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Items: 1 to 50 of 156

1.

Schistosoma mansoni Infection-Induced Transcriptional Changes in Hepatic Macrophage Metabolism Correlate With an Athero-Protective Phenotype.

Cortes-Selva D, Elvington AF, Ready A, Rajwa B, Pearce EJ, Randolph GJ, Fairfax KC.

Front Immunol. 2018 Nov 12;9:2580. doi: 10.3389/fimmu.2018.02580. eCollection 2018.

2.

Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis.

Huang LH, Zinselmeyer BH, Chang CH, Saunders BT, Elvington A, Baba O, Broekelmann TJ, Qi L, Rueve JS, Swartz MA, Kim BS, Mecham RP, Wiig H, Thomas MJ, Sorci-Thomas MG, Randolph GJ.

Cell Metab. 2018 Nov 5. pii: S1550-4131(18)30638-7. doi: 10.1016/j.cmet.2018.10.006. [Epub ahead of print]

PMID:
30415924
3.

Macrophage Biology, Classification, and Phenotype in Cardiovascular Disease: JACC Macrophage in CVD Series (Part 1).

Williams JW, Giannarelli C, Rahman A, Randolph GJ, Kovacic JC.

J Am Coll Cardiol. 2018 Oct 30;72(18):2166-2180. doi: 10.1016/j.jacc.2018.08.2148. Review.

PMID:
30360826
4.

Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models.

Kim K, Shim D, Lee JS, Zaitsev K, Williams JW, Kim KW, Jang MY, Seok Jang H, Yun TJ, Lee SH, Yoon WK, Prat A, Seidah NG, Choi J, Lee SP, Yoon SH, Nam JW, Seong JK, Oh GT, Randolph GJ, Artyomov MN, Cheong C, Choi JH.

Circ Res. 2018 Oct 26;123(10):1127-1142. doi: 10.1161/CIRCRESAHA.118.312804.

PMID:
30359200
5.

Lymph nodes go with the flow.

Czepielewski RS, Randolph GJ.

J Exp Med. 2018 Nov 5;215(11):2699-2701. doi: 10.1084/jem.20181898. Epub 2018 Oct 24.

PMID:
30355618
6.

Kidney-resident macrophages promote a proangiogenic environment in the normal and chronically ischemic mouse kidney.

Puranik AS, Leaf IA, Jensen MA, Hedayat AF, Saad A, Kim KW, Saadalla AM, Woollard JR, Kashyap S, Textor SC, Grande JP, Lerman A, Simari RD, Randolph GJ, Duffield JS, Lerman LO.

Sci Rep. 2018 Sep 17;8(1):13948. doi: 10.1038/s41598-018-31887-4.

7.

A novel role for C-C motif chemokine receptor 2 during infection with hypervirulent Mycobacterium tuberculosis.

Dunlap MD, Howard N, Das S, Scott N, Ahmed M, Prince O, Rangel-Moreno J, Rosa BA, Martin J, Kaushal D, Kaplan G, Mitreva M, Kim KW, Randolph GJ, Khader SA.

Mucosal Immunol. 2018 Nov;11(6):1727-1742. doi: 10.1038/s41385-018-0071-y. Epub 2018 Aug 16.

PMID:
30115997
8.

Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice.

Gomez D, Baylis RA, Durgin BG, Newman AAC, Alencar GF, Mahan S, St Hilaire C, Müller W, Waisman A, Francis SE, Pinteaux E, Randolph GJ, Gram H, Owens GK.

Nat Med. 2018 Sep;24(9):1418-1429. doi: 10.1038/s41591-018-0124-5. Epub 2018 Jul 23.

PMID:
30038218
9.

Limited Macrophage Positional Dynamics in Progressing or Regressing Murine Atherosclerotic Plaques-Brief Report.

Williams JW, Martel C, Potteaux S, Esaulova E, Ingersoll MA, Elvington A, Saunders BT, Huang LH, Habenicht AJ, Zinselmeyer BH, Randolph GJ.

Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1702-1710. doi: 10.1161/ATVBAHA.118.311319.

PMID:
29903736
10.

Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.

Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, Korenfeld D, Mathyer ME, Kim H, Huang LH, Duncan D, Bregman H, Keskin A, Santeford A, Apte RS, Sehgal R, Johnson B, Amarasinghe GK, Soares MP, Satoh T, Akira S, Hai T, de Guzman Strong C, Auclair K, Roddy TP, Biller SA, Jovanovic M, Klechevsky E, Stewart KM, Randolph GJ, Artyomov MN.

Nature. 2018 Apr;556(7702):501-504. doi: 10.1038/s41586-018-0052-z. Epub 2018 Apr 18.

11.

Contribution of metabolic disease to bone fragility in MAGP1-deficient mice.

Turecamo SE, Walji TA, Broekelmann TJ, Williams JW, Ivanov S, Wee NK, Procknow JD, McManus MR, Randolph GJ, Scheller EL, Mecham RP, Craft CS.

Matrix Biol. 2018 Apr;67:1-14. doi: 10.1016/j.matbio.2018.02.022. Epub 2018 Mar 5.

PMID:
29519758
12.

Editorial overview: Innate immunity: The finely tuned STING of innate immunity.

Randolph GJ.

Curr Opin Immunol. 2018 Feb;50:v-vii. doi: 10.1016/j.coi.2018.01.003. Epub 2018 Feb 20. No abstract available.

PMID:
29475574
13.

Cardiac Lymphatic Vessels, Transport, and Healing of the Infarcted Heart.

Huang LH, Lavine KJ, Randolph GJ.

JACC Basic Transl Sci. 2017 Aug;2(4):477-483. doi: 10.1016/j.jacbts.2017.02.005. Epub 2017 Aug 28.

14.

Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression.

Zhu Y, Herndon JM, Sojka DK, Kim KW, Knolhoff BL, Zuo C, Cullinan DR, Luo J, Bearden AR, Lavine KJ, Yokoyama WM, Hawkins WG, Fields RC, Randolph GJ, DeNardo DG.

Immunity. 2017 Sep 19;47(3):597. doi: 10.1016/j.immuni.2017.08.018. No abstract available.

15.

Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression.

Zhu Y, Herndon JM, Sojka DK, Kim KW, Knolhoff BL, Zuo C, Cullinan DR, Luo J, Bearden AR, Lavine KJ, Yokoyama WM, Hawkins WG, Fields RC, Randolph GJ, DeNardo DG.

Immunity. 2017 Aug 15;47(2):323-338.e6. doi: 10.1016/j.immuni.2017.07.014. Erratum in: Immunity. 2017 Sep 19;47(3):597.

16.

Thermoneutrality but Not UCP1 Deficiency Suppresses Monocyte Mobilization Into Blood.

Williams JW, Elvington A, Ivanov S, Kessler S, Luehmann H, Baba O, Saunders BT, Kim KW, Johnson MW, Craft CS, Choi JH, Sorci-Thomas MG, Zinselmeyer BH, Brestoff JR, Liu Y, Randolph GJ.

Circ Res. 2017 Sep 1;121(6):662-676. doi: 10.1161/CIRCRESAHA.117.311519. Epub 2017 Jul 10.

17.

Sphingosine-1-Phosphate as the Lymphocyte's Ticket to Ride and Survive.

Chang CH, Randolph GJ.

Dev Cell. 2017 Jun 19;41(6):576-578. doi: 10.1016/j.devcel.2017.06.006. Review.

18.

A Polecat's View of Patrolling Monocytes.

Williams JW, Randolph GJ, Zinselmeyer BH.

Circ Res. 2017 May 26;120(11):1699-1701. doi: 10.1161/CIRCRESAHA.117.311021. No abstract available.

19.

Pillars Article: Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking. Science. 1998. 282: 480-483.

Randolph GJ, Beaulieu S, Lebecque S, Steinman RM, Muller WA.

J Immunol. 2017 Jun 1;198(11):4191-4194. No abstract available.

20.

Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity.

Westerterp M, Gautier EL, Ganda A, Molusky MM, Wang W, Fotakis P, Wang N, Randolph GJ, D'Agati VD, Yvan-Charvet L, Tall AR.

Cell Metab. 2017 Jun 6;25(6):1294-1304.e6. doi: 10.1016/j.cmet.2017.04.005. Epub 2017 May 4.

21.

Monocyte differentiation and antigen-presenting functions.

Jakubzick CV, Randolph GJ, Henson PM.

Nat Rev Immunol. 2017 Jun;17(6):349-362. doi: 10.1038/nri.2017.28. Epub 2017 Apr 24. Review.

PMID:
28436425
22.

Myeloid cells pave the way for lymphatic system development and maintenance.

Ivanov S, Randolph GJ.

Pflugers Arch. 2017 Apr;469(3-4):465-472. doi: 10.1007/s00424-017-1951-9. Epub 2017 Feb 20. Review.

23.

Corrigendum: Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability.

Evrard SM, Lecce L, Michelis KC, Nomura-Kitabayashi A, Pandey G, Purushothaman KR, d'Escamard V, Li JR, Hadri L, Fujitani K, Moreno PR, Benard L, Rimmele P, Cohain A, Mecham B, Randolph GJ, Nabel EG, Hajjar R, Fuster V, Boehm M, Kovacic JC.

Nat Commun. 2017 Feb 16;8:14710. doi: 10.1038/ncomms14710. No abstract available.

24.

Defensin-chemokine heteromeric complexes derived from heterocellular activation-a possible target to inhibit CCL5 in cardiovascular settings.

Baba O, Liu Y, Randolph GJ.

Ann Transl Med. 2016 Dec;4(24):497. doi: 10.21037/atm.2016.11.46. No abstract available.

25.

CD36 deficiency impairs the small intestinal barrier and induces subclinical inflammation in mice.

Cifarelli V, Ivanov S, Xie Y, Son NH, Saunders BT, Pietka TA, Shew TM, Yoshino J, Sundaresan S, Davidson NO, Goldberg IJ, Gelman AE, Zinselmeyer BH, Randolph GJ, Abumrad NA.

Cell Mol Gastroenterol Hepatol. 2017 Jan;3(1):82-98. doi: 10.1016/j.jcmgh.2016.09.001.

26.

The Lymphatic System: Integral Roles in Immunity.

Randolph GJ, Ivanov S, Zinselmeyer BH, Scallan JP.

Annu Rev Immunol. 2017 Apr 26;35:31-52. doi: 10.1146/annurev-immunol-041015-055354. Epub 2016 Nov 14. Review.

27.

CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses.

Chong SZ, Evrard M, Devi S, Chen J, Lim JY, See P, Zhang Y, Adrover JM, Lee B, Tan L, Li JL, Liong KH, Phua C, Balachander A, Boey A, Liebl D, Tan SM, Chan JK, Balabanian K, Harris JE, Bianchini M, Weber C, Duchene J, Lum J, Poidinger M, Chen Q, Rénia L, Wang CI, Larbi A, Randolph GJ, Weninger W, Looney MR, Krummel MF, Biswas SK, Ginhoux F, Hidalgo A, Bachelerie F, Ng LG.

J Exp Med. 2016 Oct 17;213(11):2293-2314. Epub 2016 Oct 10.

28.

Mafb lineage tracing to distinguish macrophages from other immune lineages reveals dual identity of Langerhans cells.

Wu X, Briseño CG, Durai V, Albring JC, Haldar M, Bagadia P, Kim KW, Randolph GJ, Murphy TL, Murphy KM.

J Exp Med. 2016 Nov 14;213(12):2553-2565. Epub 2016 Oct 17.

29.

Lymphoid Aggregates Remodel Lymphatic Collecting Vessels that Serve Mesenteric Lymph Nodes in Crohn Disease.

Randolph GJ, Bala S, Rahier JF, Johnson MW, Wang PL, Nalbantoglu I, Dubuquoy L, Chau A, Pariente B, Kartheuser A, Zinselmeyer BH, Colombel JF.

Am J Pathol. 2016 Dec;186(12):3066-3073. doi: 10.1016/j.ajpath.2016.07.026. Epub 2016 Oct 13.

30.

Trafficking patterns of mononuclear phagocytes.

Randolph GJ.

Nat Rev Immunol. 2016 Nov;16(11):660. doi: 10.1038/nri.2016.110. Epub 2016 Oct 10. No abstract available.

PMID:
27721482
31.

Homegrown Macrophages.

Kim KW, Zhang N, Choi K, Randolph GJ.

Immunity. 2016 Sep 20;45(3):468-470. doi: 10.1016/j.immuni.2016.09.006. Review.

32.

MHC II+ resident peritoneal and pleural macrophages rely on IRF4 for development from circulating monocytes.

Kim KW, Williams JW, Wang YT, Ivanov S, Gilfillan S, Colonna M, Virgin HW, Gautier EL, Randolph GJ.

J Exp Med. 2016 Sep 19;213(10):1951-9. doi: 10.1084/jem.20160486. Epub 2016 Aug 22.

33.

PET/MRI of Hypoxic Atherosclerosis Using 64Cu-ATSM in a Rabbit Model.

Nie X, Laforest R, Elvington A, Randolph GJ, Zheng J, Voller T, Abendschein DR, Lapi SE, Woodard PK.

J Nucl Med. 2016 Dec;57(12):2006-2011. Epub 2016 Jul 7.

34.

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation.

Lampropoulou V, Sergushichev A, Bambouskova M, Nair S, Vincent EE, Loginicheva E, Cervantes-Barragan L, Ma X, Huang SC, Griss T, Weinheimer CJ, Khader S, Randolph GJ, Pearce EJ, Jones RG, Diwan A, Diamond MS, Artyomov MN.

Cell Metab. 2016 Jul 12;24(1):158-66. doi: 10.1016/j.cmet.2016.06.004. Epub 2016 Jun 30.

35.

Imaging of hypoxia in mouse atherosclerotic plaques with (64)Cu-ATSM.

Nie X, Randolph GJ, Elvington A, Bandara N, Zheleznyak A, Gropler RJ, Woodard PK, Lapi SE.

Nucl Med Biol. 2016 Sep;43(9):534-542. doi: 10.1016/j.nucmedbio.2016.05.011. Epub 2016 May 30.

36.

Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability.

Evrard SM, Lecce L, Michelis KC, Nomura-Kitabayashi A, Pandey G, Purushothaman KR, d'Escamard V, Li JR, Hadri L, Fujitani K, Moreno PR, Benard L, Rimmele P, Cohain A, Mecham B, Randolph GJ, Nabel EG, Hajjar R, Fuster V, Boehm M, Kovacic JC.

Nat Commun. 2016 Jun 24;7:11853. doi: 10.1038/ncomms11853.

37.

CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability.

Ivanov S, Scallan JP, Kim KW, Werth K, Johnson MW, Saunders BT, Wang PL, Kuan EL, Straub AC, Ouhachi M, Weinstein EG, Williams JW, Briseño C, Colonna M, Isakson BE, Gautier EL, Förster R, Davis MJ, Zinselmeyer BH, Randolph GJ.

J Clin Invest. 2016 Apr 1;126(4):1581-91. doi: 10.1172/JCI84518. Epub 2016 Mar 21.

38.

Corrigendum: KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.

Shankman LS, Gomez D, Cherepanova OA, Salmon M, Alencar GF, Haskins RM, Swiatlowska P, Newman AA, Greene ES, Straub AC, Isakson B, Randolph GJ, Owens GK.

Nat Med. 2016 Feb;22(2):217. doi: 10.1038/nm0216-217a. No abstract available.

39.

PET/CT Imaging of Chemokine Receptors in Inflammatory Atherosclerosis Using Targeted Nanoparticles.

Luehmann HP, Detering L, Fors BP, Pressly ED, Woodard PK, Randolph GJ, Gropler RJ, Hawker CJ, Liu Y.

J Nucl Med. 2016 Jul;57(7):1124-9. doi: 10.2967/jnumed.115.166751. Epub 2016 Jan 21.

40.

Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis.

Lu Q, Yokoyama CC, Williams JW, Baldridge MT, Jin X, DesRochers B, Bricker T, Wilen CB, Bagaitkar J, Loginicheva E, Sergushichev A, Kreamalmeyer D, Keller BC, Zhao Y, Kambal A, Green DR, Martinez J, Dinauer MC, Holtzman MJ, Crouch EC, Beatty W, Boon AC, Zhang H, Randolph GJ, Artyomov MN, Virgin HW.

Cell Host Microbe. 2016 Jan 13;19(1):102-13. doi: 10.1016/j.chom.2015.12.011.

41.

CCR7: Unifying Disparate Journeys to the Lymph Node.

Randolph GJ.

J Immunol. 2016 Jan 1;196(1):3-4. doi: 10.4049/jimmunol.1502372. No abstract available.

42.

Self-renewing resident arterial macrophages arise from embryonic CX3CR1(+) precursors and circulating monocytes immediately after birth.

Ensan S, Li A, Besla R, Degousee N, Cosme J, Roufaiel M, Shikatani EA, El-Maklizi M, Williams JW, Robins L, Li C, Lewis B, Yun TJ, Lee JS, Wieghofer P, Khattar R, Farrokhi K, Byrne J, Ouzounian M, Zavitz CC, Levy GA, Bauer CM, Libby P, Husain M, Swirski FK, Cheong C, Prinz M, Hilgendorf I, Randolph GJ, Epelman S, Gramolini AO, Cybulsky MI, Rubin BB, Robbins CS.

Nat Immunol. 2016 Feb;17(2):159-68. doi: 10.1038/ni.3343. Epub 2015 Dec 7.

PMID:
26642357
43.

Flow Cytometric Analysis of Mononuclear Phagocytes in Nondiseased Human Lung and Lung-Draining Lymph Nodes.

Desch AN, Gibbings SL, Goyal R, Kolde R, Bednarek J, Bruno T, Slansky JE, Jacobelli J, Mason R, Ito Y, Messier E, Randolph GJ, Prabagar M, Atif SM, Segura E, Xavier RJ, Bratton DL, Janssen WJ, Henson PM, Jakubzick CV.

Am J Respir Crit Care Med. 2016 Mar 15;193(6):614-26. doi: 10.1164/rccm.201507-1376OC.

44.

Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity.

Fonseca DM, Hand TW, Han SJ, Gerner MY, Glatman Zaretsky A, Byrd AL, Harrison OJ, Ortiz AM, Quinones M, Trinchieri G, Brenchley JM, Brodsky IE, Germain RN, Randolph GJ, Belkaid Y.

Cell. 2015 Oct 8;163(2):354-66. doi: 10.1016/j.cell.2015.08.030.

45.

NADPH oxidase controls neutrophilic response to sterile inflammation in mice by regulating the IL-1α/G-CSF axis.

Bagaitkar J, Pech NK, Ivanov S, Austin A, Zeng MY, Pallat S, Huang G, Randolph GJ, Dinauer MC.

Blood. 2015 Dec 17;126(25):2724-33. doi: 10.1182/blood-2015-05-644773. Epub 2015 Oct 6.

46.

The role of the lymphatic system in cholesterol transport.

Huang LH, Elvington A, Randolph GJ.

Front Pharmacol. 2015 Sep 2;6:182. doi: 10.3389/fphar.2015.00182. eCollection 2015. Review.

47.

The pancreas anatomy conditions the origin and properties of resident macrophages.

Calderon B, Carrero JA, Ferris ST, Sojka DK, Moore L, Epelman S, Murphy KM, Yokoyama WM, Randolph GJ, Unanue ER.

J Exp Med. 2015 Sep 21;212(10):1497-512. doi: 10.1084/jem.20150496. Epub 2015 Sep 7.

48.

Macrophages Subvert Adaptive Immunity to Urinary Tract Infection.

Mora-Bau G, Platt AM, van Rooijen N, Randolph GJ, Albert ML, Ingersoll MA.

PLoS Pathog. 2015 Jul 16;11(7):e1005044. doi: 10.1371/journal.ppat.1005044. eCollection 2015 Jul.

49.

Macrophage Supply and Demand at the Core of the Necrotic Granuloma.

Randolph GJ.

Cell Host Microbe. 2015 Jul 8;18(1):3-4. doi: 10.1016/j.chom.2015.06.014.

50.

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.

Shankman LS, Gomez D, Cherepanova OA, Salmon M, Alencar GF, Haskins RM, Swiatlowska P, Newman AA, Greene ES, Straub AC, Isakson B, Randolph GJ, Owens GK.

Nat Med. 2015 Jun;21(6):628-37. doi: 10.1038/nm.3866. Epub 2015 May 18. Erratum in: Nat Med. 2016 Feb;22(2):217.

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