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Items: 21

1.

Duplex DNA-Invading γ-Modified Peptide Nucleic Acids Enable Rapid Identification of Bloodstream Infections in Whole Blood.

Nölling J, Rapireddy S, Amburg JI, Crawford EM, Prakash RA, Rabson AR, Tang YW, Singer A.

MBio. 2016 Apr 19;7(2):e00345-16. doi: 10.1128/mBio.00345-16.

2.

Synthesis of optically pure γPNA monomers: a comparative study.

Manna A, Rapireddy S, Sureshkumar G, Ly DH.

Tetrahedron. 2015 May 27;71(21):3507-3514. doi: 10.1016/j.tet.2015.03.052. Epub 2015 Mar 20.

3.

MiniPEG-γPNA.

Manna A, Rapireddy S, Bahal R, Ly DH.

Methods Mol Biol. 2014;1050:1-12. doi: 10.1007/978-1-62703-553-8_1.

PMID:
24297346
4.

Antitumor effects of EGFR antisense guanidine-based peptide nucleic acids in cancer models.

Thomas SM, Sahu B, Rapireddy S, Bahal R, Wheeler SE, Procopio EM, Kim J, Joyce SC, Contrucci S, Wang Y, Chiosea SI, Lathrop KL, Watkins S, Grandis JR, Armitage BA, Ly DH.

ACS Chem Biol. 2013 Feb 15;8(2):345-52. doi: 10.1021/cb3003946. Epub 2012 Nov 9.

5.

First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy.

Sen M, Thomas SM, Kim S, Yeh JI, Ferris RL, Johnson JT, Duvvuri U, Lee J, Sahu N, Joyce S, Freilino ML, Shi H, Li C, Ly D, Rapireddy S, Etter JP, Li PK, Wang L, Chiosea S, Seethala RR, Gooding WE, Chen X, Kaminski N, Pandit K, Johnson DE, Grandis JR.

Cancer Discov. 2012 Aug;2(8):694-705. doi: 10.1158/2159-8290.CD-12-0191. Epub 2012 Jun 20.

6.

Effect of backbone flexibility on charge transfer rates in peptide nucleic acid duplexes.

Wierzbinski E, de Leon A, Yin X, Balaeff A, Davis KL, Rapireddy S, Venkatramani R, Keinan S, Ly DH, Madrid M, Beratan DN, Achim C, Waldeck DH.

J Am Chem Soc. 2012 Jun 6;134(22):9335-42. doi: 10.1021/ja301677z. Epub 2012 May 21. Erratum in: J Am Chem Soc. 2012 Aug 8;134(31):13141. Reppireddy, Srinivas [corrected to Rapireddy, Srinivas].

PMID:
22548314
7.

Electronic barcoding of a viral gene at the single-molecule level.

Singer A, Rapireddy S, Ly DH, Meller A.

Nano Lett. 2012 Mar 14;12(3):1722-8. doi: 10.1021/nl300372a. Epub 2012 Feb 24.

8.

RTD-1mimic containing γPNA scaffold exhibits broad-spectrum antibacterial activities.

Rapireddy S, Nhon L, Meehan RE, Franks J, Stolz DB, Tran D, Selsted ME, Ly DH.

J Am Chem Soc. 2012 Mar 7;134(9):4041-4. doi: 10.1021/ja211867j. Epub 2012 Feb 22.

9.

Sequence-unrestricted, Watson-Crick recognition of double helical B-DNA by (R)-miniPEG-γPNAs.

Bahal R, Sahu B, Rapireddy S, Lee CM, Ly DH.

Chembiochem. 2012 Jan 2;13(1):56-60. doi: 10.1002/cbic.201100646. Epub 2011 Dec 1. No abstract available.

PMID:
22135012
10.

Coordination-driven inversion of handedness in ligand-modified PNA.

Bezer S, Rapireddy S, Skorik YA, Ly DH, Achim C.

Inorg Chem. 2011 Dec 5;50(23):11929-37. doi: 10.1021/ic200855p. Epub 2011 Nov 7.

PMID:
22059624
11.

Effect of Steric Constraint at the γ-Backbone Position on the Conformations and Hybridization Properties of PNAs.

Crawford MJ, Rapireddy S, Bahal R, Sacui I, Ly DH.

J Nucleic Acids. 2011;2011:652702. doi: 10.4061/2011/652702. Epub 2011 May 25.

12.

Sequence specificity at targeting double-stranded DNA with a γ-PNA oligomer modified with guanidinium G-clamp nucleobases.

Kuhn H, Sahu B, Rapireddy S, Ly DH, Frank-Kamenetskii MD.

Artif DNA PNA XNA. 2010 Jul;1(1):45-53.

13.

Synthesis and characterization of conformationally preorganized, (R)-diethylene glycol-containing γ-peptide nucleic acids with superior hybridization properties and water solubility.

Sahu B, Sacui I, Rapireddy S, Zanotti KJ, Bahal R, Armitage BA, Ly DH.

J Org Chem. 2011 Jul 15;76(14):5614-27. doi: 10.1021/jo200482d. Epub 2011 Jun 15.

14.

Strand invasion of mixed-sequence, double-helical B-DNA by γ-peptide nucleic acids containing G-clamp nucleobases under physiological conditions.

Rapireddy S, Bahal R, Ly DH.

Biochemistry. 2011 May 17;50(19):3913-8. doi: 10.1021/bi2002554. Epub 2011 Apr 25.

15.

Crystal structure of chiral gammaPNA with complementary DNA strand: insights into the stability and specificity of recognition and conformational preorganization.

Yeh JI, Shivachev B, Rapireddy S, Crawford MJ, Gil RR, Du S, Madrid M, Ly DH.

J Am Chem Soc. 2010 Aug 11;132(31):10717-27. doi: 10.1021/ja907225d.

16.

The structure of a gamma-modified peptide nucleic acid duplex.

He W, Crawford MJ, Rapireddy S, Madrid M, Gil RR, Ly DH, Achim C.

Mol Biosyst. 2010 Sep;6(9):1619-29. doi: 10.1039/c002254c. Epub 2010 Apr 13.

PMID:
20386807
17.

Strand invasion of extended, mixed-sequence B-DNA by gammaPNAs.

He G, Rapireddy S, Bahal R, Sahu B, Ly DH.

J Am Chem Soc. 2009 Sep 2;131(34):12088-90. doi: 10.1021/ja900228j.

18.

A simple cytosine to G-clamp nucleobase substitution enables chiral gamma-PNAs to invade mixed-sequence double-helical B-form DNA.

Chenna V, Rapireddy S, Sahu B, Ausin C, Pedroso E, Ly DH.

Chembiochem. 2008 Oct 13;9(15):2388-91. doi: 10.1002/cbic.200800441. No abstract available.

PMID:
18816545
19.

Strand invasion of mixed-sequence B-DNA by acridine-linked, gamma-peptide nucleic acid (gamma-PNA).

Rapireddy S, He G, Roy S, Armitage BA, Ly DH.

J Am Chem Soc. 2007 Dec 19;129(50):15596-600. Epub 2007 Nov 21.

PMID:
18027941
20.

Cell-permeable peptide nucleic acid designed to bind to the 5'-untranslated region of E-cadherin transcript induces potent and sequence-specific antisense effects.

Dragulescu-Andrasi A, Rapireddy S, He G, Bhattacharya B, Hyldig-Nielsen JJ, Zon G, Ly DH.

J Am Chem Soc. 2006 Dec 20;128(50):16104-12.

PMID:
17165763
21.

A simple gamma-backbone modification preorganizes peptide nucleic acid into a helical structure.

Dragulescu-Andrasi A, Rapireddy S, Frezza BM, Gayathri C, Gil RR, Ly DH.

J Am Chem Soc. 2006 Aug 9;128(31):10258-67.

PMID:
16881656

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