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Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer.

Lee T, Christov PP, Shaw S, Tarr JC, Zhao B, Veerasamy N, Jeon KO, Mills JJ, Bian Z, Sensintaffar JL, Arnold AL, Fogarty SA, Perry E, Ramsey HE, Cook RS, Hollingshead M, Davis Millin M, Lee KM, Koss B, Budhraja A, Opferman JT, Kim K, Arteaga CL, Moore WJ, Olejniczak ET, Savona MR, Fesik SW.

J Med Chem. 2019 Apr 25;62(8):3971-3988. doi: 10.1021/acs.jmedchem.8b01991. Epub 2019 Apr 16.


BET inhibitors reduce cell size and induce reversible cell cycle arrest in AML.

Zhang S, Zhao Y, Heaster TM, Fischer MA, Stengel KR, Zhou X, Ramsey H, Zhou MM, Savona MR, Skala MC, Hiebert SW.

J Cell Biochem. 2018 Nov 11. doi: 10.1002/jcb.28005. [Epub ahead of print]


A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia.

Ramsey HE, Fischer MA, Lee T, Gorska AE, Arrate MP, Fuller L, Boyd KL, Strickland SA, Sensintaffar J, Hogdal LJ, Ayers GD, Olejniczak ET, Fesik SW, Savona MR.

Cancer Discov. 2018 Dec;8(12):1566-1581. doi: 10.1158/2159-8290.CD-18-0140. Epub 2018 Sep 5.


Muscle fibers and their synapses differentially adapt to aging and endurance training.

Deschenes MR, Li S, Adan MA, Oh JJ, Ramsey HC.

Exp Gerontol. 2018 Jun;106:183-191. doi: 10.1016/j.exger.2018.03.010. Epub 2018 Mar 14.


Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice.

Lorenz V, Ramsey H, Liu ZJ, Italiano J Jr, Hoffmeister K, Bihorel S, Mager D, Hu Z, Slayton WB, Kile BT, Sola-Visner M, Ferrer-Marin F.

Thromb Haemost. 2017 Dec;117(12):2322-2333. doi: 10.1160/TH17-06-0433. Epub 2017 Dec 6.


Developmental differences between newborn and adult mice in response to romiplostim.

Sparger KA, Ramsey H, Lorenz V, Liu ZJ, Feldman HA, Li N, Laforest T, Sola-Visner MC.

Platelets. 2018 Jun;29(4):365-372. doi: 10.1080/09537104.2017.1316481. Epub 2017 May 26.


IEX-1 deficiency induces browning of white adipose tissue and resists diet-induced obesity.

Shahid M, Javed AA, Chandra D, Ramsey HE, Shah D, Khan MF, Zhao L, Wu MX.

Sci Rep. 2016 Apr 11;6:24135. doi: 10.1038/srep24135.


Anti-OX40L alone or in combination with anti-CD40L and CTLA4Ig does not inhibit the humoral and cellular response to a major grass pollen allergen.

Gattringer M, Baranyi U, Pilat N, Hock K, Klaus C, Ramsey HE, Wrba F, Valenta R, Wekerle T.

Clin Exp Allergy. 2016 Feb;46(2):354-64. doi: 10.1111/cea.12661.


Rapamycin and CTLA4Ig synergize to induce stable mixed chimerism without the need for CD40 blockade.

Pilat N, Klaus C, Schwarz C, Hock K, Oberhuber R, Schwaiger E, Gattringer M, Ramsey H, Baranyi U, Zelger B, Brandacher G, Wrba F, Wekerle T.

Am J Transplant. 2015 Jun;15(6):1568-79. doi: 10.1111/ajt.13154. Epub 2015 Mar 17.


Mitoquinone restores platelet production in irradiation-induced thrombocytopenia.

Ramsey H, Zhang Q, Wu MX.

Platelets. 2015;26(5):459-66. doi: 10.3109/09537104.2014.935315. Epub 2014 Jul 15.


Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan.

Liu ZJ, Hoffmeister KM, Hu Z, Mager DE, Ait-Oudhia S, Debrincat MA, Pleines I, Josefsson EC, Kile BT, Italiano J Jr, Ramsey H, Grozovsky R, Veng-Pedersen P, Chavda C, Sola-Visner M.

Blood. 2014 May 29;123(22):3381-9. doi: 10.1182/blood-2013-06-508200. Epub 2014 Mar 5.


The role of enhanced external counter pulsation therapy in clinical practice.

Sharma U, Ramsey HK, Tak T.

Clin Med Res. 2013 Dec;11(4):226-32. doi: 10.3121/cmr.2013.1169.


Stress-induced hematopoietic failure in the absence of immediate early response gene X-1 (IEX-1, IER3).

Ramsey H, Zhang Q, Brown DE, Steensma DP, Lin CP, Wu MX.

Haematologica. 2014 Feb;99(2):282-91. doi: 10.3324/haematol.2013.092452. Epub 2013 Sep 20.


Deubiquitinating enzyme Usp12 is a novel co-activator of the androgen receptor.

Burska UL, Harle VJ, Coffey K, Darby S, Ramsey H, O'Neill D, Logan IR, Gaughan L, Robson CN.

J Biol Chem. 2013 Nov 8;288(45):32641-50. doi: 10.1074/jbc.M113.485912. Epub 2013 Sep 21.


Engraftment of retrovirally transduced Bet v 1-GFP expressing bone marrow cells leads to allergen-specific tolerance.

Gattringer M, Baranyi U, Pilat N, Hock K, Klaus C, Buchberger E, Ramsey H, Iacomini J, Valenta R, Wekerle T.

Immunobiology. 2013 Sep;218(9):1139-46. doi: 10.1016/j.imbio.2013.03.007. Epub 2013 Mar 30.


Anti-LFA-1 or rapamycin overcome costimulation blockade-resistant rejection in sensitized bone marrow recipients.

Ramsey H, Pilat N, Hock K, Klaus C, Unger L, Schwarz C, Baranyi U, Gattringer M, Schwaiger E, Wrba F, Wekerle T.

Transpl Int. 2013 Feb;26(2):206-18. doi: 10.1111/tri.12021. Epub 2012 Dec 13.


Dipeptidyl peptidase IV (DPPIV/CD26) inhibition does not improve engraftment of unfractionated syngeneic or allogeneic bone marrow after nonmyeloablative conditioning.

Schwaiger E, Klaus C, Matheeussen V, Baranyi U, Pilat N, Ramsey H, Korom S, De Meester I, Wekerle T.

Exp Hematol. 2012 Feb;40(2):97-106. doi: 10.1016/j.exphem.2011.10.010. Epub 2011 Nov 13.


A20 modulates lipid metabolism and energy production to promote liver regeneration.

Damrauer SM, Studer P, da Silva CG, Longo CR, Ramsey HE, Csizmadia E, Shrikhande GV, Scali ST, Libermann TA, Bhasin MK, Ferran C.

PLoS One. 2011 Mar 17;6(3):e17715. doi: 10.1371/journal.pone.0017715.


A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression.

Ramsey HE, Da Silva CG, Longo CR, Csizmadia E, Studer P, Patel VI, Damrauer SM, Siracuse JJ, Daniel S, Ferran C.

Liver Transpl. 2009 Nov;15(11):1613-21. doi: 10.1002/lt.21879.


GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.

Tran DQ, Andersson J, Wang R, Ramsey H, Unutmaz D, Shevach EM.

Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13445-50. doi: 10.1073/pnas.0901944106. Epub 2009 Jul 27.


Overcoming nontechnical barriers to the implementation of sustainable solutions in industry.

Satterfield MB, Kolb CE, Peoples R, Adams GL, Schuster DS, Ramsey HC, Stechel E, Wood-Black F, Garant RJ, Abraham MA.

Environ Sci Technol. 2009 Jun 15;43(12):4221-6.


The human set and transposase domain protein Metnase interacts with DNA Ligase IV and enhances the efficiency and accuracy of non-homologous end-joining.

Hromas R, Wray J, Lee SH, Martinez L, Farrington J, Corwin LK, Ramsey H, Nickoloff JA, Williamson EA.

DNA Repair (Amst). 2008 Dec 1;7(12):1927-37. doi: 10.1016/j.dnarep.2008.08.002. Epub 2008 Sep 18.


CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner.

Andersson J, Tran DQ, Pesu M, Davidson TS, Ramsey H, O'Shea JJ, Shevach EM.

J Exp Med. 2008 Sep 1;205(9):1975-81. doi: 10.1084/jem.20080308. Epub 2008 Aug 18.


The universal NF-kappaB inhibitor a20 protects from transplant vasculopathy by differentially affecting apoptosis in endothelial and smooth muscle cells.

Daniel S, Patel VI, Shrikhande GV, Scali ST, Ramsey HE, Csizmadia E, Benhaga N, Fisher MD, Arvelo MB, Ferran C.

Transplant Proc. 2006 Dec;38(10):3225-7.


The IL-17 cytokine family members are inhibitors of human hematopoietic progenitor proliferation.

Broxmeyer HE, Starnes T, Ramsey H, Cooper S, Dahl R, Williamson E, Hromas R.

Blood. 2006 Jul 15;108(2):770. No abstract available.


A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia.

Patel VI, Daniel S, Longo CR, Shrikhande GV, Scali ST, Czismadia E, Groft CM, Shukri T, Motley-Dore C, Ramsey HE, Fisher MD, Grey ST, Arvelo MB, Ferran C.

FASEB J. 2006 Jul;20(9):1418-30.


The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair.

Lee SH, Oshige M, Durant ST, Rasila KK, Williamson EA, Ramsey H, Kwan L, Nickoloff JA, Hromas R.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18075-80. Epub 2005 Dec 6.


Field demonstration of the combined effects of absorption and evapotranspiration on septic system drainfield capacity.

Rainwater K, Jackson A, Ingram W, Lee CY, Thompson D, Mollhagen T, Ramsey H, Urban L.

Water Environ Res. 2005 Mar-Apr;77(2):150-61.


AML1-FOG2 fusion protein in myelodysplasia.

Chan EM, Comer EM, Brown FC, Richkind KE, Holmes ML, Chong BH, Shiffman R, Zhang DE, Slovak ML, Willman CL, Noguchi CT, Li Y, Heiber DJ, Kwan L, Chan RJ, Vance GH, Ramsey HC, Hromas RA.

Blood. 2005 Jun 1;105(11):4523-6. Epub 2005 Feb 10.


Identification of a human B-cell/myeloid common progenitor by the absence of CXCR4.

Hou YH, Srour EF, Ramsey H, Dahl R, Broxmeyer HE, Hromas R.

Blood. 2005 May 1;105(9):3488-92. Epub 2005 Jan 13.


Redox regulation of the embryonic stem cell transcription factor oct-4 by thioredoxin.

Guo Y, Einhorn L, Kelley M, Hirota K, Yodoi J, Reinbold R, Scholer H, Ramsey H, Hromas R.

Stem Cells. 2004;22(3):259-64.


Fusion of AML1/Runx1 to copine VIII, a novel member of the copine family, in an aggressive acute myelogenous leukemia with t(12;21) translocation.

Ramsey H, Zhang DE, Richkind K, Burcoglu-O'Ral A, Hromas R.

Leukemia. 2003 Aug;17(8):1665-6. No abstract available.


The homeoprotein Hex is required for hemangioblast differentiation.

Guo Y, Chan R, Ramsey H, Li W, Xie X, Shelley WC, Martinez-Barbera JP, Bort B, Zaret K, Yoder M, Hromas R.

Blood. 2003 Oct 1;102(7):2428-35. Epub 2003 Jun 5.


Update on late relapse of germ cell tumor: a clinical and molecular analysis.

George DW, Foster RS, Hromas RA, Robertson KA, Vance GH, Ulbright TM, Gobbett TA, Heiber DJ, Heerema NA, Ramsey HC, Thurston VC, Jung SH, Shen J, Finch DE, Kelley MR, Einhorn LH.

J Clin Oncol. 2003 Jan 1;21(1):113-22.


Down-regulation of the myeloid homeobox protein Hex is essential for normal T-cell development.

Mack DL, Leibowitz DS, Cooper S, Ramsey H, Broxmeyer HE, Hromas R.

Immunology. 2002 Dec;107(4):444-51.


Endothelial induction of the T-cell chemokine CCL21 in T-cell autoimmune diseases.

Christopherson KW 2nd, Hood AF, Travers JB, Ramsey H, Hromas RA.

Blood. 2003 Feb 1;101(3):801-6. Epub 2002 Sep 26.


The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression.

Guo Y, Costa R, Ramsey H, Starnes T, Vance G, Robertson K, Kelley M, Reinbold R, Scholer H, Hromas R.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3663-7. Epub 2002 Mar 12.


Vinblastine versus vinblastine plus oral estramustine phosphate for patients with hormone-refractory prostate cancer: A Hoosier Oncology Group and Fox Chase Network phase III trial.

Hudes G, Einhorn L, Ross E, Balsham A, Loehrer P, Ramsey H, Sprandio J, Entmacher M, Dugan W, Ansari R, Monaco F, Hanna M, Roth B.

J Clin Oncol. 1999 Oct;17(10):3160-6.


Phase II study of topotecan in metastatic hormone-refractory prostate cancer.

Hudes GR, Kosierowski R, Greenberg R, Ramsey HE, Fox SC, Ozols RF, McAleer CA, Giantonio BJ.

Invest New Drugs. 1995;13(3):235-40.


Outbreaks of syphilis in rural Texas towns, 1991-1992.

Schulte JM, Ramsey HA, Paffel JM, Roberts MA, Williams RL, Blass CM, Bell CE, Simpson DM.

South Med J. 1994 Apr;87(4):493-6.


Surgery for epitympanic cholesteatoma: evaluation of training and experience.

Palva T, Ramsey H.

Am J Otol. 1993 Jan;14(1):82-7.


Development of an in vivo perfusion system for bovine fetal small intestine.

Tyler HD, Tate LP Jr, Ramsey HA, Longmuir IS.

Adv Exp Med Biol. 1992;316:441-5. No abstract available.


Altered concentrations of aldosterone in neonatal calves during chronic hypoxia and the subsequent recovery period.

Tyler H, Ramsey H.

Adv Exp Med Biol. 1992;317:521-4. No abstract available.


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