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Items: 22

1.

Expression, purification, and characterization of a human complement component C3 analog that lacks the C-terminal C345c domain.

Ramyar KX, Xu X, White NM, Keightley A, Geisbrecht BV.

J Immunol Methods. 2019 Oct;473:112633. doi: 10.1016/j.jim.2019.07.005. Epub 2019 Jul 15.

PMID:
31319063
2.

Using disruptive insertional mutagenesis to identify the in situ structure-function landscape of the Shigella translocator protein IpaB.

Barta ML, Tachiyama S, Muthuramalingam M, Arizmendi O, Villanueva CE, Ramyar KX, Geisbrecht BV, Lovell S, Battaile KP, Picking WL, Picking WD.

Protein Sci. 2018 Aug;27(8):1392-1406. doi: 10.1002/pro.3428. Epub 2018 May 3.

3.

Identification of Surface-Exposed Protein Radicals and A Substrate Oxidation Site in A-Class Dye-Decolorizing Peroxidase from Thermomonospora curvata.

Shrestha R, Chen X, Ramyar KX, Hayati Z, Carlson EA, Bossmann SH, Song L, Geisbrecht BV, Li P.

ACS Catal. 2016 Dec 2;6(12):8036-8047. doi: 10.1021/acscatal.6b01952. Epub 2016 Oct 12.

4.

A structurally dynamic N-terminal region drives function of the staphylococcal peroxidase inhibitor (SPIN).

de Jong NWM, Ploscariu NT, Ramyar KX, Garcia BL, Herrera AI, Prakash O, Katz BB, Leidal KG, Nauseef WM, van Kessel KPM, van Strijp JAG, Geisbrecht BV.

J Biol Chem. 2018 Feb 16;293(7):2260-2271. doi: 10.1074/jbc.RA117.000134. Epub 2018 Jan 5.

5.

Immune evasion by a staphylococcal inhibitor of myeloperoxidase.

de Jong NWM, Ramyar KX, Guerra FE, Nijland R, Fevre C, Voyich JM, McCarthy AJ, Garcia BL, van Kessel KPM, van Strijp JAG, Geisbrecht BV, Haas PA.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9439-9444. doi: 10.1073/pnas.1707032114. Epub 2017 Aug 14.

6.

The structural basis for inhibition of the classical and lectin complement pathways by S. aureus extracellular adherence protein.

Woehl JL, Ramyar KX, Katz BB, Walker JK, Geisbrecht BV.

Protein Sci. 2017 Aug;26(8):1595-1608. doi: 10.1002/pro.3195. Epub 2017 May 31.

7.

NlpC/P60 domain-containing proteins of Mycobacterium avium subspecies paratuberculosis that differentially bind and hydrolyze peptidoglycan.

Bannantine JP, Lingle CK, Adam PR, Ramyar KX, McWhorter WJ, Stabel JR, Picking WD, Geisbrecht BV.

Protein Sci. 2016 Apr;25(4):840-51. doi: 10.1002/pro.2884. Epub 2016 Feb 14.

8.

Identification of peptidic inhibitors of the alternative complement pathway based on Staphylococcus aureus SCIN proteins.

Summers BJ, Garcia BL, Woehl JL, Ramyar KX, Yao X, Geisbrecht BV.

Mol Immunol. 2015 Oct;67(2 Pt B):193-205. doi: 10.1016/j.molimm.2015.05.012. Epub 2015 Jun 4.

9.

The extracellular adherence protein from Staphylococcus aureus inhibits the classical and lectin pathways of complement by blocking formation of the C3 proconvertase.

Woehl JL, Stapels DAC, Garcia BL, Ramyar KX, Keightley A, Ruyken M, Syriga M, Sfyroera G, Weber AB, Zolkiewski M, Ricklin D, Lambris JD, Rooijakkers SHM, Geisbrecht BV.

J Immunol. 2014 Dec 15;193(12):6161-6171. doi: 10.4049/jimmunol.1401600. Epub 2014 Nov 7.

10.

Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors.

Stapels DA, Ramyar KX, Bischoff M, von Köckritz-Blickwede M, Milder FJ, Ruyken M, Eisenbeis J, McWhorter WJ, Herrmann M, van Kessel KP, Geisbrecht BV, Rooijakkers SH.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13187-92. doi: 10.1073/pnas.1407616111. Epub 2014 Aug 26.

11.

A structurally dynamic N-terminal helix is a key functional determinant in staphylococcal complement inhibitor (SCIN) proteins.

Garcia BL, Summers BJ, Ramyar KX, Tzekou A, Lin Z, Ricklin D, Lambris JD, Laity JH, Geisbrecht BV.

J Biol Chem. 2013 Jan 25;288(4):2870-81. doi: 10.1074/jbc.M112.426858. Epub 2012 Dec 11.

12.

MAP1272c encodes an NlpC/P60 protein, an antigen detected in cattle with Johne's disease.

Bannantine JP, Lingle CK, Stabel JR, Ramyar KX, Garcia BL, Raeber AJ, Schacher P, Kapur V, Geisbrecht BV.

Clin Vaccine Immunol. 2012 Jul;19(7):1083-92. doi: 10.1128/CVI.00195-12. Epub 2012 May 16.

13.

Biochemical and structural basis for inhibition of Enterococcus faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin.

Skaff DA, Ramyar KX, McWhorter WJ, Barta ML, Geisbrecht BV, Miziorko HM.

Biochemistry. 2012 Jun 12;51(23):4713-22. doi: 10.1021/bi300037k. Epub 2012 May 25.

14.

Diversity in the C3b [corrected] contact residues and tertiary structures of the staphylococcal complement inhibitor (SCIN) protein family.

Garcia BL, Summers BJ, Lin Z, Ramyar KX, Ricklin D, Kamath DV, Fu ZQ, Lambris JD, Geisbrecht BV.

J Biol Chem. 2012 Jan 2;287(1):628-40. doi: 10.1074/jbc.M111.298984. Epub 2011 Nov 15. Erratum in: J Biol Chem. 2012 Mar 16;287(12):9329.

15.

Advances in understanding the structure, function, and mechanism of the SCIN and Efb families of Staphylococcal immune evasion proteins.

Garcia BL, Ramyar KX, Ricklin D, Lambris JD, Geisbrecht BV.

Adv Exp Med Biol. 2012;946:113-33. doi: 10.1007/978-1-4614-0106-3_7. Review.

16.

Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b.

Garcia BL, Ramyar KX, Tzekou A, Ricklin D, McWhorter WJ, Lambris JD, Geisbrecht BV.

J Mol Biol. 2010 Sep 10;402(1):17-29. doi: 10.1016/j.jmb.2010.07.029. Epub 2010 Jul 21.

17.

Crystallization of human complement component C3b in the presence of a staphylococcal complement-inhibitor protein (SCIN).

Garcia BL, Tzekou A, Ramyar KX, McWhorter WJ, Ricklin D, Lambris JD, Geisbrecht BV.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 May 1;65(Pt 5):482-5. doi: 10.1107/S174430910901207X. Epub 2009 Apr 24.

18.

Characterization of Ehp, a secreted complement inhibitory protein from Staphylococcus aureus.

Hammel M, Sfyroera G, Pyrpassopoulos S, Ricklin D, Ramyar KX, Pop M, Jin Z, Lambris JD, Geisbrecht BV.

J Biol Chem. 2007 Oct 12;282(41):30051-61. Epub 2007 Aug 15.

19.

Nuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells.

Lassen KG, Ramyar KX, Bailey JR, Zhou Y, Siliciano RF.

PLoS Pathog. 2006 Jul;2(7):e68.

20.

Crystallization and X-ray diffraction analysis of the complement component-3 (C3) inhibitory domain of Efb from Staphylococcus aureus.

Hammel M, Ramyar KX, Spencer CT, Geisbrecht BV.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Mar 1;62(Pt 3):285-8. Epub 2006 Feb 24.

21.

Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab.

Cho HS, Mason K, Ramyar KX, Stanley AM, Gabelli SB, Denney DW Jr, Leahy DJ.

Nature. 2003 Feb 13;421(6924):756-60.

PMID:
12610629
22.

A mammalian expression vector for expression and purification of secreted proteins for structural studies.

Leahy DJ, Dann CE 3rd, Longo P, Perman B, Ramyar KX.

Protein Expr Purif. 2000 Dec;20(3):500-6.

PMID:
11087690

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