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Mechanical Ventilation for ARDS During Extracorporeal Life Support: Research and Practice.

Abrams D, Schmidt M, Pham T, Beitler JR, Fan E, Goligher EC, McNamee JJ, Patroniti N, Wilcox ME, Combes A, Ferguson ND, McAuley DF, Pesenti A, Quintel M, Fraser J, Hodgson CL, Hough CL, Mercat A, Mueller T, Pellegrino V, Ranieri VM, Rowan K, Shekar K, Brochard L, Brodie D; International ECMO Network (ECMONet).

Am J Respir Crit Care Med. 2019 Nov 14. doi: 10.1164/rccm.201907-1283CI. [Epub ahead of print]


Determinants of the effect of extracorporeal carbon dioxide removal in the SUPERNOVA trial: implications for trial design.

Goligher EC, Combes A, Brodie D, Ferguson ND, Pesenti AM, Ranieri VM, Slutsky AS; SUPERNOVA investigators (European Society of Intensive Care Medicine trials group)  and for the International ECMO Network (ECMONet).

Intensive Care Med. 2019 Sep;45(9):1219-1230. doi: 10.1007/s00134-019-05708-9. Epub 2019 Aug 20.


Alveolar recruitment in acute respiratory distress syndrome: should we open the lung (no matter what) or may accept (part of) the lung closed?

Del Sorbo L, Tonetti T, Ranieri VM.

Intensive Care Med. 2019 Oct;45(10):1436-1439. doi: 10.1007/s00134-019-05734-7. Epub 2019 Aug 16. No abstract available.


Efficacy and safety of lower versus higher CO2 extraction devices to allow ultraprotective ventilation: secondary analysis of the SUPERNOVA study.

Combes A, Tonetti T, Fanelli V, Pham T, Pesenti A, Mancebo J, Brodie D, Ranieri VM.

Thorax. 2019 Dec;74(12):1179-1181. doi: 10.1136/thoraxjnl-2019-213591. Epub 2019 Aug 13.


Acute Tubular Injury is Associated With Severe Traumatic Brain Injury: in Vitro Study on Human Tubular Epithelial Cells.

Civiletti F, Assenzio B, Mazzeo AT, Medica D, Giaretta F, Deambrosis I, Fanelli V, Ranieri VM, Cantaluppi V, Mascia L.

Sci Rep. 2019 Apr 15;9(1):6090. doi: 10.1038/s41598-019-42147-4.


Feasibility and safety of extracorporeal CO2 removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study.

Combes A, Fanelli V, Pham T, Ranieri VM; European Society of Intensive Care Medicine Trials Group and the “Strategy of Ultra-Protective lung ventilation with Extracorporeal CO2 Removal for New-Onset moderate to severe ARDS” (SUPERNOVA) investigators.

Intensive Care Med. 2019 May;45(5):592-600. doi: 10.1007/s00134-019-05567-4. Epub 2019 Feb 21.


Feasibility of lung microdialysis to assess metabolism during clinical ex vivo lung perfusion.

Mazzeo AT, Fanelli V, Boffini M, Medugno M, Filippini C, Simonato E, Costamagna A, Delsedime L, Brazzi L, Rinaldi M, Ranieri VM, Mascia L.

J Heart Lung Transplant. 2019 Mar;38(3):267-276. doi: 10.1016/j.healun.2018.12.015. Epub 2018 Dec 20.


Extracorporeal organ support (ECOS) in critical illness and acute kidney injury: from native to artificial organ crosstalk.

Husain-Syed F, Ricci Z, Brodie D, Vincent JL, Ranieri VM, Slutsky AS, Taccone FS, Gattinoni L, Ronco C.

Intensive Care Med. 2018 Sep;44(9):1447-1459. doi: 10.1007/s00134-018-5329-z. Epub 2018 Jul 24. Review.


Prone Positioning for ARDS: still misunderstood and misused.

Pugliese F, Babetto C, Alessandri F, Ranieri VM.

J Thorac Dis. 2018 Jun;10(Suppl 17):S2079-S2082. doi: 10.21037/jtd.2018.04.157. No abstract available.


Extracorporeal CO2 Removal May Improve Renal Function of Patients with Acute Respiratory Distress Syndrome and Acute Kidney Injury: An Open-Label, Interventional Clinical Trial.

Fanelli V, Cantaluppi V, Alessandri F, Costamagna A, Cappello P, Brazzi L, Pugliese F, Biancone L, Terragni P, Ranieri VM.

Am J Respir Crit Care Med. 2018 Sep 1;198(5):687-690. doi: 10.1164/rccm.201712-2575LE. No abstract available.


Assessing Risk and Treatment Responsiveness in ARDS. Beyond Physiology.

Del Sorbo L, Nava S, Rubenfeld G, Thompson T, Ranieri VM.

Am J Respir Crit Care Med. 2018 Jun 15;197(12):1516-1518. doi: 10.1164/rccm.201802-0273ED. No abstract available.


Research in Extracorporeal Life Support: A Call to Action.

Brodie D, Vincent JL, Brochard LJ, Combes A, Ferguson ND, Hodgson CL, Laffey JG, Mercat A, Pesenti A, Quintel M, Slutsky AS, Ranieri VM; International ECMO Network (ECMONet).

Chest. 2018 Apr;153(4):788-791. doi: 10.1016/j.chest.2017.12.024. Epub 2018 Jan 31. No abstract available.


Comparison of the efficacy and safety of FP-1201-lyo (intravenously administered recombinant human interferon beta-1a) and placebo in the treatment of patients with moderate or severe acute respiratory distress syndrome: study protocol for a randomized controlled trial.

Bellingan G, Brealey D, Mancebo J, Mercat A, Patroniti N, Pettilä V, Quintel M, Vincent JL, Maksimow M, Jalkanen M, Piippo I, Ranieri VM.

Trials. 2017 Nov 13;18(1):536. doi: 10.1186/s13063-017-2234-7.


Mechanical ventilation: we have come a long way but still have a long road ahead.

Alessandri F, Pugliese F, Ranieri VM.

Lancet Respir Med. 2017 Dec;5(12):922-924. doi: 10.1016/S2213-2600(17)30431-9. Epub 2017 Nov 8. Review. No abstract available.


Prone Position for Acute Respiratory Distress Syndrome. A Systematic Review and Meta-Analysis.

Munshi L, Del Sorbo L, Adhikari NKJ, Hodgson CL, Wunsch H, Meade MO, Uleryk E, Mancebo J, Pesenti A, Ranieri VM, Fan E.

Ann Am Thorac Soc. 2017 Oct;14(Supplement_4):S280-S288. doi: 10.1513/AnnalsATS.201704-343OT. Review.


The Role of Rescue Therapies in the Treatment of Severe ARDS.

Alessandri F, Pugliese F, Ranieri VM.

Respir Care. 2018 Jan;63(1):92-101. doi: 10.4187/respcare.05752. Epub 2017 Oct 24. Review.


Extracorporeal Organ Support: From Technological Tool to Clinical Strategy Supporting Severe Organ Failure.

Ranieri VM, Brodie D, Vincent JL.

JAMA. 2017 Sep 26;318(12):1105-1106. doi: 10.1001/jama.2017.10108. No abstract available.


Respiratory support in patients with acute respiratory distress syndrome: an expert opinion.

Chiumello D, Brochard L, Marini JJ, Slutsky AS, Mancebo J, Ranieri VM, Thompson BT, Papazian L, Schultz MJ, Amato M, Gattinoni L, Mercat A, Pesenti A, Talmor D, Vincent JL.

Crit Care. 2017 Sep 12;21(1):240. doi: 10.1186/s13054-017-1820-0. Review.


Treatment limitations in the era of ECMO.

Brodie D, Curtis JR, Vincent JL, Bakker J, Brown CE, Creteur J, Papazian L, Sladen RN, Ranieri VM; participants in the Round Table Conference.

Lancet Respir Med. 2017 Oct;5(10):769-770. doi: 10.1016/S2213-2600(17)30263-1. Epub 2017 Jul 10. No abstract available.


A fixed correction of absolute transpulmonary pressure may not be ideal for clinical use : Discussion on "Accuracy of esophageal pressure to assess transpulmonary pressure during mechanical ventilation".

Baedorf Kassis E, Loring SH, Talmor D, Terragni P, Mascia L, Ranieri VM.

Intensive Care Med. 2017 Sep;43(9):1436-1437. doi: 10.1007/s00134-017-4823-z. Epub 2017 May 15. No abstract available.


Reversed differential cyanosis during veno-arterial extracorporeal membrane oxygenation in infants: the reevaluation of an old phenomenon.

Di Nardo M, Stoppa F, David P, Lorusso R, Ranieri VM, Mascia L.

Eur J Heart Fail. 2017 May;19 Suppl 2:117-119. doi: 10.1002/ejhf.855. Review. No abstract available.


An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome.

Fan E, Del Sorbo L, Goligher EC, Hodgson CL, Munshi L, Walkey AJ, Adhikari NKJ, Amato MBP, Branson R, Brower RG, Ferguson ND, Gajic O, Gattinoni L, Hess D, Mancebo J, Meade MO, McAuley DF, Pesenti A, Ranieri VM, Rubenfeld GD, Rubin E, Seckel M, Slutsky AS, Talmor D, Thompson BT, Wunsch H, Uleryk E, Brozek J, Brochard LJ; American Thoracic Society, European Society of Intensive Care Medicine, and Society of Critical Care Medicine.

Am J Respir Crit Care Med. 2017 May 1;195(9):1253-1263. doi: 10.1164/rccm.201703-0548ST. Erratum in: Am J Respir Crit Care Med. 2017 Jun 1;195(11):1540.


Fifty Years of Research in ARDS. Is Extracorporeal Circulation the Future of Acute Respiratory Distress Syndrome Management?

Combes A, Pesenti A, Ranieri VM.

Am J Respir Crit Care Med. 2017 May 1;195(9):1161-1170. doi: 10.1164/rccm.201701-0217CP. Review.


Pharmacogenomic influence on sepsis outcome in critically ill patients.

Allegra S, Fatiguso G, Baietto L, Corcione S, Favata F, Ariaudo A, Pagani N, Ranieri VM, De Rosa FG, Di Perri G, D'Avolio A.

Infez Med. 2017 Mar 1;25(1):45-49.


Extracorporeal carbon dioxide removal (ECCO2R) in patients with acute respiratory failure.

Morelli A, Del Sorbo L, Pesenti A, Ranieri VM, Fan E.

Intensive Care Med. 2017 Apr;43(4):519-530. doi: 10.1007/s00134-016-4673-0. Epub 2017 Jan 28. Review.


New training on percutaneous tracheostomy.

Terragni P, Brazzi L, Ranieri VM.

Minerva Anestesiol. 2017 Apr;83(4):423. doi: 10.23736/S0375-9393.17.11866-3. Epub 2017 Jan 25. No abstract available.


ECCO2R in COPD exacerbation only for the right patients and with the right strategy.

Del Sorbo L, Fan E, Nava S, Ranieri VM.

Intensive Care Med. 2016 Nov;42(11):1830-1831. Epub 2016 Sep 1. No abstract available.


Accuracy of esophageal pressure to assess transpulmonary pressure during mechanical ventilation.

Terragni P, Mascia L, Fanelli V, Biondi-Zoccai G, Ranieri VM.

Intensive Care Med. 2017 Jan;43(1):142-143. doi: 10.1007/s00134-016-4589-8. Epub 2016 Oct 15. No abstract available.


Polymyxin-B hemoperfusion in septic patients: analysis of a multicenter registry.

Cutuli SL, Artigas A, Fumagalli R, Monti G, Ranieri VM, Ronco C, Antonelli M; EUPHAS 2 Collaborative Group.

Ann Intensive Care. 2016 Dec;6(1):77. doi: 10.1186/s13613-016-0178-9. Epub 2016 Aug 8.


Physiological Correlation of Airway Pressure and Transpulmonary Pressure Stress Index on Respiratory Mechanics in Acute Respiratory Failure.

Pan C, Chen L, Zhang YH, Liu W, Urbino R, Ranieri VM, Qiu HB, Yang Y.

Chin Med J (Engl). 2016 Jul 20;129(14):1652-7. doi: 10.4103/0366-6999.185855.


Effects of dexmedetomidine and propofol on patient-ventilator interaction in difficult-to-wean, mechanically ventilated patients: a prospective, open-label, randomised, multicentre study.

Conti G, Ranieri VM, Costa R, Garratt C, Wighton A, Spinazzola G, Urbino R, Mascia L, Ferrone G, Pohjanjousi P, Ferreyra G, Antonelli M.

Crit Care. 2016 Jul 2;20(1):206. doi: 10.1186/s13054-016-1386-2.


Heart rate reduction with esmolol is associated with improved arterial elastance in patients with septic shock: a prospective observational study.

Morelli A, Singer M, Ranieri VM, D'Egidio A, Mascia L, Orecchioni A, Piscioneri F, Guarracino F, Greco E, Peruzzi M, Biondi-Zoccai G, Frati G, Romano SM.

Intensive Care Med. 2016 Oct;42(10):1528-1534. doi: 10.1007/s00134-016-4351-2. Epub 2016 Apr 21.


Therapeutic drug monitoring for meropenem after the extracorporeal membrane oxygenation circuit change in children: is it necessary?

Di Nardo M, Cairoli S, Goffredo BM, Stoppa F, D'Argenio P, Corsetti T, Ranieri VM.

Minerva Anestesiol. 2016 Sep;82(9):1018-9. Epub 2016 Apr 20. No abstract available.


Venovenous extracorporeal membrane oxygenation for acute respiratory failure : A clinical review from an international group of experts.

Fan E, Gattinoni L, Combes A, Schmidt M, Peek G, Brodie D, Muller T, Morelli A, Ranieri VM, Pesenti A, Brochard L, Hodgson C, Van Kiersbilck C, Roch A, Quintel M, Papazian L.

Intensive Care Med. 2016 May;42(5):712-724. doi: 10.1007/s00134-016-4314-7. Epub 2016 Mar 23. Review.


The Berlin definition met our needs: yes.

Del Sorbo L, Ranieri VM, Ferguson ND.

Intensive Care Med. 2016 May;42(5):643-647. doi: 10.1007/s00134-016-4286-7. Epub 2016 Mar 23. No abstract available.


Long-Term Quality of Life Among Survivors of Severe Sepsis: Analyses of Two International Trials.

Yende S, Austin S, Rhodes A, Finfer S, Opal S, Thompson T, Bozza FA, LaRosa SP, Ranieri VM, Angus DC.

Crit Care Med. 2016 Aug;44(8):1461-7. doi: 10.1097/CCM.0000000000001658.


Intratracheal Administration of Small Interfering RNA Targeting Fas Reduces Lung Ischemia-Reperfusion Injury.

Del Sorbo L, Costamagna A, Muraca G, Rotondo G, Civiletti F, Vizio B, Bosco O, Martin Conte EL, Frati G, Delsedime L, Lupia E, Fanelli V, Ranieri VM.

Crit Care Med. 2016 Aug;44(8):e604-13. doi: 10.1097/CCM.0000000000001601.


Association between driving pressure and development of postoperative pulmonary complications in patients undergoing mechanical ventilation for general anaesthesia: a meta-analysis of individual patient data.

Neto AS, Hemmes SN, Barbas CS, Beiderlinden M, Fernandez-Bustamante A, Futier E, Gajic O, El-Tahan MR, Ghamdi AA, Günay E, Jaber S, Kokulu S, Kozian A, Licker M, Lin WQ, Maslow AD, Memtsoudis SG, Reis Miranda D, Moine P, Ng T, Paparella D, Ranieri VM, Scavonetto F, Schilling T, Selmo G, Severgnini P, Sprung J, Sundar S, Talmor D, Treschan T, Unzueta C, Weingarten TN, Wolthuis EK, Wrigge H, Amato MB, Costa EL, de Abreu MG, Pelosi P, Schultz MJ; PROVE Network Investigators.

Lancet Respir Med. 2016 Apr;4(4):272-80. doi: 10.1016/S2213-2600(16)00057-6. Epub 2016 Mar 4. Review. Erratum in: Lancet Respir Med. 2016 Jun;4(6):e34.


Steroids are part of rescue therapy in ARDS patients with refractory hypoxemia: no.

Thompson BT, Ranieri VM.

Intensive Care Med. 2016 May;42(5):921-923. doi: 10.1007/s00134-016-4255-1. Epub 2016 Feb 16. No abstract available.


Neuromuscular Blocking Agent Cisatracurium Attenuates Lung Injury by Inhibition of Nicotinic Acetylcholine Receptor-α1.

Fanelli V, Morita Y, Cappello P, Ghazarian M, Sugumar B, Delsedime L, Batt J, Ranieri VM, Zhang H, Slutsky AS.

Anesthesiology. 2016 Jan;124(1):132-40. doi: 10.1097/ALN.0000000000000907.


How much esophageal pressure-guided end-expiratory transpulmonary pressure is sufficient to maintain lung recruitment in lavage-induced lung injury?

Huang Y, Tang R, Chen Q, Pan C, Liu S, Hui X, Li Y, Yang Y, Ranieri VM, Qiu H.

J Trauma Acute Care Surg. 2016 Feb;80(2):302-7. doi: 10.1097/TA.0000000000000900.


Ventilatory Management During Normothermic Ex Vivo Lung Perfusion: Effects on Clinical Outcomes.

Terragni PP, Fanelli V, Boffini M, Filippini C, Cappello P, Ricci D, Del Sorbo L, Faggiano C, Brazzi L, Frati G, Venuta F, Mascia L, Rinaldi M, Ranieri VM.

Transplantation. 2016 May;100(5):1128-35. doi: 10.1097/TP.0000000000000929.


The authors reply.

Del Sorbo L, Nava S, Ranieri VM.

Crit Care Med. 2015 Sep;43(9):e391. doi: 10.1097/CCM.0000000000001154. No abstract available.


Development and validation of an ultra performance liquid chromatography tandem mass method for sildenafil and N-desmethyl sildenafil plasma determination and quantification.

Simiele M, Pensi D, Pasero D, Ivaldi F, Rinaldi M, Di Perri G, Ranieri VM, D'Avolio A.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Sep 15;1001:35-40. doi: 10.1016/j.jchromb.2015.07.023. Epub 2015 Jul 17.


Pharmacokinetics of high dosage of linezolid in two morbidly obese patients.

Corcione S, Pagani N, Baietto L, Fanelli V, Urbino R, Ranieri VM, Di Perri G, D'Avolio A, De Rosa FG.

J Antimicrob Chemother. 2015 Oct;70(10):2925. doi: 10.1093/jac/dkv238. Epub 2015 Aug 7. No abstract available.


Pharmacokinetics of high dosage of linezolid in two morbidly obese patients-authors' response.

Corcione S, Pagani N, Baietto L, Fanelli V, Urbino R, Ranieri VM, Di Perri G, D'Avolio A, De Rosa FG.

J Antimicrob Chemother. 2015 Nov;70(11):3169. doi: 10.1093/jac/dkv240. Epub 2015 Aug 5. No abstract available.


Noninvasive ventilation in critically ill patients.

Gregoretti C, Pisani L, Cortegiani A, Ranieri VM.

Crit Care Clin. 2015 Jul;31(3):435-57. doi: 10.1016/j.ccc.2015.03.002. Review.


The authors reply.

Del Sorbo L, Nava S, Ranieri VM.

Crit Care Med. 2015 Jul;43(7):e261-2. doi: 10.1097/CCM.0000000000000994. No abstract available.


Pharmacokinetics of high dosage of linezolid in two morbidly obese patients.

Corcione S, Pagani N, Baietto L, Fanelli V, Urbino R, Ranieri VM, Di Perri G, D'Avolio A, De Rosa FG.

J Antimicrob Chemother. 2015 Aug;70(8):2417-8. doi: 10.1093/jac/dkv126. Epub 2015 May 8. No abstract available. Erratum in: J Antimicrob Chemother. 2015 Oct;70(10):2925.


Perioperative cardiovascular monitoring of high-risk patients: a consensus of 12.

Vincent JL, Pelosi P, Pearse R, Payen D, Perel A, Hoeft A, Romagnoli S, Ranieri VM, Ichai C, Forget P, Della Rocca G, Rhodes A.

Crit Care. 2015 May 8;19:224. doi: 10.1186/s13054-015-0932-7. Review.

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