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Items: 1 to 50 of 128

1.

Small GTPase ARF6 Is a Coincidence-Detection Code for RPH3A Polarization in Neutrophil Polarization.

Ren C, Yuan Q, Jian X, Randazzo PA, Tang W, Wu D.

J Immunol. 2020 Feb 15;204(4):1012-1021. doi: 10.4049/jimmunol.1901080. Epub 2020 Jan 10.

3.

Bacillus subtilis Regulators MntR and Zur Participate in Redox Cycling, Antibiotic Sensitivity, and Cell Wall Plasticity.

Randazzo P, Anba-Mondoloni J, Aubert-Frambourg A, Guillot A, Pechoux C, Vidic J, Auger S.

J Bacteriol. 2020 Feb 11;202(5). pii: e00547-19. doi: 10.1128/JB.00547-19. Print 2020 Feb 11.

PMID:
31818924
4.

The ArfGAP ASAP1 Controls Actin Stress Fiber Organization via Its N-BAR Domain.

Gasilina A, Vitali T, Luo R, Jian X, Randazzo PA.

iScience. 2019 Dec 20;22:166-180. doi: 10.1016/j.isci.2019.11.015. Epub 2019 Nov 14.

5.

Interaction of the N terminus of ADP-ribosylation factor with the PH domain of the GTPase-activating protein ASAP1 requires phosphatidylinositol 4,5-bisphosphate.

Roy NS, Jian X, Soubias O, Zhai P, Hall JR, Dagher JN, Coussens NP, Jenkins LM, Luo R, Akpan IO, Hall MD, Byrd RA, Yohe ME, Randazzo PA.

J Biol Chem. 2019 Nov 15;294(46):17354-17370. doi: 10.1074/jbc.RA119.009269. Epub 2019 Oct 6.

PMID:
31591270
6.

Nanolipid-Trehalose Conjugates and Nano-Assemblies as Putative Autophagy Inducers.

Colombo E, Biocotino M, Frapporti G, Randazzo P, Christodoulou MS, Piccoli G, Polito L, Seneci P, Passarella D.

Pharmaceutics. 2019 Aug 20;11(8). pii: E422. doi: 10.3390/pharmaceutics11080422.

7.

Multiplex genome editing of microorganisms using CRISPR-Cas.

Adiego-Pérez B, Randazzo P, Daran JM, Verwaal R, Roubos JA, Daran-Lapujade P, van der Oost J.

FEMS Microbiol Lett. 2019 Apr 1;366(8). pii: fnz086. doi: 10.1093/femsle/fnz086.

8.

ARF GTPases and their GEFs and GAPs: concepts and challenges.

Sztul E, Chen PW, Casanova JE, Cherfils J, Dacks JB, Lambright DG, Lee FS, Randazzo PA, Santy LC, Schürmann A, Wilhelmi I, Yohe ME, Kahn RA.

Mol Biol Cell. 2019 May 15;30(11):1249-1271. doi: 10.1091/mbc.E18-12-0820. Review.

9.

Identification of Isoform 2 Acid-Sensing Ion Channel Inhibitors as Tool Compounds for Target Validation Studies in CNS.

Bencheva LI, De Matteo M, Ferrante L, Ferrara M, Prandi A, Randazzo P, Ronzoni S, Sinisi R, Seneci P, Summa V, Gallo M, Veneziano M, Cellucci A, Mazzocchi N, Menegon A, Di Fabio R.

ACS Med Chem Lett. 2019 Feb 7;10(4):627-632. doi: 10.1021/acsmedchemlett.8b00591. eCollection 2019 Apr 11.

10.

Functional Expression and Characterization of Human Myristoylated-Arf1 in Nanodisc Membrane Mimetics.

Li Y, Soubias O, Li J, Sun S, Randazzo PA, Byrd RA.

Biochemistry. 2019 Mar 12;58(10):1423-1431. doi: 10.1021/acs.biochem.8b01323. Epub 2019 Feb 20.

PMID:
30735034
11.

ARAP2 inhibits Akt independently of its effects on focal adhesions.

Luo R, Chen PW, Kuo JC, Jenkins L, Jian X, Waterman CM, Randazzo PA.

Biol Cell. 2018 Dec;110(12):257-270. doi: 10.1111/boc.201800044. Epub 2018 Sep 10.

12.

The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding.

Madigan JP, Hou F, Ye L, Hu J, Dong A, Tempel W, Yohe ME, Randazzo PA, Jenkins LMM, Gottesman MM, Tong Y.

J Biol Chem. 2018 Oct 19;293(42):16142-16159. doi: 10.1074/jbc.RA118.003525. Epub 2018 Aug 24.

13.

Revisiting the in vivo GlnR-binding sites at the genome scale in Bacillus subtilis.

Randazzo P, Aucouturier A, Delumeau O, Auger S.

BMC Res Notes. 2017 Aug 23;10(1):422. doi: 10.1186/s13104-017-2703-9.

14.

Arf GAPs and molecular motors.

Luo R, Reed CE, Sload JA, Wordeman L, Randazzo PA, Chen PW.

Small GTPases. 2019 May;10(3):196-209. doi: 10.1080/21541248.2017.1308850. Epub 2017 Apr 21.

15.

Arf GAPs: A family of proteins with disparate functions that converge on a common structure, the integrin adhesion complex.

Vitali T, Girald-Berlingeri S, Randazzo PA, Chen PW.

Small GTPases. 2019 Jul;10(4):280-288. doi: 10.1080/21541248.2017.1299271. Epub 2017 Mar 31.

16.

Direct functional interaction of the kinesin-13 family member kinesin-like protein 2A (Kif2A) and Arf GAP with GTP-binding protein-like, ankyrin repeats and PH domains 1 (AGAP1).

Luo R, Chen PW, Wagenbach M, Jian X, Jenkins L, Wordeman L, Randazzo PA.

J Biol Chem. 2016 Dec 2;291(49):25761. No abstract available.

17.

The MarR-like protein PchR (YvmB) regulates expression of genes involved in pulcherriminic acid biosynthesis and in the initiation of sporulation in Bacillus subtilis.

Randazzo P, Aubert-Frambourg A, Guillot A, Auger S.

BMC Microbiol. 2016 Aug 20;16(1):190. doi: 10.1186/s12866-016-0807-3.

18.

Direct Functional Interaction of the Kinesin-13 Family Member Kinesin-like Protein 2A (Kif2A) and Arf GAP with GTP-binding Protein-like, Ankyrin Repeats and PH Domains1 (AGAP1).

Luo R, Chen PW, Wagenbach M, Jian X, Jenkins L, Wordeman L, Randazzo PA.

J Biol Chem. 2016 Oct 7;291(41):21350-21362. doi: 10.1074/jbc.M116.732479. Epub 2016 Aug 16. Erratum in: J Biol Chem. 2016 Dec 2;291(49):25761.

19.

Allosteric properties of PH domains in Arf regulatory proteins.

Roy NS, Yohe ME, Randazzo PA, Gruschus JM.

Cell Logist. 2016 Apr 26;6(2):e1181700. eCollection 2016 Apr-Jun. Review.

20.

The Arf GTPase-activating Protein, ASAP1, Binds Nonmuscle Myosin 2A to Control Remodeling of the Actomyosin Network.

Chen PW, Jian X, Heissler SM, Le K, Luo R, Jenkins LM, Nagy A, Moss J, Sellers JR, Randazzo PA.

J Biol Chem. 2016 Apr 1;291(14):7517-26. doi: 10.1074/jbc.M115.701292. Epub 2016 Feb 17.

21.

Polygenic analysis and targeted improvement of the complex trait of high acetic acid tolerance in the yeast Saccharomyces cerevisiae.

Meijnen JP, Randazzo P, Foulquié-Moreno MR, van den Brink J, Vandecruys P, Stojiljkovic M, Dumortier F, Zalar P, Boekhout T, Gunde-Cimerman N, Kokošar J, Štajdohar M, Curk T, Petrovič U, Thevelein JM.

Biotechnol Biofuels. 2016 Jan 6;9:5. doi: 10.1186/s13068-015-0421-x. eCollection 2016.

22.

Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B.

Li S, Liang YH, Mariano J, Metzger MB, Stringer DK, Hristova VA, Li J, Randazzo PA, Tsai YC, Ji X, Weissman AM.

J Biol Chem. 2015 Dec 18;290(51):30225-39. doi: 10.1074/jbc.M115.685867. Epub 2015 Oct 16.

23.

Molecular Basis for Cooperative Binding of Anionic Phospholipids to the PH Domain of the Arf GAP ASAP1.

Jian X, Tang WK, Zhai P, Roy NS, Luo R, Gruschus JM, Yohe ME, Chen PW, Li Y, Byrd RA, Xia D, Randazzo PA.

Structure. 2015 Nov 3;23(11):1977-88. doi: 10.1016/j.str.2015.08.008. Epub 2015 Sep 10.

24.

Simple in vitro assay of Arf GAPs and preparation of Arf proteins as substrates.

Chen PW, Jian X, Luo R, Randazzo PA.

Methods Cell Biol. 2015;130:69-80. doi: 10.1016/bs.mcb.2015.03.021. Epub 2015 Jun 11.

PMID:
26360029
25.

Inhibition of Cytohesins Protects against Genetic Models of Motor Neuron Disease.

Zhai J, Zhang L, Mojsilovic-Petrovic J, Jian X, Thomas J, Homma K, Schmitz A, Famulok M, Ichijo H, Argon Y, Randazzo PA, Kalb RG.

J Neurosci. 2015 Jun 17;35(24):9088-105. doi: 10.1523/JNEUROSCI.5032-13.2015.

26.

ArfGAPs: key regulators for receptor sorting.

Shiba Y, Randazzo PA.

Receptors Clin Investig. 2014 Jun 13;1(5):e158.

27.

Activation of Gαi at the Golgi by GIV/Girdin imposes finiteness in Arf1 signaling.

Lo IC, Gupta V, Midde KK, Taupin V, Lopez-Sanchez I, Kufareva I, Abagyan R, Randazzo PA, Farquhar MG, Ghosh P.

Dev Cell. 2015 Apr 20;33(2):189-203. doi: 10.1016/j.devcel.2015.02.009. Epub 2015 Apr 9.

28.

The Arf6 GTPase-activating proteins ARAP2 and ACAP1 define distinct endosomal compartments that regulate integrin α5β1 traffic.

Chen PW, Luo R, Jian X, Randazzo PA.

J Biol Chem. 2014 Oct 31;289(44):30237-48. doi: 10.1074/jbc.M114.596155. Epub 2014 Sep 15.

29.

The importance of seeing surface (effects).

Gruschus JM, Byrd RA, Randazzo PA.

Structure. 2014 Mar 4;22(3):363-5. doi: 10.1016/j.str.2014.02.005.

30.

ArfGAP3 regulates the transport of cation-independent mannose 6-phosphate receptor in the post-Golgi compartment.

Shiba Y, Kametaka S, Waguri S, Presley JF, Randazzo PA.

Curr Biol. 2013 Oct 7;23(19):1945-51. doi: 10.1016/j.cub.2013.07.087. Epub 2013 Sep 26.

31.

ARAP2 signals through Arf6 and Rac1 to control focal adhesion morphology.

Chen PW, Jian X, Yoon HY, Randazzo PA.

J Biol Chem. 2013 Feb 22;288(8):5849-60. doi: 10.1074/jbc.M112.415778. Epub 2013 Jan 7.

32.

The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2.

Hosokawa H, Dip PV, Merkulova M, Bakulina A, Zhuang Z, Khatri A, Jian X, Keating SM, Bueler SA, Rubinstein JL, Randazzo PA, Ausiello DA, Grüber G, Marshansky V.

J Biol Chem. 2013 Feb 22;288(8):5896-913. doi: 10.1074/jbc.M112.409169. Epub 2013 Jan 3.

33.

Quantitative Analysis of Guanine Nucleotide Exchange Factors (GEFs) as Enzymes.

Randazzo PA, Jian X, Chen PW, Zhai P, Soubias O, Northup JK.

Cell Logist. 2014 Jan 9;3:e27609. eCollection 2013.

34.

Nucleotide exchange factors: Kinetic analyses and the rationale for studying kinetics of GEFs.

Northup JK, Jian X, Randazzo PA.

Cell Logist. 2012 Jul 1;2(3):140-146.

35.

Approaches to studying Arf GAPs in cells: in vitro assay with isolated focal adhesions.

Chen PW, Jian X, Luo R, Randazzo PA.

Curr Protoc Cell Biol. 2012 Jun;Chapter 17:Unit17.13. doi: 10.1002/0471143030.cb1713s55. Review.

PMID:
23129116
36.

ArfGAP1 function in COPI mediated membrane traffic: currently debated models and comparison to other coat-binding ArfGAPs.

Shiba Y, Randazzo PA.

Histol Histopathol. 2012 Sep;27(9):1143-53. doi: 10.14670/HH-27.1143. Review.

PMID:
22806901
37.

The pleckstrin homology (PH) domain of the Arf exchange factor Brag2 is an allosteric binding site.

Jian X, Gruschus JM, Sztul E, Randazzo PA.

J Biol Chem. 2012 Jul 13;287(29):24273-83. doi: 10.1074/jbc.M112.368084. Epub 2012 May 21.

38.

GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.

Luo R, Akpan IO, Hayashi R, Sramko M, Barr V, Shiba Y, Randazzo PA.

J Biol Chem. 2012 May 18;287(21):17176-85. doi: 10.1074/jbc.M111.334458. Epub 2012 Mar 27.

39.

ArfGAP1 promotes COPI vesicle formation by facilitating coatomer polymerization.

Shiba Y, Luo R, Hinshaw JE, Szul T, Hayashi R, Sztul E, Nagashima K, Baxa U, Randazzo PA.

Cell Logist. 2011 Jul-Dec;1(4):139-154. doi: 10.4161/cl.1.4.18896. Epub 2011 Jul 1.

40.

Novel C-terminal motif within Sec7 domain of guanine nucleotide exchange factors regulates ADP-ribosylation factor (ARF) binding and activation.

Lowery J, Szul T, Seetharaman J, Jian X, Su M, Forouhar F, Xiao R, Acton TB, Montelione GT, Lin H, Wright JW, Lee E, Holloway ZG, Randazzo PA, Tong L, Sztul E.

J Biol Chem. 2011 Oct 21;286(42):36898-906. doi: 10.1074/jbc.M111.230631. Epub 2011 Aug 2.

41.

Phosphatidylinositol-4-phosphate 5-kinase and GEP100/Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 through Arf6 protein.

Sakurai A, Jian X, Lee CJ, Manavski Y, Chavakis E, Donaldson J, Randazzo PA, Gutkind JS.

J Biol Chem. 2011 Sep 30;286(39):34335-45. doi: 10.1074/jbc.M111.259499. Epub 2011 Jul 27.

42.

GEFH1 binds ASAP1 and regulates podosome formation.

Shiba Y, Randazzo PA.

Biochem Biophys Res Commun. 2011 Mar 25;406(4):574-9. doi: 10.1016/j.bbrc.2011.02.093. Epub 2011 Feb 23.

43.

ARAP1 association with CIN85 affects epidermal growth factor receptor endocytic trafficking.

Yoon HY, Kales SC, Luo R, Lipkowitz S, Randazzo PA.

Biol Cell. 2011 Apr;103(4):171-84. doi: 10.1042/BC20100154.

44.

PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1.

Kang SA, Lee ES, Yoon HY, Randazzo PA, Lee ST.

J Biol Chem. 2010 Aug 20;285(34):26013-21. doi: 10.1074/jbc.M109.088971. Epub 2010 Jun 16.

45.

Arf GAPs: gatekeepers of vesicle generation.

Spang A, Shiba Y, Randazzo PA.

FEBS Lett. 2010 Jun 18;584(12):2646-51. doi: 10.1016/j.febslet.2010.04.005. Epub 2010 Apr 13. Review.

46.

Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras.

Sakurai A, Gavard J, Annas-Linhares Y, Basile JR, Amornphimoltham P, Palmby TR, Yagi H, Zhang F, Randazzo PA, Li X, Weigert R, Gutkind JS.

Mol Cell Biol. 2010 Jun;30(12):3086-98. doi: 10.1128/MCB.01652-09. Epub 2010 Apr 12.

47.

Modifications to the C-terminus of Arf1 alter cell functions and protein interactions.

Jian X, Cavenagh M, Gruschus JM, Randazzo PA, Kahn RA.

Traffic. 2010 Jun;11(6):732-42. doi: 10.1111/j.1600-0854.2010.01054.x. Epub 2010 Feb 27.

48.

ACAP-A/B are ArfGAP homologs in dictyostelium involved in sporulation but not in chemotaxis.

Chen PW, Randazzo PA, Parent CA.

PLoS One. 2010 Jan 7;5(1):e8624. doi: 10.1371/journal.pone.0008624.

49.

A PH domain in the Arf GTPase-activating protein (GAP) ARAP1 binds phosphatidylinositol 3,4,5-trisphosphate and regulates Arf GAP activity independently of recruitment to the plasma membranes.

Campa F, Yoon HY, Ha VL, Szentpetery Z, Balla T, Randazzo PA.

J Biol Chem. 2009 Oct 9;284(41):28069-83. doi: 10.1074/jbc.M109.028266. Epub 2009 Aug 7.

50.

Regulation of membrane trafficking and organ separation by the NEVERSHED ARF-GAP protein.

Liljegren SJ, Leslie ME, Darnielle L, Lewis MW, Taylor SM, Luo R, Geldner N, Chory J, Randazzo PA, Yanofsky MF, Ecker JR.

Development. 2009 Jun;136(11):1909-18. doi: 10.1242/dev.033605.

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