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Items: 1 to 50 of 113


ARF GTPases and their GEFs and GAPs: concepts and challenges.

Sztul E, Chen PW, Casanova JE, Cherfils J, Dacks JB, Lambright DG, Lee FS, Randazzo PA, Santy LC, Schürmann A, Wilhelmi I, Yohe ME, Kahn RA.

Mol Biol Cell. 2019 May 15;30(11):1249-1271. doi: 10.1091/mbc.E18-12-0820.


Functional Expression and Characterization of Human Myristoylated-Arf1 in Nanodisc Membrane Mimetics.

Li Y, Soubias O, Li J, Sun S, Randazzo PA, Byrd RA.

Biochemistry. 2019 Mar 12;58(10):1423-1431. doi: 10.1021/acs.biochem.8b01323. Epub 2019 Feb 20.


ARAP2 inhibits Akt independently of its effects on focal adhesions.

Luo R, Chen PW, Kuo JC, Jenkins L, Jian X, Waterman CM, Randazzo PA.

Biol Cell. 2018 Dec;110(12):257-270. doi: 10.1111/boc.201800044. Epub 2018 Sep 10.


The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding.

Madigan JP, Hou F, Ye L, Hu J, Dong A, Tempel W, Yohe ME, Randazzo PA, Jenkins LMM, Gottesman MM, Tong Y.

J Biol Chem. 2018 Oct 19;293(42):16142-16159. doi: 10.1074/jbc.RA118.003525. Epub 2018 Aug 24.


Arf GAPs and molecular motors.

Luo R, Reed CE, Sload JA, Wordeman L, Randazzo PA, Chen PW.

Small GTPases. 2019 May;10(3):196-209. doi: 10.1080/21541248.2017.1308850. Epub 2017 Apr 21.


Arf GAPs: A family of proteins with disparate functions that converge on a common structure, the integrin adhesion complex.

Vitali T, Girald-Berlingeri S, Randazzo PA, Chen PW.

Small GTPases. 2019 Jul;10(4):280-288. doi: 10.1080/21541248.2017.1299271. Epub 2017 Mar 31.


Direct functional interaction of the kinesin-13 family member kinesin-like protein 2A (Kif2A) and Arf GAP with GTP-binding protein-like, ankyrin repeats and PH domains 1 (AGAP1).

Luo R, Chen PW, Wagenbach M, Jian X, Jenkins L, Wordeman L, Randazzo PA.

J Biol Chem. 2016 Dec 2;291(49):25761. No abstract available.


Direct Functional Interaction of the Kinesin-13 Family Member Kinesin-like Protein 2A (Kif2A) and Arf GAP with GTP-binding Protein-like, Ankyrin Repeats and PH Domains1 (AGAP1).

Luo R, Chen PW, Wagenbach M, Jian X, Jenkins L, Wordeman L, Randazzo PA.

J Biol Chem. 2016 Oct 7;291(41):21350-21362. doi: 10.1074/jbc.M116.732479. Epub 2016 Aug 16. Erratum in: J Biol Chem. 2016 Dec 2;291(49):25761.


Allosteric properties of PH domains in Arf regulatory proteins.

Roy NS, Yohe ME, Randazzo PA, Gruschus JM.

Cell Logist. 2016 Apr 26;6(2):e1181700. eCollection 2016 Apr-Jun. Review.


The Arf GTPase-activating Protein, ASAP1, Binds Nonmuscle Myosin 2A to Control Remodeling of the Actomyosin Network.

Chen PW, Jian X, Heissler SM, Le K, Luo R, Jenkins LM, Nagy A, Moss J, Sellers JR, Randazzo PA.

J Biol Chem. 2016 Apr 1;291(14):7517-26. doi: 10.1074/jbc.M115.701292. Epub 2016 Feb 17.


Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B.

Li S, Liang YH, Mariano J, Metzger MB, Stringer DK, Hristova VA, Li J, Randazzo PA, Tsai YC, Ji X, Weissman AM.

J Biol Chem. 2015 Dec 18;290(51):30225-39. doi: 10.1074/jbc.M115.685867. Epub 2015 Oct 16.


Molecular Basis for Cooperative Binding of Anionic Phospholipids to the PH Domain of the Arf GAP ASAP1.

Jian X, Tang WK, Zhai P, Roy NS, Luo R, Gruschus JM, Yohe ME, Chen PW, Li Y, Byrd RA, Xia D, Randazzo PA.

Structure. 2015 Nov 3;23(11):1977-88. doi: 10.1016/j.str.2015.08.008. Epub 2015 Sep 10.


Simple in vitro assay of Arf GAPs and preparation of Arf proteins as substrates.

Chen PW, Jian X, Luo R, Randazzo PA.

Methods Cell Biol. 2015;130:69-80. doi: 10.1016/bs.mcb.2015.03.021. Epub 2015 Jun 11.


Inhibition of Cytohesins Protects against Genetic Models of Motor Neuron Disease.

Zhai J, Zhang L, Mojsilovic-Petrovic J, Jian X, Thomas J, Homma K, Schmitz A, Famulok M, Ichijo H, Argon Y, Randazzo PA, Kalb RG.

J Neurosci. 2015 Jun 17;35(24):9088-105. doi: 10.1523/JNEUROSCI.5032-13.2015.


ArfGAPs: key regulators for receptor sorting.

Shiba Y, Randazzo PA.

Receptors Clin Investig. 2014 Jun 13;1(5):e158.


Activation of Gαi at the Golgi by GIV/Girdin imposes finiteness in Arf1 signaling.

Lo IC, Gupta V, Midde KK, Taupin V, Lopez-Sanchez I, Kufareva I, Abagyan R, Randazzo PA, Farquhar MG, Ghosh P.

Dev Cell. 2015 Apr 20;33(2):189-203. doi: 10.1016/j.devcel.2015.02.009. Epub 2015 Apr 9.


The Arf6 GTPase-activating proteins ARAP2 and ACAP1 define distinct endosomal compartments that regulate integrin α5β1 traffic.

Chen PW, Luo R, Jian X, Randazzo PA.

J Biol Chem. 2014 Oct 31;289(44):30237-48. doi: 10.1074/jbc.M114.596155. Epub 2014 Sep 15.


The importance of seeing surface (effects).

Gruschus JM, Byrd RA, Randazzo PA.

Structure. 2014 Mar 4;22(3):363-5. doi: 10.1016/j.str.2014.02.005.


ArfGAP3 regulates the transport of cation-independent mannose 6-phosphate receptor in the post-Golgi compartment.

Shiba Y, Kametaka S, Waguri S, Presley JF, Randazzo PA.

Curr Biol. 2013 Oct 7;23(19):1945-51. doi: 10.1016/j.cub.2013.07.087. Epub 2013 Sep 26.


ARAP2 signals through Arf6 and Rac1 to control focal adhesion morphology.

Chen PW, Jian X, Yoon HY, Randazzo PA.

J Biol Chem. 2013 Feb 22;288(8):5849-60. doi: 10.1074/jbc.M112.415778. Epub 2013 Jan 7.


The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2.

Hosokawa H, Dip PV, Merkulova M, Bakulina A, Zhuang Z, Khatri A, Jian X, Keating SM, Bueler SA, Rubinstein JL, Randazzo PA, Ausiello DA, Grüber G, Marshansky V.

J Biol Chem. 2013 Feb 22;288(8):5896-913. doi: 10.1074/jbc.M112.409169. Epub 2013 Jan 3.


Quantitative Analysis of Guanine Nucleotide Exchange Factors (GEFs) as Enzymes.

Randazzo PA, Jian X, Chen PW, Zhai P, Soubias O, Northup JK.

Cell Logist. 2014 Jan 9;3:e27609. eCollection 2013.


Nucleotide exchange factors: Kinetic analyses and the rationale for studying kinetics of GEFs.

Northup JK, Jian X, Randazzo PA.

Cell Logist. 2012 Jul 1;2(3):140-146.


Approaches to studying Arf GAPs in cells: in vitro assay with isolated focal adhesions.

Chen PW, Jian X, Luo R, Randazzo PA.

Curr Protoc Cell Biol. 2012 Jun;Chapter 17:Unit17.13. doi: 10.1002/0471143030.cb1713s55. Review.


ArfGAP1 function in COPI mediated membrane traffic: currently debated models and comparison to other coat-binding ArfGAPs.

Shiba Y, Randazzo PA.

Histol Histopathol. 2012 Sep;27(9):1143-53. doi: 10.14670/HH-27.1143. Review.


The pleckstrin homology (PH) domain of the Arf exchange factor Brag2 is an allosteric binding site.

Jian X, Gruschus JM, Sztul E, Randazzo PA.

J Biol Chem. 2012 Jul 13;287(29):24273-83. doi: 10.1074/jbc.M112.368084. Epub 2012 May 21.


GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.

Luo R, Akpan IO, Hayashi R, Sramko M, Barr V, Shiba Y, Randazzo PA.

J Biol Chem. 2012 May 18;287(21):17176-85. doi: 10.1074/jbc.M111.334458. Epub 2012 Mar 27.


ArfGAP1 promotes COPI vesicle formation by facilitating coatomer polymerization.

Shiba Y, Luo R, Hinshaw JE, Szul T, Hayashi R, Sztul E, Nagashima K, Baxa U, Randazzo PA.

Cell Logist. 2011 Jul-Dec;1(4):139-154. doi: 10.4161/cl.1.4.18896. Epub 2011 Jul 1.


Novel C-terminal motif within Sec7 domain of guanine nucleotide exchange factors regulates ADP-ribosylation factor (ARF) binding and activation.

Lowery J, Szul T, Seetharaman J, Jian X, Su M, Forouhar F, Xiao R, Acton TB, Montelione GT, Lin H, Wright JW, Lee E, Holloway ZG, Randazzo PA, Tong L, Sztul E.

J Biol Chem. 2011 Oct 21;286(42):36898-906. doi: 10.1074/jbc.M111.230631. Epub 2011 Aug 2.


Phosphatidylinositol-4-phosphate 5-kinase and GEP100/Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 through Arf6 protein.

Sakurai A, Jian X, Lee CJ, Manavski Y, Chavakis E, Donaldson J, Randazzo PA, Gutkind JS.

J Biol Chem. 2011 Sep 30;286(39):34335-45. doi: 10.1074/jbc.M111.259499. Epub 2011 Jul 27.


GEFH1 binds ASAP1 and regulates podosome formation.

Shiba Y, Randazzo PA.

Biochem Biophys Res Commun. 2011 Mar 25;406(4):574-9. doi: 10.1016/j.bbrc.2011.02.093. Epub 2011 Feb 23.


ARAP1 association with CIN85 affects epidermal growth factor receptor endocytic trafficking.

Yoon HY, Kales SC, Luo R, Lipkowitz S, Randazzo PA.

Biol Cell. 2011 Apr;103(4):171-84. doi: 10.1042/BC20100154.


PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1.

Kang SA, Lee ES, Yoon HY, Randazzo PA, Lee ST.

J Biol Chem. 2010 Aug 20;285(34):26013-21. doi: 10.1074/jbc.M109.088971. Epub 2010 Jun 16.


Arf GAPs: gatekeepers of vesicle generation.

Spang A, Shiba Y, Randazzo PA.

FEBS Lett. 2010 Jun 18;584(12):2646-51. doi: 10.1016/j.febslet.2010.04.005. Epub 2010 Apr 13. Review.


Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras.

Sakurai A, Gavard J, Annas-Linhares Y, Basile JR, Amornphimoltham P, Palmby TR, Yagi H, Zhang F, Randazzo PA, Li X, Weigert R, Gutkind JS.

Mol Cell Biol. 2010 Jun;30(12):3086-98. doi: 10.1128/MCB.01652-09. Epub 2010 Apr 12.


Modifications to the C-terminus of Arf1 alter cell functions and protein interactions.

Jian X, Cavenagh M, Gruschus JM, Randazzo PA, Kahn RA.

Traffic. 2010 Jun;11(6):732-42. doi: 10.1111/j.1600-0854.2010.01054.x. Epub 2010 Feb 27.


ACAP-A/B are ArfGAP homologs in dictyostelium involved in sporulation but not in chemotaxis.

Chen PW, Randazzo PA, Parent CA.

PLoS One. 2010 Jan 7;5(1):e8624. doi: 10.1371/journal.pone.0008624.


A PH domain in the Arf GTPase-activating protein (GAP) ARAP1 binds phosphatidylinositol 3,4,5-trisphosphate and regulates Arf GAP activity independently of recruitment to the plasma membranes.

Campa F, Yoon HY, Ha VL, Szentpetery Z, Balla T, Randazzo PA.

J Biol Chem. 2009 Oct 9;284(41):28069-83. doi: 10.1074/jbc.M109.028266. Epub 2009 Aug 7.


Regulation of membrane trafficking and organ separation by the NEVERSHED ARF-GAP protein.

Liljegren SJ, Leslie ME, Darnielle L, Lewis MW, Taylor SM, Luo R, Geldner N, Chory J, Randazzo PA, Yanofsky MF, Ecker JR.

Development. 2009 Jun;136(11):1909-18. doi: 10.1242/dev.033605.


Arf GAP2 is positively regulated by coatomer and cargo.

Luo R, Ha VL, Hayashi R, Randazzo PA.

Cell Signal. 2009 Jul;21(7):1169-79. doi: 10.1016/j.cellsig.2009.03.006. Epub 2009 Mar 16.


Arf GTPase-activating proteins and their potential role in cell migration and invasion.

Campa F, Randazzo PA.

Cell Adh Migr. 2008 Oct-Dec;2(4):258-62. Epub 2008 Oct 9.


Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4.

Mazelova J, Astuto-Gribble L, Inoue H, Tam BM, Schonteich E, Prekeris R, Moritz OL, Randazzo PA, Deretic D.

EMBO J. 2009 Feb 4;28(3):183-92. doi: 10.1038/emboj.2008.267. Epub 2009 Jan 15.


Journey to the ends of the Arf.

Gruschus JM, Chen PW, Luo R, Randazzo PA.

Structure. 2009 Jan 14;17(1):2-4. doi: 10.1016/j.str.2008.12.002. No abstract available.


Contribution of AZAP-Type Arf GAPs to cancer cell migration and invasion.

Ha VL, Luo R, Nie Z, Randazzo PA.

Adv Cancer Res. 2008;101:1-28. doi: 10.1016/S0065-230X(08)00401-6. Review.


Autoinhibition of Arf GTPase-activating protein activity by the BAR domain in ASAP1.

Jian X, Brown P, Schuck P, Gruschus JM, Balbo A, Hinshaw JE, Randazzo PA.

J Biol Chem. 2009 Jan 16;284(3):1652-63. doi: 10.1074/jbc.M804218200. Epub 2008 Nov 18.


ARAP1 regulates endocytosis of EGFR.

Yoon HY, Lee JS, Randazzo PA.

Traffic. 2008 Dec;9(12):2236-52. doi: 10.1111/j.1600-0854.2008.00839.x. Epub 2008 Oct 8.


Consensus nomenclature for the human ArfGAP domain-containing proteins.

Kahn RA, Bruford E, Inoue H, Logsdon JM Jr, Nie Z, Premont RT, Randazzo PA, Satake M, Theibert AB, Zapp ML, Cassel D.

J Cell Biol. 2008 Sep 22;182(6):1039-44. doi: 10.1083/jcb.200806041. Review.


Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome.

Inoue H, Ha VL, Prekeris R, Randazzo PA.

Mol Biol Cell. 2008 Oct;19(10):4224-37. doi: 10.1091/mbc.E08-03-0290. Epub 2008 Aug 6.


Dynamic interaction between Arf GAP and PH domains of ASAP1 in the regulation of GAP activity.

Luo R, Miller Jenkins LM, Randazzo PA, Gruschus J.

Cell Signal. 2008 Nov;20(11):1968-77. doi: 10.1016/j.cellsig.2008.07.007. Epub 2008 Jul 11.


Kinetic analysis of Arf GAP1 indicates a regulatory role for coatomer.

Luo R, Randazzo PA.

J Biol Chem. 2008 Aug 8;283(32):21965-77. doi: 10.1074/jbc.M802268200. Epub 2008 Jun 9.

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