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All (animal) models (of neurodegeneration) are wrong. Are they also useful?

Ransohoff RM.

J Exp Med. 2018 Dec 3;215(12):2955-2958. doi: 10.1084/jem.20182042. Epub 2018 Nov 20.


Immune-cell crosstalk in multiple sclerosis.

Ransohoff RM.

Nature. 2018 Nov;563(7730):194-195. doi: 10.1038/d41586-018-07063-z. No abstract available.


Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1I249/M280 Variant.

Cardona SM, Kim SV, Church KA, Torres VO, Cleary IA, Mendiola AS, Saville SP, Watowich SS, Parker-Thornburg J, Soto-Ospina A, Araque P, Ransohoff RM, Cardona AE.

Front Cell Neurosci. 2018 Oct 17;12:365. doi: 10.3389/fncel.2018.00365. eCollection 2018.


TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation.

Zhang CJ, Jiang M, Zhou H, Liu W, Wang C, Kang Z, Han B, Zhang Q, Chen X, Xiao J, Fisher A, Kaiser WJ, Murayama MA, Iwakura Y, Gao J, Carman J, Dongre A, Dubyak G, Abbott DW, Shi FD, Ransohoff RM, Li X.

J Clin Invest. 2018 Dec 3;128(12):5399-5412. doi: 10.1172/JCI121901. Epub 2018 Oct 29.


Author Correction: TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons.

Maatouk L, Compagnion AC, Sauvage MC, Bemelmans AP, Leclere-Turbant S, Cirotteau V, Tohme M, Beke A, Trichet M, Bazin V, Trawick BN, Ransohoff RM, Tronche F, Manoury B, Vyas S.

Nat Commun. 2018 Aug 1;9(1):3109. doi: 10.1038/s41467-018-05680-w.


TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons.

Maatouk L, Compagnion AC, Sauvage MC, Bemelmans AP, Leclere-Turbant S, Cirotteau V, Tohme M, Beke A, Trichet M, Bazin V, Trawick BN, Ransohoff RM, Tronche F, Manoury B, Vyas S.

Nat Commun. 2018 Jun 22;9(1):2450. doi: 10.1038/s41467-018-04569-y. Erratum in: Nat Commun. 2018 Aug 1;9(1):3109.


Biomimetic post-capillary venule expansions for leukocyte adhesion studies.

Benson BL, Li L, Myers JT, Dorand RD, Gurkan UA, Huang AY, Ransohoff RM.

Sci Rep. 2018 Jun 19;8(1):9328. doi: 10.1038/s41598-018-27566-z.


The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.

Cheng-Hathaway PJ, Reed-Geaghan EG, Jay TR, Casali BT, Bemiller SM, Puntambekar SS, von Saucken VE, Williams RY, Karlo JC, Moutinho M, Xu G, Ransohoff RM, Lamb BT, Landreth GE.

Mol Neurodegener. 2018 Jun 1;13(1):29. doi: 10.1186/s13024-018-0262-8.


A whole-genome sequence study identifies genetic risk factors for neuromyelitis optica.

Estrada K, Whelan CW, Zhao F, Bronson P, Handsaker RE, Sun C, Carulli JP, Harris T, Ransohoff RM, McCarroll SA, Day-Williams AG, Greenberg BM, MacArthur DG.

Nat Commun. 2018 May 16;9(1):1929. doi: 10.1038/s41467-018-04332-3.


Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy.

Spiller KJ, Restrepo CR, Khan T, Dominique MA, Fang TC, Canter RG, Roberts CJ, Miller KR, Ransohoff RM, Trojanowski JQ, Lee VM.

Nat Neurosci. 2018 Mar;21(3):329-340. doi: 10.1038/s41593-018-0083-7. Epub 2018 Feb 20.


Laquinimod attenuates inflammation by modulating macrophage functions in traumatic brain injury mouse model.

Katsumoto A, Miranda AS, Butovsky O, Teixeira AL, Ransohoff RM, Lamb BT.

J Neuroinflammation. 2018 Jan 30;15(1):26. doi: 10.1186/s12974-018-1075-y.


Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.

Tagge CA, Fisher AM, Minaeva OV, Gaudreau-Balderrama A, Moncaster JA, Zhang XL, Wojnarowicz MW, Casey N, Lu H, Kokiko-Cochran ON, Saman S, Ericsson M, Onos KD, Veksler R, Senatorov VV Jr, Kondo A, Zhou XZ, Miry O, Vose LR, Gopaul KR, Upreti C, Nowinski CJ, Cantu RC, Alvarez VE, Hildebrandt AM, Franz ES, Konrad J, Hamilton JA, Hua N, Tripodis Y, Anderson AT, Howell GR, Kaufer D, Hall GF, Lu KP, Ransohoff RM, Cleveland RO, Kowall NW, Stein TD, Lamb BT, Huber BR, Moss WC, Friedman A, Stanton PK, McKee AC, Goldstein LE.

Brain. 2018 Feb 1;141(2):422-458. doi: 10.1093/brain/awx350.


Infiltrating macrophages are broadly activated at the early stage to support acute skeletal muscle injury repair.

Wang X, Zhao W, Ransohoff RM, Zhou L.

J Neuroimmunol. 2018 Apr 15;317:55-66. doi: 10.1016/j.jneuroim.2018.01.004. Epub 2018 Jan 4.


Specks of insight into Alzheimer's disease.

Ransohoff RM.

Nature. 2017 Dec 21;552(7685):342-343. doi: 10.1038/d41586-017-08668-6. No abstract available.


GRP78 autoantibodies initiate the breakdown of the blood-brain barrier in neuromyelitis optica.

Shimizu F, Ransohoff RM.

Oncotarget. 2017 Nov 21;8(63):106175-106176. doi: 10.18632/oncotarget.22589. eCollection 2017 Dec 5. No abstract available.


TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.

Bemiller SM, McCray TJ, Allan K, Formica SV, Xu G, Wilson G, Kokiko-Cochran ON, Crish SD, Lasagna-Reeves CA, Ransohoff RM, Landreth GE, Lamb BT.

Mol Neurodegener. 2017 Oct 16;12(1):74. doi: 10.1186/s13024-017-0216-6.


Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution.

Mathys H, Adaikkan C, Gao F, Young JZ, Manet E, Hemberg M, De Jager PL, Ransohoff RM, Regev A, Tsai LH.

Cell Rep. 2017 Oct 10;21(2):366-380. doi: 10.1016/j.celrep.2017.09.039.


Effect of PF-00547659 on Central Nervous System Immune Surveillance and Circulating β7+ T Cells in Crohn's Disease: Report of the TOSCA Study.

D'Haens G, Vermeire S, Vogelsang H, Allez M, Desreumaux P, Van Gossum A, Sandborn WJ, Baumgart DC, Ransohoff RM, Comer GM, Ahmad A, Cataldi F, Cheng J, Clare R, Gorelick KJ, Kaminski A, Pradhan V, Rivers S, Sikpi MO, Zhang Y, Hassan-Zahraee M, Reinisch W, Stuve O.

J Crohns Colitis. 2018 Jan 24;12(2):188-196. doi: 10.1093/ecco-jcc/jjx128.


Traumatic Brain Injury in hTau Model Mice: Enhanced Acute Macrophage Response and Altered Long-Term Recovery.

Kokiko-Cochran ON, Saber M, Puntambekar S, Bemiller SM, Katsumoto A, Lee YS, Bhaskar K, Ransohoff RM, Lamb BT.

J Neurotrauma. 2018 Jan 1;35(1):73-84. doi: 10.1089/neu.2017.5203. Epub 2017 Nov 1.


Polymorphic regulation of mitochondrial fission and fusion modifies phenotypes of microglia in neuroinflammation.

Katoh M, Wu B, Nguyen HB, Thai TQ, Yamasaki R, Lu H, Rietsch AM, Zorlu MM, Shinozaki Y, Saitoh Y, Saitoh S, Sakoh T, Ikenaka K, Koizumi S, Ransohoff RM, Ohno N.

Sci Rep. 2017 Jul 10;7(1):4942. doi: 10.1038/s41598-017-05232-0.


Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica.

Shimizu F, Schaller KL, Owens GP, Cotleur AC, Kellner D, Takeshita Y, Obermeier B, Kryzer TJ, Sano Y, Kanda T, Lennon VA, Ransohoff RM, Bennett JL.

Sci Transl Med. 2017 Jul 5;9(397). pii: eaai9111. doi: 10.1126/scitranslmed.aai9111.


IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression.

Wang C, Zhang CJ, Martin BN, Bulek K, Kang Z, Zhao J, Bian G, Carman JA, Gao J, Dongre A, Xue H, Miller SD, Qian Y, Hambardzumyan D, Hamilton T, Ransohoff RM, Li X.

Nat Commun. 2017 May 31;8:15508. doi: 10.1038/ncomms15508.


An environment-dependent transcriptional network specifies human microglia identity.

Gosselin D, Skola D, Coufal NG, Holtman IR, Schlachetzki JCM, Sajti E, Jaeger BN, O'Connor C, Fitzpatrick C, Pasillas MP, Pena M, Adair A, Gonda DD, Levy ML, Ransohoff RM, Gage FH, Glass CK.

Science. 2017 Jun 23;356(6344). pii: eaal3222. doi: 10.1126/science.aal3222. Epub 2017 May 25.


Should We Stop Saying 'Glia' and 'Neuroinflammation'?

Masgrau R, Guaza C, Ransohoff RM, Galea E.

Trends Mol Med. 2017 Jun;23(6):486-500. doi: 10.1016/j.molmed.2017.04.005. Epub 2017 May 9. Review.


Correction: Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice.

Saederup N, Cardona AE, Croft K, Mizutani M, Cotleur AC, Tsou CL, Ransohoff RM, Charo IF.

PLoS One. 2017 Apr 27;12(4):e0176931. doi: 10.1371/journal.pone.0176931. eCollection 2017.


CD62L is not a reliable biomarker for predicting PML risk in natalizumab-treated R-MS patients. Author Response.

Cahir-McFarland E, Ransohoff RM, Lieberman L, Plavina T.

Neurology. 2016 Aug 30;87(9):958-9. doi: 10.​1212/​01.​wnl.​0000496643.​57775.​41. No abstract available.


Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.

Jay TR, Hirsch AM, Broihier ML, Miller CM, Neilson LE, Ransohoff RM, Lamb BT, Landreth GE.

J Neurosci. 2017 Jan 18;37(3):637-647. doi: 10.1523/JNEUROSCI.2110-16.2016.


Effects of neuromyelitis optica-IgG at the blood-brain barrier in vitro.

Takeshita Y, Obermeier B, Cotleur AC, Spampinato SF, Shimizu F, Yamamoto E, Sano Y, Kryzer TJ, Lennon VA, Kanda T, Ransohoff RM.

Neurol Neuroimmunol Neuroinflamm. 2016 Dec 19;4(1):e311. doi: 10.1212/NXI.0000000000000311. eCollection 2017 Jan.


Identification and Function of Fibrocytes in Skeletal Muscle Injury Repair and Muscular Dystrophy.

Wang X, Zhao W, Ransohoff RM, Zhou L.

J Immunol. 2016 Dec 15;197(12):4750-4761. Epub 2016 Nov 9.


A Neuroprotective Effect of the Glutamate Receptor Antagonist MK801 on Long-Term Cognitive and Behavioral Outcomes Secondary to Experimental Cerebral Malaria.

de Miranda AS, Brant F, Vieira LB, Rocha NP, Vieira ÉLM, Rezende GHS, de Oliveira Pimentel PM, Moraes MFD, Ribeiro FM, Ransohoff RM, Teixeira MM, Machado FS, Rachid MA, Teixeira AL.

Mol Neurobiol. 2017 Nov;54(9):7063-7082. doi: 10.1007/s12035-016-0226-3. Epub 2016 Oct 28.


Efficient derivation of microglia-like cells from human pluripotent stem cells.

Muffat J, Li Y, Yuan B, Mitalipova M, Omer A, Corcoran S, Bakiasi G, Tsai LH, Aubourg P, Ransohoff RM, Jaenisch R.

Nat Med. 2016 Nov;22(11):1358-1367. doi: 10.1038/nm.4189. Epub 2016 Sep 26.



Roberts WK, Blachère NE, Frank MO, Dousmanis A, Ransohoff RM, Darnell RB.

Ann Neurol. 2016 Nov;80(5):793-794. doi: 10.1002/ana.24784. Epub 2016 Oct 19. No abstract available.


CCR2 deficiency does not provide sustained improvement of muscular dystrophy in mdx5cv mice.

Zhao W, Wang X, Ransohoff RM, Zhou L.

FASEB J. 2017 Jan;31(1):35-46. doi: 10.1096/fj.201600619R. Epub 2016 Sep 21.


Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus.

Varvel NH, Neher JJ, Bosch A, Wang W, Ransohoff RM, Miller RJ, Dingledine R.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5665-74. doi: 10.1073/pnas.1604263113. Epub 2016 Sep 6.


How neuroinflammation contributes to neurodegeneration.

Ransohoff RM.

Science. 2016 Aug 19;353(6301):777-83. doi: 10.1126/science.aag2590. Review.


A polarizing question: do M1 and M2 microglia exist?

Ransohoff RM.

Nat Neurosci. 2016 Jul 26;19(8):987-91. doi: 10.1038/nn.4338. Review.


CX3CR1-dependent recruitment of mature NK cells into the central nervous system contributes to control autoimmune neuroinflammation.

Hertwig L, Hamann I, Romero-Suarez S, Millward JM, Pietrek R, Chanvillard C, Stuis H, Pollok K, Ransohoff RM, Cardona AE, Infante-Duarte C.

Eur J Immunol. 2016 Aug;46(8):1984-96. doi: 10.1002/eji.201546194. Epub 2016 Jul 14.


The roles of inflammation and immune mechanisms in Alzheimer's disease.

Van Eldik LJ, Carrillo MC, Cole PE, Feuerbach D, Greenberg BD, Hendrix JA, Kennedy M, Kozauer N, Margolin RA, Molinuevo JL, Mueller R, Ransohoff RM, Wilcock DM, Bain L, Bales K.

Alzheimers Dement (N Y). 2016 May 30;2(2):99-109. doi: 10.1016/j.trci.2016.05.001. eCollection 2016 Jun. Review.


Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion.

Otvos B, Silver DJ, Mulkearns-Hubert EE, Alvarado AG, Turaga SM, Sorensen MD, Rayman P, Flavahan WA, Hale JS, Stoltz K, Sinyuk M, Wu Q, Jarrar A, Kim SH, Fox PL, Nakano I, Rich JN, Ransohoff RM, Finke J, Kristensen BW, Vogelbaum MA, Lathia JD.

Stem Cells. 2016 Aug;34(8):2026-39. doi: 10.1002/stem.2393. Epub 2016 May 27.


The blood-brain barrier.

Obermeier B, Verma A, Ransohoff RM.

Handb Clin Neurol. 2016;133:39-59. doi: 10.1016/B978-0-444-63432-0.00003-7. Review.


Neuroinflammation: Surprises from the sanitary engineers.

Ransohoff RM.

Nature. 2016 Apr 14;532(7598):185-6. doi: 10.1038/nature17881. Epub 2016 Apr 6. No abstract available.


T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis.

Martin BN, Wang C, Zhang CJ, Kang Z, Gulen MF, Zepp JA, Zhao J, Bian G, Do JS, Min B, Pavicic PG Jr, El-Sanadi C, Fox PL, Akitsu A, Iwakura Y, Sarkar A, Wewers MD, Kaiser WJ, Mocarski ES, Rothenberg ME, Hise AG, Dubyak GR, Ransohoff RM, Li X.

Nat Immunol. 2016 May;17(5):583-92. doi: 10.1038/ni.3389. Epub 2016 Mar 21.


Microglial Physiology and Pathophysiology: Insights from Genome-wide Transcriptional Profiling.

Crotti A, Ransohoff RM.

Immunity. 2016 Mar 15;44(3):505-515. doi: 10.1016/j.immuni.2016.02.013. Review.


Neutrophil depletion after subarachnoid hemorrhage improves memory via NMDA receptors.

Provencio JJ, Swank V, Lu H, Brunet S, Baltan S, Khapre RV, Seerapu H, Kokiko-Cochran ON, Lamb BT, Ransohoff RM.

Brain Behav Immun. 2016 May;54:233-242. doi: 10.1016/j.bbi.2016.02.007. Epub 2016 Feb 9.


CD62L is not a reliable biomarker for predicting PML risk in natalizumab-treated R-MS patients.

Lieberman LA, Zeng W, Singh C, Wang W, Otipoby KL, Loh C, Plavina T, Gorelik L, Ransohoff RM, Cahir-McFarland E.

Neurology. 2016 Jan 26;86(4):375-81. doi: 10.1212/WNL.0000000000002314. Epub 2015 Dec 30. Erratum in: Neurology. 2016 Aug 30;87(9):960.


SIV/SHIV Infection Triggers Vascular Inflammation, Diminished Expression of Krüppel-like Factor 2 and Endothelial Dysfunction.

Panigrahi S, Freeman ML, Funderburg NT, Mudd JC, Younes SA, Sieg SF, Zidar DA, Paiardini M, Villinger F, Calabrese LH, Ransohoff RM, Jain MK, Lederman MM.

J Infect Dis. 2016 May 1;213(9):1419-27. doi: 10.1093/infdis/jiv749. Epub 2015 Dec 15.


Spatiotemporal ablation of CXCR2 on oligodendrocyte lineage cells: Role in myelin repair.

Liu L, Spangler LC, Prager B, Benson B, Hu B, Shi S, Love A, Zhang C, Yu M, Cotleur AC, Ransohoff RM.

Neurol Neuroimmunol Neuroinflamm. 2015 Nov 19;2(6):e174. doi: 10.1212/NXI.0000000000000174. eCollection 2015 Dec.


Ccr2 deletion dissociates cavity size and tau pathology after mild traumatic brain injury.

Gyoneva S, Kim D, Katsumoto A, Kokiko-Cochran ON, Lamb BT, Ransohoff RM.

J Neuroinflammation. 2015 Dec 3;12:228. doi: 10.1186/s12974-015-0443-0.


REMOVED: Identification of a unique molecular and functional microglia signature in health and disease.

Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, Koeglsperger T, Dake B, Wu PM, Doykan CE, Fanek Z, Liu L, Chen Z, Rothstein JD, Ransohoff RM, Gygi SP, Antel JP, Weiner HL.

Int J Dev Neurosci. 2015 Dec;47(Pt A):5. doi: 10.1016/j.ijdevneu.2015.04.022. Epub 2015 Nov 5.


CX3CR1 deficiency delays acute skeletal muscle injury repair by impairing macrophage functions.

Zhao W, Lu H, Wang X, Ransohoff RM, Zhou L.

FASEB J. 2016 Jan;30(1):380-93. doi: 10.1096/fj.14-270090. Epub 2015 Oct 6.

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