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Items: 1 to 50 of 316

1.

Oncolytic influenza virus infection restores immunocompetence of lung tumor-associated alveolar macrophages.

Masemann D, Köther K, Kuhlencord M, Varga G, Roth J, Lichty BD, Rapp UR, Wixler V, Ludwig S.

Oncoimmunology. 2018 Feb 12;7(5):e1423171. doi: 10.1080/2162402X.2017.1423171. eCollection 2018.

2.

Impaired neuronal maturation of hippocampal neural progenitor cells in mice lacking CRAF.

Pfeiffer V, Götz R, Camarero G, Heinsen H, Blum R, Rapp UR.

PLoS One. 2018 Mar 28;13(3):e0192067. doi: 10.1371/journal.pone.0192067. eCollection 2018.

3.

Cysts mark the early stage of metastatic tumor development in non-small cell lung cancer.

Thakur C, Rapp UR, Rudel T.

Oncotarget. 2017 Dec 30;9(5):6518-6535. doi: 10.18632/oncotarget.23785. eCollection 2018 Jan 19.

4.

Lung cancer-associated pulmonary hypertension: Role of microenvironmental inflammation based on tumor cell-immune cell cross-talk.

Pullamsetti SS, Kojonazarov B, Storn S, Gall H, Salazar Y, Wolf J, Weigert A, El-Nikhely N, Ghofrani HA, Krombach GA, Fink L, Gattenlöhner S, Rapp UR, Schermuly RT, Grimminger F, Seeger W, Savai R.

Sci Transl Med. 2017 Nov 15;9(416). pii: eaai9048. doi: 10.1126/scitranslmed.aai9048.

PMID:
29141888
5.

Non-invasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate.

Mehta A, Cordero J, Dobersch S, Romero-Olmedo AJ, Savai R, Bodner J, Chao CM, Fink L, Guzmán-Díaz E, Singh I, Dobreva G, Rapp UR, Günther S, Ilinskaya ON, Bellusci S, Dammann RH, Braun T, Seeger W, Gattenlöhner S, Tresch A, Günther A, Barreto G.

EMBO Mol Med. 2016 Dec 1;8(12):1380-1389. doi: 10.15252/emmm.201606382. Print 2016 Dec.

6.

Germline variant FGFR4  p.G388R exposes a membrane-proximal STAT3 binding site.

Ulaganathan VK, Sperl B, Rapp UR, Ullrich A.

Nature. 2015 Dec 24;528(7583):570-4. doi: 10.1038/nature16449. Epub 2015 Dec 16.

PMID:
26675719
7.

C-Raf deficiency leads to hearing loss and increased noise susceptibility.

de Iriarte Rodríguez R, Magariños M, Pfeiffer V, Rapp UR, Varela-Nieto I.

Cell Mol Life Sci. 2015 Oct;72(20):3983-98. doi: 10.1007/s00018-015-1919-x. Epub 2015 May 15.

8.

In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B.

Silva IT, Carvalho A, Lang KL, Dudek SE, Masemann D, Durán FJ, Caro MS, Rapp UR, Wixler V, Schenkel EP, Simões CM, Ludwig S.

PLoS One. 2015 Feb 12;10(2):e0117794. doi: 10.1371/journal.pone.0117794. eCollection 2015.

9.

Elimination of B-RAF in oncogenic C-RAF-expressing alveolar epithelial type II cells reduces MAPK signal intensity and lung tumor growth.

Zanucco E, El-Nikhely N, Götz R, Weidmann K, Pfeiffer V, Savai R, Seeger W, Ullrich A, Rapp UR.

J Biol Chem. 2014 Sep 26;289(39):26804-16. doi: 10.1074/jbc.M114.558999. Epub 2014 Aug 5.

10.

Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase.

Sibilski C, Mueller T, Kollipara L, Zahedi RP, Rapp UR, Rudel T, Baljuls A.

J Biol Chem. 2013 Dec 6;288(49):35237-52. doi: 10.1074/jbc.M113.490235. Epub 2013 Oct 24.

11.

Ablation of BRaf impairs neuronal differentiation in the postnatal hippocampus and cerebellum.

Pfeiffer V, Götz R, Xiang C, Camarero G, Braun A, Zhang Y, Blum R, Heinsen H, Nieswandt B, Rapp UR.

PLoS One. 2013;8(3):e58259. doi: 10.1371/journal.pone.0058259. Epub 2013 Mar 7.

12.

E-cadherin controls bronchiolar progenitor cells and onset of preneoplastic lesions in mice.

Ceteci F, Ceteci S, Zanucco E, Thakur C, Becker M, El-Nikhely N, Fink L, Seeger W, Savai R, Rapp UR.

Neoplasia. 2012 Dec;14(12):1164-77.

13.

MYC-induced epigenetic activation of GATA4 in lung adenocarcinoma.

Castro IC, Breiling A, Luetkenhaus K, Ceteci F, Hausmann S, Kress S, Lyko F, Rudel T, Rapp UR.

Mol Cancer Res. 2013 Feb;11(2):161-72. doi: 10.1158/1541-7786.MCR-12-0414-T. Epub 2012 Dec 13.

14.

MK3 controls Polycomb target gene expression via negative feedback on ERK.

Prickaerts P, Niessen HE, Mouchel-Vielh E, Dahlmans VE, van den Akker GG, Geijselaers C, Adriaens ME, Spaapen F, Takihara Y, Rapp UR, Peronnet F, Voncken JW.

Epigenetics Chromatin. 2012 Aug 7;5(1):12. doi: 10.1186/1756-8935-5-12.

15.

Role of melanoma inhibitor of apoptosis (ML-IAP) protein, a member of the baculoviral IAP repeat (BIR) domain family, in the regulation of C-RAF kinase and cell migration.

Oberoi-Khanuja TK, Karreman C, Larisch S, Rapp UR, Rajalingam K.

J Biol Chem. 2012 Aug 17;287(34):28445-55. doi: 10.1074/jbc.M112.341297. Epub 2012 Jun 18.

16.

The tumor suppressor DiRas3 forms a complex with H-Ras and C-RAF proteins and regulates localization, dimerization, and kinase activity of C-RAF.

Baljuls A, Beck M, Oenel A, Robubi A, Kroschewski R, Hekman M, Rudel T, Rapp UR.

J Biol Chem. 2012 Jun 29;287(27):23128-40. doi: 10.1074/jbc.M112.343780. Epub 2012 May 17.

17.

Combinatorial treatment of mammospheres with trastuzumab and salinomycin efficiently targets HER2-positive cancer cells and cancer stem cells.

Oak PS, Kopp F, Thakur C, Ellwart JW, Rapp UR, Ullrich A, Wagner E, Knyazev P, Roidl A.

Int J Cancer. 2012 Dec 15;131(12):2808-19. doi: 10.1002/ijc.27595. Epub 2012 May 21.

18.

Expression of B-RAF V600E in type II pneumocytes causes abnormalities in alveolar formation, airspace enlargement and tumor formation in mice.

Zanucco E, Götz R, Potapenko T, Carraretto I, Ceteci S, Ceteci F, Seeger W, Savai R, Rapp UR.

PLoS One. 2011;6(12):e29093. doi: 10.1371/journal.pone.0029093. Epub 2011 Dec 14.

20.

Specific antibody-receptor interactions trigger InlAB-independent uptake of Listeria monocytogenes into tumor cell lines.

Heisig M, Frentzen A, Bergmann B, Galmbacher K, Gentschev I, Hotz C, Schoen C, Stritzker J, Fensterle J, Rapp UR, Goebel W.

BMC Microbiol. 2011 Jul 11;11:163. doi: 10.1186/1471-2180-11-163.

21.

Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase.

Baljuls A, Mahr R, Schwarzenau I, Müller T, Polzien L, Hekman M, Rapp UR.

J Biol Chem. 2011 May 6;286(18):16491-503. doi: 10.1074/jbc.M110.194167. Epub 2011 Mar 18.

22.

BAD contributes to RAF-mediated proliferation and cooperates with B-RAF-V600E in cancer signaling.

Polzien L, Baljuls A, Albrecht M, Hekman M, Rapp UR.

J Biol Chem. 2011 May 20;286(20):17934-44. doi: 10.1074/jbc.M110.177345. Epub 2011 Feb 11.

23.

Polycomb group protein Bmi1 negatively regulates IL-10 expression in activated macrophages.

Sienerth AR, Scheuermann C, Galmiche A, Rapp UR, Becker M.

Immunol Cell Biol. 2011 Oct;89(7):812-6. doi: 10.1038/icb.2010.160. Epub 2011 Jan 11.

PMID:
21221124
24.

RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development.

Magariños M, Aburto MR, Sánchez-Calderón H, Muñoz-Agudo C, Rapp UR, Varela-Nieto I.

PLoS One. 2010 Dec 28;5(12):e14435. doi: 10.1371/journal.pone.0014435.

25.

Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part.

Polzien L, Baljuls A, Roth HM, Kuper J, Benz R, Schweimer K, Hekman M, Rapp UR.

Biochim Biophys Acta. 2011 Feb;1810(2):162-9. doi: 10.1016/j.bbagen.2010.11.002. Epub 2010 Nov 24.

PMID:
21081150
26.

Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.

Molzan M, Schumacher B, Ottmann C, Baljuls A, Polzien L, Weyand M, Thiel P, Rose R, Rose M, Kuhenne P, Kaiser M, Rapp UR, Kuhlmann J, Ottmann C.

Mol Cell Biol. 2010 Oct;30(19):4698-711. doi: 10.1128/MCB.01636-09. Epub 2010 Aug 2.

27.

Shigella mediated depletion of macrophages in a murine breast cancer model is associated with tumor regression.

Galmbacher K, Heisig M, Hotz C, Wischhusen J, Galmiche A, Bergmann B, Gentschev I, Goebel W, Rapp UR, Fensterle J.

PLoS One. 2010 Mar 8;5(3):e9572. doi: 10.1371/journal.pone.0009572.

28.

Can BAD pores be good? New insights from examining BAD as a target of RAF kinases.

Polzien L, Benz R, Rapp UR.

Adv Enzyme Regul. 2010;50(1):147-59. doi: 10.1016/j.advenzreg.2009.10.025. Epub 2009 Nov 4. No abstract available.

PMID:
19895838
29.

Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation.

Polzien L, Baljuls A, Rennefahrt UE, Fischer A, Schmitz W, Zahedi RP, Sickmann A, Metz R, Albert S, Benz R, Hekman M, Rapp UR.

J Biol Chem. 2009 Oct 9;284(41):28004-20. doi: 10.1074/jbc.M109.010702. Epub 2009 Aug 10.

30.

MYC is a metastasis gene for non-small-cell lung cancer.

Rapp UR, Korn C, Ceteci F, Karreman C, Luetkenhaus K, Serafin V, Zanucco E, Castro I, Potapenko T.

PLoS One. 2009 Jun 24;4(6):e6029. doi: 10.1371/journal.pone.0006029.

31.

A-RAF kinase functions in ARF6 regulated endocytic membrane traffic.

Nekhoroshkova E, Albert S, Becker M, Rapp UR.

PLoS One. 2009;4(2):e4647. doi: 10.1371/journal.pone.0004647. Epub 2009 Feb 27.

32.

Polycomb group protein Bmi1 is required for growth of RAF driven non-small-cell lung cancer.

Becker M, Korn C, Sienerth AR, Voswinckel R, Luetkenhaus K, Ceteci F, Rapp UR.

PLoS One. 2009;4(1):e4230. doi: 10.1371/journal.pone.0004230. Epub 2009 Jan 19.

33.

RAF expression in human astrocytic tumors.

Hagemann C, Gloger J, Anacker J, Said HM, Gerngras S, Kühnel S, Meyer C, Rapp UR, Kämmerer U, Vordermark D, Flentje M, Roosen K, Vince GH.

Int J Mol Med. 2009 Jan;23(1):17-31.

PMID:
19082503
34.

Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins.

Fischer A, Baljuls A, Reinders J, Nekhoroshkova E, Sibilski C, Metz R, Albert S, Rajalingam K, Hekman M, Rapp UR.

J Biol Chem. 2009 Jan 30;284(5):3183-94. doi: 10.1074/jbc.M804795200. Epub 2008 Dec 2.

35.

X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility.

Dogan T, Harms GS, Hekman M, Karreman C, Oberoi TK, Alnemri ES, Rapp UR, Rajalingam K.

Nat Cell Biol. 2008 Dec;10(12):1447-55. doi: 10.1038/ncb1804. Epub 2008 Nov 16. Erratum in: Nat Cell Biol. 2009 Jan;11(1):110.

PMID:
19011619
36.

Improvement of the live vaccine strain Salmonella enterica serovar Typhi Ty21a for antigen delivery via the hemolysin secretion system of Escherichia coli.

Hotz C, Fensterle J, Goebel W, Meyer SR, Kirchgraber G, Heisig M, Fürer A, Dietrich G, Rapp UR, Gentschev I.

Int J Med Microbiol. 2009 Feb;299(2):109-19. doi: 10.1016/j.ijmm.2008.06.006. Epub 2008 Aug 15.

PMID:
18706861
37.

Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites.

Baljuls A, Schmitz W, Mueller T, Zahedi RP, Sickmann A, Hekman M, Rapp UR.

J Biol Chem. 2008 Oct 3;283(40):27239-54. doi: 10.1074/jbc.M801782200. Epub 2008 Jul 28.

38.

Isoform-specific interaction of C-RAF with mitochondria.

Galmiche A, Fueller J, Santel A, Krohne G, Wittig I, Doye A, Rolando M, Flatau G, Lemichez E, Rapp UR.

J Biol Chem. 2008 May 23;283(21):14857-66. doi: 10.1074/jbc.M709098200. Epub 2008 Mar 20.

39.

Phospho-ERK staining is a poor indicator of the mutational status of BRAF and NRAS in human melanoma.

Houben R, Vetter-Kauczok CS, Ortmann S, Rapp UR, Broecker EB, Becker JC.

J Invest Dermatol. 2008 Aug;128(8):2003-12. doi: 10.1038/jid.2008.30. Epub 2008 Mar 6.

40.

Regulation of pyruvate kinase type M2 by A-Raf: a possible glycolytic stop or go mechanism.

Mazurek S, Drexler HC, Troppmair J, Eigenbrodt E, Rapp UR.

Anticancer Res. 2007 Nov-Dec;27(6B):3963-71.

41.

Oncogene-induced plasticity and cancer stem cells.

Rapp UR, Ceteci F, Schreck R.

Cell Cycle. 2008 Jan 1;7(1):45-51. Epub 2007 Oct 22. Review.

PMID:
18196970
42.

Cancer immunotherapy based on recombinant Salmonella enterica serovar Typhimurium aroA strains secreting prostate-specific antigen and cholera toxin subunit B.

Fensterle J, Bergmann B, Yone CL, Hotz C, Meyer SR, Spreng S, Goebel W, Rapp UR, Gentschev I.

Cancer Gene Ther. 2008 Feb;15(2):85-93. Epub 2007 Dec 14.

PMID:
18084243
43.

Thrombopoietin inhibits nerve growth factor-induced neuronal differentiation and ERK signalling.

Samoylenko A, Byts N, Rajalingam K, von Ahsen N, Rapp UR, Ehrenreich H, Sirén AL.

Cell Signal. 2008 Jan;20(1):154-62. Epub 2007 Oct 12.

PMID:
18006272
44.

TPK1, a Ca(2+)-regulated Arabidopsis vacuole two-pore K(+) channel is activated by 14-3-3 proteins.

Latz A, Becker D, Hekman M, Müller T, Beyhl D, Marten I, Eing C, Fischer A, Dunkel M, Bertl A, Rapp UR, Hedrich R.

Plant J. 2007 Nov;52(3):449-59. Epub 2007 Aug 31.

45.

Disruption of tumor cell adhesion promotes angiogenic switch and progression to micrometastasis in RAF-driven murine lung cancer.

Ceteci F, Ceteci S, Karreman C, Kramer BW, Asan E, Götz R, Rapp UR.

Cancer Cell. 2007 Aug;12(2):145-59.

46.

Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARbeta/delta gene.

Müller-Brüsselbach S, Ebrahimsade S, Jäkel J, Eckhardt J, Rapp UR, Peters JM, Moll R, Müller R.

Int J Oncol. 2007 Sep;31(3):607-11.

PMID:
17671688
47.

The farnesyltransferase inhibitor R115777 (ZARNESTRA) enhances the pro-apoptotic activity of interferon-alpha through the inhibition of multiple survival pathways.

Caraglia M, Marra M, Viscomi C, D'Alessandro AM, Budillon A, Meo G, Arra C, Barbieri A, Rapp UR, Baldi A, Tassone P, Venuta S, Abbruzzese A, Tagliaferri P.

Int J Cancer. 2007 Nov 15;121(10):2317-30. Erratum in: Int J Cancer. 2008 Apr 15;122(8):1922.

48.

B- and C-RAF display essential differences in their binding to Ras: the isotype-specific N terminus of B-RAF facilitates Ras binding.

Fischer A, Hekman M, Kuhlmann J, Rubio I, Wiese S, Rapp UR.

J Biol Chem. 2007 Sep 7;282(36):26503-16. Epub 2007 Jul 16.

49.
50.

Ras oncogenes and their downstream targets.

Rajalingam K, Schreck R, Rapp UR, Albert S.

Biochim Biophys Acta. 2007 Aug;1773(8):1177-95. Epub 2007 Jan 28. Review.

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