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Items: 18

1.

Design and synthesis of potent, isoxazole-containing renin inhibitors.

Fournier PA, Arbour M, Cauchon E, Chen A, Chefson A, Ducharme Y, Falgueyret JP, Gagné S, Grimm E, Han Y, Houle R, Lacombe P, Lévesque JF, MacDonald D, Mackay B, McKay D, Percival MD, Ramtohul Y, St-Jacques R, Toulmond S.

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2670-4. doi: 10.1016/j.bmcl.2012.03.014. Epub 2012 Mar 11.

PMID:
22450130
2.

Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics.

Tan CM, Therien AG, Lu J, Lee SH, Caron A, Gill CJ, Lebeau-Jacob C, Benton-Perdomo L, Monteiro JM, Pereira PM, Elsen NL, Wu J, Deschamps K, Petcu M, Wong S, Daigneault E, Kramer S, Liang L, Maxwell E, Claveau D, Vaillancourt J, Skorey K, Tam J, Wang H, Meredith TC, Sillaots S, Wang-Jarantow L, Ramtohul Y, Langlois E, Landry F, Reid JC, Parthasarathy G, Sharma S, Baryshnikova A, Lumb KJ, Pinho MG, Soisson SM, Roemer T.

Sci Transl Med. 2012 Mar 21;4(126):126ra35. doi: 10.1126/scitranslmed.3003592.

3.

3,4-Diarylpiperidines as potent renin inhibitors.

Lacombe P, Arbour M, Aspiotis R, Cauchon E, Chen A, Dubé D, Falgueyret JP, Fournier PA, Gallant M, Grimm E, Han Y, Juteau H, Liu S, Mellon C, Ramtohul Y, Simard D, St-Jacques R, Tsui GC.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):1953-7. doi: 10.1016/j.bmcl.2012.01.044. Epub 2012 Jan 26.

PMID:
22325946
4.

Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series.

Lachance N, Gareau Y, Guiral S, Huang Z, Isabel E, Leclerc JP, Léger S, Martins E, Nadeau C, Oballa RM, Ouellet SG, Powell DA, Ramtohul YK, Tranmer GK, Trinh T, Wang H, Zhang L.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):980-4. doi: 10.1016/j.bmcl.2011.12.002. Epub 2011 Dec 8.

PMID:
22209206
5.

Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series.

Lachance N, Guiral S, Huang Z, Leclerc JP, Li CS, Oballa RM, Ramtohul YK, Wang H, Wu J, Zhang L.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):623-7. doi: 10.1016/j.bmcl.2011.10.070. Epub 2011 Oct 28.

PMID:
22101133
6.

Conversion of systemically-distributed triazole-based stearoyl-CoA desaturase (SCD) uHTS hits into liver-targeted SCD inhibitors.

Leclerc JP, Falgueyret JP, Girardin M, Guay J, Guiral S, Huang Z, Li CS, Oballa R, Ramtohul YK, Skorey K, Tawa P, Wang H, Zhang L.

Bioorg Med Chem Lett. 2011 Nov 1;21(21):6505-9. doi: 10.1016/j.bmcl.2011.08.073. Epub 2011 Aug 25.

PMID:
21924609
7.

Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: from systemic to liver-targeting inhibitors.

Ramtohul YK, Powell D, Leclerc JP, Leger S, Oballa R, Black C, Isabel E, Li CS, Crane S, Robichaud J, Guay J, Guiral S, Zhang L, Huang Z.

Bioorg Med Chem Lett. 2011 Oct 1;21(19):5692-6. doi: 10.1016/j.bmcl.2011.08.037. Epub 2011 Aug 12.

PMID:
21871798
8.

Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia.

Oballa RM, Belair L, Black WC, Bleasby K, Chan CC, Desroches C, Du X, Gordon R, Guay J, Guiral S, Hafey MJ, Hamelin E, Huang Z, Kennedy B, Lachance N, Landry F, Li CS, Mancini J, Normandin D, Pocai A, Powell DA, Ramtohul YK, Skorey K, Sørensen D, Sturkenboom W, Styhler A, Waddleton DM, Wang H, Wong S, Xu L, Zhang L.

J Med Chem. 2011 Jul 28;54(14):5082-96. doi: 10.1021/jm200319u. Epub 2011 Jun 28.

PMID:
21661758
9.

2-Aryl benzimidazoles: human SCD1-specific stearoyl coenzyme-A desaturase inhibitors.

Powell DA, Ramtohul Y, Lebrun ME, Oballa R, Bhat S, Falgueyret JP, Guiral S, Huang Z, Skorey K, Tawa P, Zhang L.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6366-9. doi: 10.1016/j.bmcl.2010.09.094. Epub 2010 Sep 19.

PMID:
20933412
10.

SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors.

Ramtohul YK, Black C, Chan CC, Crane S, Guay J, Guiral S, Huang Z, Oballa R, Xu LJ, Zhang L, Li CS.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1593-7. doi: 10.1016/j.bmcl.2010.01.083. Epub 2010 Jan 21.

PMID:
20137926
11.

A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors.

Zhang L, Ramtohul Y, Gagné S, Styhler A, Wang H, Guay J, Huang Z.

J Biomol Screen. 2010 Feb;15(2):169-76. doi: 10.1177/1087057109356208. Epub 2010 Jan 19.

PMID:
20086206
12.

Thiazole analog as stearoyl-CoA desaturase 1 inhibitor.

Li CS, Belair L, Guay J, Murgasva R, Sturkenboom W, Ramtohul YK, Zhang L, Huang Z.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):5214-7. doi: 10.1016/j.bmcl.2009.07.015. Epub 2009 Jul 9.

PMID:
19632834
13.

Pd-catalyzed enantioselective aerobic oxidation of secondary alcohols: applications to the total synthesis of alkaloids.

Krishnan S, Bagdanoff JT, Ebner DC, Ramtohul YK, Tambar UK, Stoltz BM.

J Am Chem Soc. 2008 Oct 15;130(41):13745-54. doi: 10.1021/ja804738b. Epub 2008 Sep 18.

14.

Direct C-arylation of beta-enamino esters and ketones with arynes.

Ramtohul YK, Chartrand A.

Org Lett. 2007 Mar 15;9(6):1029-32. Epub 2007 Feb 20.

PMID:
17309270
15.
16.

Palladium-catalyzed oxidative wacker cyclizations in nonpolar organic solvents with molecular oxygen: a stepping stone to asymmetric aerobic cyclizations.

Trend RM, Ramtohul YK, Ferreira EM, Stoltz BM.

Angew Chem Int Ed Engl. 2003 Jun 30;42(25):2892-5. No abstract available.

PMID:
12833351
17.

Synthesis and evaluation of keto-glutamine analogues as inhibitors of hepatitis A virus 3C proteinase.

Ramtohul YK, James MN, Vederas JC.

J Org Chem. 2002 May 17;67(10):3169-78.

PMID:
12003522
18.

Serine and threonine beta-lactones: a new class of hepatitis A virus 3C cysteine proteinase inhibitors.

Lall MS, Ramtohul YK, James MN, Vederas JC.

J Org Chem. 2002 Mar 8;67(5):1536-47.

PMID:
11871884

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