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Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy.

Katschke KJ Jr, Xi H, Cox C, Truong T, Malato Y, Lee WP, McKenzie B, Arceo R, Tao J, Rangell L, Reichelt M, Diehl L, Elstrott J, Weimer RM, Campagne MVL.

Sci Rep. 2018 May 9;8(1):7348. doi: 10.1038/s41598-018-25557-8.


Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma.

Salphati L, Alicke B, Heffron TP, Shahidi-Latham S, Nishimura M, Cao T, Carano RA, Cheong J, Greve J, Koeppen H, Lau S, Lee LB, Nannini-Pepe M, Pang J, Plise EG, Quiason C, Rangell L, Zhang X, Gould SE, Phillips HS, Olivero AG.

Drug Metab Dispos. 2016 Dec;44(12):1881-1889. Epub 2016 Sep 16.


High cell-surface density of HER2 deforms cell membranes.

Chung I, Reichelt M, Shao L, Akita RW, Koeppen H, Rangell L, Schaefer G, Mellman I, Sliwkowski MX.

Nat Commun. 2016 Sep 7;7:12742. doi: 10.1038/ncomms12742.


Preclinical Safety Profile of a Depleting Antibody against CRTh2 for Asthma: Well Tolerated Despite Unexpected CRTh2 Expression on Vascular Pericytes in the Central Nervous System and Gastric Mucosa.

Rajapaksa KS, Huang T, Sharma N, Liu S, Solon M, Reyes A, Paul S, Yee A, Tao J, Chalasani S, Bien-Ly N, Barck K, Carano RA, Wang J, Rangell L, Bremer M, Danilenko DM, Katavolos P, Hotzel I, Reif K, Austin CD.

Toxicol Sci. 2016 Jul;152(1):72-84. doi: 10.1093/toxsci/kfw067. Epub 2016 Apr 21.


Enhancing full-length antibody production by signal peptide engineering.

Zhou Y, Liu P, Gan Y, Sandoval W, Katakam AK, Reichelt M, Rangell L, Reilly D.

Microb Cell Fact. 2016 Mar 2;15:47. doi: 10.1186/s12934-016-0445-3.


IL-33 amplifies an innate immune response in the degenerating retina.

Xi H, Katschke KJ Jr, Li Y, Truong T, Lee WP, Diehl L, Rangell L, Tao J, Arceo R, Eastham-Anderson J, Hackney JA, Iglesias A, Cote-Sierra J, Elstrott J, Weimer RM, van Lookeren Campagne M.

J Exp Med. 2016 Feb 8;213(2):189-207. doi: 10.1084/jem.20150894. Epub 2016 Jan 11.


Depletion of the central metabolite NAD leads to oncosis-mediated cell death.

Del Nagro C, Xiao Y, Rangell L, Reichelt M, O'Brien T.

J Biol Chem. 2014 Dec 19;289(51):35182-92. doi: 10.1074/jbc.M114.580159. Epub 2014 Oct 29.


An antimesothelin-monomethyl auristatin e conjugate with potent antitumor activity in ovarian, pancreatic, and mesothelioma models.

Scales SJ, Gupta N, Pacheco G, Firestein R, French DM, Koeppen H, Rangell L, Barry-Hamilton V, Luis E, Chuh J, Zhang Y, Ingle GS, Fourie-O'Donohue A, Kozak KR, Ross S, Dennis MS, Spencer SD.

Mol Cancer Ther. 2014 Nov;13(11):2630-40. doi: 10.1158/1535-7163.MCT-14-0487-T. Epub 2014 Sep 23.


Homeostatic IL-23 receptor signaling limits Th17 response through IL-22-mediated containment of commensal microbiota.

Shih VF, Cox J, Kljavin NM, Dengler HS, Reichelt M, Kumar P, Rangell L, Kolls JK, Diehl L, Ouyang W, Ghilardi N.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13942-7. doi: 10.1073/pnas.1323852111. Epub 2014 Sep 8.


Biomarker analyses from a placebo-controlled phase II study evaluating erlotinib±onartuzumab in advanced non-small cell lung cancer: MET expression levels are predictive of patient benefit.

Koeppen H, Yu W, Zha J, Pandita A, Penuel E, Rangell L, Raja R, Mohan S, Patel R, Desai R, Fu L, Do A, Parab V, Xia X, Januario T, Louie SG, Filvaroff E, Shames DS, Wistuba I, Lipkind M, Huang J, Lazarov M, Ramakrishnan V, Amler L, Phan SC, Patel P, Peterson A, Yauch RL.

Clin Cancer Res. 2014 Sep 1;20(17):4488-98. doi: 10.1158/1078-0432.CCR-13-1836. Epub 2014 Mar 31.


Chk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell death.

Del Nagro CJ, Choi J, Xiao Y, Rangell L, Mohan S, Pandita A, Zha J, Jackson PK, O'Brien T.

Cell Cycle. 2014;13(2):303-14. doi: 10.4161/cc.27055. Epub 2013 Feb 1.


The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling.

Mukhopadhyay S, Wen X, Ratti N, Loktev A, Rangell L, Scales SJ, Jackson PK.

Cell. 2013 Jan 17;152(1-2):210-23. doi: 10.1016/j.cell.2012.12.026.


Equilibrative nucleoside transporter 3 deficiency perturbs lysosome function and macrophage homeostasis.

Hsu CL, Lin W, Seshasayee D, Chen YH, Ding X, Lin Z, Suto E, Huang Z, Lee WP, Park H, Xu M, Sun M, Rangell L, Lutman JL, Ulufatu S, Stefanich E, Chalouni C, Sagolla M, Diehl L, Fielder P, Dean B, Balazs M, Martin F.

Science. 2012 Jan 6;335(6064):89-92. doi: 10.1126/science.1213682. Epub 2011 Dec 15.


A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable.

Tian H, Biehs B, Warming S, Leong KG, Rangell L, Klein OD, de Sauvage FJ.

Nature. 2011 Sep 18;478(7368):255-9. doi: 10.1038/nature10408. Erratum in: Nature. 2012 Feb 2;482(7383):120.


Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse.

Wilson DG, Phamluong K, Li L, Sun M, Cao TC, Liu PS, Modrusan Z, Sandoval WN, Rangell L, Carano RA, Peterson AS, Solloway MJ.

J Cell Biol. 2011 May 30;193(5):935-51. doi: 10.1083/jcb.201007162. Epub 2011 May 23. Erratum in: J Cell Biol. 2011 Jul 25;194(2):347.


Sustained release formulations of rhVEGF₁₆₅ produce a durable response in a murine model of peripheral angiogenesis.

Daugherty AL, Rangell LK, Eckert R, Zavala-Solorio J, Peale F, Mrsny RJ.

Eur J Pharm Biopharm. 2011 Jun;78(2):289-97. doi: 10.1016/j.ejpb.2011.03.011. Epub 2011 Mar 21.


Functional characterization of putative cilia genes by high-content analysis.

Lai CK, Gupta N, Wen X, Rangell L, Chih B, Peterson AS, Bazan JF, Li L, Scales SJ.

Mol Biol Cell. 2011 Apr;22(7):1104-19. doi: 10.1091/mbc.E10-07-0596. Epub 2011 Feb 2.


The role of unconscious volition in psychoanalysis: commentary on Meissner.

Rangell L.

J Am Psychoanal Assoc. 2009 Oct;57(5):1157-65; author reply 1167-8. doi: 10.1177/0003065109342588. No abstract available.


Polar localization of virulence-related Esx-1 secretion in mycobacteria.

Carlsson F, Joshi SA, Rangell L, Brown EJ.

PLoS Pathog. 2009 Jan;5(1):e1000285. doi: 10.1371/journal.ppat.1000285. Epub 2009 Jan 30.


Genetic deletion of JAM-C reveals a role in myeloid progenitor generation.

Praetor A, McBride JM, Chiu H, Rangell L, Cabote L, Lee WP, Cupp J, Danilenko DM, Fong S.

Blood. 2009 Feb 26;113(9):1919-28. doi: 10.1182/blood-2008-06-159574. Epub 2008 Dec 24.


Reconciliation: the continuing role of theory.

Rangell L.

J Am Acad Psychoanal Dyn Psychiatry. 2008 Summer;36(2):217-33. doi: 10.1521/jaap.2008.36.2.217.


A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis.

Katschke KJ Jr, Helmy KY, Steffek M, Xi H, Yin J, Lee WP, Gribling P, Barck KH, Carano RA, Taylor RE, Rangell L, Diehl L, Hass PE, Wiesmann C, van Lookeren Campagne M.

J Exp Med. 2007 Jun 11;204(6):1319-25. Epub 2007 Jun 4.


Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies.

Gerber HP, Wu X, Yu L, Wiesmann C, Liang XH, Lee CV, Fuh G, Olsson C, Damico L, Xie D, Meng YG, Gutierrez J, Corpuz R, Li B, Hall L, Rangell L, Ferrando R, Lowman H, Peale F, Ferrara N.

Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3478-83. Epub 2007 Feb 20.


Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth.

Fan B, Brennan J, Grant D, Peale F, Rangell L, Kirchhofer D.

Dev Biol. 2007 Mar 1;303(1):222-30. Epub 2006 Nov 10.


Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis.

Föger N, Rangell L, Danilenko DM, Chan AC.

Science. 2006 Aug 11;313(5788):839-42.


Somatic mutations lead to an oncogenic deletion of met in lung cancer.

Kong-Beltran M, Seshagiri S, Zha J, Zhu W, Bhawe K, Mendoza N, Holcomb T, Pujara K, Stinson J, Fu L, Severin C, Rangell L, Schwall R, Amler L, Wickramasinghe D, Yauch R.

Cancer Res. 2006 Jan 1;66(1):283-9.


The mitochondrial inner membrane protein mitofilin controls cristae morphology.

John GB, Shang Y, Li L, Renken C, Mannella CA, Selker JM, Rangell L, Bennett MJ, Zha J.

Mol Biol Cell. 2005 Mar;16(3):1543-54. Epub 2005 Jan 12.


The theory of psychoanalysis: vicissitudes of its evolution.

Rangell L.

J Am Psychoanal Assoc. 2002 Winter;50(4):1109-37. No abstract available.


Prostate stem cell antigen as therapy target: tissue expression and in vivo efficacy of an immunoconjugate.

Ross S, Spencer SD, Holcomb I, Tan C, Hongo J, Devaux B, Rangell L, Keller GA, Schow P, Steeves RM, Lutz RJ, Frantz G, Hillan K, Peale F, Tobin P, Eberhard D, Rubin MA, Lasky LA, Koeppen H.

Cancer Res. 2002 May 1;62(9):2546-53.


Identification of an angiogenic mitogen selective for endocrine gland endothelium.

LeCouter J, Kowalski J, Foster J, Hass P, Zhang Z, Dillard-Telm L, Frantz G, Rangell L, DeGuzman L, Keller GA, Peale F, Gurney A, Hillan KJ, Ferrara N.

Nature. 2001 Aug 30;412(6850):877-84.


Psychoanalytic psychotherapy: the enduring legacy of psychoanalysis.

Rangell L.

Psychoanal Rev. 2001 Feb;88(1):1-14. No abstract available.


Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo.

Xin X, Yang S, Ingle G, Zlot C, Rangell L, Kowalski J, Schwall R, Ferrara N, Gerritsen ME.

Am J Pathol. 2001 Mar;158(3):1111-20.


Pex22p of Pichia pastoris, essential for peroxisomal matrix protein import, anchors the ubiquitin-conjugating enzyme, Pex4p, on the peroxisomal membrane.

Koller A, Snyder WB, Faber KN, Wenzel TJ, Rangell L, Keller GA, Subramani S.

J Cell Biol. 1999 Jul 12;146(1):99-112.


Pex19p interacts with Pex3p and Pex10p and is essential for peroxisome biogenesis in Pichia pastoris.

Snyder WB, Faber KN, Wenzel TJ, Koller A, Lüers GH, Rangell L, Keller GA, Subramani S.

Mol Biol Cell. 1999 Jun;10(6):1745-61.


VEGF is required for growth and survival in neonatal mice.

Gerber HP, Hillan KJ, Ryan AM, Kowalski J, Keller GA, Rangell L, Wright BD, Radtke F, Aguet M, Ferrara N.

Development. 1999 Mar;126(6):1149-59.


Peroxisome degradation by microautophagy in Pichia pastoris: identification of specific steps and morphological intermediates.

Sakai Y, Koller A, Rangell LK, Keller GA, Subramani S.

J Cell Biol. 1998 May 4;141(3):625-36.


Normal platelets and megakaryocytes are produced in vivo in the absence of thrombopoietin.

Bunting S, Widmer R, Lipari T, Rangell L, Steinmetz H, Carver-Moore K, Moore MW, Keller GA, de Sauvage FJ.

Blood. 1997 Nov 1;90(9):3423-9.


Psychoanalytic realities and the analytic goal.

Rangell L.

Int J Psychoanal. 1995 Feb;76 ( Pt 1):15-8. No abstract available.


The psychoanalytic theory of change.

Rangell L.

Int J Psychoanal. 1992 Autumn;73 ( Pt 3):415-28.



Rangell L.

J Am Psychoanal Assoc. 1991;39(1):3-23. Review.


Seventeen: a developmental view.

Rangell L.

Adolesc Psychiatry. 1989;16:92-117. No abstract available.


Action theory within the structural view.

Rangell L.

Int J Psychoanal. 1989;70 ( Pt 2):189-203. Review.


The future of psychoanalysis: the scientific crossroads.

Rangell L.

Psychoanal Q. 1988 Jul;57(3):313-40. No abstract available.


The decision to terminate one's life: psychoanalytic thoughts on suicide.

Rangell L.

Suicide Life Threat Behav. 1988 Spring;18(1):28-46. No abstract available.


A core process in psychoanalytic treatment.

Rangell L.

Psychoanal Q. 1987 Jan;56(1):222-49.


The executive functions of the ego. An extension of the concept of ego autonomy.

Rangell L.

Psychoanal Study Child. 1986;41:1-37. No abstract available.


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