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Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT.
Merkle PS, Gotfryd K, Cuendet MA, Leth-Espensen KZ, Gether U, Loland CJ, Rand KD.
Sci Adv. 2018 May 11;4(5):eaar6179. doi: 10.1126/sciadv.aar6179. eCollection 2018 May.
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Glycine Perturbs Local and Global Conformational Flexibility of a Transmembrane Helix.
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Biochemistry. 2018 Feb 27;57(8):1326-1337. doi: 10.1021/acs.biochem.7b01197. Epub 2018 Feb 9.
UV Photodissociation Mass Spectrometry Accurately Localize Sites of Backbone Deuteration in Peptides.
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A Poly-ADP-Ribose Trigger Releases the Auto-Inhibition of a Chromatin Remodeling Oncogene.
Singh HR, Nardozza AP, Möller IR, Knobloch G, Kistemaker HAV, Hassler M, Harrer N, Blessing C, Eustermann S, Kotthoff C, Huet S, Mueller-Planitz F, Filippov DV, Timinszky G, Rand KD, Ladurner AG.
Mol Cell. 2017 Dec 7;68(5):860-871.e7. doi: 10.1016/j.molcel.2017.11.019.
Conformational characterization of nerve growth factor-β reveals that its regulatory pro-part domain stabilizes three loop regions in its mature part.
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J Biol Chem. 2017 Oct 6;292(40):16665-16676. doi: 10.1074/jbc.M117.803320. Epub 2017 Aug 10.
The extraordinary thermal stability of EstA from S. islandicus is independent of post translational modifications.
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Protein Sci. 2017 Sep;26(9):1819-1827. doi: 10.1002/pro.3220. Epub 2017 Jul 13.
The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed β2-Microglobulin through Distinct Binding Sites.
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Expression, Purification and Characterization of GMZ2'.10C, a Complex Disulphide-Bonded Fusion Protein Vaccine Candidate against the Asexual and Sexual Life-Stages of the Malaria-Causing Plasmodium falciparum Parasite.
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Pharm Res. 2017 Sep;34(9):1970-1983. doi: 10.1007/s11095-017-2208-1. Epub 2017 Jun 23.
Construct design, production, and characterization of Plasmodium falciparum 48/45 R0.6C subunit protein produced in Lactococcus lactis as candidate vaccine.
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Microb Cell Fact. 2017 May 31;16(1):97. doi: 10.1186/s12934-017-0710-0.
Coordinates and intervals in graph-based reference genomes.
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BMC Bioinformatics. 2017 May 18;18(1):263. doi: 10.1186/s12859-017-1678-9.
Thiol-ene Monolithic Pepsin Microreactor with a 3D-Printed Interface for Efficient UPLC-MS Peptide Mapping Analyses.
Jönsson A, Svejdal RR, Bøgelund N, Nguyen TTTN, Flindt H, Kutter JP, Rand KD, Lafleur JP.
Anal Chem. 2017 Apr 18;89(8):4573-4580. doi: 10.1021/acs.analchem.6b05103. Epub 2017 Apr 4.
Removal of N-Linked Glycosylations at Acidic pH by PNGase A Facilitates Hydrogen/Deuterium Exchange Mass Spectrometry Analysis of N-Linked Glycoproteins.
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A Two-pronged Binding Mechanism of IgG to the Neonatal Fc Receptor Controls Complex Stability and IgG Serum Half-life.
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A simple sheathless CE-MS interface with a sub-micrometer electrical contact fracture for sensitive analysis of peptide and protein samples.
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Anal Chim Acta. 2016 Sep 14;936:157-67. doi: 10.1016/j.aca.2016.07.002. Epub 2016 Jul 5.
Fully Automated Electro Membrane Extraction Autosampler for LC-MS Systems Allowing Soft Extractions for High-Throughput Applications.
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Investigating the Role of Artemin Glycosylation.
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Conformational Analysis of Proteins in Highly Concentrated Solutions by Dialysis-Coupled Hydrogen/Deuterium Exchange Mass Spectrometry.
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J Am Soc Mass Spectrom. 2016 Apr;27(4):669-76. doi: 10.1007/s13361-015-1331-7. Epub 2016 Feb 9.
Direct coupling of a flow-flow electromembrane extraction probe to LC-MS.
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Anal Chim Acta. 2016 Jan 28;905:93-9. doi: 10.1016/j.aca.2015.12.014. Epub 2015 Dec 18.
Probing the Binding Interfaces of Protein Complexes Using Gas-Phase H/D Exchange Mass Spectrometry.
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Structure. 2016 Feb 2;24(2):310-8. doi: 10.1016/j.str.2015.11.013. Epub 2015 Dec 31.
Conformational Destabilization of Immunoglobulin G Increases the Low pH Binding Affinity with the Neonatal Fc Receptor.
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Rapid and simple preparation of thiol-ene emulsion-templated monoliths and their application as enzymatic microreactors.
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Getting to the core of protein pharmaceuticals--Comprehensive structure analysis by mass spectrometry.
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Investigating the interaction between the neonatal Fc receptor and monoclonal antibody variants by hydrogen/deuterium exchange mass spectrometry.
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Simple setup for gas-phase H/D exchange mass spectrometry coupled to electron transfer dissociation and ion mobility for analysis of polypeptide structure on a liquid chromatographic time scale.
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Sites involved in intra- and interdomain allostery associated with the activation of factor VIIa pinpointed by hydrogen-deuterium exchange and electron transfer dissociation mass spectrometry.
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J Biol Chem. 2014 Dec 19;289(51):35388-96. doi: 10.1074/jbc.M114.614297. Epub 2014 Oct 24.
Dissecting the binding mode of low affinity phage display peptide ligands to protein targets by hydrogen/deuterium exchange coupled to mass spectrometry.
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Measuring the hydrogen/deuterium exchange of proteins at high spatial resolution by mass spectrometry: overcoming gas-phase hydrogen/deuterium scrambling.
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Substrate- and cofactor-independent inhibition of histone demethylase KDM4C.
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A conformational investigation of propeptide binding to the integral membrane protein γ-glutamyl carboxylase using nanodisc hydrogen exchange mass spectrometry.
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Biochemistry. 2014 Mar 11;53(9):1511-20. doi: 10.1021/bi401536m. Epub 2014 Feb 26.
Site-specific analysis of gas-phase hydrogen/deuterium exchange of peptides and proteins by electron transfer dissociation.
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Anal Chem. 2012 Feb 21;84(4):1931-40. doi: 10.1021/ac202918j. Epub 2012 Feb 3.
Spatially resolved protein hydrogen exchange measured by matrix-assisted laser desorption ionization in-source decay.
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Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization.
Kim M, Sun ZY, Rand KD, Shi X, Song L, Cheng Y, Fahmy AF, Majumdar S, Ofek G, Yang Y, Kwong PD, Wang JH, Engen JR, Wagner G, Reinherz EL.
Nat Struct Mol Biol. 2011 Oct 16;18(11):1235-43. doi: 10.1038/nsmb.2154.
ETD in a traveling wave ion guide at tuned Z-spray ion source conditions allows for site-specific hydrogen/deuterium exchange measurements.
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J Am Soc Mass Spectrom. 2011 Oct;22(10):1784-93. doi: 10.1007/s13361-011-0196-7. Epub 2011 Jul 9.
Conformational transitions in the membrane scaffold protein of phospholipid bilayer nanodiscs.
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Mol Cell Proteomics. 2011 Sep;10(9):M111.010876. doi: 10.1074/mcp.M111.010876. Epub 2011 Jun 29.
False EX1 signatures caused by sample carryover during HX MS analyses.
Fang J, Rand KD, Beuning PJ, Engen JR.
Int J Mass Spectrom. 2011 Apr 30;302(1-3):19-25.
Loss of ammonia during electron-transfer dissociation of deuterated peptides as an inherent gauge of gas-phase hydrogen scrambling.
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Conformational analysis of membrane proteins in phospholipid bilayer nanodiscs by hydrogen exchange mass spectrometry.
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Conformational dynamics of the Escherichia coli DNA polymerase manager proteins UmuD and UmuD'.
Fang J, Rand KD, Silva MC, Wales TE, Engen JR, Beuning PJ.
J Mol Biol. 2010 Apr 23;398(1):40-53. doi: 10.1016/j.jmb.2010.02.040. Epub 2010 Mar 4.
Gas-phase hydrogen/deuterium exchange in a traveling wave ion guide for the examination of protein conformations.
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Protein hydrogen exchange measured at single-residue resolution by electron transfer dissociation mass spectrometry.
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Electron transfer dissociation facilitates the measurement of deuterium incorporation into selectively labeled peptides with single residue resolution.
Zehl M, Rand KD, Jensen ON, Jørgensen TJ.
J Am Chem Soc. 2008 Dec 24;130(51):17453-9. doi: 10.1021/ja805573h.
Gas-phase fragmentation of peptides by MALDI in-source decay with limited amide hydrogen (1H/2H) scrambling.
Bache N, Rand KD, Roepstorff P, Jørgensen TJ.
Anal Chem. 2008 Aug 15;80(16):6431-5. doi: 10.1021/ac800902a. Epub 2008 Jul 22.
Hydrogen atom scrambling in selectively labeled anionic peptides upon collisional activation by MALDI tandem time-of-flight mass spectrometry.
Bache N, Rand KD, Roepstorff P, Ploug M, Jørgensen TJ.
J Am Soc Mass Spectrom. 2008 Dec;19(12):1719-25. doi: 10.1016/j.jasms.2008.05.021. Epub 2008 Jun 11.
Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor.
Svensson LA, Bondensgaard K, Nørskov-Lauritsen L, Christensen L, Becker P, Andersen MD, Maltesen MJ, Rand KD, Breinholt J.
J Biol Chem. 2008 Jul 4;283(27):19085-94. doi: 10.1074/jbc.M801202200. Epub 2008 May 8.
The origins of enhanced activity in factor VIIa analogs and the interplay between key allosteric sites revealed by hydrogen exchange mass spectrometry.
Rand KD, Andersen MD, Olsen OH, Jørgensen TJ, Ostergaard H, Jensen ON, Stennicke HR, Persson E.
J Biol Chem. 2008 May 9;283(19):13378-87. doi: 10.1074/jbc.M709716200. Epub 2008 Mar 14.
Electron capture dissociation proceeds with a low degree of intramolecular migration of peptide amide hydrogens.
Rand KD, Adams CM, Zubarev RA, Jørgensen TJ.
J Am Chem Soc. 2008 Jan 30;130(4):1341-9. doi: 10.1021/ja076448i. Epub 2008 Jan 3.
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