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Items: 1 to 50 of 230

1.

Structure of the substrate-engaged SecA-SecY protein translocation machine.

Ma C, Wu X, Sun D, Park E, Catipovic MA, Rapoport TA, Gao N, Li L.

Nat Commun. 2019 Jun 28;10(1):2872. doi: 10.1038/s41467-019-10918-2.

2.

Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding.

Twomey EC, Ji Z, Wales TE, Bodnar NO, Ficarro SB, Marto JA, Engen JR, Rapoport TA.

Science. 2019 Aug 2;365(6452). pii: eaax1033. doi: 10.1126/science.aax1033. Epub 2019 Jun 27.

PMID:
31249135
3.

Peroxisome protein import recapitulated in Xenopus egg extracts.

Romano FB, Blok NB, Rapoport TA.

J Cell Biol. 2019 Jun 3;218(6):2021-2034. doi: 10.1083/jcb.201901152. Epub 2019 Apr 10.

PMID:
30971414
4.

Protein translocation by the SecA ATPase occurs by a power-stroke mechanism.

Catipovic MA, Bauer BW, Loparo JJ, Rapoport TA.

EMBO J. 2019 May 2;38(9). pii: e101140. doi: 10.15252/embj.2018101140. Epub 2019 Mar 15.

PMID:
30877095
5.

Reconstituting the reticular ER network - mechanistic implications and open questions.

Wang N, Rapoport TA.

J Cell Sci. 2019 Jan 22;132(4). pii: jcs227611. doi: 10.1242/jcs.227611. Review.

6.

Structure of the post-translational protein translocation machinery of the ER membrane.

Wu X, Cabanos C, Rapoport TA.

Nature. 2019 Feb;566(7742):136-139. doi: 10.1038/s41586-018-0856-x. Epub 2018 Dec 31.

7.

The ER morphology-regulating lunapark protein induces the formation of stacked bilayer discs.

Wang S, Powers RE, Gold VA, Rapoport TA.

Life Sci Alliance. 2018 Jan 19;1(1):e201700014. doi: 10.26508/lsa.201700014. eCollection 2018 Jan.

8.

Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4.

Bodnar NO, Kim KH, Ji Z, Wales TE, Svetlov V, Nudler E, Engen JR, Walz T, Rapoport TA.

Nat Struct Mol Biol. 2018 Jul;25(7):616-622. doi: 10.1038/s41594-018-0085-x. Epub 2018 Jul 2.

9.

Mechanistic insights into ER-associated protein degradation.

Wu X, Rapoport TA.

Curr Opin Cell Biol. 2018 Aug;53:22-28. doi: 10.1016/j.ceb.2018.04.004. Epub 2018 Apr 30. Review.

10.

Endoplasmic Reticulum Network Formation with Xenopus Egg Extracts.

Wang S, Romano FB, Rapoport TA.

Cold Spring Harb Protoc. 2019 Feb 1;2019(2):pdb.prot097204. doi: 10.1101/pdb.prot097204.

PMID:
29475993
11.

Unraveling the sequence of cytosolic reactions in the export of GspB adhesin from Streptococcus gordonii.

Chen Y, Bensing BA, Seepersaud R, Mi W, Liao M, Jeffrey PD, Shajahan A, Sonon RN, Azadi P, Sullam PM, Rapoport TA.

J Biol Chem. 2018 Apr 6;293(14):5360-5373. doi: 10.1074/jbc.RA117.000963. Epub 2018 Feb 9.

12.

Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3.

Schoebel S, Mi W, Stein A, Ovchinnikov S, Pavlovicz R, DiMaio F, Baker D, Chambers MG, Su H, Li D, Rapoport TA, Liao M.

Nature. 2017 Aug 17;548(7667):352-355. doi: 10.1038/nature23314. Epub 2017 Jul 6.

13.

Structural and Mechanistic Insights into Protein Translocation.

Rapoport TA, Li L, Park E.

Annu Rev Cell Dev Biol. 2017 Oct 6;33:369-390. doi: 10.1146/annurev-cellbio-100616-060439. Epub 2017 May 31. Review.

PMID:
28564553
14.

Molecular Mechanism of Substrate Processing by the Cdc48 ATPase Complex.

Bodnar NO, Rapoport TA.

Cell. 2017 May 4;169(4):722-735.e9. doi: 10.1016/j.cell.2017.04.020.

15.

Two alternative binding mechanisms connect the protein translocation Sec71-Sec72 complex with heat shock proteins.

Tripathi A, Mandon EC, Gilmore R, Rapoport TA.

J Biol Chem. 2017 May 12;292(19):8007-8018. doi: 10.1074/jbc.M116.761122. Epub 2017 Mar 12.

16.

Reconstitution of the tubular endoplasmic reticulum network with purified components.

Powers RE, Wang S, Liu TY, Rapoport TA.

Nature. 2017 Mar 9;543(7644):257-260. doi: 10.1038/nature21387. Epub 2017 Feb 22.

17.

Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network.

Wang S, Tukachinsky H, Romano FB, Rapoport TA.

Elife. 2016 Sep 13;5. pii: e18605. doi: 10.7554/eLife.18605.

18.

Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD.

Baldridge RD, Rapoport TA.

Cell. 2016 Jul 14;166(2):394-407. doi: 10.1016/j.cell.2016.05.048. Epub 2016 Jun 16.

19.

Fusion of the endoplasmic reticulum by membrane-bound GTPases.

Hu J, Rapoport TA.

Semin Cell Dev Biol. 2016 Dec;60:105-111. doi: 10.1016/j.semcdb.2016.06.001. Epub 2016 Jun 3. Review.

PMID:
27269373
20.

Crystal structure of a substrate-engaged SecY protein-translocation channel.

Li L, Park E, Ling J, Ingram J, Ploegh H, Rapoport TA.

Nature. 2016 Mar 17;531(7594):395-399. doi: 10.1038/nature17163. Epub 2016 Mar 7.

21.

Data publication with the structural biology data grid supports live analysis.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P.

Nat Commun. 2016 Mar 7;7:10882. doi: 10.1038/ncomms10882.

22.

Mechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion protein.

Chen Y, Seepersaud R, Bensing BA, Sullam PM, Rapoport TA.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1190-9. doi: 10.1073/pnas.1600494113. Epub 2016 Feb 16.

23.

Structures of the double-ring AAA ATPase Pex1-Pex6 involved in peroxisome biogenesis.

Tan D, Blok NB, Rapoport TA, Walz T.

FEBS J. 2016 Mar;283(6):986-92. doi: 10.1111/febs.13569. Epub 2015 Nov 12. Review.

24.

Involvement of VAT-1 in Phosphatidylserine Transfer from the Endoplasmic Reticulum to Mitochondria.

Junker M, Rapoport TA.

Traffic. 2015 Dec;16(12):1306-17. doi: 10.1111/tra.12336. Epub 2015 Oct 25.

25.

Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy.

Blok NB, Tan D, Wang RY, Penczek PA, Baker D, DiMaio F, Rapoport TA, Walz T.

Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4017-25. doi: 10.1073/pnas.1500257112. Epub 2015 Jul 13.

26.

Conformational Changes of the Clamp of the Protein Translocation ATPase SecA.

Chen Y, Bauer BW, Rapoport TA, Gumbart JC.

J Mol Biol. 2015 Jul 17;427(14):2348-59. doi: 10.1016/j.jmb.2015.05.003. Epub 2015 May 14.

27.

Cis and trans interactions between atlastin molecules during membrane fusion.

Liu TY, Bian X, Romano FB, Shemesh T, Rapoport TA, Hu J.

Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1851-60. doi: 10.1073/pnas.1504368112. Epub 2015 Mar 30.

28.

Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon.

Junne T, Wong J, Studer C, Aust T, Bauer BW, Beibel M, Bhullar B, Bruccoleri R, Eichenberger J, Estoppey D, Hartmann N, Knapp B, Krastel P, Melin N, Oakeley EJ, Oberer L, Riedl R, Roma G, Schuierer S, Petersen F, Tallarico JA, Rapoport TA, Spiess M, Hoepfner D.

J Cell Sci. 2015 Mar 15;128(6):1217-29. doi: 10.1242/jcs.165746. Epub 2015 Jan 22.

29.

A model for the generation and interconversion of ER morphologies.

Shemesh T, Klemm RW, Romano FB, Wang S, Vaughan J, Zhuang X, Tukachinsky H, Kozlov MM, Rapoport TA.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):E5243-51. doi: 10.1073/pnas.1419997111. Epub 2014 Nov 17.

30.

Key steps in ERAD of luminal ER proteins reconstituted with purified components.

Stein A, Ruggiano A, Carvalho P, Rapoport TA.

Cell. 2014 Sep 11;158(6):1375-1388. doi: 10.1016/j.cell.2014.07.050.

31.

A "push and slide" mechanism allows sequence-insensitive translocation of secretory proteins by the SecA ATPase.

Bauer BW, Shemesh T, Chen Y, Rapoport TA.

Cell. 2014 Jun 5;157(6):1416-29. doi: 10.1016/j.cell.2014.03.063.

32.

An ER protein functionally couples neutral lipid metabolism on lipid droplets to membrane lipid synthesis in the ER.

Markgraf DF, Klemm RW, Junker M, Hannibal-Bach HK, Ejsing CS, Rapoport TA.

Cell Rep. 2014 Jan 16;6(1):44-55. doi: 10.1016/j.celrep.2013.11.046. Epub 2013 Dec 27.

33.

Multiple mechanisms determine ER network morphology during the cell cycle in Xenopus egg extracts.

Wang S, Romano FB, Field CM, Mitchison TJ, Rapoport TA.

J Cell Biol. 2013 Dec 9;203(5):801-14. doi: 10.1083/jcb.201308001. Epub 2013 Dec 2.

34.

Structural analysis and optimization of the covalent association between SpyCatcher and a peptide Tag.

Li L, Fierer JO, Rapoport TA, Howarth M.

J Mol Biol. 2014 Jan 23;426(2):309-17. doi: 10.1016/j.jmb.2013.10.021. Epub 2013 Oct 23.

35.

Structure of the SecY channel during initiation of protein translocation.

Park E, Ménétret JF, Gumbart JC, Ludtke SJ, Li W, Whynot A, Rapoport TA, Akey CW.

Nature. 2014 Feb 6;506(7486):102-6. doi: 10.1038/nature12720. Epub 2013 Oct 23.

36.

Stacked endoplasmic reticulum sheets are connected by helicoidal membrane motifs.

Terasaki M, Shemesh T, Kasthuri N, Klemm RW, Schalek R, Hayworth KJ, Hand AR, Yankova M, Huber G, Lichtman JW, Rapoport TA, Kozlov MM.

Cell. 2013 Jul 18;154(2):285-96. doi: 10.1016/j.cell.2013.06.031.

37.

A conserved role for atlastin GTPases in regulating lipid droplet size.

Klemm RW, Norton JP, Cole RA, Li CS, Park SH, Crane MM, Li L, Jin D, Boye-Doe A, Liu TY, Shibata Y, Lu H, Rapoport TA, Farese RV Jr, Blackstone C, Guo Y, Mak HY.

Cell Rep. 2013 May 30;3(5):1465-75. doi: 10.1016/j.celrep.2013.04.015. Epub 2013 May 16.

38.

Bacterial protein translocation requires only one copy of the SecY complex in vivo.

Park E, Rapoport TA.

J Cell Biol. 2012 Sep 3;198(5):881-93. doi: 10.1083/jcb.201205140. Epub 2012 Aug 27.

39.

Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion.

Liu TY, Bian X, Sun S, Hu X, Klemm RW, Prinz WA, Rapoport TA, Hu J.

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):E2146-54. doi: 10.1073/pnas.1208385109. Epub 2012 Jul 16.

40.

The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae.

Anwar K, Klemm RW, Condon A, Severin KN, Zhang M, Ghirlando R, Hu J, Rapoport TA, Prinz WA.

J Cell Biol. 2012 Apr 16;197(2):209-17. doi: 10.1083/jcb.201111115.

41.

Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance.

Nguyen TT, Lewandowska A, Choi JY, Markgraf DF, Junker M, Bilgin M, Ejsing CS, Voelker DR, Rapoport TA, Shaw JM.

Traffic. 2012 Jun;13(6):880-90. doi: 10.1111/j.1600-0854.2012.01352.x. Epub 2012 Apr 8.

42.

Mechanisms of Sec61/SecY-mediated protein translocation across membranes.

Park E, Rapoport TA.

Annu Rev Biophys. 2012;41:21-40. doi: 10.1146/annurev-biophys-050511-102312. Epub 2011 Dec 16. Review.

PMID:
22224601
43.

Weaving the web of ER tubules.

Hu J, Prinz WA, Rapoport TA.

Cell. 2011 Dec 9;147(6):1226-31. doi: 10.1016/j.cell.2011.11.022. Review. Erratum in: Cell. 2012 Feb 17;148(4):832.

44.

Preserving the membrane barrier for small molecules during bacterial protein translocation.

Park E, Rapoport TA.

Nature. 2011 May 12;473(7346):239-42. doi: 10.1038/nature10014.

45.

Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes.

Bian X, Klemm RW, Liu TY, Zhang M, Sun S, Sui X, Liu X, Rapoport TA, Hu J.

Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):3976-81. doi: 10.1073/pnas.1101643108. Epub 2011 Feb 22.

46.

Processing and turnover of the Hedgehog protein in the endoplasmic reticulum.

Chen X, Tukachinsky H, Huang CH, Jao C, Chu YR, Tang HY, Mueller B, Schulman S, Rapoport TA, Salic A.

J Cell Biol. 2011 Mar 7;192(5):825-38. doi: 10.1083/jcb.201008090. Epub 2011 Feb 28.

47.

Mechanisms determining the morphology of the peripheral ER.

Shibata Y, Shemesh T, Prinz WA, Palazzo AF, Kozlov MM, Rapoport TA.

Cell. 2010 Nov 24;143(5):774-88. doi: 10.1016/j.cell.2010.11.007.

48.

A preliminary report on my life in science.

Rapoport TA.

Mol Biol Cell. 2010 Nov 15;21(22):3770-2. doi: 10.1091/mbc.E10-05-0398.

49.

Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p.

Carvalho P, Stanley AM, Rapoport TA.

Cell. 2010 Nov 12;143(4):579-91. doi: 10.1016/j.cell.2010.10.028.

50.

Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners.

Schulman S, Wang B, Li W, Rapoport TA.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15027-32. doi: 10.1073/pnas.1009972107. Epub 2010 Aug 9.

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