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Items: 47


A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy.

Hicks JK, Bishop JR, Gammal RS, Sangkuhl K, Bousman CA, Leeder JS, Llerena A, Mueller DJ, Ramsey LB, Scott SA, Skaar TC, Caudle KE, Klein TE, Gaedigk A.

Clin Pharmacol Ther. 2019 Oct 30. doi: 10.1002/cpt.1661. [Epub ahead of print] No abstract available.


Asparaginase formulation impacts hypertriglyceridemia during therapy for acute lymphoblastic leukemia.

Finch ER, Smith CA, Yang W, Liu Y, Kornegay NM, Panetta JC, Crews KR, Molinelli AR, Cheng C, Pei D, Ramsey LB, Karol SE, Inaba H, Sandlund JT, Metzger M, Evans WE, Jeha S, Pui CH, Relling MV.

Pediatr Blood Cancer. 2019 Oct 14:e28040. doi: 10.1002/pbc.28040. [Epub ahead of print]


Pharmacogenetics of treating pediatric anxiety and depression.

Ramsey LB, Bishop JR, Strawn JR.

Pharmacogenomics. 2019 Aug;20(12):867-870. doi: 10.2217/pgs-2019-0088. No abstract available.


Thyroid Function Screening in Children and Adolescents With Mood and Anxiety Disorders.

Luft MJ, Aldrich SL, Poweleit E, Prows CA, Martin LJ, DelBello MP, Keeshin BR, Ramsey LB, Strawn JR.

J Clin Psychiatry. 2019 Aug 6;80(5). pii: 18m12626. doi: 10.4088/JCP.18m12626.


Gene-Based Dose Optimization in Children.

Ramsey LB, Brown JT, Vear SI, Bishop JR, Van Driest SL.

Annu Rev Pharmacol Toxicol. 2019 Jul 5. doi: 10.1146/annurev-pharmtox-010919-023459. [Epub ahead of print]


Interpreting and Implementing Clinical Pharmacogenetic Tests: Perspectives From Service Providers.

Hachad H, Ramsey LB, Scott SA.

Clin Pharmacol Ther. 2019 Aug;106(2):298-301. doi: 10.1002/cpt.1494. Epub 2019 Jun 4. No abstract available.


Pharmacogenetics of Sertraline Tolerability and Response in Pediatric Anxiety and Depressive Disorders.

Poweleit EA, Aldrich SL, Martin LJ, Hahn D, Strawn JR, Ramsey LB.

J Child Adolesc Psychopharmacol. 2019 Jun;29(5):348-361. doi: 10.1089/cap.2019.0017. Epub 2019 May 8.


Asparaginase combined with discontinuous dexamethasone improves antileukemic efficacy without increasing osteonecrosis in preclinical models.

Karol SE, Janke LJ, Panetta JC, Ramsey LB, Cai X, Payton MA, Jenkins DA, Evans WE, Relling MV.

PLoS One. 2019 May 6;14(5):e0216328. doi: 10.1371/journal.pone.0216328. eCollection 2019.


Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing.

Cavallari LH, Van Driest SL, Prows CA, Bishop JR, Limdi NA, Pratt VM, Ramsey LB, Smith DM, Tuteja S, Duong BQ, Hicks JK, Lee JC, Obeng AO, Beitelshees AL, Bell GC, Blake K, Crona DJ, Dressler L, Gregg RA, Hines LJ, Scott SA, Shelton RC, Weitzel KW, Johnson JA, Peterson JF, Empey PE, Skaar TC; IGNITE Network.

Genet Med. 2019 Oct;21(10):2255-2263. doi: 10.1038/s41436-019-0484-3. Epub 2019 Mar 21.


Influence of CYP2C19 Metabolizer Status on Escitalopram/Citalopram Tolerability and Response in Youth With Anxiety and Depressive Disorders.

Aldrich SL, Poweleit EA, Prows CA, Martin LJ, Strawn JR, Ramsey LB.

Front Pharmacol. 2019 Feb 19;10:99. doi: 10.3389/fphar.2019.00099. eCollection 2019.


CYP2C19-Guided Escitalopram and Sertraline Dosing in Pediatric Patients: A Pharmacokinetic Modeling Study.

Strawn JR, Poweleit EA, Ramsey LB.

J Child Adolesc Psychopharmacol. 2019 Jun;29(5):340-347. doi: 10.1089/cap.2018.0160. Epub 2019 Feb 28.


Delayed methotrexate clearance in patients with acute lymphoblastic leukemia concurrently receiving dasatinib.

Ramsey LB, Mizuno T, Vinks AA, O'Brien MM.

Pediatr Blood Cancer. 2019 May;66(5):e27618. doi: 10.1002/pbc.27618. Epub 2019 Jan 24.


Racial Differences in Escitalopram/Citalopram-Related Weight Gain in Children and Adolescents: A Natural Language Processing-Based Electronic Medical Record Study.

Ramsey LB, Aldrich SL, Poweleit E, Prows CA, Martin LJ, Strawn JR.

J Child Adolesc Psychopharmacol. 2019 Mar;29(2):162-163. doi: 10.1089/cap.2018.0110. Epub 2018 Nov 14. No abstract available.


Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma.

Rahrmann EP, Wolf NK, Otto GM, Heltemes-Harris L, Ramsey LB, Shu J, LaRue RS, Linden MA, Rathe SK, Starr TK, Farrar MA, Moriarity BS, Largaespada DA.

Mol Cancer Res. 2019 Feb;17(2):567-582. doi: 10.1158/1541-7786.MCR-18-0582. Epub 2018 Oct 24.


Implementation of Pharmacogenetics at Cincinnati Children's Hospital Medical Center: Lessons Learned Over 14 Years of Personalizing Medicine.

Ramsey LB, Prows CA, Zhang K, Saldaña SN, Sorter MT, Pestian JP, Wenstrup RJ, Vinks AA, Glauser TA.

Clin Pharmacol Ther. 2019 Jan;105(1):49-52. doi: 10.1002/cpt.1165. Epub 2018 Jul 29. Review. No abstract available.


Consensus Guideline for Use of Glucarpidase in Patients with High-Dose Methotrexate Induced Acute Kidney Injury and Delayed Methotrexate Clearance.

Ramsey LB, Balis FM, O'Brien MM, Schmiegelow K, Pauley JL, Bleyer A, Widemann BC, Askenazi D, Bergeron S, Shirali A, Schwartz S, Vinks AA, Heldrup J.

Oncologist. 2018 Jan;23(1):52-61. doi: 10.1634/theoncologist.2017-0243. Epub 2017 Oct 27.


Impact of Pharmacogenetics on Efficacy and Safety of Statin Therapy for Dyslipidemia.

Maxwell WD, Ramsey LB, Johnson SG, Moore KG, Shtutman M, Schoonover JH, Kawaguchi-Suzuki M.

Pharmacotherapy. 2017 Sep;37(9):1172-1190. doi: 10.1002/phar.1981. Epub 2017 Aug 23. Review.


Genetics of pleiotropic effects of dexamethasone.

Ramsey LB, Pounds S, Cheng C, Cao X, Yang W, Smith C, Karol SE, Liu C, Panetta JC, Inaba H, Rubnitz JE, Metzger ML, Ribeiro RC, Sandlund JT, Jeha S, Pui CH, Evans WE, Relling MV.

Pharmacogenet Genomics. 2017 Aug;27(8):294-302. doi: 10.1097/FPC.0000000000000293.


Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival.

Katerndahl CDS, Heltemes-Harris LM, Willette MJL, Henzler CM, Frietze S, Yang R, Schjerven H, Silverstein KAT, Ramsey LB, Hubbard G, Wells AD, Kuiper RP, Scheijen B, van Leeuwen FN, Müschen M, Kornblau SM, Farrar MA.

Nat Immunol. 2017 Jun;18(6):694-704. doi: 10.1038/ni.3716. Epub 2017 Apr 3.


Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia.

Karol SE, Larsen E, Cheng C, Cao X, Yang W, Ramsey LB, Fernandez CA, McCorkle JR, Paugh SW, Autry RJ, Lopez-Lopez E, Diouf B, Jeha S, Pui CH, Raetz EA, Winick NJ, Carroll WL, Hunger SP, Loh ML, Devidas M, Evans WE, Yang JJ, Relling MV.

Leukemia. 2017 Jun;31(6):1325-1332. doi: 10.1038/leu.2017.24. Epub 2017 Jan 18.


Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy.

Liu Y, Fernandez CA, Smith C, Yang W, Cheng C, Panetta JC, Kornegay N, Liu C, Ramsey LB, Karol SE, Janke LJ, Larsen EC, Winick N, Carroll WL, Loh ML, Raetz EA, Hunger SP, Devidas M, Yang JJ, Mullighan CG, Zhang J, Evans WE, Jeha S, Pui CH, Relling MV.

Clin Pharmacol Ther. 2017 Jul;102(1):131-140. doi: 10.1002/cpt.629. Epub 2017 Apr 4.


Learning Health Systems as Facilitators of Precision Medicine.

Ramsey LB, Mizuno T, Vinks AA, Margolis PA.

Clin Pharmacol Ther. 2017 Mar;101(3):359-367. doi: 10.1002/cpt.594. Review. No abstract available.


Asparaginase Potentiates Glucocorticoid-Induced Osteonecrosis in a Mouse Model.

Liu C, Janke LJ, Kawedia JD, Ramsey LB, Cai X, Mattano LA Jr, Boyd KL, Funk AJ, Relling MV.

PLoS One. 2016 Mar 11;11(3):e0151433. doi: 10.1371/journal.pone.0151433. eCollection 2016.


Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia.

Karol SE, Mattano LA Jr, Yang W, Maloney KW, Smith C, Liu C, Ramsey LB, Fernandez CA, Chang TY, Neale G, Cheng C, Mardis E, Fulton R, Scheet P, San Lucas FA, Larsen EC, Loh ML, Raetz EA, Hunger SP, Devidas M, Relling MV.

Blood. 2016 Feb 4;127(5):558-64. doi: 10.1182/blood-2015-10-673848. Epub 2015 Nov 20.


Antileukemic Efficacy of Continuous vs Discontinuous Dexamethasone in Murine Models of Acute Lymphoblastic Leukemia.

Ramsey LB, Janke LJ, Payton MA, Cai X, Paugh SW, Karol SE, Kamdem Kamdem L, Cheng C, Williams RT, Jeha S, Pui CH, Evans WE, Relling MV.

PLoS One. 2015 Aug 7;10(8):e0135134. doi: 10.1371/journal.pone.0135134. eCollection 2015.


Genome-wide analysis links NFATC2 with asparaginase hypersensitivity.

Fernandez CA, Smith C, Yang W, Mullighan CG, Qu C, Larsen E, Bowman WP, Liu C, Ramsey LB, Chang T, Karol SE, Loh ML, Raetz EA, Winick NJ, Hunger SP, Carroll WL, Jeha S, Pui CH, Evans WE, Devidas M, Relling MV.

Blood. 2015 Jul 2;126(1):69-75. doi: 10.1182/blood-2015-02-628800. Epub 2015 May 18.


NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells.

Paugh SW, Bonten EJ, Savic D, Ramsey LB, Thierfelder WE, Gurung P, Malireddi RK, Actis M, Mayasundari A, Min J, Coss DR, Laudermilk LT, Panetta JC, McCorkle JR, Fan Y, Crews KR, Stocco G, Wilkinson MR, Ferreira AM, Cheng C, Yang W, Karol SE, Fernandez CA, Diouf B, Smith C, Hicks JK, Zanut A, Giordanengo A, Crona D, Bianchi JJ, Holmfeldt L, Mullighan CG, den Boer ML, Pieters R, Jeha S, Dunwell TL, Latif F, Bhojwani D, Carroll WL, Pui CH, Myers RM, Guy RK, Kanneganti TD, Relling MV, Evans WE.

Nat Genet. 2015 Jun;47(6):607-14. doi: 10.1038/ng.3283. Epub 2015 May 4.


Effect of premedications in a murine model of asparaginase hypersensitivity.

Fernandez CA, Smith C, Karol SE, Ramsey LB, Liu C, Pui CH, Jeha S, Evans WE, Finkelman FD, Relling MV.

J Pharmacol Exp Ther. 2015 Mar;352(3):541-51. doi: 10.1124/jpet.114.220780. Epub 2015 Jan 8.


A comprehensive evaluation of collapsing methods using simulated and real data: excellent annotation of functionality and large sample sizes required.

Dering C, König IR, Ramsey LB, Relling MV, Yang W, Ziegler A.

Front Genet. 2014 Sep 15;5:323. doi: 10.3389/fgene.2014.00323. eCollection 2014.


Severe hypertriglyceridaemia during therapy for childhood acute lymphoblastic leukaemia.

Bhojwani D, Darbandi R, Pei D, Ramsey LB, Chemaitilly W, Sandlund JT, Cheng C, Pui CH, Relling MV, Jeha S, Metzger ML.

Eur J Cancer. 2014 Oct;50(15):2685-94. doi: 10.1016/j.ejca.2014.06.023. Epub 2014 Jul 30.


HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies.

Fernandez CA, Smith C, Yang W, Daté M, Bashford D, Larsen E, Bowman WP, Liu C, Ramsey LB, Chang T, Turner V, Loh ML, Raetz EA, Winick NJ, Hunger SP, Carroll WL, Onengut-Gumuscu S, Chen WM, Concannon P, Rich SS, Scheet P, Jeha S, Pui CH, Evans WE, Devidas M, Relling MV.

Blood. 2014 Aug 21;124(8):1266-76. doi: 10.1182/blood-2014-03-563742. Epub 2014 Jun 26.


The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update.

Ramsey LB, Johnson SG, Caudle KE, Haidar CE, Voora D, Wilke RA, Maxwell WD, McLeod HL, Krauss RM, Roden DM, Feng Q, Cooper-DeHoff RM, Gong L, Klein TE, Wadelius M, Niemi M.

Clin Pharmacol Ther. 2014 Oct;96(4):423-8. doi: 10.1038/clpt.2014.125. Epub 2014 Jun 11.


Host thiopurine methyltransferase status affects mercaptopurine antileukemic effectiveness in a murine model.

Ramsey LB, Janke LJ, Edick MJ, Cheng C, Williams RT, Sherr CJ, Evans WE, Relling MV.

Pharmacogenet Genomics. 2014 May;24(5):263-71. doi: 10.1097/FPC.0000000000000044.


Pharmacogenomics of acute lymphoid leukemia: new insights into treatment toxicity and efficacy.

Relling MV, Ramsey LB.

Hematology Am Soc Hematol Educ Program. 2013;2013:126-30. doi: 10.1182/asheducation-2013.1.126. Review.


Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitors.

Waibel M, Solomon VS, Knight DA, Ralli RA, Kim SK, Banks KM, Vidacs E, Virely C, Sia KC, Bracken LS, Collins-Underwood R, Drenberg C, Ramsey LB, Meyer SC, Takiguchi M, Dickins RA, Levine R, Ghysdael J, Dawson MA, Lock RB, Mullighan CG, Johnstone RW.

Cell Rep. 2013 Nov 27;5(4):1047-59. doi: 10.1016/j.celrep.2013.10.038. Epub 2013 Nov 21.


Genome-wide study of methotrexate clearance replicates SLCO1B1.

Ramsey LB, Panetta JC, Smith C, Yang W, Fan Y, Winick NJ, Martin PL, Cheng C, Devidas M, Pui CH, Evans WE, Hunger SP, Loh M, Relling MV.

Blood. 2013 Feb 7;121(6):898-904. doi: 10.1182/blood-2012-08-452839. Epub 2012 Dec 11.


Concordance of DMET plus genotyping results with those of orthogonal genotyping methods.

Fernandez CA, Smith C, Yang W, Lorier R, Crews KR, Kornegay N, Hicks JK, Stewart CF, Kawedia JD, Ramsey LB, Liu C, Evans WE, Relling MV, Broeckel U.

Clin Pharmacol Ther. 2012 Sep;92(3):360-5. doi: 10.1038/clpt.2012.95. Epub 2012 Aug 8.


PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity.

Stocco G, Yang W, Crews KR, Thierfelder WE, Decorti G, Londero M, Franca R, Rabusin M, Valsecchi MG, Pei D, Cheng C, Paugh SW, Ramsey LB, Diouf B, McCorkle JR, Jones TS, Pui CH, Relling MV, Evans WE.

Hum Mol Genet. 2012 Nov 1;21(21):4793-804. doi: 10.1093/hmg/dds302. Epub 2012 Jul 30.


The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy.

Wilke RA, Ramsey LB, Johnson SG, Maxwell WD, McLeod HL, Voora D, Krauss RM, Roden DM, Feng Q, Cooper-Dehoff RM, Gong L, Klein TE, Wadelius M, Niemi M; Clinical Pharmacogenomics Implementation Consortium (CPIC).

Clin Pharmacol Ther. 2012 Jul;92(1):112-7. doi: 10.1038/clpt.2012.57. Epub 2012 May 23.


IL-7 functionally segregates the pro-B cell stage by regulating transcription of recombination mediators across cell cycle.

Johnson K, Chaumeil J, Micsinai M, Wang JM, Ramsey LB, Baracho GV, Rickert RC, Strino F, Kluger Y, Farrar MA, Skok JA.

J Immunol. 2012 Jun 15;188(12):6084-92. doi: 10.4049/jimmunol.1200368. Epub 2012 May 11.


Substrain-specific differences in survival and osteonecrosis incidence in a mouse model.

Kawedia JD, Janke L, Funk AJ, Ramsey LB, Liu C, Jenkins D, Boyd KL, Relling MV.

Comp Med. 2012 Dec;62(6):466-71.


Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition.

Ramsey LB, Bruun GH, Yang W, Treviño LR, Vattathil S, Scheet P, Cheng C, Rosner GL, Giacomini KM, Fan Y, Sparreboom A, Mikkelsen TS, Corydon TJ, Pui CH, Evans WE, Relling MV.

Genome Res. 2012 Jan;22(1):1-8. doi: 10.1101/gr.129668.111. Epub 2011 Dec 6.


Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia.

Heltemes-Harris LM, Willette MJ, Ramsey LB, Qiu YH, Neeley ES, Zhang N, Thomas DA, Koeuth T, Baechler EC, Kornblau SM, Farrar MA.

J Exp Med. 2011 Jun 6;208(6):1135-49. doi: 10.1084/jem.20101947. Epub 2011 May 23.


Functional characterization of liver enhancers that regulate drug-associated transporters.

Kim MJ, Skewes-Cox P, Fukushima H, Hesselson S, Yee SW, Ramsey LB, Nguyen L, Eshragh JL, Castro RA, Wen CC, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Relling MV, Giacomini KM, Kroetz DL, Ahituv N.

Clin Pharmacol Ther. 2011 Apr;89(4):571-8. doi: 10.1038/clpt.2010.353. Epub 2011 Mar 2.


Tonic BCR signaling represses receptor editing via Raf- and calcium-dependent signaling pathways.

Ramsey LB, Vegoe AL, Miller AT, Cooke MP, Farrar MA.

Immunol Lett. 2011 Mar 30;135(1-2):74-7. doi: 10.1016/j.imlet.2010.09.018. Epub 2010 Oct 7.


RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci.

Hewitt SL, Yin B, Ji Y, Chaumeil J, Marszalek K, Tenthorey J, Salvagiotto G, Steinel N, Ramsey LB, Ghysdael J, Farrar MA, Sleckman BP, Schatz DG, Busslinger M, Bassing CH, Skok JA.

Nat Immunol. 2009 Jun;10(6):655-64. doi: 10.1038/ni.1735. Erratum in: Nat Immunol. 2009 Jun;10(6). doi: 10.1038/ni.1735. Nat Immunol. 2009 Sep;10(9):1034. Nat Immunol. 2010 Mar;11(4):355-6.


B cell receptor basal signaling regulates antigen-induced Ig light chain rearrangements.

Schram BR, Tze LE, Ramsey LB, Liu J, Najera L, Vegoe AL, Hardy RR, Hippen KL, Farrar MA, Behrens TW.

J Immunol. 2008 Apr 1;180(7):4728-41.

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