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Items: 1 to 50 of 174

1.

IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis.

Chen G, Sun L, Kato T, Okuda K, Martino MB, Abzhanova A, Lin JM, Gilmore RC, Batson BD, O'Neal YK, Volmer AS, Dang H, Deng Y, Randell SH, Button B, Livraghi-Butrico A, Kesimer M, Ribeiro CM, O'Neal WK, Boucher RC.

J Clin Invest. 2019 Oct 1;129(10):4433-4450. doi: 10.1172/JCI125669.

2.

Indoor dust acts as an adjuvant to promote sensitization to peanut through the airway.

Smeekens JM, Immormino RM, Balogh PA, Randell SH, Kulis MD, Moran TP.

Clin Exp Allergy. 2019 Aug 24. doi: 10.1111/cea.13486. [Epub ahead of print]

PMID:
31444814
3.

Identification of an emphysema-associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts.

Parker MM, Hao Y, Guo F, Pham B, Chase R, Platig J, Cho MH, Hersh CP, Thannickal VJ, Crapo J, Washko G, Randell SH, Silverman EK, San José Estépar R, Zhou X, Castaldi PJ.

Elife. 2019 Jul 25;8. pii: e42720. doi: 10.7554/eLife.42720.

4.

Cyclic compression increases F508 Del CFTR expression in ciliated human airway epithelium.

Marozkina N, Bosch J, Cotton C, Smith L, Seckler J, Zaman K, Rehman S, Periasamy A, Gaston H, Altawallbeh G, Davis M, Jones DR, Schilz R, Randell SH, Gaston B.

Am J Physiol Lung Cell Mol Physiol. 2019 Aug 1;317(2):L247-L258. doi: 10.1152/ajplung.00020.2019. Epub 2019 May 22.

PMID:
31116581
5.

XBP1S Regulates MUC5B in a Promoter Variant-Dependent Pathway in Idiopathic Pulmonary Fibrosis Airway Epithelia.

Chen G, Ribeiro CMP, Sun L, Okuda K, Kato T, Gilmore RC, Martino MB, Dang H, Abzhanova A, Lin JM, Hull-Ryde EA, Volmer AS, Randell SH, Livraghi-Butrico A, Deng Y, Scherer PE, Stripp BR, O'Neal WK, Boucher RC.

Am J Respir Crit Care Med. 2019 Jul 15;200(2):220-234. doi: 10.1164/rccm.201810-1972OC. Erratum in: Am J Respir Crit Care Med. 2019 Oct 15;200(8):1074.

PMID:
30973754
6.

Challenges Facing Airway Epithelial Cell-Based Therapy for Cystic Fibrosis.

Berical A, Lee RE, Randell SH, Hawkins F.

Front Pharmacol. 2019 Feb 8;10:74. doi: 10.3389/fphar.2019.00074. eCollection 2019. Review.

7.

ABL kinase inhibition promotes lung regeneration through expansion of an SCGB1A1+ SPC+ cell population following bacterial pneumonia.

Khatri A, Kraft BD, Tata PR, Randell SH, Piantadosi CA, Pendergast AM.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1603-1612. doi: 10.1073/pnas.1816030116. Epub 2019 Jan 17.

8.

Pulmonary Neuroendocrine Cells Secrete γ-Aminobutyric Acid to Induce Goblet Cell Hyperplasia in Primate Models.

Barrios J, Kho AT, Aven L, Mitchel JA, Park JA, Randell SH, Miller LA, Tantisira KG, Ai X.

Am J Respir Cell Mol Biol. 2019 Jun;60(6):687-694. doi: 10.1165/rcmb.2018-0179OC.

PMID:
30571139
9.

Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways.

Okuda K, Chen G, Subramani DB, Wolf M, Gilmore RC, Kato T, Radicioni G, Kesimer M, Chua M, Dang H, Livraghi-Butrico A, Ehre C, Doerschuk CM, Randell SH, Matsui H, Nagase T, O'Neal WK, Boucher RC.

Am J Respir Crit Care Med. 2019 Mar 15;199(6):715-727. doi: 10.1164/rccm.201804-0734OC.

PMID:
30352166
10.

Intercellular Communication between Airway Epithelial Cells Is Mediated by Exosome-Like Vesicles.

Gupta R, Radicioni G, Abdelwahab S, Dang H, Carpenter J, Chua M, Mieczkowski PA, Sheridan JT, Randell SH, Kesimer M.

Am J Respir Cell Mol Biol. 2019 Feb;60(2):209-220. doi: 10.1165/rcmb.2018-0156OC.

PMID:
30230353
11.

Factor XIIIA-expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking.

Porrello A, Leslie PL, Harrison EB, Gorentla BK, Kattula S, Ghosh SK, Azam SH, Holtzhausen A, Chao YL, Hayward MC, Waugh TA, Bae S, Godfrey V, Randell SH, Oderup C, Makowski L, Weiss J, Wilkerson MD, Hayes DN, Earp HS, Baldwin AS, Wolberg AS, Pecot CV.

Nat Commun. 2018 May 18;9(1):1988. doi: 10.1038/s41467-018-04355-w.

12.

Paper Spray Mass Spectrometry for High-Throughput Quantification of Nicotine and Cotinine.

Keating JE, Minges JT, Randell SH, Glish GL.

Anal Methods. 2018;10(1):46-50. doi: 10.1039/C7AY02204B. Epub 2017 Nov 28.

13.

Correction: Molecular Subtypes in Head and Neck Cancer Exhibit Distinct Patterns of Chromosomal Gain and Loss of Canonical Cancer Genes.

Walter V, Yin X, Wilkerson MD, Cabanski CR, Zhao N, Du Y, Ang MK, Hayward MC, Salazar AH, Hoadley KA, Fritchie K, Sailey CJ, Weissler MC, Shockley WW, Zanation AM, Hackman T, Thorne LB, Funkhouser WD, Muldrew KL, Olshan AF, Randell SH, Wright FA, Shores CG, Hayes DN.

PLoS One. 2018 Mar 15;13(3):e0194674. doi: 10.1371/journal.pone.0194674. eCollection 2018.

14.

Chronic E-Cigarette Exposure Alters the Human Bronchial Epithelial Proteome.

Ghosh A, Coakley RC, Mascenik T, Rowell TR, Davis ES, Rogers K, Webster MJ, Dang H, Herring LE, Sassano MF, Livraghi-Butrico A, Van Buren SK, Graves LM, Herman MA, Randell SH, Alexis NE, Tarran R.

Am J Respir Crit Care Med. 2018 Jul 1;198(1):67-76. doi: 10.1164/rccm.201710-2033OC.

15.

Molecular characterization of gene regulatory networks in primary human tracheal and bronchial epithelial cells.

Gillen AE, Yang R, Cotton CU, Perez A, Randell SH, Leir SH, Harris A.

J Cyst Fibros. 2018 Jul;17(4):444-453. doi: 10.1016/j.jcf.2018.01.009. Epub 2018 Feb 17.

16.

A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis.

Panganiban RA, Sun M, Dahlin A, Park HR, Kan M, Himes BE, Mitchel JA, Iribarren C, Jorgenson E, Randell SH, Israel E, Tantisira K, Shore S, Park JA, Weiss ST, Wu AC, Lu Q.

J Allergy Clin Immunol. 2018 Nov;142(5):1469-1478.e2. doi: 10.1016/j.jaci.2017.11.040. Epub 2018 Jan 9.

17.

A Slippery Cause of a Slimy Problem: Mucin Induction by an Esterified Lipid.

Randell SH, Zeldin DC.

Am J Respir Cell Mol Biol. 2017 Dec;57(6):633-634. doi: 10.1165/rcmb.2017-0275ED. No abstract available.

18.

Impaired Ciliogenesis in differentiating human bronchial epithelia exposed to non-Cytotoxic doses of multi-walled carbon Nanotubes.

Snyder RJ, Hussain S, Tucker CJ, Randell SH, Garantziotis S.

Part Fibre Toxicol. 2017 Nov 13;14(1):44. doi: 10.1186/s12989-017-0225-1.

19.

Loss of β Epithelial Sodium Channel Function in Meibomian Glands Produces Pseudohypoaldosteronism 1-Like Ocular Disease in Mice.

Yu D, Saini Y, Chen G, Ghio AJ, Dang H, Burns KA, Wang Y, Davis RM, Randell SH, Esther CR Jr, Paulsen F, Boucher RC.

Am J Pathol. 2018 Jan;188(1):95-110. doi: 10.1016/j.ajpath.2017.09.016. Epub 2017 Oct 26.

20.

Evaluation of a SPLUNC1-derived peptide for the treatment of cystic fibrosis lung disease.

Terryah ST, Fellner RC, Ahmad S, Moore PJ, Reidel B, Sesma JI, Kim CS, Garland AL, Scott DW, Sabater JR, Carpenter J, Randell SH, Kesimer M, Abraham WM, Arendshorst WJ, Tarran R.

Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L192-L205. doi: 10.1152/ajplung.00546.2016. Epub 2017 Oct 5.

21.

Beware Cold Agglutinins in Organ Donors! Ex Vivo Lung Perfusion From an Uncontrolled Donation After Circulatory-Determination-of-Death Donor With a Cold Agglutinin: A Case Report.

Venkataraman A, Blackwell JW, Funkhouser WK, Birchard KR, Beamer SE, Simmons WT, Randell SH, Egan TM.

Transplant Proc. 2017 Sep;49(7):1678-1681. doi: 10.1016/j.transproceed.2017.04.004.

22.

UHRF1 is required for basal stem cell proliferation in response to airway injury.

Xiang H, Yuan L, Gao X, Alexander PB, Lopez O, Lau C, Ding Y, Chong M, Sun T, Chen R, Liu SQ, Wu H, Wan Y, Randell SH, Li QJ, Wang XF.

Cell Discov. 2017 Jun 13;3:17019. doi: 10.1038/celldisc.2017.19. eCollection 2017.

23.

Ets homologous factor (EHF) has critical roles in epithelial dysfunction in airway disease.

Fossum SL, Mutolo MJ, Tugores A, Ghosh S, Randell SH, Jones LC, Leir SH, Harris A.

J Biol Chem. 2017 Jun 30;292(26):10938-10949. doi: 10.1074/jbc.M117.775304. Epub 2017 May 1.

24.

Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome Coronavirus.

Anthony SJ, Gilardi K, Menachery VD, Goldstein T, Ssebide B, Mbabazi R, Navarrete-Macias I, Liang E, Wells H, Hicks A, Petrosov A, Byarugaba DK, Debbink K, Dinnon KH, Scobey T, Randell SH, Yount BL, Cranfield M, Johnson CK, Baric RS, Lipkin WI, Mazet JA.

MBio. 2017 Apr 4;8(2). pii: e00373-17. doi: 10.1128/mBio.00373-17.

25.

Conditional reprogramming and long-term expansion of normal and tumor cells from human biospecimens.

Liu X, Krawczyk E, Suprynowicz FA, Palechor-Ceron N, Yuan H, Dakic A, Simic V, Zheng YL, Sripadhan P, Chen C, Lu J, Hou TW, Choudhury S, Kallakury B, Tang DG, Darling T, Thangapazham R, Timofeeva O, Dritschilo A, Randell SH, Albanese C, Agarwal S, Schlegel R.

Nat Protoc. 2017 Feb;12(2):439-451. doi: 10.1038/nprot.2016.174. Epub 2017 Jan 26.

26.

Pharmacological Rescue of Conditionally Reprogrammed Cystic Fibrosis Bronchial Epithelial Cells.

Gentzsch M, Boyles SE, Cheluvaraju C, Chaudhry IG, Quinney NL, Cho C, Dang H, Liu X, Schlegel R, Randell SH.

Am J Respir Cell Mol Biol. 2017 May;56(5):568-574. doi: 10.1165/rcmb.2016-0276MA.

27.

An Official American Thoracic Society Workshop Report 2015. Stem Cells and Cell Therapies in Lung Biology and Diseases.

Wagner DE, Cardoso WV, Gilpin SE, Majka S, Ott H, Randell SH, Thébaud B, Waddell T, Weiss DJ; ATS Subcommittee on Stem Cells and Cell Therapies.

Ann Am Thorac Soc. 2016 Aug;13(8):S259-78. doi: 10.1513/AnnalsATS.201606-466ST.

PMID:
27509163
28.

Restoration of R117H CFTR folding and function in human airway cells through combination treatment with VX-809 and VX-770.

Gentzsch M, Ren HY, Houck SA, Quinney NL, Cholon DM, Sopha P, Chaudhry IG, Das J, Dokholyan NV, Randell SH, Cyr DM.

Am J Physiol Lung Cell Mol Physiol. 2016 Sep 1;311(3):L550-9. doi: 10.1152/ajplung.00186.2016. Epub 2016 Jul 8.

29.

Characterization of Rat Meibomian Gland Ion and Fluid Transport.

Yu D, Davis RM, Aita M, Burns KA, Clapp PW, Gilmore RC, Chua M, O'Neal WK, Schlegel R, Randell SH, C Boucher R.

Invest Ophthalmol Vis Sci. 2016 Apr 1;57(4):2328-43. doi: 10.1167/iovs.15-17945.

30.

Corrigendum: A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.

Menachery VD, Yount BL Jr, Debbink K, Agnihothram S, Gralinski LE, Plante JA, Graham RL, Scobey T, Ge XY, Donaldson EF, Randell SH, Lanzavecchia A, Marasco WA, Shi ZL, Baric RS.

Nat Med. 2016 Apr;22(4):446. doi: 10.1038/nm0416-446d. No abstract available.

PMID:
27050591
31.

Compressive Stress Causes an Unjamming Transition and an Epithelial-Mesenchymal Transition in the Airway Epithelium in Asthma.

Park JA, Mitchel JA, Qazvini NT, Kim JH, Park CY, Butler JP, Israel E, Randell SH, Shore SA, Drazen JM, Fredberg JJ.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S102. doi: 10.1513/AnnalsATS.201506-382MG. No abstract available.

32.

SARS-like WIV1-CoV poised for human emergence.

Menachery VD, Yount BL Jr, Sims AC, Debbink K, Agnihothram SS, Gralinski LE, Graham RL, Scobey T, Plante JA, Royal SR, Swanstrom J, Sheahan TP, Pickles RJ, Corti D, Randell SH, Lanzavecchia A, Marasco WA, Baric RS.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3048-53. doi: 10.1073/pnas.1517719113. Epub 2016 Mar 14.

33.

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.

Menachery VD, Yount BL Jr, Debbink K, Agnihothram S, Gralinski LE, Plante JA, Graham RL, Scobey T, Ge XY, Donaldson EF, Randell SH, Lanzavecchia A, Marasco WA, Shi ZL, Baric RS.

Nat Med. 2015 Dec;21(12):1508-13. doi: 10.1038/nm.3985. Epub 2015 Nov 9. Erratum in: Nat Med. 2016 Apr;22(4):446.

34.

The dual phosphodiesterase 3 and 4 inhibitor RPL554 stimulates CFTR and ciliary beating in primary cultures of bronchial epithelia.

Turner MJ, Matthes E, Billet A, Ferguson AJ, Thomas DY, Randell SH, Ostrowski LE, Abbott-Banner K, Hanrahan JW.

Am J Physiol Lung Cell Mol Physiol. 2016 Jan 1;310(1):L59-70. doi: 10.1152/ajplung.00324.2015. Epub 2015 Nov 6.

35.

GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells.

Gao X, Bali AS, Randell SH, Hogan BL.

J Cell Biol. 2015 Nov 9;211(3):669-82. doi: 10.1083/jcb.201506014. Epub 2015 Nov 2.

36.

IL-13 Augments Compressive Stress-Induced Tissue Factor Expression in Human Airway Epithelial Cells.

Mitchel JA, Antoniak S, Lee JH, Kim SH, McGill M, Kasahara DI, Randell SH, Israel E, Shore SA, Mackman N, Park JA.

Am J Respir Cell Mol Biol. 2016 Apr;54(4):524-31. doi: 10.1165/rcmb.2015-0252OC.

37.

Unjamming and cell shape in the asthmatic airway epithelium.

Park JA, Kim JH, Bi D, Mitchel JA, Qazvini NT, Tantisira K, Park CY, McGill M, Kim SH, Gweon B, Notbohm J, Steward R Jr, Burger S, Randell SH, Kho AT, Tambe DT, Hardin C, Shore SA, Israel E, Weitz DA, Tschumperlin DJ, Henske EP, Weiss ST, Manning ML, Butler JP, Drazen JM, Fredberg JJ.

Nat Mater. 2015 Oct;14(10):1040-8. doi: 10.1038/nmat4357. Epub 2015 Aug 3.

38.

Impact of Acute Intermittent Exercise on Natural Killer Cells in Breast Cancer Survivors.

Evans ES, Hackney AC, McMurray RG, Randell SH, Muss HB, Deal AM, Battaglini CL.

Integr Cancer Ther. 2015 Sep;14(5):436-45. doi: 10.1177/1534735415580681. Epub 2015 Apr 14.

PMID:
25873292
39.

Hypoxic epithelial necrosis triggers neutrophilic inflammation via IL-1 receptor signaling in cystic fibrosis lung disease.

Fritzsching B, Zhou-Suckow Z, Trojanek JB, Schubert SC, Schatterny J, Hirtz S, Agrawal R, Muley T, Kahn N, Sticht C, Gunkel N, Welte T, Randell SH, Länger F, Schnabel P, Herth FJ, Mall MA.

Am J Respir Crit Care Med. 2015 Apr 15;191(8):902-13. doi: 10.1164/rccm.201409-1610OC.

40.

A genetic variant of p53 restricts the mucous secretory phenotype by regulating SPDEF and Bcl-2 expression.

Chand HS, Montano G, Huang X, Randell SH, Mebratu Y, Petersen H, Tesfaigzi Y.

Nat Commun. 2014 Nov 27;5:5567. doi: 10.1038/ncomms6567.

41.

Localization of Burkholderia cepacia complex bacteria in cystic fibrosis lungs and interactions with Pseudomonas aeruginosa in hypoxic mucus.

Schwab U, Abdullah LH, Perlmutt OS, Albert D, Davis CW, Arnold RR, Yankaskas JR, Gilligan P, Neubauer H, Randell SH, Boucher RC.

Infect Immun. 2014 Nov;82(11):4729-45. doi: 10.1128/IAI.01876-14. Epub 2014 Aug 25.

42.

IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells.

Tadokoro T, Wang Y, Barak LS, Bai Y, Randell SH, Hogan BL.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3641-9. doi: 10.1073/pnas.1409781111. Epub 2014 Aug 18.

43.

Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.

Hogan BL, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CC, Niklason L, Calle E, Le A, Randell SH, Rock J, Snitow M, Krummel M, Stripp BR, Vu T, White ES, Whitsett JA, Morrisey EE.

Cell Stem Cell. 2014 Aug 7;15(2):123-38. doi: 10.1016/j.stem.2014.07.012. Review.

44.

Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis.

Cholon DM, Quinney NL, Fulcher ML, Esther CR Jr, Das J, Dokholyan NV, Randell SH, Boucher RC, Gentzsch M.

Sci Transl Med. 2014 Jul 23;6(246):246ra96. doi: 10.1126/scitranslmed.3008680.

45.

A biomimetic multicellular model of the airways using primary human cells.

Sellgren KL, Butala EJ, Gilmour BP, Randell SH, Grego S.

Lab Chip. 2014 Sep 7;14(17):3349-58. doi: 10.1039/c4lc00552j.

PMID:
25000964
46.

Mutations in RSPH1 cause primary ciliary dyskinesia with a unique clinical and ciliary phenotype.

Knowles MR, Ostrowski LE, Leigh MW, Sears PR, Davis SD, Wolf WE, Hazucha MJ, Carson JL, Olivier KN, Sagel SD, Rosenfeld M, Ferkol TW, Dell SD, Milla CE, Randell SH, Yin W, Sannuti A, Metjian HM, Noone PG, Noone PJ, Olson CA, Patrone MV, Dang H, Lee HS, Hurd TW, Gee HY, Otto EA, Halbritter J, Kohl S, Kircher M, Krischer J, Bamshad MJ, Nickerson DA, Hildebrandt F, Shendure J, Zariwala MA.

Am J Respir Crit Care Med. 2014 Mar 15;189(6):707-17. doi: 10.1164/rccm.201311-2047OC.

47.

Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity.

Chen G, Korfhagen TR, Karp CL, Impey S, Xu Y, Randell SH, Kitzmiller J, Maeda Y, Haitchi HM, Sridharan A, Senft AP, Whitsett JA.

Am J Respir Crit Care Med. 2014 Feb 1;189(3):301-13. doi: 10.1164/rccm.201306-1181OC.

48.

Breaking the in vitro alveolar type II cell proliferation barrier while retaining ion transport properties.

Bove PF, Dang H, Cheluvaraju C, Jones LC, Liu X, O'Neal WK, Randell SH, Schlegel R, Boucher RC.

Am J Respir Cell Mol Biol. 2014 Apr;50(4):767-76. doi: 10.1165/rcmb.2013-0071OC.

49.

Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus.

Scobey T, Yount BL, Sims AC, Donaldson EF, Agnihothram SS, Menachery VD, Graham RL, Swanstrom J, Bove PF, Kim JD, Grego S, Randell SH, Baric RS.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16157-62. doi: 10.1073/pnas.1311542110. Epub 2013 Sep 16.

50.

Effect of apical hyperosmotic sodium challenge and amiloride on sodium transport in human bronchial epithelial cells from cystic fibrosis donors.

Rasgado-Flores H, Krishna Mandava V, Siman H, Van Driessche W, Pilewski JM, Randell SH, Bridges RJ.

Am J Physiol Cell Physiol. 2013 Dec 1;305(11):C1114-22. doi: 10.1152/ajpcell.00166.2013. Epub 2013 Aug 28.

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