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Items: 29

1.

High-resolution crystal structure of parathyroid hormone 1 receptor in complex with a peptide agonist.

Ehrenmann J, Schöppe J, Klenk C, Rappas M, Kummer L, Doré AS, Plückthun A.

Nat Struct Mol Biol. 2018 Dec;25(12):1086-1092. doi: 10.1038/s41594-018-0151-4. Epub 2018 Nov 19.

PMID:
30455434
2.

BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands.

Day M, Rappas M, Ptasinska K, Boos D, Oliver AW, Pearl LH.

Elife. 2018 Oct 8;7. pii: e39979. doi: 10.7554/eLife.39979.

3.

Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727.

Robertson N, Rappas M, Doré AS, Brown J, Bottegoni G, Koglin M, Cansfield J, Jazayeri A, Cooke RM, Marshall FH.

Nature. 2018 Jan 3;553(7686):111-114. doi: 10.1038/nature25025.

PMID:
29300009
4.

Corrigendum: Crystal structure of the GLP-1 receptor bound to a peptide agonist.

Jazayeri A, Rappas M, Brown AJH, Kean J, Errey JC, Robertson NJ, Fiez-Vandal C, Andrews SP, Congreve M, Bortolato A, Mason JS, Baig AH, Teobald I, Doré AS, Weir M, Cooke RM, Marshall FH.

Nature. 2017 Aug 3;548(7665):122. doi: 10.1038/nature23311. Epub 2017 Jul 12.

PMID:
28700581
5.

Crystal structure of the GLP-1 receptor bound to a peptide agonist.

Jazayeri A, Rappas M, Brown AJH, Kean J, Errey JC, Robertson NJ, Fiez-Vandal C, Andrews SP, Congreve M, Bortolato A, Mason JS, Baig AH, Teobald I, Doré AS, Weir M, Cooke RM, Marshall FH.

Nature. 2017 Jun 8;546(7657):254-258. doi: 10.1038/nature22800. Epub 2017 May 31. Erratum in: Nature. 2017 Aug 3;548(7665):122.

PMID:
28562585
6.

Structural insight into allosteric modulation of protease-activated receptor 2.

Cheng RKY, Fiez-Vandal C, Schlenker O, Edman K, Aggeler B, Brown DG, Brown GA, Cooke RM, Dumelin CE, Doré AS, Geschwindner S, Grebner C, Hermansson NO, Jazayeri A, Johansson P, Leong L, Prihandoko R, Rappas M, Soutter H, Snijder A, Sundström L, Tehan B, Thornton P, Troast D, Wiggin G, Zhukov A, Marshall FH, Dekker N.

Nature. 2017 May 4;545(7652):112-115. doi: 10.1038/nature22309. Epub 2017 Apr 26.

PMID:
28445455
7.

Intracellular allosteric antagonism of the CCR9 receptor.

Oswald C, Rappas M, Kean J, Doré AS, Errey JC, Bennett K, Deflorian F, Christopher JA, Jazayeri A, Mason JS, Congreve M, Cooke RM, Marshall FH.

Nature. 2016 Dec 15;540(7633):462-465. doi: 10.1038/nature20606. Epub 2016 Dec 7.

PMID:
27926729
8.

Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4(TopBP1).

Qu M, Rappas M, Wardlaw CP, Garcia V, Ren JY, Day M, Carr AM, Oliver AW, Du LL, Pearl LH.

Mol Cell. 2013 Sep 26;51(6):723-736. doi: 10.1016/j.molcel.2013.08.030.

9.

Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans.

Boos D, Sanchez-Pulido L, Rappas M, Pearl LH, Oliver AW, Ponting CP, Diffley JF.

Curr Biol. 2011 Jul 12;21(13):1152-7. doi: 10.1016/j.cub.2011.05.057. Epub 2011 Jun 23.

10.

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1.

Rappas M, Oliver AW, Pearl LH.

Nucleic Acids Res. 2011 Jan;39(1):313-24. doi: 10.1093/nar/gkq743. Epub 2010 Aug 19. Erratum in: Nucleic Acids Res. 2013 Apr;41(8):4741.

11.

Coupling sigma factor conformation to RNA polymerase reorganisation for DNA melting.

Burrows PC, Joly N, Cannon WV, Cámara BP, Rappas M, Zhang X, Dawes K, Nixon BT, Wigneshweraraj SR, Buck M.

J Mol Biol. 2009 Mar 27;387(2):306-19. doi: 10.1016/j.jmb.2009.01.052. Epub 2009 Jan 31.

12.

Organization of an activator-bound RNA polymerase holoenzyme.

Bose D, Pape T, Burrows PC, Rappas M, Wigneshweraraj SR, Buck M, Zhang X.

Mol Cell. 2008 Nov 7;32(3):337-46. doi: 10.1016/j.molcel.2008.09.015.

13.

Visualizing the organization and reorganization of transcription complexes for gene expression.

Burrows PC, Wigneshweraraj S, Bose D, Joly N, Schumacher J, Rappas M, Pape T, Stockley PG, Zhang X, Buck M.

Biochem Soc Trans. 2008 Aug;36(Pt 4):776-9. doi: 10.1042/BST0360776.

PMID:
18631157
14.

Mechanism of homotropic control to coordinate hydrolysis in a hexameric AAA+ ring ATPase.

Schumacher J, Joly N, Claeys-Bouuaert IL, Aziz SA, Rappas M, Zhang X, Buck M.

J Mol Biol. 2008 Aug 1;381(1):1-12. doi: 10.1016/j.jmb.2008.05.075. Epub 2008 Jun 5.

PMID:
18599077
15.

Modus operandi of the bacterial RNA polymerase containing the sigma54 promoter-specificity factor.

Wigneshweraraj S, Bose D, Burrows PC, Joly N, Schumacher J, Rappas M, Pape T, Zhang X, Stockley P, Severinov K, Buck M.

Mol Microbiol. 2008 May;68(3):538-46. doi: 10.1111/j.1365-2958.2008.06181.x. Epub 2008 Mar 4. Review.

16.

Dissecting the ATP hydrolysis pathway of bacterial enhancer-binding proteins.

Bose D, Joly N, Pape T, Rappas M, Schumacher J, Buck M, Zhang X.

Biochem Soc Trans. 2008 Feb;36(Pt 1):83-8. doi: 10.1042/BST0360083. Review.

PMID:
18208391
17.

Trapping of a transcription complex using a new nucleotide analogue: AMP aluminium fluoride.

Joly N, Rappas M, Buck M, Zhang X.

J Mol Biol. 2008 Feb 1;375(5):1206-11. Epub 2007 Nov 22.

18.

Coupling nucleotide hydrolysis to transcription activation performance in a bacterial enhancer binding protein.

Joly N, Rappas M, Wigneshweraraj SR, Zhang X, Buck M.

Mol Microbiol. 2007 Nov;66(3):583-95. Epub 2007 Sep 19.

19.

Sensor I threonine of the AAA+ ATPase transcriptional activator PspF is involved in coupling nucleotide triphosphate hydrolysis to the restructuring of sigma 54-RNA polymerase.

Schumacher J, Joly N, Rappas M, Bradley D, Wigneshweraraj SR, Zhang X, Buck M.

J Biol Chem. 2007 Mar 30;282(13):9825-33. Epub 2007 Jan 22.

20.

Different quaternary structures of human RECQ1 are associated with its dual enzymatic activity.

Muzzolini L, Beuron F, Patwardhan A, Popuri V, Cui S, Niccolini B, Rappas M, Freemont PS, Vindigni A.

PLoS Biol. 2007 Feb;5(2):e20.

21.

Bacterial enhancer-binding proteins: unlocking sigma54-dependent gene transcription.

Rappas M, Bose D, Zhang X.

Curr Opin Struct Biol. 2007 Feb;17(1):110-6. Epub 2006 Dec 6. Review.

PMID:
17157497
22.

A second paradigm for gene activation in bacteria.

Buck M, Bose D, Burrows P, Cannon W, Joly N, Pape T, Rappas M, Schumacher J, Wigneshweraraj S, Zhang X.

Biochem Soc Trans. 2006 Dec;34(Pt 6):1067-71.

PMID:
17073752
23.

Structures and organisation of AAA+ enhancer binding proteins in transcriptional activation.

Schumacher J, Joly N, Rappas M, Zhang X, Buck M.

J Struct Biol. 2006 Oct;156(1):190-9. Epub 2006 Feb 20. Review.

PMID:
16531068
24.

Structural basis of the nucleotide driven conformational changes in the AAA+ domain of transcription activator PspF.

Rappas M, Schumacher J, Niwa H, Buck M, Zhang X.

J Mol Biol. 2006 Mar 24;357(2):481-92. Epub 2006 Jan 13.

PMID:
16430918
25.

Protein-induced DNA bending clarifies the architectural organization of the sigma54-dependent glnAp2 promoter.

Huo YX, Tian ZX, Rappas M, Wen J, Chen YC, You CH, Zhang X, Buck M, Wang YP, Kolb A.

Mol Microbiol. 2006 Jan;59(1):168-80.

26.

The second paradigm for activation of transcription.

Wigneshweraraj SR, Burrows PC, Bordes P, Schumacher J, Rappas M, Finn RD, Cannon WV, Zhang X, Buck M.

Prog Nucleic Acid Res Mol Biol. 2005;79:339-69. Review. No abstract available.

PMID:
16096032
27.

Molecular determinants for PspA-mediated repression of the AAA transcriptional activator PspF.

Elderkin S, Bordes P, Jones S, Rappas M, Buck M.

J Bacteriol. 2005 May;187(9):3238-48.

28.

Structural insights into the activity of enhancer-binding proteins.

Rappas M, Schumacher J, Beuron F, Niwa H, Bordes P, Wigneshweraraj S, Keetch CA, Robinson CV, Buck M, Zhang X.

Science. 2005 Mar 25;307(5717):1972-5.

29.

Mechanisms of ATPases--a multi-disciplinary approach.

Rappas M, Niwa H, Zhang X.

Curr Protein Pept Sci. 2004 Apr;5(2):89-105.

PMID:
15078220

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