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Items: 42

1.

S100A10 is a critical mediator of GAS6/AXL-induced angiogenesis in renal cell carcinoma.

Xiao Y, Zhao H, Tian L, Nolley R, Diep AN, Ernst A, Fuh KC, Miao YR, von Eyben R, Leppert JT, Brooks JD, Peehl DM, Giaccia AJ, Rankin EB.

Cancer Res. 2019 Oct 4. pii: canres.1366.2019. doi: 10.1158/0008-5472.CAN-19-1366. [Epub ahead of print]

PMID:
31585940
2.

Genomics and molecular mechanisms of high grade serous ovarian cancer: the 12th Biennial Rivkin Center Ovarian Cancer Research Symposium.

Rankin EB.

Int J Gynecol Cancer. 2019 Aug;29(Suppl 2):s7-s11. doi: 10.1136/ijgc-2019-000490.

PMID:
31462542
3.

Hypoxia-Induced Phenotypes that Mediate Tumor Heterogeneity.

Qian J, Rankin EB.

Adv Exp Med Biol. 2019;1136:43-55. doi: 10.1007/978-3-030-12734-3_3. Review.

PMID:
31201715
4.

Collagen Remodeling in the Hypoxic Tumor-Mesothelial Niche Promotes Ovarian Cancer Metastasis.

Natarajan S, Foreman KM, Soriano MI, Rossen NS, Shehade H, Fregoso DR, Eggold JT, Krishnan V, Dorigo O, Krieg AJ, Heilshorn SC, Sinha S, Fuh KC, Rankin EB.

Cancer Res. 2019 May 1;79(9):2271-2284. doi: 10.1158/0008-5472.CAN-18-2616. Epub 2019 Mar 12.

5.

Erythropoiesis, EPO, macrophages, and bone.

Eggold JT, Rankin EB.

Bone. 2019 Feb;119:36-41. doi: 10.1016/j.bone.2018.03.014. Epub 2018 Mar 15. Review.

PMID:
29551752
6.

Targeting integrins with RGD-conjugated gold nanoparticles in radiotherapy decreases the invasive activity of breast cancer cells.

Wu PH, Onodera Y, Ichikawa Y, Rankin EB, Giaccia AJ, Watanabe Y, Qian W, Hashimoto T, Shirato H, Nam JM.

Int J Nanomedicine. 2017 Jul 14;12:5069-5085. doi: 10.2147/IJN.S137833. eCollection 2017.

7.

Hypoxia: Signaling the Metastatic Cascade.

Rankin EB, Nam JM, Giaccia AJ.

Trends Cancer. 2016 Jun;2(6):295-304. doi: 10.1016/j.trecan.2016.05.006. Epub 2016 Jun 2. Review.

8.

Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data.

Sinha S, Thomas D, Chan S, Gao Y, Brunen D, Torabi D, Reinisch A, Hernandez D, Chan A, Rankin EB, Bernards R, Majeti R, Dill DL.

Nat Commun. 2017 May 31;8:15580. doi: 10.1038/ncomms15580.

9.

Reprogramming the immunological microenvironment through radiation and targeting Axl.

Aguilera TA, Rafat M, Castellini L, Shehade H, Kariolis MS, Hui AB, Stehr H, von Eyben R, Jiang D, Ellies LG, Koong AC, Diehn M, Rankin EB, Graves EE, Giaccia AJ.

Nat Commun. 2016 Dec 23;7:13898. doi: 10.1038/ncomms13898.

10.

Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies.

Kariolis MS, Miao YR, Diep A, Nash SE, Olcina MM, Jiang D, Jones DS 2nd, Kapur S, Mathews II, Koong AC, Rankin EB, Cochran JR, Giaccia AJ.

J Clin Invest. 2017 Jan 3;127(1):183-198. doi: 10.1172/JCI85610. Epub 2016 Nov 28.

11.

The Receptor Tyrosine Kinase AXL in Cancer Progression.

Rankin EB, Giaccia AJ.

Cancers (Basel). 2016 Nov 9;8(11). pii: E103. Review.

12.

AXL modulates extracellular matrix protein expression and is essential for invasion and metastasis in endometrial cancer.

Divine LM, Nguyen MR, Meller E, Desai RA, Arif B, Rankin EB, Bligard KH, Meyerson C, Hagemann IS, Massad M, Thaker PH, Hagemann AR, McCourt CK, Powell MA, Mutch DG, Fuh KC.

Oncotarget. 2016 Nov 22;7(47):77291-77305. doi: 10.18632/oncotarget.12637.

13.

Cabozantinib inhibits tumor growth and metastasis of a patient-derived xenograft model of papillary renal cell carcinoma with MET mutation.

Zhao H, Nolley R, Chan AMW, Rankin EB, Peehl DM.

Cancer Biol Ther. 2017 Nov 2;18(11):863-871. doi: 10.1080/15384047.2016.1219816. Epub 2016 Aug 11.

14.

Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling.

Mirzamohammadi F, Papaioannou G, Inloes JB, Rankin EB, Xie H, Schipani E, Orkin SH, Kobayashi T.

Nat Commun. 2016 Jun 22;7:12047. doi: 10.1038/ncomms12047.

15.

Hypoxic control of metastasis.

Rankin EB, Giaccia AJ.

Science. 2016 Apr 8;352(6282):175-80. doi: 10.1126/science.aaf4405. Epub 2016 Apr 7. Review.

16.

Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma.

Zhou L, Liu XD, Sun M, Zhang X, German P, Bai S, Ding Z, Tannir N, Wood CG, Matin SF, Karam JA, Tamboli P, Sircar K, Rao P, Rankin EB, Laird DA, Hoang AG, Walker CL, Giaccia AJ, Jonasch E.

Oncogene. 2016 May;35(21):2687-97. doi: 10.1038/onc.2015.343. Epub 2015 Sep 14.

17.

Biology of the bone marrow microenvironment and myelodysplastic syndromes.

Rankin EB, Narla A, Park JK, Lin S, Sakamoto KM.

Mol Genet Metab. 2015 Sep-Oct;116(1-2):24-8. doi: 10.1016/j.ymgme.2015.07.004. Epub 2015 Jul 20. Review.

18.

Corrigendum: Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin.

Wu C, Rankin EB, Castellini L, Alcudia JF, LaGory EL, Andersen R, Rhodes SD, Wilson TL, Mohammad KS, Castillo AB, Guise TA, Schipani E, Giaccia AJ.

Genes Dev. 2015 Jun 1;29(11):1202. No abstract available.

19.

Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin.

Wu C, Rankin EB, Castellini L, Alcudia JF, LaGory EL, Andersen R, Rhodes SD, Wilson TL, Mohammad KS, Castillo AB, Guise TA, Schipani E, Giaccia AJ.

Genes Dev. 2015 Apr 15;29(8):817-31. doi: 10.1101/gad.255000.114. Epub 2015 Apr 6. Erratum in: Genes Dev. 2015 Jun 1;29(11):1202. Fernandez-Alcudia, Javier [corrected to Alcudia, Javier F].

20.

Hypoxic induction of AKAP12 variant 2 shifts PKA-mediated protein phosphorylation to enhance migration and metastasis of melanoma cells.

Finger EC, Castellini L, Rankin EB, Vilalta M, Krieg AJ, Jiang D, Banh A, Zundel W, Powell MB, Giaccia AJ.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4441-6. doi: 10.1073/pnas.1418164112. Epub 2015 Mar 19.

21.

Osteoblasts: a novel source of erythropoietin.

Wu C, Giaccia AJ, Rankin EB.

Curr Osteoporos Rep. 2014 Dec;12(4):428-32. doi: 10.1007/s11914-014-0236-x. Review.

22.

Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.

Rankin EB, Fuh KC, Castellini L, Viswanathan K, Finger EC, Diep AN, LaGory EL, Kariolis MS, Chan A, Lindgren D, Axelson H, Miao YR, Krieg AJ, Giaccia AJ.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13373-8. doi: 10.1073/pnas.1404848111. Epub 2014 Sep 3.

23.

Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development.

Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Rankin EB, Giaccia AJ, Schipani E.

Dev Biol. 2014 Sep 1;393(1):124-36. doi: 10.1016/j.ydbio.2014.06.013. Epub 2014 Jun 24.

24.

PHD inhibition mitigates and protects against radiation-induced gastrointestinal toxicity via HIF2.

Taniguchi CM, Miao YR, Diep AN, Wu C, Rankin EB, Atwood TF, Xing L, Giaccia AJ.

Sci Transl Med. 2014 May 14;6(236):236ra64. doi: 10.1126/scitranslmed.3008523.

25.

Regulation of Bone Marrow Angiogenesis by Osteoblasts during Bone Development and Homeostasis.

Schipani E, Wu C, Rankin EB, Giaccia AJ.

Front Endocrinol (Lausanne). 2013 Jul 10;4:85. doi: 10.3389/fendo.2013.00085. eCollection 2013.

26.

CTGF is a therapeutic target for metastatic melanoma.

Finger EC, Cheng CF, Williams TR, Rankin EB, Bedogni B, Tachiki L, Spong S, Giaccia AJ, Powell MB.

Oncogene. 2014 Feb 27;33(9):1093-100. doi: 10.1038/onc.2013.47. Epub 2013 Feb 25.

27.

Blood and bones: osteoblastic HIF signaling regulates erythropoiesis.

Wu C, Rankin EB, Giaccia AJ.

Cell Cycle. 2012 Jun 15;11(12):2221-2. doi: 10.4161/cc.20635. Epub 2012 Jun 15. No abstract available.

28.

The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO.

Rankin EB, Wu C, Khatri R, Wilson TL, Andersen R, Araldi E, Rankin AL, Yuan J, Kuo CJ, Schipani E, Giaccia AJ.

Cell. 2012 Mar 30;149(1):63-74. doi: 10.1016/j.cell.2012.01.051.

29.

A central role for hypoxic signaling in cartilage, bone, and hematopoiesis.

Rankin EB, Giaccia AJ, Schipani E.

Curr Osteoporos Rep. 2011 Jun;9(2):46-52. doi: 10.1007/s11914-011-0047-2. Review.

30.

AXL is an essential factor and therapeutic target for metastatic ovarian cancer.

Rankin EB, Fuh KC, Taylor TE, Krieg AJ, Musser M, Yuan J, Wei K, Kuo CJ, Longacre TA, Giaccia AJ.

Cancer Res. 2010 Oct 1;70(19):7570-9. doi: 10.1158/0008-5472.CAN-10-1267. Epub 2010 Sep 21.

31.

Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth.

Krieg AJ, Rankin EB, Chan D, Razorenova O, Fernandez S, Giaccia AJ.

Mol Cell Biol. 2010 Jan;30(1):344-53. doi: 10.1128/MCB.00444-09.

32.

Hypoxia-inducible factor 2 regulates hepatic lipid metabolism.

Rankin EB, Rha J, Selak MA, Unger TL, Keith B, Liu Q, Haase VH.

Mol Cell Biol. 2009 Aug;29(16):4527-38. doi: 10.1128/MCB.00200-09. Epub 2009 Jun 15.

33.

Bringing H2AX into the angiogenesis family.

Rankin EB, Giaccia AJ, Hammond EM.

Cancer Cell. 2009 Jun 2;15(6):459-61. doi: 10.1016/j.ccr.2009.05.004.

34.

Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis.

Kimura K, Iwano M, Higgins DF, Yamaguchi Y, Nakatani K, Harada K, Kubo A, Akai Y, Rankin EB, Neilson EG, Haase VH, Saito Y.

Am J Physiol Renal Physiol. 2008 Oct;295(4):F1023-9. doi: 10.1152/ajprenal.90209.2008. Epub 2008 Jul 30.

35.

Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice.

Rankin EB, Rha J, Unger TL, Wu CH, Shutt HP, Johnson RS, Simon MC, Keith B, Haase VH.

Oncogene. 2008 Sep 11;27(40):5354-8. doi: 10.1038/onc.2008.160. Epub 2008 May 19.

36.

The role of hypoxia-inducible factors in tumorigenesis.

Rankin EB, Giaccia AJ.

Cell Death Differ. 2008 Apr;15(4):678-85. doi: 10.1038/cdd.2008.21. Epub 2008 Feb 15. Review.

37.

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo.

Rankin EB, Biju MP, Liu Q, Unger TL, Rha J, Johnson RS, Simon MC, Keith B, Haase VH.

J Clin Invest. 2007 Apr;117(4):1068-77.

38.
39.

Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice.

Rankin EB, Higgins DF, Walisser JA, Johnson RS, Bradfield CA, Haase VH.

Mol Cell Biol. 2005 Apr;25(8):3163-72.

40.

Putative intestine-specific enhancers located in 5' sequence of the CDX1 gene regulate CDX1 expression in the intestine.

Rankin EB, Xu W, Silberg DG, Suh E.

Am J Physiol Gastrointest Liver Physiol. 2004 May;286(5):G872-80. Epub 2004 Jan 8.

41.

An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growth.

Rankin EB, Yu D, Jiang J, Shen H, Pearce EJ, Goldschmidt MH, Levy DE, Golovkina TV, Hunter CA, Thomas-Tikhonenko A.

Cancer Biol Ther. 2003 Nov-Dec;2(6):687-93.

PMID:
14688478
42.

DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines.

Suh ER, Ha CS, Rankin EB, Toyota M, Traber PG.

J Biol Chem. 2002 Sep 27;277(39):35795-800. Epub 2002 Jul 17.

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