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Items: 13


Acquired Nisin Resistance in Staphylococcus aureus Involves Constitutive Activation of an Intrinsic Peptide Antibiotic Detoxification Module.

Randall CP, Gupta A, Utley-Drew B, Lee SY, Morrison-Williams G, O'Neill AJ.

mSphere. 2018 Dec 12;3(6). pii: e00633-18. doi: 10.1128/mSphereDirect.00633-18.


N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors.

Charlton MH, Aleksis R, Saint-Leger A, Gupta A, Loza E, Ribas de Pouplana L, Kaula I, Gustina D, Madre M, Lola D, Jaudzems K, Edmund G, Randall CP, Kime L, O'Neill AJ, Goessens W, Jirgensons A, Finn PW.

ACS Med Chem Lett. 2018 Jan 18;9(2):84-88. doi: 10.1021/acsmedchemlett.7b00374. eCollection 2018 Feb 8.


Revisiting unexploited antibiotics in search of new antibacterial drug candidates: the case of γ-actinorhodin.

Nass NM, Farooque S, Hind C, Wand ME, Randall CP, Sutton JM, Seipke RF, Rayner CM, O'Neill AJ.

Sci Rep. 2017 Dec 12;7(1):17419. doi: 10.1038/s41598-017-17232-1.


Cryptic silver resistance is prevalent and readily activated in certain Gram-negative pathogens.

Elkrewi E, Randall CP, Ooi N, Cottell JL, O'Neill AJ.

J Antimicrob Chemother. 2017 Nov 1;72(11):3043-3046. doi: 10.1093/jac/dkx258.


Impact of Exposure of Methicillin-Resistant Staphylococcus aureus to Polyhexanide In Vitro and In Vivo.

Renzoni A, Von Dach E, Landelle C, Diene SM, Manzano C, Gonzales R, Abdelhady W, Randall CP, Bonetti EJ, Baud D, O'Neill AJ, Bayer A, Cherkaoui A, Schrenzel J, Harbarth S, François P.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00272-17. doi: 10.1128/AAC.00272-17. Print 2017 Oct.


Targeting Multiple Aminoacyl-tRNA Synthetases Overcomes the Resistance Liabilities Associated with Antibacterial Inhibitors Acting on a Single Such Enzyme.

Randall CP, Rasina D, Jirgensons A, O'Neill AJ.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6359-61. doi: 10.1128/AAC.00674-16. Print 2016 Oct.


A Polymorphism in leuS Confers Reduced Susceptibility to GSK2251052 in a Clinical Isolate of Staphylococcus aureus.

Gupta A, Monteferrante C, Rasina D, Leitis G, Randall CP, Tomlinson JH, Jirgensons A, Goessens WH, Hays JP, O'Neill AJ.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):3219-21. doi: 10.1128/AAC.02940-15. Print 2016 May.


Silver resistance in Gram-negative bacteria: a dissection of endogenous and exogenous mechanisms.

Randall CP, Gupta A, Jackson N, Busse D, O'Neill AJ.

J Antimicrob Chemother. 2015 Apr;70(4):1037-46. doi: 10.1093/jac/dku523. Epub 2015 Jan 6.


Design, synthesis and evaluation of second generation MurF inhibitors based on a cyanothiophene scaffold.

Hrast M, Anderluh M, Knez D, Randall CP, Barreteau H, O'Neill AJ, Blanot D, Gobec S.

Eur J Med Chem. 2014 Feb 12;73:83-96. doi: 10.1016/j.ejmech.2013.11.031. Epub 2013 Dec 12.


Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF.

Hrast M, Turk S, Sosič I, Knez D, Randall CP, Barreteau H, Contreras-Martel C, Dessen A, O'Neill AJ, Mengin-Lecreulx D, Blanot D, Gobec S.

Eur J Med Chem. 2013 Aug;66:32-45. doi: 10.1016/j.ejmech.2013.05.013. Epub 2013 May 21.


The target of daptomycin is absent from Escherichia coli and other gram-negative pathogens.

Randall CP, Mariner KR, Chopra I, O'Neill AJ.

Antimicrob Agents Chemother. 2013 Jan;57(1):637-9. doi: 10.1128/AAC.02005-12. Epub 2012 Oct 31.


The silver cation (Ag+): antistaphylococcal activity, mode of action and resistance studies.

Randall CP, Oyama LB, Bostock JM, Chopra I, O'Neill AJ.

J Antimicrob Chemother. 2013 Jan;68(1):131-8. doi: 10.1093/jac/dks372. Epub 2012 Sep 25.


In vitro studies indicate a high resistance potential for the lantibiotic nisin in Staphylococcus aureus and define a genetic basis for nisin resistance.

Blake KL, Randall CP, O'Neill AJ.

Antimicrob Agents Chemother. 2011 May;55(5):2362-8. doi: 10.1128/AAC.01077-10. Epub 2011 Feb 7.

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