RAP2 mediates mechanoresponses of the Hippo pathway.
Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, Park HW, Wang X, Yu FX, Chien S, Wang CY, Ren B, Engler AJ, Guan KL.
Meng Z, et al.
Nature. 2018 Aug;560(7720):655-660. doi: 10.1038/s41586-018-0444-0. Epub 2018 Aug 22.
Nature. 2018.
PMID: 30135582
Free PMC article.
Mechanistically, matrix stiffness acts through phospholipase Cgamma1 (PLCgamma1) to influence levels of phosphatidylinositol 4,5-bisphosphate and phosphatidic acid, which activates RAP2 through PDZGEF1 and PDZGEF2 (also known as RAPGEF2 and RAPGEF6). At low stiffness, acti …
Mechanistically, matrix stiffness acts through phospholipase Cgamma1 (PLCgamma1) to influence levels of phosphatidylinositol 4,5-bisphosphat …