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Items: 30

1.

Galectin-1-driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance.

Nambiar DK, Aguilera T, Cao H, Kwok S, Kong C, Bloomstein J, Wang Z, Rangan VS, Jiang D, von Eyben R, Liang R, Agarwal S, Colevas AD, Korman A, Allen CT, Uppaluri R, Koong AC, Giaccia A, Le QT.

J Clin Invest. 2019 Nov 11. pii: 129025. doi: 10.1172/JCI129025. [Epub ahead of print]

2.

Uncialamycin as a novel payload for antibody drug conjugate (ADC) based targeted cancer therapy.

Chowdari NS, Pan C, Rao C, Langley DR, Sivaprakasam P, Sufi B, Derwin D, Wang Y, Kwok E, Passmore D, Rangan VS, Deshpande S, Cardarelli P, Vite G, Gangwar S.

Bioorg Med Chem Lett. 2019 Feb 1;29(3):466-470. doi: 10.1016/j.bmcl.2018.12.021. Epub 2018 Dec 11.

PMID:
30579797
3.

A Novel, Fully Human Anti-fucosyl-GM1 Antibody Demonstrates Potent In Vitro and In Vivo Antitumor Activity in Preclinical Models of Small Cell Lung Cancer.

Ponath P, Menezes D, Pan C, Chen B, Oyasu M, Strachan D, LeBlanc H, Sun H, Wang XT, Rangan VS, Deshpande S, Cristea S, Park KS, Sage J, Cardarelli PM.

Clin Cancer Res. 2018 Oct 15;24(20):5178-5189. doi: 10.1158/1078-0432.CCR-18-0018. Epub 2018 Jul 18.

4.

Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab.

Ramagopal UA, Liu W, Garrett-Thomson SC, Bonanno JB, Yan Q, Srinivasan M, Wong SC, Bell A, Mankikar S, Rangan VS, Deshpande S, Korman AJ, Almo SC.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4223-E4232. doi: 10.1073/pnas.1617941114. Epub 2017 May 8.

5.

Validation of an integrated series of ligand-binding assays for the quantitative determination of antibody-drug conjugates in biological matrices.

Myler H, Rangan VS, Kozhich A, Hoffpauir B, Dail D, Cummings J, Saewert M, Manney A, Liu A, Rao C, Wang J, Pillutla R, DeSilva B.

Bioanalysis. 2016 Mar;8(6):519-31. doi: 10.4155/bio.16.13. Epub 2016 Feb 26.

PMID:
26915587
6.

Quantitative bioanalysis of antibody-conjugated payload in monkey plasma using a hybrid immuno-capture LC-MS/MS approach: Assay development, validation, and a case study.

Liu A, Kozhich A, Passmore D, Gu H, Wong R, Zambito F, Rangan VS, Myler H, Aubry AF, Arnold ME, Wang J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:54-62. doi: 10.1016/j.jchromb.2015.08.007. Epub 2015 Aug 12.

PMID:
26310897
7.

An integrated multiplatform bioanalytical strategy for antibody-drug conjugates: a novel case study.

Myler H, Rangan VS, Wang J, Kozhich A, Cummings JA, Neely R, Dail D, Liu A, Wang B, Vezina HE, Freebern W, Sung MC, Passmore D, Deshpande S, Kempe T, Gu H, Saewert M, Manney A, Lute J, Zambito F, Wong RL, Piccoli SP, Aubry AF, Pillutla R, Arnold M, DeSilva B.

Bioanalysis. 2015;7(13):1569-82. doi: 10.4155/bio.15.80.

PMID:
26226308
8.

Challenges in antibody-drug conjugate discovery: a bioconjugation and analytical perspective.

Rao C, Rangan VS, Deshpande S.

Bioanalysis. 2015;7(13):1561-4. doi: 10.4155/bio.15.81. No abstract available.

9.

Biotransformation and stability of antibody-drug conjugates: payload metabolism and linker cleavage delineation.

Rangan VS, Myler H, Kozhich A, Wang J, Randazzo R, Deshpande S.

Bioanalysis. 2015;7(11):1319-23. doi: 10.4155/bio.15.50. No abstract available.

PMID:
26110704
10.

Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models.

Sankaranarayanan S, Barten DM, Vana L, Devidze N, Yang L, Cadelina G, Hoque N, DeCarr L, Keenan S, Lin A, Cao Y, Snyder B, Zhang B, Nitla M, Hirschfeld G, Barrezueta N, Polson C, Wes P, Rangan VS, Cacace A, Albright CF, Meredith J Jr, Trojanowski JQ, Lee VM, Brunden KR, Ahlijanian M.

PLoS One. 2015 May 1;10(5):e0125614. doi: 10.1371/journal.pone.0125614. eCollection 2015.

11.

Pharmacokinetic characterization of BMS-936561, an anti-CD70 antibody-drug conjugate, in preclinical animal species and prediction of its pharmacokinetics in humans.

Wang H, Rangan VS, Sung MC, Passmore D, Kempe T, Wang X, Thevanayagam L, Pan C, Rao C, Srinivasan M, Zhang Q, Gangwar S, Deshpande S, Cardarelli P, Marathe P, Yang Z.

Biopharm Drug Dispos. 2016 Mar;37(2):93-106. doi: 10.1002/bdd.1953. Epub 2015 May 15.

PMID:
25869904
12.

An unusual presentation of neurofibroma masquerading as a vascular hamartoma, post-iatrogenic intervention.

Shah AM, Dash SP, Das SP, Rangan VS, Bhartiya SC.

J Clin Diagn Res. 2015 Jan;9(1):PD18-9. doi: 10.7860/JCDR/2015/9852.5442. Epub 2015 Jan 1.

13.

A quantitative human monoclonal antibody immunoassay using anti-idiotypic antibody as a membrane antigen surrogate with surface-plasmon-resonance detection.

Wong RB, Lee AH, Rangan VS, Cheng KC.

Biotechnol Appl Biochem. 2009 May;53(Pt 1):51-61. doi: 10.1042/BA20080072.

PMID:
18680480
14.

Production of human monoclonal antibody in eggs of chimeric chickens.

Zhu L, van de Lavoir MC, Albanese J, Beenhouwer DO, Cardarelli PM, Cuison S, Deng DF, Deshpande S, Diamond JH, Green L, Halk EL, Heyer BS, Kay RM, Kerchner A, Leighton PA, Mather CM, Morrison SL, Nikolov ZL, Passmore DB, Pradas-Monne A, Preston BT, Rangan VS, Shi M, Srinivasan M, White SG, Winters-Digiacinto P, Wong S, Zhou W, Etches RJ.

Nat Biotechnol. 2005 Sep;23(9):1159-69. Epub 2005 Aug 28.

15.

Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity.

Joshi AK, Zhang L, Rangan VS, Smith S.

J Biol Chem. 2003 Aug 29;278(35):33142-9. Epub 2003 Jun 18.

16.

Engineering of an active animal fatty acid synthase dimer with only one competent subunit.

Joshi AK, Rangan VS, Witkowski A, Smith S.

Chem Biol. 2003 Feb;10(2):169-73.

PMID:
12618189
17.

Mapping the functional topology of the animal fatty acid synthase by mutant complementation in vitro.

Rangan VS, Joshi AK, Smith S.

Biochemistry. 2001 Sep 11;40(36):10792-9.

PMID:
11535054
18.

The human thioesterase II protein binds to a site on HIV-1 Nef critical for CD4 down-regulation.

Cohen GB, Rangan VS, Chen BK, Smith S, Baltimore D.

J Biol Chem. 2000 Jul 28;275(30):23097-105.

22.

Regulatory elements in the first intron of the rat fatty acid synthase gene.

Oskouian B, Rangan VS, Smith S.

Biochem J. 1997 May 15;324 ( Pt 1):113-21.

29.

Structural organization of the multifunctional animal fatty-acid synthase.

Witkowski A, Rangan VS, Randhawa ZI, Amy CM, Smith S.

Eur J Biochem. 1991 Jun 15;198(3):571-9.

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