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Items: 15

1.

Anti-fungal activity of a novel triazole, PC1244, against emerging azole-resistant Aspergillus fumigatus and other species of Aspergillus.

Colley T, Sharma C, Alanio A, Kimura G, Daly L, Nakaoki T, Nishimoto Y, Bretagne S, Kizawa Y, Strong P, Rapeport G, Ito K, Meis JF, Chowdhary A.

J Antimicrob Chemother. 2019 Oct 1;74(10):2950-2958. doi: 10.1093/jac/dkz302.

2.

In vitro antifungal activity of a novel topical triazole PC945 against emerging yeast Candida auris.

Rudramurthy SM, Colley T, Abdolrasouli A, Ashman J, Dhaliwal M, Kaur H, Armstrong-James D, Strong P, Rapeport G, Schelenz S, Ito K, Chakrabarti A.

J Antimicrob Chemother. 2019 Oct 1;74(10):2943-2949. doi: 10.1093/jac/dkz280.

3.

Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection.

Colley T, Sehra G, Daly L, Kimura G, Nakaoki T, Nishimoto Y, Kizawa Y, Strong P, Rapeport G, Ito K.

Sci Rep. 2019 Jul 1;9(1):9482. doi: 10.1038/s41598-019-45890-w.

4.

Current approaches to the discovery of novel inhaled medicines.

Strong P, Ito K, Murray J, Rapeport G.

Drug Discov Today. 2018 Oct;23(10):1705-1717. doi: 10.1016/j.drudis.2018.05.017. Epub 2018 May 20. Review.

5.

Reduced Nasal Viral Load and IFN Responses in Infants with Respiratory Syncytial Virus Bronchiolitis and Respiratory Failure.

Thwaites RS, Coates M, Ito K, Ghazaly M, Feather C, Abdulla F, Tunstall T, Jain P, Cass L, Rapeport G, Hansel TT, Nadel S, Openshaw P.

Am J Respir Crit Care Med. 2018 Oct 15;198(8):1074-1084. doi: 10.1164/rccm.201712-2567OC.

6.

Late therapeutic intervention with a respiratory syncytial virus L-protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium.

Brookes DW, Coates M, Allen H, Daly L, Constant S, Huang S, Hows M, Davis A, Cass L, Ayrton J, Knowles I, Strong P, Rapeport G, Ito K.

Br J Pharmacol. 2018 Jun;175(12):2520-2534. doi: 10.1111/bph.14221. Epub 2018 May 2.

7.

In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection.

Colley T, Sehra G, Chowdhary A, Alanio A, Kelly SL, Kizawa Y, Armstrong-James D, Fisher MC, Warrilow AGS, Parker JE, Kelly DE, Kimura G, Nishimoto Y, Sunose M, Onions S, Crepin D, Lagasse F, Crittall M, Shannon J, McConville M, King-Underwood J, Naylor A, Bretagne S, Murray J, Ito K, Strong P, Rapeport G.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e01941-17. doi: 10.1128/AAC.01941-17. Print 2018 May.

8.

Effects of intranasally dosed posaconazole on fungal load and biomarkers in Aspergillus fumigatus infected immunocompromised mice.

Kimura G, Nakaoki T, Nishimoto Y, Suzuki Y, Rapeport G, Strong P, Ito K, Kizawa Y.

Mycoses. 2017 Nov;60(11):728-735. doi: 10.1111/myc.12653. Epub 2017 Jul 11.

PMID:
28699245
9.

Preclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor.

Coates M, Brookes D, Kim YI, Allen H, Fordyce EAF, Meals EA, Colley T, Ciana CL, Parra GF, Sherbukhin V, Stockwell JA, Thomas JC, Hunt SF, Anderson-Dring L, Onions ST, Cass L, Murray PJ, Ito K, Strong P, DeVincenzo JP, Rapeport G.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00737-17. doi: 10.1128/AAC.00737-17. Print 2017 Sep.

10.

In Vivo Biomarker Analysis of the Effects of Intranasally Dosed PC945, a Novel Antifungal Triazole, on Aspergillus fumigatus Infection in Immunocompromised Mice.

Kimura G, Nakaoki T, Colley T, Rapeport G, Strong P, Ito K, Kizawa Y.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00124-17. doi: 10.1128/AAC.00124-17. Print 2017 Sep.

11.

Discovery of novel benzothienoazepine derivatives as potent inhibitors of respiratory syncytial virus.

Fordyce EAF, Brookes DW, Lise-Ciana C, Coates MS, Hunt SF, Ito K, King-Underwood J, Onions ST, Parra GF, Rapeport G, Sherbukhin V, Stockwell JA, Strong P, Thomas JC, Murray J.

Bioorg Med Chem Lett. 2017 May 15;27(10):2201-2206. doi: 10.1016/j.bmcl.2017.03.053. Epub 2017 Mar 23.

PMID:
28372911
12.

Nasosorption as a Minimally Invasive Sampling Procedure: Mucosal Viral Load and Inflammation in Primary RSV Bronchiolitis.

Thwaites RS, Ito K, Chingono JMS, Coates M, Jarvis HC, Tunstall T, Anderson-Dring L, Cass L, Rapeport G, Openshaw PJ, Nadel S, Hansel TT.

J Infect Dis. 2017 Apr 15;215(8):1240-1244. doi: 10.1093/infdis/jix150.

13.

In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection.

Colley T, Alanio A, Kelly SL, Sehra G, Kizawa Y, Warrilow AGS, Parker JE, Kelly DE, Kimura G, Anderson-Dring L, Nakaoki T, Sunose M, Onions S, Crepin D, Lagasse F, Crittall M, Shannon J, Cooke M, Bretagne S, King-Underwood J, Murray J, Ito K, Strong P, Rapeport G.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02280-16. doi: 10.1128/AAC.02280-16. Print 2017 May.

14.

Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma.

Onions ST, Ito K, Charron CE, Brown RJ, Colucci M, Frickel F, Hardy G, Joly K, King-Underwood J, Kizawa Y, Knowles I, Murray PJ, Novak A, Rani A, Rapeport G, Smith A, Strong P, Taddei DM, Williams JG.

J Med Chem. 2016 Mar 10;59(5):1727-46. doi: 10.1021/acs.jmedchem.5b01029. Epub 2016 Feb 4.

PMID:
26800309
15.

Combining fMRI with a pharmacokinetic model to determine which brain areas activated by painful stimulation are specifically modulated by remifentanil.

Wise RG, Rogers R, Painter D, Bantick S, Ploghaus A, Williams P, Rapeport G, Tracey I.

Neuroimage. 2002 Aug;16(4):999-1014.

PMID:
12202088

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