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Items: 1 to 50 of 152

1.

Analysis of Paramyxovirus Transcription and Replication by High-Throughput Sequencing.

Wignall-Fleming EB, Hughes DJ, Vattipally S, Modha S, Goodbourn S, Davison AJ, Randall RE.

J Virol. 2019 Aug 13;93(17). pii: e00571-19. doi: 10.1128/JVI.00571-19. Print 2019 Sep 1.

2.

The switch between acute and persistent paramyxovirus infection caused by single amino acid substitutions in the RNA polymerase P subunit.

Young DF, Wignall-Fleming EB, Busse DC, Pickin MJ, Hankinson J, Randall EM, Tavendale A, Davison AJ, Lamont D, Tregoning JS, Goodbourn S, Randall RE.

PLoS Pathog. 2019 Feb 11;15(2):e1007561. doi: 10.1371/journal.ppat.1007561. eCollection 2019 Feb.

3.

Mini viral RNAs act as innate immune agonists during influenza virus infection.

Te Velthuis AJW, Long JC, Bauer DLV, Fan RLY, Yen HL, Sharps J, Siegers JY, Killip MJ, French H, Oliva-Martín MJ, Randall RE, de Wit E, van Riel D, Poon LLM, Fodor E.

Nat Microbiol. 2018 Nov;3(11):1234-1242. doi: 10.1038/s41564-018-0240-5. Epub 2018 Sep 17.

4.

Modular cell-based platform for high throughput identification of compounds that inhibit a viral interferon antagonist of choice.

Vasou A, Paulus C, Narloch J, Gage ZO, Rameix-Welti MA, Eléouët JF, Nevels M, Randall RE, Adamson CS.

Antiviral Res. 2018 Feb;150:79-92. doi: 10.1016/j.antiviral.2017.10.012. Epub 2017 Oct 14.

5.

Human interactome of the influenza B virus NS1 protein.

Patzina C, Botting CH, García-Sastre A, Randall RE, Hale BG.

J Gen Virol. 2017 Sep;98(9):2267-2273. doi: 10.1099/jgv.0.000909. Epub 2017 Sep 4.

6.

Targeting Pattern Recognition Receptors (PRR) for Vaccine Adjuvantation: From Synthetic PRR Agonists to the Potential of Defective Interfering Particles of Viruses.

Vasou A, Sultanoglu N, Goodbourn S, Randall RE, Kostrikis LG.

Viruses. 2017 Jul 13;9(7). pii: E186. doi: 10.3390/v9070186. Review.

7.

Taxonomy of the order Mononegavirales: update 2017.

Amarasinghe GK, Bào Y, Basler CF, Bavari S, Beer M, Bejerman N, Blasdell KR, Bochnowski A, Briese T, Bukreyev A, Calisher CH, Chandran K, Collins PL, Dietzgen RG, Dolnik O, Dürrwald R, Dye JM, Easton AJ, Ebihara H, Fang Q, Formenty P, Fouchier RAM, Ghedin E, Harding RM, Hewson R, Higgins CM, Hong J, Horie M, James AP, Jiāng D, Kobinger GP, Kondo H, Kurath G, Lamb RA, Lee B, Leroy EM, Li M, Maisner A, Mühlberger E, Netesov SV, Nowotny N, Patterson JL, Payne SL, Paweska JT, Pearson MN, Randall RE, Revill PA, Rima BK, Rota P, Rubbenstroth D, Schwemmle M, Smither SJ, Song Q, Stone DM, Takada A, Terregino C, Tesh RB, Tomonaga K, Tordo N, Towner JS, Vasilakis N, Volchkov VE, Wahl-Jensen V, Walker PJ, Wang B, Wang D, Wang F, Wang LF, Werren JH, Whitfield AE, Yan Z, Ye G, Kuhn JH.

Arch Virol. 2017 Aug;162(8):2493-2504. doi: 10.1007/s00705-017-3311-7. Epub 2017 Apr 7.

8.

Within host RNA virus persistence: mechanisms and consequences.

Randall RE, Griffin DE.

Curr Opin Virol. 2017 Apr;23:35-42. doi: 10.1016/j.coviro.2017.03.001. Epub 2017 Mar 17. Review.

9.

Single-cell studies of IFN-β promoter activation by wild-type and NS1-defective influenza A viruses.

Killip MJ, Jackson D, Pérez-Cidoncha M, Fodor E, Randall RE.

J Gen Virol. 2017 Mar;98(3):357-363. doi: 10.1099/jgv.0.000687. Epub 2017 Mar 20.

10.

Human IFIT1 Inhibits mRNA Translation of Rubulaviruses but Not Other Members of the Paramyxoviridae Family.

Young DF, Andrejeva J, Li X, Inesta-Vaquera F, Dong C, Cowling VH, Goodbourn S, Randall RE.

J Virol. 2016 Sep 29;90(20):9446-56. doi: 10.1128/JVI.01056-16. Print 2016 Oct 15.

11.

Genome Sequence of the Parainfluenza Virus 5 Strain That Persistently Infects AGS Cells.

Wignall-Fleming E, Young DF, Goodbourn S, Davison AJ, Randall RE.

Genome Announc. 2016 Jul 21;4(4). pii: e00653-16. doi: 10.1128/genomeA.00653-16.

12.

Identification of Novel Inhibitors of the Type I Interferon Induction Pathway Using Cell-Based High-Throughput Screening.

Gage ZO, Vasou A, Gray DW, Randall RE, Adamson CS.

J Biomol Screen. 2016 Oct;21(9):978-88. doi: 10.1177/1087057116656314. Epub 2016 Jun 29.

13.

Taxonomy of the order Mononegavirales: update 2016.

Afonso CL, Amarasinghe GK, Bányai K, Bào Y, Basler CF, Bavari S, Bejerman N, Blasdell KR, Briand FX, Briese T, Bukreyev A, Calisher CH, Chandran K, Chéng J, Clawson AN, Collins PL, Dietzgen RG, Dolnik O, Domier LL, Dürrwald R, Dye JM, Easton AJ, Ebihara H, Farkas SL, Freitas-Astúa J, Formenty P, Fouchier RA, Fù Y, Ghedin E, Goodin MM, Hewson R, Horie M, Hyndman TH, Jiāng D, Kitajima EW, Kobinger GP, Kondo H, Kurath G, Lamb RA, Lenardon S, Leroy EM, Li CX, Lin XD, Liú L, Longdon B, Marton S, Maisner A, Mühlberger E, Netesov SV, Nowotny N, Patterson JL, Payne SL, Paweska JT, Randall RE, Rima BK, Rota P, Rubbenstroth D, Schwemmle M, Shi M, Smither SJ, Stenglein MD, Stone DM, Takada A, Terregino C, Tesh RB, Tian JH, Tomonaga K, Tordo N, Towner JS, Vasilakis N, Verbeek M, Volchkov VE, Wahl-Jensen V, Walsh JA, Walker PJ, Wang D, Wang LF, Wetzel T, Whitfield AE, Xiè JT, Yuen KY, Zhang YZ, Kuhn JH.

Arch Virol. 2016 Aug;161(8):2351-60. doi: 10.1007/s00705-016-2880-1. Epub 2016 May 23.

14.

Bluetongue Virus NS4 Protein Is an Interferon Antagonist and a Determinant of Virus Virulence.

Ratinier M, Shaw AE, Barry G, Gu Q, Di Gialleonardo L, Janowicz A, Varela M, Randall RE, Caporale M, Palmarini M.

J Virol. 2016 May 12;90(11):5427-39. doi: 10.1128/JVI.00422-16. Print 2016 Jun 1.

15.

Generation of Recombinant Oropouche Viruses Lacking the Nonstructural Protein NSm or NSs.

Tilston-Lunel NL, Acrani GO, Randall RE, Elliott RM.

J Virol. 2015 Dec 23;90(5):2616-27. doi: 10.1128/JVI.02849-15.

16.

Human IFNAR2 deficiency: Lessons for antiviral immunity.

Duncan CJ, Mohamad SM, Young DF, Skelton AJ, Leahy TR, Munday DC, Butler KM, Morfopoulou S, Brown JR, Hubank M, Connell J, Gavin PJ, McMahon C, Dempsey E, Lynch NE, Jacques TS, Valappil M, Cant AJ, Breuer J, Engelhardt KR, Randall RE, Hambleton S.

Sci Transl Med. 2015 Sep 30;7(307):307ra154. doi: 10.1126/scitranslmed.aac4227.

17.

In memoriam--Richard M. Elliott (1954-2015).

Brennan B, Weber F, Kormelink R, Schnettler E, Bouloy M, Failloux AB, Weaver SC, Fazakerley JK, Fragkoudis R, Harris M, Barr JN, Palese P, García-Sastre A, Dalziel RG, Dutia BM, Lowen AC, Steel J, Randall RE, Paul Duprex W, Rice CM, Tesh RB, Murphy FA, Ebihara H, Vasconcelos PF, Nunes MR, Fooks AR, Smith GL, Goodfellow I, Pappu HR, Lamb RA, Paterson RG, Higgs S, Vanlandingham DL, Dietzgen RG, Stephen Lodmell J, Nichol ST, Daly J, Ullman DE, Plyusnin A, Plyusnina A, Efstathiou S, Hewson R, Tordo N, Cherry S, Boutell C, Hosie MJ, Murcia PR, Neil JC, Palmarini M, Patel AH, Willett BJ, Kohl A, McLauchlan J.

J Gen Virol. 2015 Aug;96(8):1975-8. doi: 10.1099/jgv.0.000241. No abstract available.

18.

Influenza virus activation of the interferon system.

Killip MJ, Fodor E, Randall RE.

Virus Res. 2015 Nov 2;209:11-22. doi: 10.1016/j.virusres.2015.02.003. Epub 2015 Feb 9. Review.

19.

Abrogation of the interferon response promotes more efficient human cytomegalovirus replication.

McSharry BP, Forbes SK, Avdic S, Randall RE, Wilkinson GW, Abendroth A, Slobedman B.

J Virol. 2015 Jan 15;89(2):1479-83. doi: 10.1128/JVI.02988-14. Epub 2014 Nov 12.

20.

Inhibitors of the interferon response enhance virus replication in vitro.

Stewart CE, Randall RE, Adamson CS.

PLoS One. 2014 Nov 12;9(11):e112014. doi: 10.1371/journal.pone.0112014. eCollection 2014.

21.

Generation of replication-proficient influenza virus NS1 point mutants with interferon-hyperinducer phenotype.

Pérez-Cidoncha M, Killip MJ, Asensio VJ, Fernández Y, Bengoechea JA, Randall RE, Ortín J.

PLoS One. 2014 Jun 2;9(6):e98668. doi: 10.1371/journal.pone.0098668. eCollection 2014.

22.

An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response.

Pérez-Cidoncha M, Killip MJ, Oliveros JC, Asensio VJ, Fernández Y, Bengoechea JA, Randall RE, Ortín J.

J Virol. 2014 May;88(9):4632-46. doi: 10.1128/JVI.00014-14. Epub 2014 Feb 26.

23.

Activation of the interferon induction cascade by influenza a viruses requires viral RNA synthesis and nuclear export.

Killip MJ, Smith M, Jackson D, Randall RE.

J Virol. 2014 Apr;88(8):3942-52. doi: 10.1128/JVI.03109-13. Epub 2014 Jan 29.

24.

Stability of the parainfluenza virus 5 genome revealed by deep sequencing of strains isolated from different hosts and following passage in cell culture.

Rima BK, Gatherer D, Young DF, Norsted H, Randall RE, Davison AJ.

J Virol. 2014 Apr;88(7):3826-36. doi: 10.1128/JVI.03351-13. Epub 2014 Jan 22.

25.

The human interferon-induced MxA protein inhibits early stages of influenza A virus infection by retaining the incoming viral genome in the cytoplasm.

Xiao H, Killip MJ, Staeheli P, Randall RE, Jackson D.

J Virol. 2013 Dec;87(23):13053-8. doi: 10.1128/JVI.02220-13. Epub 2013 Sep 18.

26.

LGP2 plays a critical role in sensitizing mda-5 to activation by double-stranded RNA.

Childs KS, Randall RE, Goodbourn S.

PLoS One. 2013 May 9;8(5):e64202. doi: 10.1371/journal.pone.0064202. Print 2013.

27.

Deep sequencing analysis of defective genomes of parainfluenza virus 5 and their role in interferon induction.

Killip MJ, Young DF, Gatherer D, Ross CS, Short JA, Davison AJ, Goodbourn S, Randall RE.

J Virol. 2013 May;87(9):4798-807. doi: 10.1128/JVI.03383-12. Epub 2013 Feb 28.

28.

STAT2 deficiency and susceptibility to viral illness in humans.

Hambleton S, Goodbourn S, Young DF, Dickinson P, Mohamad SM, Valappil M, McGovern N, Cant AJ, Hackett SJ, Ghazal P, Morgan NV, Randall RE.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3053-8. doi: 10.1073/pnas.1220098110. Epub 2013 Feb 7.

29.

ISG56/IFIT1 is primarily responsible for interferon-induced changes to patterns of parainfluenza virus type 5 transcription and protein synthesis.

Andrejeva J, Norsted H, Habjan M, Thiel V, Goodbourn S, Randall RE.

J Gen Virol. 2013 Jan;94(Pt 1):59-68. doi: 10.1099/vir.0.046797-0. Epub 2012 Oct 10.

30.

Influenza virus A infection of human monocyte and macrophage subpopulations reveals increased susceptibility associated with cell differentiation.

Hoeve MA, Nash AA, Jackson D, Randall RE, Dransfield I.

PLoS One. 2012;7(1):e29443. doi: 10.1371/journal.pone.0029443. Epub 2012 Jan 4.

31.

Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis.

Killip MJ, Young DF, Precious BL, Goodbourn S, Randall RE.

J Gen Virol. 2012 Feb;93(Pt 2):299-307. doi: 10.1099/vir.0.037531-0. Epub 2011 Nov 2.

32.

Failure to activate the IFN-β promoter by a paramyxovirus lacking an interferon antagonist.

Killip MJ, Young DF, Ross CS, Chen S, Goodbourn S, Randall RE.

Virology. 2011 Jun 20;415(1):39-46. doi: 10.1016/j.virol.2011.03.027. Epub 2011 Apr 22.

33.

A transient homotypic interaction model for the influenza A virus NS1 protein effector domain.

Kerry PS, Ayllon J, Taylor MA, Hass C, Lewis A, García-Sastre A, Randall RE, Hale BG, Russell RJ.

PLoS One. 2011 Mar 28;6(3):e17946. doi: 10.1371/journal.pone.0017946.

34.

Innate sensing of HIV-infected cells.

Lepelley A, Louis S, Sourisseau M, Law HK, Pothlichet J, Schilte C, Chaperot L, Plumas J, Randall RE, Si-Tahar M, Mammano F, Albert ML, Schwartz O.

PLoS Pathog. 2011 Feb;7(2):e1001284. doi: 10.1371/journal.ppat.1001284. Epub 2011 Feb 17.

35.

Heterocellular induction of interferon by negative-sense RNA viruses.

Chen S, Short JA, Young DF, Killip MJ, Schneider M, Goodbourn S, Randall RE.

Virology. 2010 Nov 25;407(2):247-55. doi: 10.1016/j.virol.2010.08.008. Epub 2010 Sep 15.

36.

Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein.

Hale BG, Kerry PS, Jackson D, Precious BL, Gray A, Killip MJ, Randall RE, Russell RJ.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1954-9. doi: 10.1073/pnas.0910715107. Epub 2010 Jan 19.

37.

Loss of function of the influenza A virus NS1 protein promotes apoptosis but this is not due to a failure to activate phosphatidylinositol 3-kinase (PI3K).

Jackson D, Killip MJ, Galloway CS, Russell RJ, Randall RE.

Virology. 2010 Jan 5;396(1):94-105. doi: 10.1016/j.virol.2009.10.004. Epub 2009 Oct 31.

38.

The regulation of type I interferon production by paramyxoviruses.

Goodbourn S, Randall RE.

J Interferon Cytokine Res. 2009 Sep;29(9):539-47. doi: 10.1089/jir.2009.0071. Review.

39.

Mumps virus Enders strain is sensitive to interferon (IFN) despite encoding a functional IFN antagonist.

Young DF, Galiano MC, Lemon K, Chen YH, Andrejeva J, Duprex WP, Rima BK, Randall RE.

J Gen Virol. 2009 Nov;90(Pt 11):2731-8. doi: 10.1099/vir.0.013722-0. Epub 2009 Jul 22.

40.

Parainfluenza virus 5 genomes are located in viral cytoplasmic bodies whilst the virus dismantles the interferon-induced antiviral state of cells.

Carlos TS, Young DF, Schneider M, Simas JP, Randall RE.

J Gen Virol. 2009 Sep;90(Pt 9):2147-56. doi: 10.1099/vir.0.012047-0. Epub 2009 May 20.

41.

Cation currents in human airway epithelial cells induced by infection with influenza A virus.

Gallacher M, Brown SG, Hale BG, Fearns R, Olver RE, Randall RE, Wilson SM.

J Physiol. 2009 Jul 1;587(Pt 13):3159-73. doi: 10.1113/jphysiol.2009.171223. Epub 2009 Apr 29.

42.

Mechanism of mda-5 Inhibition by paramyxovirus V proteins.

Childs KS, Andrejeva J, Randall RE, Goodbourn S.

J Virol. 2009 Feb;83(3):1465-73. doi: 10.1128/JVI.01768-08. Epub 2008 Nov 19.

43.

CDK/ERK-mediated phosphorylation of the human influenza A virus NS1 protein at threonine-215.

Hale BG, Knebel A, Botting CH, Galloway CS, Precious BL, Jackson D, Elliott RM, Randall RE.

Virology. 2009 Jan 5;383(1):6-11. doi: 10.1016/j.virol.2008.10.002. Epub 2008 Nov 13.

44.

The multifunctional NS1 protein of influenza A viruses.

Hale BG, Randall RE, Ortín J, Jackson D.

J Gen Virol. 2008 Oct;89(Pt 10):2359-76. doi: 10.1099/vir.0.2008/004606-0. Review.

PMID:
18796704
45.

Structure of an avian influenza A virus NS1 protein effector domain.

Hale BG, Barclay WS, Randall RE, Russell RJ.

Virology. 2008 Aug 15;378(1):1-5. doi: 10.1016/j.virol.2008.05.026. Epub 2008 Jun 27.

46.

STAT-1- and IRF-3-dependent pathways are not essential for repression of ICP0-null mutant herpes simplex virus type 1 in human fibroblasts.

Everett RD, Young DF, Randall RE, Orr A.

J Virol. 2008 Sep;82(17):8871-81. doi: 10.1128/JVI.00613-08. Epub 2008 Jun 25.

47.

Crystal structure of human IPS-1/MAVS/VISA/Cardif caspase activation recruitment domain.

Potter JA, Randall RE, Taylor GL.

BMC Struct Biol. 2008 Feb 28;8:11. doi: 10.1186/1472-6807-8-11.

48.
49.

Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation.

Hale BG, Batty IH, Downes CP, Randall RE.

J Biol Chem. 2008 Jan 18;283(3):1372-80. Epub 2007 Nov 20.

50.

Catalytic turnover of STAT1 allows PIV5 to dismantle the interferon-induced anti-viral state of cells.

Precious BL, Carlos TS, Goodbourn S, Randall RE.

Virology. 2007 Nov 10;368(1):114-21. Epub 2007 Jul 19.

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