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Items: 1 to 50 of 171

1.

Treatment of volumetric muscle loss in mice using nanofibrillar scaffolds enhances vascular organization and integration.

Nakayama KH, Quarta M, Paine P, Alcazar C, Karakikes I, Garcia V, Abilez OJ, Calvo NS, Simmons CS, Rando TA, Huang NF.

Commun Biol. 2019 May 7;2:170. doi: 10.1038/s42003-019-0416-4. eCollection 2019.

2.

Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle.

Wosczyna MN, Konishi CT, Perez Carbajal EE, Wang TT, Walsh RA, Gan Q, Wagner MW, Rando TA.

Cell Rep. 2019 May 14;27(7):2029-2035.e5. doi: 10.1016/j.celrep.2019.04.074.

3.

mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism.

Tang H, Inoki K, Brooks SV, Okazawa H, Lee M, Wang J, Kim M, Kennedy CL, Macpherson PCD, Ji X, Van Roekel S, Fraga DA, Wang K, Zhu J, Wang Y, Sharp ZD, Miller RA, Rando TA, Goldman D, Guan KL, Shrager JB.

Aging Cell. 2019 Jun;18(3):e12943. doi: 10.1111/acel.12943. Epub 2019 Mar 29.

4.

Stem Cell Quiescence: Dynamism, Restraint, and Cellular Idling.

van Velthoven CTJ, Rando TA.

Cell Stem Cell. 2019 Feb 7;24(2):213-225. doi: 10.1016/j.stem.2019.01.001. Review.

PMID:
30735649
5.

Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series.

Hurria A, Carpenter CR, McFarland F, Lundebjerg NE, de Cabo R, Ferrucci L, Studenski SA, Barzilai N, Briggs JP, Ix JH, Kitzman DW, Kuchel GA, Musi N, Newman JC, Rando TA, Smith AK, Walston JD, Kirkland JL, Yung R.

J Am Geriatr Soc. 2019 Mar;67(3):428-433. doi: 10.1111/jgs.15788. Epub 2019 Jan 29.

PMID:
30693953
6.

Honey bee Royalactin unlocks conserved pluripotency pathway in mammals.

Wan DC, Morgan SL, Spencley AL, Mariano N, Chang EY, Shankar G, Luo Y, Li TH, Huh D, Huynh SK, Garcia JM, Dovey CM, Lumb J, Liu L, Brown KV, Bermudez A, Luong R, Zeng H, Mascetti VL, Pitteri SJ, Wang J, Tu H, Quarta M, Sebastiano V, Nusse R, Rando TA, Carette JE, Bazan JF, Wang KC.

Nat Commun. 2018 Dec 4;9(1):5078. doi: 10.1038/s41467-018-06256-4.

7.

Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration.

Sahu A, Mamiya H, Shinde SN, Cheikhi A, Winter LL, Vo NV, Stolz D, Roginskaya V, Tang WY, St Croix C, Sanders LH, Franti M, Van Houten B, Rando TA, Barchowsky A, Ambrosio F.

Nat Commun. 2018 Nov 19;9(1):4859. doi: 10.1038/s41467-018-07253-3.

8.

The regenerative rehabilitation collection: a forum for an emerging field.

Ambrosio F, Rando TA.

NPJ Regen Med. 2018 Oct 19;3:20. doi: 10.1038/s41536-018-0058-z. eCollection 2018. No abstract available.

9.

Biomechanics show stem cell necessity for effective treatment of volumetric muscle loss using bioengineered constructs.

Quarta M, Cromie Lear MJ, Blonigan J, Paine P, Chacon R, Rando TA.

NPJ Regen Med. 2018 Oct 10;3:18. doi: 10.1038/s41536-018-0057-0. eCollection 2018.

10.

Rehabilitative exercise and spatially patterned nanofibrillar scaffolds enhance vascularization and innervation following volumetric muscle loss.

Nakayama KH, Alcazar C, Yang G, Quarta M, Paine P, Doan L, Davies A, Rando TA, Huang NF.

NPJ Regen Med. 2018 Sep 17;3:16. doi: 10.1038/s41536-018-0054-3. eCollection 2018.

11.

Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells.

Liu L, Charville GW, Cheung TH, Yoo B, Santos PJ, Schroeder M, Rando TA.

Cell Stem Cell. 2018 Oct 4;23(4):544-556.e4. doi: 10.1016/j.stem.2018.08.019. Epub 2018 Sep 20.

PMID:
30244867
12.

Bioengineered Viral Platform for Intramuscular Passive Vaccine Delivery to Human Skeletal Muscle.

Paulk NK, Pekrun K, Charville GW, Maguire-Nguyen K, Wosczyna MN, Xu J, Zhang Y, Lisowski L, Yoo B, Vilches-Moure JG, Lee GK, Shrager JB, Rando TA, Kay MA.

Mol Ther Methods Clin Dev. 2018 Jul 24;10:144-155. doi: 10.1016/j.omtm.2018.06.001. eCollection 2018 Sep 21.

13.

A Muscle Stem Cell Support Group: Coordinated Cellular Responses in Muscle Regeneration.

Wosczyna MN, Rando TA.

Dev Cell. 2018 Jul 16;46(2):135-143. doi: 10.1016/j.devcel.2018.06.018. Review.

14.

Monitoring disease activity noninvasively in the mdx model of Duchenne muscular dystrophy.

Filareto A, Maguire-Nguyen K, Gan Q, Aldanondo G, Machado L, Chamberlain JS, Rando TA.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7741-7746. doi: 10.1073/pnas.1802425115. Epub 2018 Jul 9.

15.

Regenerative Rehabilitation: Applied Biophysics Meets Stem Cell Therapeutics.

Rando TA, Ambrosio F.

Cell Stem Cell. 2018 Apr 5;22(4):608. doi: 10.1016/j.stem.2018.03.010. No abstract available.

16.

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging.

Leeman DS, Hebestreit K, Ruetz T, Webb AE, McKay A, Pollina EA, Dulken BW, Zhao X, Yeo RW, Ho TT, Mahmoudi S, Devarajan K, Passegué E, Rando TA, Frydman J, Brunet A.

Science. 2018 Mar 16;359(6381):1277-1283. doi: 10.1126/science.aag3048. Epub 2018 Mar 15.

17.

Regenerative Rehabilitation: Applied Biophysics Meets Stem Cell Therapeutics.

Rando TA, Ambrosio F.

Cell Stem Cell. 2018 Mar 1;22(3):306-309. doi: 10.1016/j.stem.2018.02.003. Review. Erratum in: Cell Stem Cell. 2018 Apr 5;22(4):608.

18.

Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential.

Judson RN, Quarta M, Oudhoff MJ, Soliman H, Yi L, Chang CK, Loi G, Vander Werff R, Cait A, Hamer M, Blonigan J, Paine P, Doan LTN, Groppa E, He W, Su L, Zhang RH, Xu P, Eisner C, Low M, Barta I, Lewis CB, Zaph C, Karimi MM, Rando TA, Rossi FM.

Cell Stem Cell. 2018 Feb 1;22(2):177-190.e7. doi: 10.1016/j.stem.2017.12.010. Epub 2018 Jan 25.

19.

The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues.

Smith AM, Maguire-Nguyen KK, Rando TA, Zasloff MA, Strange KB, Yin VP.

NPJ Regen Med. 2017 Mar 3;2:4. doi: 10.1038/s41536-017-0008-1. eCollection 2017.

20.

mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance.

Haller S, Kapuria S, Riley RR, O'Leary MN, Schreiber KH, Andersen JK, Melov S, Que J, Rando TA, Rock J, Kennedy BK, Rodgers JT, Jasper H.

Cell Stem Cell. 2017 Dec 7;21(6):806-818.e5. doi: 10.1016/j.stem.2017.11.008.

21.

Transcriptional Profiling of Quiescent Muscle Stem Cells In Vivo.

van Velthoven CTJ, de Morree A, Egner IM, Brett JO, Rando TA.

Cell Rep. 2017 Nov 14;21(7):1994-2004. doi: 10.1016/j.celrep.2017.10.037.

22.

Smad3 initiates oxidative stress and proteolysis that underlies diaphragm dysfunction during mechanical ventilation.

Tang H, L Kennedy C, Lee M, Gao Y, Xia H, Olguin F, Fraga DA, Ayers K, Choi S, Kim M, Tehrani A, Sowb YA, Rando TA, Shrager JB.

Sci Rep. 2017 Nov 6;7(1):14530. doi: 10.1038/s41598-017-11978-4.

23.

Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence.

de Morrée A, van Velthoven CTJ, Gan Q, Salvi JS, Klein JDD, Akimenko I, Quarta M, Biressi S, Rando TA.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E8996-E9005. doi: 10.1073/pnas.1708725114. Epub 2017 Oct 9.

24.

Macrophage-released ADAMTS1 promotes muscle stem cell activation.

Du H, Shih CH, Wosczyna MN, Mueller AA, Cho J, Aggarwal A, Rando TA, Feldman BJ.

Nat Commun. 2017 Sep 22;8(1):669. doi: 10.1038/s41467-017-00522-7.

25.

Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss.

Quarta M, Cromie M, Chacon R, Blonigan J, Garcia V, Akimenko I, Hamer M, Paine P, Stok M, Shrager JB, Rando TA.

Nat Commun. 2017 Jun 20;8:15613. doi: 10.1038/ncomms15613.

26.

HGFA Is an Injury-Regulated Systemic Factor that Induces the Transition of Stem Cells into GAlert.

Rodgers JT, Schroeder MD, Ma C, Rando TA.

Cell Rep. 2017 Apr 18;19(3):479-486. doi: 10.1016/j.celrep.2017.03.066.

27.

Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion.

Stearns-Reider KM, D'Amore A, Beezhold K, Rothrauff B, Cavalli L, Wagner WR, Vorp DA, Tsamis A, Shinde S, Zhang C, Barchowsky A, Rando TA, Tuan RS, Ambrosio F.

Aging Cell. 2017 Jun;16(3):518-528. doi: 10.1111/acel.12578. Epub 2017 Mar 30.

28.

Deltex2 represses MyoD expression and inhibits myogenic differentiation by acting as a negative regulator of Jmjd1c.

Luo D, de Morree A, Boutet S, Quach N, Natu V, Rustagi A, Rando TA.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3071-E3080. doi: 10.1073/pnas.1613592114. Epub 2017 Mar 28.

29.

Fleeting factors, turning back time.

Rando TA.

Nat Biotechnol. 2017 Mar 7;35(3):218-220. doi: 10.1038/nbt.3817. No abstract available.

PMID:
28267729
30.

Interaction between epigenetic and metabolism in aging stem cells.

Brunet A, Rando TA.

Curr Opin Cell Biol. 2017 Apr;45:1-7. doi: 10.1016/j.ceb.2016.12.009. Epub 2017 Jan 24. Review.

31.

Intronic polyadenylation of PDGFRα in resident stem cells attenuates muscle fibrosis.

Mueller AA, van Velthoven CT, Fukumoto KD, Cheung TH, Rando TA.

Nature. 2016 Dec 8;540(7632):276-279. doi: 10.1038/nature20160. Epub 2016 Nov 28.

32.

An artificial niche preserves the quiescence of muscle stem cells and enhances their therapeutic efficacy.

Quarta M, Brett JO, DiMarco R, De Morree A, Boutet SC, Chacon R, Gibbons MC, Garcia VA, Su J, Shrager JB, Heilshorn S, Rando TA.

Nat Biotechnol. 2016 Jul;34(7):752-9. doi: 10.1038/nbt.3576. Epub 2016 May 30.

33.

UTX in muscle regeneration--the right dose and the right time.

Liu L, Rando TA.

J Clin Invest. 2016 Apr 1;126(4):1233-5. doi: 10.1172/JCI86798. Epub 2016 Mar 21.

34.

Stem cells and healthy aging.

Goodell MA, Rando TA.

Science. 2015 Dec 4;350(6265):1199-204. doi: 10.1126/science.aab3388. Review.

PMID:
26785478
35.

Synergizing Engineering and Biology to Treat and Model Skeletal Muscle Injury and Disease.

Bursac N, Juhas M, Rando TA.

Annu Rev Biomed Eng. 2015;17:217-42. doi: 10.1146/annurev-bioeng-071114-040640. Review.

36.

H3K4me3 Breadth Is Linked to Cell Identity and Transcriptional Consistency.

Benayoun BA, Pollina EA, Ucar D, Mahmoudi S, Karra K, Wong ED, Devarajan K, Daugherty AC, Kundaje AB, Mancini E, Hitz BC, Gupta R, Rando TA, Baker JC, Snyder MP, Cherry JM, Brunet A.

Cell. 2015 Nov 19;163(5):1281-1286. doi: 10.1016/j.cell.2015.10.051. Epub 2015 Nov 19. No abstract available.

37.

Isolation of skeletal muscle stem cells by fluorescence-activated cell sorting.

Liu L, Cheung TH, Charville GW, Rando TA.

Nat Protoc. 2015 Oct;10(10):1612-24. doi: 10.1038/nprot.2015.110. Epub 2015 Sep 24.

38.

Ex Vivo Expansion and In Vivo Self-Renewal of Human Muscle Stem Cells.

Charville GW, Cheung TH, Yoo B, Santos PJ, Lee GK, Shrager JB, Rando TA.

Stem Cell Reports. 2015 Oct 13;5(4):621-32. doi: 10.1016/j.stemcr.2015.08.004. Epub 2015 Sep 3.

39.

Mimicking the niche: cytokines expand muscle stem cells.

Quarta M, Rando TA.

Cell Res. 2015 Jul;25(7):761-2. doi: 10.1038/cr.2015.78. Epub 2015 Jun 26.

40.

A Wnt-TGFβ2 axis induces a fibrogenic program in muscle stem cells from dystrophic mice.

Biressi S, Miyabara EH, Gopinath SD, Carlig PM, Rando TA.

Sci Transl Med. 2014 Dec 17;6(267):267ra176. doi: 10.1126/scitranslmed.3008411.

41.

Geroscience: linking aging to chronic disease.

Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, Franceschi C, Lithgow GJ, Morimoto RI, Pessin JE, Rando TA, Richardson A, Schadt EE, Wyss-Coray T, Sierra F.

Cell. 2014 Nov 6;159(4):709-13. doi: 10.1016/j.cell.2014.10.039.

42.

Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation.

Tang AH, Rando TA.

EMBO J. 2014 Dec 1;33(23):2782-97. doi: 10.15252/embj.201488278. Epub 2014 Oct 14.

43.

The JAK-STAT pathway is critical in ventilator-induced diaphragm dysfunction.

Tang H, Smith IJ, Hussain SN, Goldberg P, Lee M, Sugiarto S, Godinez GL, Singh BK, Payan DG, Rando TA, Kinsella TM, Shrager JB.

Mol Med. 2015 Feb 19;20:579-89. doi: 10.2119/molmed.2014.00049.

44.

Translational strategies and challenges in regenerative medicine.

Dimmeler S, Ding S, Rando TA, Trounson A.

Nat Med. 2014 Aug;20(8):814-21. doi: 10.1038/nm.3627.

PMID:
25100527
45.

H3K4me3 breadth is linked to cell identity and transcriptional consistency.

Benayoun BA, Pollina EA, Ucar D, Mahmoudi S, Karra K, Wong ED, Devarajan K, Daugherty AC, Kundaje AB, Mancini E, Hitz BC, Gupta R, Rando TA, Baker JC, Snyder MP, Cherry JM, Brunet A.

Cell. 2014 Jul 31;158(3):673-88. doi: 10.1016/j.cell.2014.06.027. Erratum in: Cell. 2015 Nov 19;163(5):1281-6.

46.

Lineage of origin in rhabdomyosarcoma informs pharmacological response.

Abraham J, Nuñez-Álvarez Y, Hettmer S, Carrió E, Chen HI, Nishijo K, Huang ET, Prajapati SI, Walker RL, Davis S, Rebeles J, Wiebush H, McCleish AT, Hampton ST, Bjornson CR, Brack AS, Wagers AJ, Rando TA, Capecchi MR, Marini FC, Ehler BR, Zarzabal LA, Goros MW, Michalek JE, Meltzer PS, Langenau DM, LeGallo RD, Mansoor A, Chen Y, Suelves M, Rubin BP, Keller C.

Genes Dev. 2014 Jul 15;28(14):1578-91. doi: 10.1101/gad.238733.114.

47.

Alive and well? Exploring disease by studying lifespan.

Brett JO, Rando TA.

Curr Opin Genet Dev. 2014 Jun;26:33-40. doi: 10.1016/j.gde.2014.05.004. Epub 2014 Jul 6. Review.

48.

mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert).

Rodgers JT, King KY, Brett JO, Cromie MJ, Charville GW, Maguire KK, Brunson C, Mastey N, Liu L, Tsai CR, Goodell MA, Rando TA.

Nature. 2014 Jun 19;510(7505):393-6. doi: 10.1038/nature13255. Epub 2014 May 25.

49.

Stem cells as vehicles for youthful regeneration of aged tissues.

Rando TA, Wyss-Coray T.

J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S39-42. doi: 10.1093/gerona/glu043. Review.

50.

FOXO3 promotes quiescence in adult muscle stem cells during the process of self-renewal.

Gopinath SD, Webb AE, Brunet A, Rando TA.

Stem Cell Reports. 2014 Mar 20;2(4):414-26. doi: 10.1016/j.stemcr.2014.02.002. eCollection 2014 Apr 8.

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