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Reelin in the Years: decline in the number of reelin immunoreactive neurons in layer II of the entorhinal cortex in aged monkeys with memory impairment.

Long JM, Perez EJ, Roberts JA, Roberts MT, Rapp PR.

Neurobiol Aging. 2019 Dec 19. pii: S0197-4580(19)30438-5. doi: 10.1016/j.neurobiolaging.2019.12.010. [Epub ahead of print]


Transcranial Magnetic Stimulation in Alzheimer's Disease: Are We Ready?

Weiler M, Stieger KC, Long JM, Rapp PR.

eNeuro. 2020 Jan 7;7(1). pii: ENEURO.0235-19.2019. doi: 10.1523/ENEURO.0235-19.2019. Print 2020 Jan/Feb. Review.


What are the threats to successful brain and cognitive aging?

Gallagher M, Okonkwo OC, Resnick SM, Jagust WJ, Benzinger TLS, Rapp PR.

Neurobiol Aging. 2019 Nov;83:130-134. doi: 10.1016/j.neurobiolaging.2019.04.016.


Cortical network dynamics are coupled with cognitive aging in rats.

Myrum C, Rossi SL, Perez EJ, Rapp PR.

Hippocampus. 2019 Dec;29(12):1165-1177. doi: 10.1002/hipo.23130. Epub 2019 Jul 23.


Isolation and Quantification Brain Region-Specific and Cell Subtype-Specific Histone (De)Acetylation in Cognitive Neuroepigenetics.

Myrum C, Rapp PR.

Methods Mol Biol. 2019;1983:265-277. doi: 10.1007/978-1-4939-9434-2_16.


HDAC3-Mediated Repression of the Nr4a Family Contributes to Age-Related Impairments in Long-Term Memory.

Kwapis JL, Alaghband Y, López AJ, Long JM, Li X, Shu G, Bodinayake KK, Matheos DP, Rapp PR, Wood MA.

J Neurosci. 2019 Jun 19;39(25):4999-5009. doi: 10.1523/JNEUROSCI.2799-18.2019. Epub 2019 Apr 18.


Estrogen Alters the Synaptic Distribution of Phospho-GluN2B in the Dorsolateral Prefrontal Cortex While Promoting Working Memory in Aged Rhesus Monkeys.

Hara Y, Crimins JL, Puri R, Wang ACJ, Motley SE, Yuk F, Ramos TM, Janssen WGM, Rapp PR, Morrison JH.

Neuroscience. 2018 Dec 1;394:303-315. doi: 10.1016/j.neuroscience.2018.09.021.


Synaptic distributions of pS214-tau in rhesus monkey prefrontal cortex are associated with spine density, but not with cognitive decline.

Crimins JL, Puri R, Calakos KC, Yuk F, Janssen WGM, Hara Y, Rapp PR, Morrison JH.

J Comp Neurol. 2019 Mar 1;527(4):856-873. doi: 10.1002/cne.24576. Epub 2018 Dec 4.


Selective Loss of Thin Spines in Area 7a of the Primate Intraparietal Sulcus Predicts Age-Related Working Memory Impairment.

Motley SE, Grossman YS, Janssen WGM, Baxter MG, Rapp PR, Dumitriu D, Morrison JH.

J Neurosci. 2018 Dec 5;38(49):10467-10478. doi: 10.1523/JNEUROSCI.1234-18.2018. Epub 2018 Oct 24.


Behavioral Impact of Long-Term Chronic Implantation of Neural Recording Devices in the Rhesus Macaque.

Kyle CT, Permenter MR, Vogt JA, Rapp PR, Barnes CA.

Neuromodulation. 2019 Jun;22(4):435-440. doi: 10.1111/ner.12794. Epub 2018 Jul 17.


Functional connectivity with the retrosplenial cortex predicts cognitive aging in rats.

Ash JA, Lu H, Taxier LR, Long JM, Yang Y, Stein EA, Rapp PR.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12286-12291. Epub 2016 Oct 10.


Sex biology contributions to vulnerability to Alzheimer's disease: A think tank convened by the Women's Alzheimer's Research Initiative.

Snyder HM, Asthana S, Bain L, Brinton R, Craft S, Dubal DB, Espeland MA, Gatz M, Mielke MM, Raber J, Rapp PR, Yaffe K, Carrillo MC.

Alzheimers Dement. 2016 Nov;12(11):1186-1196. doi: 10.1016/j.jalz.2016.08.004. Epub 2016 Sep 27. Review.


Constituents and functional implications of the rat default mode network.

Hsu LM, Liang X, Gu H, Brynildsen JK, Stark JA, Ash JA, Lin CP, Lu H, Rapp PR, Stein EA, Yang Y.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4541-7. doi: 10.1073/pnas.1601485113. Epub 2016 Jul 20.


Diverse Synaptic Distributions of G Protein-coupled Estrogen Receptor 1 in Monkey Prefrontal Cortex with Aging and Menopause.

Crimins JL, Wang AC, Yuk F, Puri R, Janssen WGM, Hara Y, Rapp PR, Morrison JH.

Cereb Cortex. 2017 Mar 1;27(3):2022-2033. doi: 10.1093/cercor/bhw050.


Estrogen Restores Multisynaptic Boutons in the Dorsolateral Prefrontal Cortex while Promoting Working Memory in Aged Rhesus Monkeys.

Hara Y, Yuk F, Puri R, Janssen WG, Rapp PR, Morrison JH.

J Neurosci. 2016 Jan 20;36(3):901-10. doi: 10.1523/JNEUROSCI.3480-13.2016.


Experience Modulates the Effects of Histone Deacetylase Inhibitors on Gene and Protein Expression in the Hippocampus: Impaired Plasticity in Aging.

Sewal AS, Patzke H, Perez EJ, Park P, Lehrmann E, Zhang Y, Becker KG, Fletcher BR, Long JM, Rapp PR.

J Neurosci. 2015 Aug 19;35(33):11729-42. doi: 10.1523/JNEUROSCI.4339-14.2015.


Head west or left, east or right: interactions between memory systems in neurocognitive aging.

Tomás Pereira I, Gallagher M, Rapp PR.

Neurobiol Aging. 2015 Nov;36(11):3067-3078. doi: 10.1016/j.neurobiolaging.2015.07.024. Epub 2015 Jul 26.


Editor's comment: Improved publication speed at Neurobiology of Aging.

Rapp PR.

Neurobiol Aging. 2015 Jun;36(6):2009. doi: 10.1016/j.neurobiolaging.2015.03.009. Epub 2015 Mar 18. No abstract available.


Epigenetic contributions to cognitive aging: disentangling mindspan and lifespan.

Spiegel AM, Sewal AS, Rapp PR.

Learn Mem. 2014 Sep 16;21(10):569-74. doi: 10.1101/lm.033506.113. Print 2014 Oct. Review.


A fine balance: Regulation of hippocampal Arc/Arg3.1 transcription, translation and degradation in a rat model of normal cognitive aging.

Fletcher BR, Hill GS, Long JM, Gallagher M, Shapiro ML, Rapp PR.

Neurobiol Learn Mem. 2014 Nov;115:58-67. doi: 10.1016/j.nlm.2014.08.007. Epub 2014 Aug 23.


Pancreatic polypeptide inhibits somatostatin secretion.

Kim W, Fiori JL, Shin YK, Okun E, Kim JS, Rapp PR, Egan JM.

FEBS Lett. 2014 Aug 25;588(17):3233-9. doi: 10.1016/j.febslet.2014.07.005. Epub 2014 Jul 11.


G-protein coupled estrogen receptor, estrogen receptor α, and progesterone receptor immunohistochemistry in the hypothalamus of aging female rhesus macaques given long-term estradiol treatment.

Naugle MM, Nguyen LT, Merceron TK, Filardo E, Janssen WG, Morrison JH, Rapp PR, Gore AC.

J Exp Zool A Ecol Genet Physiol. 2014 Aug;321(7):399-414. doi: 10.1002/jez.1871. Epub 2014 May 24.


Differential effects of aging on dendritic spines in visual cortex and prefrontal cortex of the rhesus monkey.

Young ME, Ohm DT, Dumitriu D, Rapp PR, Morrison JH.

Neuroscience. 2014 Aug 22;274:33-43. doi: 10.1016/j.neuroscience.2014.05.008. Epub 2014 May 20.


Reassessing the effects of histone deacetylase inhibitors on hippocampal memory and cognitive aging.

Castellano JF, Fletcher BR, Patzke H, Long JM, Sewal A, Kim DH, Kelley-Bell B, Rapp PR.

Hippocampus. 2014 Aug;24(8):1006-16. doi: 10.1002/hipo.22286. Epub 2014 Apr 30.


Age-related brain expression and regulation of the chemokine CCL4/MIP-1β in APP/PS1 double-transgenic mice.

Zhu M, Allard JS, Zhang Y, Perez E, Spangler EL, Becker KG, Rapp PR.

J Neuropathol Exp Neurol. 2014 Apr;73(4):362-74. doi: 10.1097/NEN.0000000000000060.


A quantitative neural network approach to understanding aging phenotypes.

Ash JA, Rapp PR.

Ageing Res Rev. 2014 May;15:44-50. doi: 10.1016/j.arr.2014.02.001. Epub 2014 Feb 15. Review.


Presynaptic mitochondrial morphology in monkey prefrontal cortex correlates with working memory and is improved with estrogen treatment.

Hara Y, Yuk F, Puri R, Janssen WG, Rapp PR, Morrison JH.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):486-91. doi: 10.1073/pnas.1311310110. Epub 2013 Dec 2.


Hilar interneuron vulnerability distinguishes aged rats with memory impairment.

Spiegel AM, Koh MT, Vogt NM, Rapp PR, Gallagher M.

J Comp Neurol. 2013 Oct 15;521(15):3508-23. doi: 10.1002/cne.23367.


Multiple clinically relevant hormone therapy regimens fail to improve cognitive function in aged ovariectomized rhesus monkeys.

Baxter MG, Roberts MT, Gee NA, Lasley BL, Morrison JH, Rapp PR.

Neurobiol Aging. 2013 Jul;34(7):1882-90. doi: 10.1016/j.neurobiolaging.2012.12.017. Epub 2013 Jan 28.


Clinically relevant hormone treatments fail to induce spinogenesis in prefrontal cortex of aged female rhesus monkeys.

Ohm DT, Bloss EB, Janssen WG, Dietz KC, Wadsworth S, Lou W, Gee NA, Lasley BL, Rapp PR, Morrison JH.

J Neurosci. 2012 Aug 22;32(34):11700-5.


CREB-binding protein levels in the rat hippocampus fail to predict chronological or cognitive aging.

Tomás Pereira I, Coletta CE, Perez EV, Kim DH, Gallagher M, Goldberg IG, Rapp PR.

Neurobiol Aging. 2013 Mar;34(3):832-44. doi: 10.1016/j.neurobiolaging.2012.07.010. Epub 2012 Aug 11.


The 87%.

Wagster MV, King JW, Resnick SM, Rapp PR.

J Gerontol A Biol Sci Med Sci. 2012 Jun;67(7):739-40. doi: 10.1093/gerona/gls140. No abstract available.


Synaptic distributions of GluA2 and PKMζ in the monkey dentate gyrus and their relationships with aging and memory.

Hara Y, Punsoni M, Yuk F, Park CS, Janssen WG, Rapp PR, Morrison JH.

J Neurosci. 2012 May 23;32(21):7336-44. doi: 10.1523/JNEUROSCI.0605-12.2012.


Mechanisms of age-related cognitive change and targets for intervention: epigenetics.

Kosik KS, Rapp PR, Raz N, Small SA, Sweatt JD, Tsai LH.

J Gerontol A Biol Sci Med Sci. 2012 Jun;67(7):741-6. doi: 10.1093/gerona/gls110. Epub 2012 Apr 20. Review.


Age-related memory impairment is associated with disrupted multivariate epigenetic coordination in the hippocampus.

Castellano JF, Fletcher BR, Kelley-Bell B, Kim DH, Gallagher M, Rapp PR.

PLoS One. 2012;7(3):e33249. doi: 10.1371/journal.pone.0033249. Epub 2012 Mar 15.


Preserved learning and memory following 5-fluorouracil and cyclophosphamide treatment in rats.

Long JM, Lee GD, Kelley-Bell B, Spangler EL, Perez EJ, Longo DL, de Cabo R, Zou S, Rapp PR.

Pharmacol Biochem Behav. 2011 Nov;100(1):205-11. doi: 10.1016/j.pbb.2011.08.012. Epub 2011 Aug 22.


Neuronal and morphological bases of cognitive decline in aged rhesus monkeys.

Hara Y, Rapp PR, Morrison JH.

Age (Dordr). 2012 Oct;34(5):1051-73. Epub 2011 Jun 28. Review.


Synaptic characteristics of dentate gyrus axonal boutons and their relationships with aging, menopause, and memory in female rhesus monkeys.

Hara Y, Park CS, Janssen WG, Punsoni M, Rapp PR, Morrison JH.

J Neurosci. 2011 May 25;31(21):7737-44. doi: 10.1523/JNEUROSCI.0822-11.2011.


Volumetric correlates of spatiotemporal working and recognition memory impairment in aged rhesus monkeys.

Shamy JL, Habeck C, Hof PR, Amaral DG, Fong SG, Buonocore MH, Stern Y, Barnes CA, Rapp PR.

Cereb Cortex. 2011 Jul;21(7):1559-73. doi: 10.1093/cercor/bhq210. Epub 2010 Dec 1.


Synaptic correlates of memory and menopause in the hippocampal dentate gyrus in rhesus monkeys.

Hara Y, Park CS, Janssen WG, Roberts MT, Morrison JH, Rapp PR.

Neurobiol Aging. 2012 Feb;33(2):421.e17-28. doi: 10.1016/j.neurobiolaging.2010.09.014. Epub 2010 Oct 27.


Synaptic estrogen receptor-alpha levels in prefrontal cortex in female rhesus monkeys and their correlation with cognitive performance.

Wang AC, Hara Y, Janssen WG, Rapp PR, Morrison JH.

J Neurosci. 2010 Sep 22;30(38):12770-6. doi: 10.1523/JNEUROSCI.3192-10.2010.


Estrogen and the aging brain: an elixir for the weary cortical network.

Dumitriu D, Rapp PR, McEwen BS, Morrison JH.

Ann N Y Acad Sci. 2010 Aug;1204:104-12. doi: 10.1111/j.1749-6632.2010.05529.x. Review.


Selective changes in thin spine density and morphology in monkey prefrontal cortex correlate with aging-related cognitive impairment.

Dumitriu D, Hao J, Hara Y, Kaufmann J, Janssen WG, Lou W, Rapp PR, Morrison JH.

J Neurosci. 2010 Jun 2;30(22):7507-15. doi: 10.1523/JNEUROSCI.6410-09.2010.


Bidirectional changes to hippocampal theta-gamma comodulation predict memory for recent spatial episodes.

Shirvalkar PR, Rapp PR, Shapiro ML.

Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7054-9. doi: 10.1073/pnas.0911184107. Epub 2010 Mar 29.


Alterations of white matter tracts following neurotoxic hippocampal lesions in macaque monkeys: a diffusion tensor imaging study.

Shamy JL, Carpenter DM, Fong SG, Murray EA, Tang CY, Hof PR, Rapp PR.

Hippocampus. 2010 Aug;20(8):906-10. doi: 10.1002/hipo.20737.


Age-related regional network of magnetic resonance imaging gray matter in the rhesus macaque.

Alexander GE, Chen K, Aschenbrenner M, Merkley TL, Santerre-Lemmon LE, Shamy JL, Skaggs WE, Buonocore MH, Rapp PR, Barnes CA.

J Neurosci. 2008 Mar 12;28(11):2710-8. doi: 10.1523/JNEUROSCI.1852-07.2008.


Interactive effects of age and estrogen on cognition and pyramidal neurons in monkey prefrontal cortex.

Hao J, Rapp PR, Janssen WG, Lou W, Lasley BL, Hof PR, Morrison JH.

Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11465-70. Epub 2007 Jun 25.


Age-related spatial learning impairment is unrelated to spinophilin immunoreactive spine number and protein levels in rat hippocampus.

Calhoun ME, Fletcher BR, Yi S, Zentko DC, Gallagher M, Rapp PR.

Neurobiol Aging. 2008 Aug;29(8):1256-64. Epub 2007 Mar 13.


Reactive plasticity in the dentate gyrus following bilateral entorhinal cortex lesions in cynomolgus monkeys.

Shamy JL, Buckmaster CA, Amaral DG, Calhoun ME, Rapp PR.

J Comp Neurol. 2007 May 10;502(2):192-201.


Selective cholinergic depletion of the hippocampus spares both behaviorally induced Arc transcription and spatial learning and memory.

Fletcher BR, Baxter MG, Guzowski JF, Shapiro ML, Rapp PR.

Hippocampus. 2007;17(3):227-34.


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