye CA, Goldman WE.

Annu Rev Microbiol. 2006;60:281-303. Review.

PMID:
16753032
40.

RNA interference in Histoplasma capsulatum demonstrates a role for alpha-(1,3)-glucan in virulence.

Rappleye CA, Engle JT, Goldman WE.

Mol Microbiol. 2004 Jul;53(1):153-65.

41.
42.

Your next....

Carmichael M, Murdock J, Rappleye C.

Newsweek. 2002 Jun 24;139(25):64-6. No abstract available.

PMID:
12096615
43.

The anaphase-promoting complex and separin are required for embryonic anterior-posterior axis formation.

Rappleye CA, Tagawa A, Lyczak R, Bowerman B, Aroian RV.

Dev Cell. 2002 Feb;2(2):195-206.

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48.

Transposition without transposase: a spontaneous mutation in bacteria.

Rappleye CA, Roth JR.

J Bacteriol. 1997 Mar;179(6):2047-52.

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