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Effect of essential amino acid supplementation and aerobic exercise on insulin sensitivity in healthy older adults: A randomized clinical trial.

Randolph AC, Markofski MM, Rasmussen BB, Volpi E.

Clin Nutr. 2019 Jun 28. pii: S0261-5614(19)30273-0. doi: 10.1016/j.clnu.2019.06.017. [Epub ahead of print]


A Modular Cytokine Analysis Method Reveals Novel Associations With Clinical Phenotypes and Identifies Sets of Co-signaling Cytokines Across Influenza Natural Infection Cohorts and Healthy Controls.

Cohen L, Fiore-Gartland A, Randolph AG, Panoskaltsis-Mortari A, Wong SS, Ralston J, Wood T, Seeds R, Huang QS, Webby RJ, Thomas PG, Hertz T.

Front Immunol. 2019 Jun 18;10:1338. doi: 10.3389/fimmu.2019.01338. eCollection 2019.


Drug potency on inhibiting late Na+ current is sensitive to gating modifier and current region where drug effects were measured.

Wu M, Tran PN, Sheng J, Randolph AL, Wu WW.

J Pharmacol Toxicol Methods. 2019 Jun 27:106605. doi: 10.1016/j.vascn.2019.106605. [Epub ahead of print]


Growth and Changing Characteristics of Pediatric Intensive Care 2001-2016.

Horak RV, Griffin JF, Brown AM, Nett ST, Christie LM, Forbes ML, Kubis S, Li S, Singleton MN, Verger JT, Markovitz BP, Burns JP, Chung SA, Randolph AG; Pediatric Acute Lung Injury and Sepsis Investigator’s (PALISI) Network.

Crit Care Med. 2019 Aug;47(8):1135-1142. doi: 10.1097/CCM.0000000000003863.


Evaluation of Mannose Binding Lectin Gene Variants in Pediatric Influenza Virus-Related Critical Illness.

Levy ER, Yip WK, Super M, Ferdinands JM, Mistry AJ, Newhams MM, Zhang Y, Su HC, McLaughlin GE, Sapru A, Loftis LL, Weiss SL, Hall MW, Cvijanovich N, Schwarz A, Tarquinio KM, Mourani PM; PALISI PICFLU Investigators, Randolph AG.

Front Immunol. 2019 May 8;10:1005. doi: 10.3389/fimmu.2019.01005. eCollection 2019.


Acute respiratory distress syndrome.

Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, Herridge M, Randolph AG, Calfee CS.

Nat Rev Dis Primers. 2019 Mar 14;5(1):18. doi: 10.1038/s41572-019-0069-0. Review.


Cost Implications of Escalating Intravenous Acetaminophen Use in Children.

Bourgeois FT, Graham DA, Kesselheim AS, Randolph AG.

JAMA Pediatr. 2019 Mar 11. doi: 10.1001/jamapediatrics.2019.0101. [Epub ahead of print] No abstract available.


Antibiotic Prescription in Young Children With Respiratory Syncytial Virus-Associated Respiratory Failure and Associated Outcomes.

Shein SL, Kong M, McKee B, O'Riordan M, Toltzis P, Randolph AG.

Pediatr Crit Care Med. 2019 Feb;20(2):101-109. doi: 10.1097/PCC.0000000000001839.


Tricyclic Antidepressant and/or γ-Aminobutyric Acid-Analog Use Is Associated With Fall Risk in Diabetic Peripheral Neuropathy.

Randolph AC, Lin YL, Volpi E, Kuo YF.

J Am Geriatr Soc. 2019 Jun;67(6):1174-1181. doi: 10.1111/jgs.15779. Epub 2019 Jan 29.


Modulation of Peroxynitrite Reduces Norepinephrine Requirements in Ovine MRSA Septic Shock.

Fukuda S, Ihara K, Andersen CR, Randolph AC, Nelson CL, Zeng Y, Kim J, DeWitt DS, Rojas JD, Koutrouvelis A, Herndon DN, Prough DS, Enkhbaatar P.

Shock. 2018 Nov 28. doi: 10.1097/SHK.0000000000001297. [Epub ahead of print]


Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative.

Li Z, Ridder BJ, Han X, Wu WW, Sheng J, Tran PN, Wu M, Randolph A, Johnstone RH, Mirams GR, Kuryshev Y, Kramer J, Wu C, Crumb WJ Jr, Strauss DG.

Clin Pharmacol Ther. 2019 Feb;105(2):466-475. doi: 10.1002/cpt.1184. Epub 2018 Aug 27.


Blood-Brain Barrier Dysfunction After Smoke Inhalation Injury, With and Without Skin Burn.

Randolph AC, Fukuda S, Ihara K, Enkhbaatar P, Micci MA.

Shock. 2019 May;51(5):634-649. doi: 10.1097/SHK.0000000000001196.


Vancomycin Monotherapy May Be Insufficient to Treat Methicillin-resistant Staphylococcus aureus Coinfection in Children With Influenza-related Critical Illness.

Randolph AG, Xu R, Novak T, Newhams MM, Bubeck Wardenburg J, Weiss SL, Sanders RC, Thomas NJ, Hall MW, Tarquinio KM, Cvijanovich N, Gedeit RG, Truemper EJ, Markovitz B, Hartman ME, Ackerman KG, Giuliano JS Jr, Shein SL, Moffitt KL; Pediatric Intensive Care Influenza Investigators from the Pediatric Acute Lung Injury and Sepsis Investigator’s Network .

Clin Infect Dis. 2019 Jan 18;68(3):365-372. doi: 10.1093/cid/ciy495.


Effect of Aerobic Exercise Training and Essential Amino Acid Supplementation for 24 Weeks on Physical Function, Body Composition and Muscle Metabolism in Healthy, Independent Older Adults: A Randomized Clinical Trial.

Markofski MM, Jennings K, Timmerman KL, Dickinson JM, Fry CS, Borack MS, Reidy PT, Deer RR, Randolph A, Rasmussen BB, Volpi E.

J Gerontol A Biol Sci Med Sci. 2018 May 10. doi: 10.1093/gerona/gly109. [Epub ahead of print]


Cytokine Profiles of Severe Influenza Virus-Related Complications in Children.

Fiore-Gartland A, Panoskaltsis-Mortari A, Agan AA, Mistry AJ, Thomas PG, Matthay MA; PALISI PICFlu Investigators, Hertz T, Randolph AG.

Front Immunol. 2017 Nov 6;8:1423. doi: 10.3389/fimmu.2017.01423. eCollection 2017.


Adipose-derived stem cells attenuate pulmonary microvascular hyperpermeability after smoke inhalation.

Ihara K, Fukuda S, Enkhtaivan B, Trujillo R, Perez-Bello D, Nelson C, Randolph A, Alharbi S, Hanif H, Herndon D, Prough D, Enkhbaatar P.

PLoS One. 2017 Oct 5;12(10):e0185937. doi: 10.1371/journal.pone.0185937. eCollection 2017.


A Biosignature Predicting Complicated Course in Children Presenting with Septic Shock. Why PERSEVERE?

Randolph AG.

Am J Respir Crit Care Med. 2017 Aug 15;196(4):411-413. doi: 10.1164/rccm.201704-0759ED. No abstract available.


SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans.

Allen EK, Randolph AG, Bhangale T, Dogra P, Ohlson M, Oshansky CM, Zamora AE, Shannon JP, Finkelstein D, Dressen A, DeVincenzo J, Caniza M, Youngblood B, Rosenberger CM, Thomas PG.

Nat Med. 2017 Aug;23(8):975-983. doi: 10.1038/nm.4370. Epub 2017 Jul 17.


Decoy peptide targeted to Toll-IL-1R domain inhibits LPS and TLR4-active metabolite morphine-3 glucuronide sensitization of sensory neurons.

Allette YM, Kim Y, Randolph AL, Smith JA, Ripsch MS, White FA.

Sci Rep. 2017 Jun 16;7(1):3741. doi: 10.1038/s41598-017-03447-9.


Evaluation of IFITM3 rs12252 Association With Severe Pediatric Influenza Infection.

Randolph AG, Yip WK, Allen EK, Rosenberger CM, Agan AA, Ash SA, Zhang Y, Bhangale TR, Finkelstein D, Cvijanovich NZ, Mourani PM, Hall MW, Su HC, Thomas PG; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network Pediatric Influenza (PICFLU) Investigators; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network Pediatric Influenza (PICFLU) Investigators.

J Infect Dis. 2017 Jul 1;216(1):14-21. doi: 10.1093/infdis/jix242.


Why So Few Randomized Trials in Pediatric Critical Care Medicine? Ask the Trialists.

Randolph AG.

Pediatr Crit Care Med. 2017 May;18(5):486-487. doi: 10.1097/PCC.0000000000001156. No abstract available.


Simulation of a Novel Schedule for Intensivist Staffing to Improve Continuity of Patient Care and Reduce Physician Burnout.

Geva A, Landrigan CP, van der Velden MG, Randolph AG.

Crit Care Med. 2017 Jul;45(7):1138-1144. doi: 10.1097/CCM.0000000000002319.


Patellar tendon reconstruction using an extended gastrocnemius flap following cryogenic injury to the knee.

Kim RH, Randolph AH, Tirre CJ, Morrey M, Jennings JM.

Knee. 2017 Jun;24(3):686-691. doi: 10.1016/j.knee.2017.01.012. Epub 2017 Mar 25.


Principal component analysis-T voxel based relaxometry of the articular cartilage: a comparison of biochemical patterns in osteoarthritis and anterior cruciate ligament subjects.

Pedoia V, Russell C, Randolph A, Li X, Majumdar S; AF-ACL Consortium.

Quant Imaging Med Surg. 2016 Dec;6(6):623-633. doi: 10.21037/qims.2016.11.03.


Mannose-Binding Lectin Levels in Critically Ill Children With Severe Infections.

Madsen EC, Levy ER, Madden K, Agan AA, Sullivan RM, Graham DA, Randolph AG.

Pediatr Crit Care Med. 2017 Feb;18(2):103-111. doi: 10.1097/PCC.0000000000001000.


Enterovirus D68 Reemerges Globally as a Severe Pathogen Targeting Children.

Randolph AG.

Pediatr Crit Care Med. 2016 Nov;17(11):1088-1089. No abstract available.


Determinants of red blood cell transfusion in pediatric trauma patients admitted to the intensive care unit.

Roumeliotis N, Ducruet T, Bateman ST, Randolph AG, Lacroix J, Emeriaud G; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.

Transfusion. 2017 Jan;57(1):187-194. doi: 10.1111/trf.13857. Epub 2016 Oct 2.


Staphylococcus aureus α-Toxin Response Distinguishes Respiratory Virus-Methicillin-Resistant S. aureus Coinfection in Children.

Yu KO, Randolph AG, Agan AA, Yip WK, Truemper EJ, Weiss SL, Ackerman KG, Schwarz AJ, Giuliano JS Jr, Hall MW, Bubeck Wardenburg J; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) PICFlu Study Group; PALISI PICFlu Study Group.

J Infect Dis. 2016 Dec 1;214(11):1638-1646. Epub 2016 Sep 20.


Proton currents constrain structural models of voltage sensor activation.

Randolph AL, Mokrab Y, Bennett AL, Sansom MS, Ramsey IS.

Elife. 2016 Aug 30;5. pii: e18017. doi: 10.7554/eLife.18017.


High Variability in the Reported Management of Hepatic Veno-Occlusive Disease in Children after Hematopoietic Stem Cell Transplantation.

Skeens MA, McArthur J, Cheifetz IM, Duncan C, Randolph AG, Stanek J, Lehman L, Bajwa R; HSCT subgroup of the Pediatric Acute Lung Injury & Sepsis Investigators (PALISI).

Biol Blood Marrow Transplant. 2016 Oct;22(10):1823-1828. doi: 10.1016/j.bbmt.2016.07.011. Epub 2016 Aug 2.


The Impact of Clinical Trials Conducted by Research Networks in Pediatric Critical Care.

Choong K, Duffett M, Cook DJ, Randolph AG.

Pediatr Crit Care Med. 2016 Sep;17(9):837-44. doi: 10.1097/PCC.0000000000000835. Review.


The authors reply.

Tasker RC, Randolph AG.

Pediatr Crit Care Med. 2016 Jun;17(6):583-4. doi: 10.1097/PCC.0000000000000762. No abstract available.


Incidence and risk factors for postoperative vomiting following atrial septal defect repair in children.

Lee J, Faraoni D, Lee S, Brown M, Odegard K, Randolph A, DiNardo JA, Yuki K.

Paediatr Anaesth. 2016 Jun;26(6):644-8. doi: 10.1111/pan.12908. Epub 2016 Apr 19.


The role of glial-specific Kir4.1 in normal and pathological states of the CNS.

Nwaobi SE, Cuddapah VA, Patterson KC, Randolph AC, Olsen ML.

Acta Neuropathol. 2016 Jul;132(1):1-21. doi: 10.1007/s00401-016-1553-1. Epub 2016 Mar 9. Review.


Pragmatic trials in critically ill children are CATCHing on.

Randolph AG.

Lancet. 2016 Apr 23;387(10029):1697-8. doi: 10.1016/S0140-6736(16)00566-3. Epub 2016 Mar 4. No abstract available.


Optimizing Virus Identification in Critically Ill Children Suspected of Having an Acute Severe Viral Infection.

Randolph AG, Agan AA, Flanagan RF, Meece JK, Fitzgerald JC, Loftis LL, Truemper EJ, Li S, Ferdinands JM; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) PICFlu Study Group.

Pediatr Crit Care Med. 2016 Apr;17(4):279-86. doi: 10.1097/PCC.0000000000000661.


Severity-of-Illness Scoring in Pediatric Critical Care: Quo Vadis?

Tasker RC, Randolph AG.

Pediatr Crit Care Med. 2016 Jan;17(1):83-5. doi: 10.1097/PCC.0000000000000559. No abstract available.


Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker.

Ju W, Nair V, Smith S, Zhu L, Shedden K, Song PXK, Mariani LH, Eichinger FH, Berthier CC, Randolph A, Lai JY, Zhou Y, Hawkins JJ, Bitzer M, Sampson MG, Thier M, Solier C, Duran-Pacheco GC, Duchateau-Nguyen G, Essioux L, Schott B, Formentini I, Magnone MC, Bobadilla M, Cohen CD, Bagnasco SM, Barisoni L, Lv J, Zhang H, Wang HY, Brosius FC, Gadegbeku CA, Kretzler M; ERCB, C-PROBE, NEPTUNE, and PKU-IgAN Consortium.

Sci Transl Med. 2015 Dec 2;7(316):316ra193. doi: 10.1126/scitranslmed.aac7071.


Pooled Sequencing of Candidate Genes Implicates Rare Variants in the Development of Asthma Following Severe RSV Bronchiolitis in Infancy.

Torgerson DG, Giri T, Druley TE, Zheng J, Huntsman S, Seibold MA, Young AL, Schweiger T, Yin-Declue H, Sajol GD, Schechtman KB, Hernandez RD, Randolph AG, Bacharier LB, Castro M.

PLoS One. 2015 Nov 20;10(11):e0142649. doi: 10.1371/journal.pone.0142649. eCollection 2015.


Anesthesiologist- and System-Related Risk Factors for Risk-Adjusted Pediatric Anesthesia-Related Cardiac Arrest.

Zgleszewski SE, Graham DA, Hickey PR, Brustowicz RM, Odegard KC, Koka R, Seefelder C, Navedo AT, Randolph AG.

Anesth Analg. 2016 Feb;122(2):482-9. doi: 10.1213/ANE.0000000000001059.


Insights into the experiences of patients with cancer in London: framework analysis of free-text data from the National Cancer Patient Experience Survey 2012/2013 from the two London Integrated Cancer Systems.

Wiseman T, Lucas G, Sangha A, Randolph A, Stapleton S, Pattison N, O'Gara G, Harris K, Pritchard-Jones K, Dolan S.

BMJ Open. 2015 Oct 19;5(10):e007792. doi: 10.1136/bmjopen-2015-007792.


Critically Ill Children Have Low Vitamin D-Binding Protein, Influencing Bioavailability of Vitamin D.

Madden K, Feldman HA, Chun RF, Smith EM, Sullivan RM, Agan AA, Keisling SM, Panoskaltsis-Mortari A, Randolph AG.

Ann Am Thorac Soc. 2015 Nov;12(11):1654-61. doi: 10.1513/AnnalsATS.201503-160OC.


Therapeutic Hypothermia in Children.

Geva A, Tasker RC, Randolph AG.

N Engl J Med. 2015 Sep 3;373(10):979. doi: 10.1056/NEJMc1508693. No abstract available.


Pediatric Pulseless Arrest With "Nonshockable" Rhythm: Does Faster Time to Epinephrine Improve Outcome?

Tasker RC, Randolph AG.

JAMA. 2015 Aug 25;314(8):776-7. doi: 10.1001/jama.2015.9527. No abstract available.


Integrative Genomics Identifies Novel Associations with APOL1 Risk Genotypes in Black NEPTUNE Subjects.

Sampson MG, Robertson CC, Martini S, Mariani LH, Lemley KV, Gillies CE, Otto EA, Kopp JB, Randolph A, Vega-Warner V, Eichinger F, Nair V, Gipson DS, Cattran DC, Johnstone DB, O'Toole JF, Bagnasco SM, Song PX, Barisoni L, Troost JP, Kretzler M, Sedor JR; Nephrotic Syndrome Study Network.

J Am Soc Nephrol. 2016 Mar;27(3):814-23. doi: 10.1681/ASN.2014111131. Epub 2015 Jul 6.


Recognizing and managing sepsis: what needs to be done?

Yealy DM, Huang DT, Delaney A, Knight M, Randolph AG, Daniels R, Nutbeam T.

BMC Med. 2015 Apr 27;13:98. doi: 10.1186/s12916-015-0335-2.


The tremendous burden of sepsis on China's youngest children.

Randolph AG.

Pediatr Crit Care Med. 2014 Nov;15(9):896-7. doi: 10.1097/PCC.0000000000000283. No abstract available.


Carbamazepine potentiates the effectiveness of morphine in a rodent model of neuropathic pain.

Due MR, Yang XF, Allette YM, Randolph AL, Ripsch MS, Wilson SM, Dustrude ET, Khanna R, White FA.

PLoS One. 2014 Sep 15;9(9):e107399. doi: 10.1371/journal.pone.0107399. eCollection 2014.


MicroRNA-21 in glomerular injury.

Lai JY, Luo J, O'Connor C, Jing X, Nair V, Ju W, Randolph A, Ben-Dov IZ, Matar RN, Briskin D, Zavadil J, Nelson RG, Tuschl T, Brosius FC 3rd, Kretzler M, Bitzer M.

J Am Soc Nephrol. 2015 Apr;26(4):805-16. doi: 10.1681/ASN.2013121274. Epub 2014 Aug 21.


Variability in IRBs regarding parental acceptance of passive consent.

Higgerson RA, Olsho LE, Christie LM, Rehder K, Doksum T, Gedeit R, Giuliano JS Jr, Brennan B, Wendlandt R, Randolph AG; PALISI PICFlu Study Investigators.

Pediatrics. 2014 Aug;134(2):e496-503. doi: 10.1542/peds.2013-4190. Epub 2014 Jul 7.

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