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Items: 1 to 50 of 69


Plant-Made Nervous Necrosis Virus-Like Particles Protect Fish Against Disease.

Marsian J, Hurdiss DL, Ranson NA, Ritala A, Paley R, Cano I, Lomonossoff GP.

Front Plant Sci. 2019 Jul 9;10:880. doi: 10.3389/fpls.2019.00880. eCollection 2019.


Metabolic control of BRISC-SHMT2 assembly regulates immune signalling.

Walden M, Tian L, Ross RL, Sykora UM, Byrne DP, Hesketh EL, Masandi SK, Cassel J, George R, Ault JR, El Oualid F, Pawłowski K, Salvino JM, Eyers PA, Ranson NA, Del Galdo F, Greenberg RA, Zeqiraj E.

Nature. 2019 Jun;570(7760):194-199. doi: 10.1038/s41586-019-1232-1. Epub 2019 May 29.


Affimer reagents as tools in diagnosing plant virus diseases.

Hesketh EL, Tiede C, Adamson H, Adams TL, Byrne MJ, Meshcheriakova Y, Kruse I, McPherson MJ, Lomonossoff GP, Tomlinson DC, Ranson NA.

Sci Rep. 2019 May 17;9(1):7524. doi: 10.1038/s41598-019-43945-6.


Securing the future of research computing in the biosciences.

Leng J, Shoura M, McLeish TCB, Real AN, Hardey M, McCafferty J, Ranson NA, Harris SA.

PLoS Comput Biol. 2019 May 16;15(5):e1006958. doi: 10.1371/journal.pcbi.1006958. eCollection 2019 May.


Cryo-EM structure and in vitro DNA packaging of a thermophilic virus with supersized T=7 capsids.

Bayfield OW, Klimuk E, Winkler DC, Hesketh EL, Chechik M, Cheng N, Dykeman EC, Minakhin L, Ranson NA, Severinov K, Steven AC, Antson AA.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3556-3561. doi: 10.1073/pnas.1813204116. Epub 2019 Feb 8.


NLRP3-Dependent and -Independent Processing of Interleukin (IL)-1β in Active Ulcerative Colitis.

Ranson N, Veldhuis M, Mitchell B, Fanning S, Cook AL, Kunde D, Eri R.

Int J Mol Sci. 2018 Dec 23;20(1). pii: E57. doi: 10.3390/ijms20010057.


Collection, pre-processing and on-the-fly analysis of data for high-resolution, single-particle cryo-electron microscopy.

Thompson RF, Iadanza MG, Hesketh EL, Rawson S, Ranson NA.

Nat Protoc. 2019 Jan;14(1):100-118. doi: 10.1038/s41596-018-0084-8.


The structure of a β2-microglobulin fibril suggests a molecular basis for its amyloid polymorphism.

Iadanza MG, Silvers R, Boardman J, Smith HI, Karamanos TK, Debelouchina GT, Su Y, Griffin RG, Ranson NA, Radford SE.

Nat Commun. 2018 Oct 30;9(1):4517. doi: 10.1038/s41467-018-06761-6.


A new era for understanding amyloid structures and disease.

Iadanza MG, Jackson MP, Hewitt EW, Ranson NA, Radford SE.

Nat Rev Mol Cell Biol. 2018 Dec;19(12):755-773. doi: 10.1038/s41580-018-0060-8. Review.


Nod-Like Receptor Pyrin-Containing Protein 6 (NLRP6) Is Up-regulated in Ileal Crohn's Disease and Differentially Expressed in Goblet Cells.

Ranson N, Veldhuis M, Mitchell B, Fanning S, Cook AL, Kunde D, Eri R.

Cell Mol Gastroenterol Hepatol. 2018 Mar 13;6(1):110-112.e8. doi: 10.1016/j.jcmgh.2018.03.001. eCollection 2018. No abstract available.


The 3.3 Å structure of a plant geminivirus using cryo-EM.

Hesketh EL, Saunders K, Fisher C, Potze J, Stanley J, Lomonossoff GP, Ranson NA.

Nat Commun. 2018 Jun 18;9(1):2369. doi: 10.1038/s41467-018-04793-6.


Approaches to altering particle distributions in cryo-electron microscopy sample preparation.

Drulyte I, Johnson RM, Hesketh EL, Hurdiss DL, Scarff CA, Porav SA, Ranson NA, Muench SP, Thompson RF.

Acta Crystallogr D Struct Biol. 2018 Jun 1;74(Pt 6):560-571. doi: 10.1107/S2059798318006496. Epub 2018 May 18. Review.


The Structure of an Infectious Human Polyomavirus and Its Interactions with Cellular Receptors.

Hurdiss DL, Frank M, Snowden JS, Macdonald A, Ranson NA.

Structure. 2018 Jun 5;26(6):839-847.e3. doi: 10.1016/j.str.2018.03.019. Epub 2018 Apr 26.


Agnoprotein Is an Essential Egress Factor during BK Polyomavirus Infection.

Panou MM, Prescott EL, Hurdiss DL, Swinscoe G, Hollinshead M, Caller LG, Morgan EL, Carlisle L, Müller M, Antoni M, Kealy D, Ranson NA, Crump CM, Macdonald A.

Int J Mol Sci. 2018 Mar 19;19(3). pii: E902. doi: 10.3390/ijms19030902.


Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus.

Baggen J, Hurdiss DL, Zocher G, Mistry N, Roberts RW, Slager JJ, Guo H, van Vliet ALW, Wahedi M, Benschop K, Duizer E, de Haan CAM, de Vries E, Casasnovas JM, de Groot RJ, Arnberg N, Stehle T, Ranson NA, Thibaut HJ, van Kuppeveld FJM.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):397-402. doi: 10.1073/pnas.1713284115. Epub 2017 Dec 28.


Regulation and Sensing of Inflammasomes and Their Impact on Intestinal Health.

Ranson N, Kunde D, Eri R.

Int J Mol Sci. 2017 Nov 9;18(11). pii: E2379. doi: 10.3390/ijms18112379. Review.


Combining high-resolution cryo-electron microscopy and mutagenesis to develop cowpea mosaic virus for bionanotechnology.

Meshcheriakova Y, Durrant A, Hesketh EL, Ranson NA, Lomonossoff GP.

Biochem Soc Trans. 2017 Dec 15;45(6):1263-1269. doi: 10.1042/BST20160312. Epub 2017 Nov 3. Review.


HBV RNA pre-genome encodes specific motifs that mediate interactions with the viral core protein that promote nucleocapsid assembly.

Patel N, White SJ, Thompson RF, Bingham R, Weiß EU, Maskell DP, Zlotnick A, Dykeman E, Tuma R, Twarock R, Ranson NA, Stockley PG.

Nat Microbiol. 2017 Jun 19;2:17098. doi: 10.1038/nmicrobiol.2017.98.


The structures of a naturally empty cowpea mosaic virus particle and its genome-containing counterpart by cryo-electron microscopy.

Hesketh EL, Meshcheriakova Y, Thompson RF, Lomonossoff GP, Ranson NA.

Sci Rep. 2017 Apr 3;7(1):539. doi: 10.1038/s41598-017-00533-w.


Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo.

Dobson CL, Devine PW, Phillips JJ, Higazi DR, Lloyd C, Popovic B, Arnold J, Buchanan A, Lewis A, Goodman J, van der Walle CF, Thornton P, Vinall L, Lowne D, Aagaard A, Olsson LL, Ridderstad Wollberg A, Welsh F, Karamanos TK, Pashley CL, Iadanza MG, Ranson NA, Ashcroft AE, Kippen AD, Vaughan TJ, Radford SE, Lowe DC.

Sci Rep. 2016 Dec 20;6:38644. doi: 10.1038/srep38644.


Secretory leukoprotease inhibitor is required for efficient quercetin-mediated suppression of TNFα secretion.

De Santis S, Kunde D, Serino G, Galleggiante V, Caruso ML, Mastronardi M, Cavalcanti E, Ranson N, Pinto A, Campiglia P, Santino A, Eri R, Chieppa M.

Oncotarget. 2016 Nov 15;7(46):75800-75809. doi: 10.18632/oncotarget.12415.


Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM.

Iadanza MG, Higgins AJ, Schiffrin B, Calabrese AN, Brockwell DJ, Ashcroft AE, Radford SE, Ranson NA.

Nat Commun. 2016 Sep 30;7:12865. doi: 10.1038/ncomms12865.


Corrigendum to 'Methods to account for movement and flexibility in cryo-EM data processing' [Methods 100 (2016) 35-41].

Rawson S, Iadanza MG, Ranson NA, Muench SP.

Methods. 2016 Jul 15;104:207. doi: 10.1016/j.ymeth.2016.05.006. Epub 2016 May 18. No abstract available.


Integrated and consumer-directed care: a necessary paradigm shift for rural chronic ill health.

Ranson NE, Terry DR, Glenister K, Adam BR, Wright J.

Aust J Prim Health. 2016;22(3):176-180. doi: 10.1071/PY15056.


Bacteriophage MS2 genomic RNA encodes an assembly instruction manual for its capsid.

Stockley PG, White SJ, Dykeman E, Manfield I, Rolfsson O, Patel N, Bingham R, Barker A, Wroblewski E, Chandler-Bostock R, Weiß EU, Ranson NA, Tuma R, Twarock R.

Bacteriophage. 2016 Mar 2;6(1):e1157666. eCollection 2016 Jan-Mar.


Crystal Structure and Proteomics Analysis of Empty Virus-like Particles of Cowpea Mosaic Virus.

Huynh NT, Hesketh EL, Saxena P, Meshcheriakova Y, Ku YC, Hoang LT, Johnson JE, Ranson NA, Lomonossoff GP, Reddy VS.

Structure. 2016 Apr 5;24(4):567-575. doi: 10.1016/j.str.2016.02.011. Epub 2016 Mar 24.


Methods to account for movement and flexibility in cryo-EM data processing.

Rawson S, Iadanza MG, Ranson NA, Muench SP.

Methods. 2016 May 1;100:35-41. doi: 10.1016/j.ymeth.2016.03.011. Epub 2016 Mar 24. Erratum in: Methods. 2016 Jul 15;104:207.


New Structural Insights into the Genome and Minor Capsid Proteins of BK Polyomavirus using Cryo-Electron Microscopy.

Hurdiss DL, Morgan EL, Thompson RF, Prescott EL, Panou MM, Macdonald A, Ranson NA.

Structure. 2016 Apr 5;24(4):528-536. doi: 10.1016/j.str.2016.02.008. Epub 2016 Mar 17.


An introduction to sample preparation and imaging by cryo-electron microscopy for structural biology.

Thompson RF, Walker M, Siebert CA, Muench SP, Ranson NA.

Methods. 2016 May 1;100:3-15. doi: 10.1016/j.ymeth.2016.02.017. Epub 2016 Feb 28.


MpUL-multi: Software for Calculation of Amyloid Fibril Mass per Unit Length from TB-TEM Images.

Iadanza MG, Jackson MP, Radford SE, Ranson NA.

Sci Rep. 2016 Feb 12;6:21078. doi: 10.1038/srep21078.


Mechanisms of assembly and genome packaging in an RNA virus revealed by high-resolution cryo-EM.

Hesketh EL, Meshcheriakova Y, Dent KC, Saxena P, Thompson RF, Cockburn JJ, Lomonossoff GP, Ranson NA.

Nat Commun. 2015 Dec 10;6:10113. doi: 10.1038/ncomms10113.


Direct Evidence for Packaging Signal-Mediated Assembly of Bacteriophage MS2.

Rolfsson Ó, Middleton S, Manfield IW, White SJ, Fan B, Vaughan R, Ranson NA, Dykeman E, Twarock R, Ford J, Kao CC, Stockley PG.

J Mol Biol. 2016 Jan 29;428(2 Pt B):431-48. doi: 10.1016/j.jmb.2015.11.014. Epub 2015 Dec 1.


pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers.

Tipping KW, Karamanos TK, Jakhria T, Iadanza MG, Goodchild SC, Tuma R, Ranson NA, Hewitt EW, Radford SE.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5691-6. doi: 10.1073/pnas.1423174112. Epub 2015 Apr 20.


Asymmetric genome organization in an RNA virus revealed via graph-theoretical analysis of tomographic data.

Geraets JA, Dykeman EC, Stockley PG, Ranson NA, Twarock R.

PLoS Comput Biol. 2015 Mar 20;11(3):e1004146. doi: 10.1371/journal.pcbi.1004146. eCollection 2015 Mar.


Revealing the density of encoded functions in a viral RNA.

Patel N, Dykeman EC, Coutts RH, Lomonossoff GP, Rowlands DJ, Phillips SE, Ranson N, Twarock R, Tuma R, Stockley PG.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2227-32. doi: 10.1073/pnas.1420812112. Epub 2015 Feb 2.


β2-Microglobulin amyloid fibril-induced membrane disruption is enhanced by endosomal lipids and acidic pH.

Goodchild SC, Sheynis T, Thompson R, Tipping KW, Xue WF, Ranson NA, Beales PA, Hewitt EW, Radford SE.

PLoS One. 2014 Aug 6;9(8):e104492. doi: 10.1371/journal.pone.0104492. eCollection 2014.


Limits of structural plasticity in a picornavirus capsid revealed by a massively expanded equine rhinitis A virus particle.

Bakker SE, Groppelli E, Pearson AR, Stockley PG, Rowlands DJ, Ranson NA.

J Virol. 2014 Jun;88(11):6093-9. doi: 10.1128/JVI.01979-13. Epub 2014 Mar 19.


The asymmetric structure of an icosahedral virus bound to its receptor suggests a mechanism for genome release.

Dent KC, Thompson R, Barker AM, Hiscox JA, Barr JN, Stockley PG, Ranson NA.

Structure. 2013 Jul 2;21(7):1225-34.


Hsc70-induced changes in clathrin-auxilin cage structure suggest a role for clathrin light chains in cage disassembly.

Young A, Stoilova-McPhie S, Rothnie A, Vallis Y, Harvey-Smith P, Ranson N, Kent H, Brodsky FM, Pearse BM, Roseman A, Smith CJ.

Traffic. 2013 Sep;14(9):987-96. doi: 10.1111/tra.12085. Epub 2013 Jun 20.


Packaging signals in single-stranded RNA viruses: nature's alternative to a purely electrostatic assembly mechanism.

Stockley PG, Twarock R, Bakker SE, Barker AM, Borodavka A, Dykeman E, Ford RJ, Pearson AR, Phillips SE, Ranson NA, Tuma R.

J Biol Phys. 2013 Mar;39(2):277-87. doi: 10.1007/s10867-013-9313-0. Epub 2013 Apr 12.


Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization.

Ariza A, Tanner SJ, Walter CT, Dent KC, Shepherd DA, Wu W, Matthews SV, Hiscox JA, Green TJ, Luo M, Elliott RM, Fooks AR, Ashcroft AE, Stonehouse NJ, Ranson NA, Barr JN, Edwards TA.

Nucleic Acids Res. 2013 Jun;41(11):5912-26. doi: 10.1093/nar/gkt268. Epub 2013 Apr 17.


Structural constraints on the three-dimensional geometry of simple viruses: case studies of a new predictive tool.

Keef T, Wardman JP, Ranson NA, Stockley PG, Twarock R.

Acta Crystallogr A. 2013 Mar;69(Pt 2):140-50. doi: 10.1107/S0108767312047150. Epub 2013 Jan 8.


Sequence-specific, RNA-protein interactions overcome electrostatic barriers preventing assembly of satellite tobacco necrosis virus coat protein.

Ford RJ, Barker AM, Bakker SE, Coutts RH, Ranson NA, Phillips SE, Pearson AR, Stockley PG.

J Mol Biol. 2013 Mar 25;425(6):1050-64. doi: 10.1016/j.jmb.2013.01.004. Epub 2013 Jan 11.


Isolation of an asymmetric RNA uncoating intermediate for a single-stranded RNA plant virus.

Bakker SE, Ford RJ, Barker AM, Robottom J, Saunders K, Pearson AR, Ranson NA, Stockley PG.

J Mol Biol. 2012 Mar 16;417(1-2):65-78. doi: 10.1016/j.jmb.2012.01.017. Epub 2012 Jan 27.


Visualising a viral RNA genome poised for release from its receptor complex.

Toropova K, Stockley PG, Ranson NA.

J Mol Biol. 2011 May 6;408(3):408-19. doi: 10.1016/j.jmb.2011.02.040. Epub 2011 Mar 2.


Simple rules for efficient assembly predict the layout of a packaged viral RNA.

Dykeman EC, Grayson NE, Toropova K, Ranson NA, Stockley PG, Twarock R.

J Mol Biol. 2011 May 6;408(3):399-407. doi: 10.1016/j.jmb.2011.02.039. Epub 2011 Feb 25. Review.


Mutually-induced conformational switching of RNA and coat protein underpins efficient assembly of a viral capsid.

Rolfsson Ó, Toropova K, Ranson NA, Stockley PG.

J Mol Biol. 2010 Aug 13;401(2):309-322. doi: 10.1016/j.jmb.2010.05.058.


Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability.

Carter SD, Dent KC, Atkins E, Foster TL, Verow M, Gorny P, Harris M, Hiscox JA, Ranson NA, Griffin S, Barr JN.

FEBS Lett. 2010 Jul 2;584(13):2786-90. doi: 10.1016/j.febslet.2010.05.006. Epub 2010 May 20.


The three-dimensional structure of genomic RNA in bacteriophage MS2: implications for assembly.

Toropova K, Basnak G, Twarock R, Stockley PG, Ranson NA.

J Mol Biol. 2008 Jan 18;375(3):824-36. Epub 2007 Sep 7.


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