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Items: 1 to 50 of 78

1.

Oxidative DNA-protein crosslinks formed in mammalian cells by abasic site lyases involved in DNA repair.

Quiñones JL, Thapar U, Wilson SH, Ramsden DA, Demple B.

DNA Repair (Amst). 2020 Mar;87:102773. doi: 10.1016/j.dnarep.2019.102773. Epub 2020 Jan 9.

PMID:
31945542
2.

The Drosophila melanogaster Ortholog of RFWD3 Functions Independently of RAD51 During DNA Repair.

Carvajal-Garcia J, Gales ER, Ramsden DA, Sekelsky J.

G3 (Bethesda). 2020 Jan 3. pii: g3.400903.2019. doi: 10.1534/g3.119.400903. [Epub ahead of print]

3.

Genetic determinants of cellular addiction to DNA polymerase theta.

Feng W, Simpson DA, Carvajal-Garcia J, Price BA, Kumar RJ, Mose LE, Wood RD, Rashid N, Purvis JE, Parker JS, Ramsden DA, Gupta GP.

Nat Commun. 2019 Sep 19;10(1):4286. doi: 10.1038/s41467-019-12234-1.

4.

Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine.

Kaminski AM, Chiruvella KK, Ramsden DA, Kunkel TA, Bebenek K, Pedersen LC.

Nucleic Acids Res. 2019 Sep 26;47(17):9410-9422. doi: 10.1093/nar/gkz680.

5.

Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining.

Pryor JM, Conlin MP, Carvajal-Garcia J, Luedeman ME, Luthman AJ, Small GW, Ramsden DA.

Science. 2018 Sep 14;361(6407):1126-1129. doi: 10.1126/science.aat2477.

6.

High-Throughput Analysis of DNA Break-Induced Chromosome Rearrangements by Amplicon Sequencing.

Brown AJ, Al-Soodani AT, Saul M, Her S, Garcia JC, Ramsden DA, Her C, Roberts SA.

Methods Enzymol. 2018;601:111-144. doi: 10.1016/bs.mie.2017.11.028. Epub 2018 Feb 21.

PMID:
29523230
7.

Polμ tumor variants decrease the efficiency and accuracy of NHEJ.

Sastre-Moreno G, Pryor JM, Díaz-Talavera A, Ruiz JF, Ramsden DA, Blanco L.

Nucleic Acids Res. 2017 Sep 29;45(17):10018-10031. doi: 10.1093/nar/gkx625.

8.

DNA Ligase IV Guides End-Processing Choice during Nonhomologous End Joining.

Conlin MP, Reid DA, Small GW, Chang HH, Watanabe G, Lieber MR, Ramsden DA, Rothenberg E.

Cell Rep. 2017 Sep 19;20(12):2810-2819. doi: 10.1016/j.celrep.2017.08.091.

9.

Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu.

Moon AF, Pryor JM, Ramsden DA, Kunkel TA, Bebenek K, Pedersen LC.

Nucleic Acids Res. 2017 Sep 6;45(15):9138-9148. doi: 10.1093/nar/gkx527.

10.

Substrate preference of Gen endonucleases highlights the importance of branched structures as DNA damage repair intermediates.

Bellendir SP, Rognstad DJ, Morris LP, Zapotoczny G, Walton WG, Redinbo MR, Ramsden DA, Sekelsky J, Erie DA.

Nucleic Acids Res. 2017 May 19;45(9):5333-5348. doi: 10.1093/nar/gkx214.

11.

Regulation of human polλ by ATM-mediated phosphorylation during non-homologous end joining.

Sastre-Moreno G, Pryor JM, Moreno-Oñate M, Herrero-Ruiz AM, Cortés-Ledesma F, Blanco L, Ramsden DA, Ruiz JF.

DNA Repair (Amst). 2017 Mar;51:31-45. doi: 10.1016/j.dnarep.2017.01.004. Epub 2017 Jan 17.

12.

Bridging of double-stranded breaks by the nonhomologous end-joining ligation complex is modulated by DNA end chemistry.

Reid DA, Conlin MP, Yin Y, Chang HH, Watanabe G, Lieber MR, Ramsden DA, Rothenberg E.

Nucleic Acids Res. 2017 Feb 28;45(4):1872-1878. doi: 10.1093/nar/gkw1221.

13.

Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks.

Wyatt DW, Feng W, Conlin MP, Yousefzadeh MJ, Roberts SA, Mieczkowski P, Wood RD, Gupta GP, Ramsden DA.

Mol Cell. 2016 Aug 18;63(4):662-673. doi: 10.1016/j.molcel.2016.06.020. Epub 2016 Jul 21.

14.

Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.

Schellenberg MJ, Perera L, Strom CN, Waters CA, Monian B, Appel CD, Vilas CK, Williams JG, Ramsden DA, Williams RS.

Nucleic Acids Res. 2016 May 5;44(8):3829-44. doi: 10.1093/nar/gkw228. Epub 2016 Apr 8.

15.

Nonhomologous end joining of complex DNA double-strand breaks with proximal thymine glycol and interplay with base excision repair.

Almohaini M, Chalasani SL, Bafail D, Akopiants K, Zhou T, Yannone SM, Ramsden DA, Hartman MCT, Povirk LF.

DNA Repair (Amst). 2016 May;41:16-26. doi: 10.1016/j.dnarep.2016.03.003. Epub 2016 Mar 24.

16.

Essential role for polymerase specialization in cellular nonhomologous end joining.

Pryor JM, Waters CA, Aza A, Asagoshi K, Strom C, Mieczkowski PA, Blanco L, Ramsden DA.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4537-45. doi: 10.1073/pnas.1505805112. Epub 2015 Aug 3.

17.

Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.

Wilson JE, Petrucelli AS, Chen L, Koblansky AA, Truax AD, Oyama Y, Rogers AB, Brickey WJ, Wang Y, Schneider M, Mühlbauer M, Chou WC, Barker BR, Jobin C, Allbritton NL, Ramsden DA, Davis BK, Ting JP.

Nat Med. 2015 Aug;21(8):906-13. doi: 10.1038/nm.3908. Epub 2015 Jun 24.

18.

Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair.

Reid DA, Keegan S, Leo-Macias A, Watanabe G, Strande NT, Chang HH, Oksuz BA, Fenyo D, Lieber MR, Ramsden DA, Rothenberg E.

Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2575-84. doi: 10.1073/pnas.1420115112. Epub 2015 May 4.

19.

Mechanism of suppression of chromosomal instability by DNA polymerase POLQ.

Yousefzadeh MJ, Wyatt DW, Takata K, Mu Y, Hensley SC, Tomida J, Bylund GO, Doublié S, Johansson E, Ramsden DA, McBride KM, Wood RD.

PLoS Genet. 2014 Oct 2;10(10):e1004654. doi: 10.1371/journal.pgen.1004654. eCollection 2014 Oct.

20.

Requirements for 5'dRP/AP lyase activity in Ku.

Strande NT, Carvajal-Garcia J, Hallett RA, Waters CA, Roberts SA, Strom C, Kuhlman B, Ramsden DA.

Nucleic Acids Res. 2014;42(17):11136-43. doi: 10.1093/nar/gku796. Epub 2014 Sep 8.

21.

The fidelity of the ligation step determines how ends are resolved during nonhomologous end joining.

Waters CA, Strande NT, Pryor JM, Strom CN, Mieczkowski P, Burkhalter MD, Oh S, Qaqish BF, Moore DT, Hendrickson EA, Ramsden DA.

Nat Commun. 2014 Jul 3;5:4286. doi: 10.1038/ncomms5286.

22.

Nonhomologous end joining: a good solution for bad ends.

Waters CA, Strande NT, Wyatt DW, Pryor JM, Ramsden DA.

DNA Repair (Amst). 2014 May;17:39-51. doi: 10.1016/j.dnarep.2014.02.008. Epub 2014 Mar 14. Review.

23.

Sustained active site rigidity during synthesis by human DNA polymerase μ.

Moon AF, Pryor JM, Ramsden DA, Kunkel TA, Bebenek K, Pedersen LC.

Nat Struct Mol Biol. 2014 Mar;21(3):253-60. doi: 10.1038/nsmb.2766. Epub 2014 Feb 2.

24.

Trimming of damaged 3' overhangs of DNA double-strand breaks by the Metnase and Artemis endonucleases.

Mohapatra S, Yannone SM, Lee SH, Hromas RA, Akopiants K, Menon V, Ramsden DA, Povirk LF.

DNA Repair (Amst). 2013 Jun 1;12(6):422-32. doi: 10.1016/j.dnarep.2013.03.005. Epub 2013 Apr 18.

25.

Resolution of complex ends by Nonhomologous end joining - better to be lucky than good?

Strande NT, Waters CA, Ramsden DA.

Genome Integr. 2012 Dec 31;3(1):10. doi: 10.1186/2041-9414-3-10.

26.

Mechanism of repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2.

Schellenberg MJ, Appel CD, Adhikari S, Robertson PD, Ramsden DA, Williams RS.

Nat Struct Mol Biol. 2012 Dec;19(12):1363-71. doi: 10.1038/nsmb.2418. Epub 2012 Oct 28.

27.

DNA polymerases in nonhomologous end joining: are there any benefits to standing out from the crowd?

Ramsden DA, Asagoshi K.

Environ Mol Mutagen. 2012 Dec;53(9):741-51. doi: 10.1002/em.21725. Epub 2012 Sep 18. Review.

PMID:
22987211
28.

Specificity of the dRP/AP lyase of Ku promotes nonhomologous end joining (NHEJ) fidelity at damaged ends.

Strande N, Roberts SA, Oh S, Hendrickson EA, Ramsden DA.

J Biol Chem. 2012 Apr 20;287(17):13686-93. doi: 10.1074/jbc.M111.329730. Epub 2012 Feb 23.

29.

Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining.

Mani RS, Yu Y, Fang S, Lu M, Fanta M, Zolner AE, Tahbaz N, Ramsden DA, Litchfield DW, Lees-Miller SP, Weinfeld M.

J Biol Chem. 2010 Nov 26;285(48):37619-29. doi: 10.1074/jbc.M109.058719. Epub 2010 Sep 17.

30.

Polymerases in nonhomologous end joining: building a bridge over broken chromosomes.

Ramsden DA.

Antioxid Redox Signal. 2011 Jun 15;14(12):2509-19. doi: 10.1089/ars.2010.3429. Epub 2010 Oct 28. Review.

31.

V(D)J recombination: Born to be wild.

Ramsden DA, Weed BD, Reddy YV.

Semin Cancer Biol. 2010 Aug;20(4):254-60. doi: 10.1016/j.semcancer.2010.06.002. Epub 2010 Jul 1. Review.

32.

Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends.

Roberts SA, Strande N, Burkhalter MD, Strom C, Havener JM, Hasty P, Ramsden DA.

Nature. 2010 Apr 22;464(7292):1214-7. doi: 10.1038/nature08926. Epub 2010 Apr 11.

33.

Activity of ribonucleotide reductase helps determine how cells repair DNA double strand breaks.

Burkhalter MD, Roberts SA, Havener JM, Ramsden DA.

DNA Repair (Amst). 2009 Nov 2;8(11):1258-63. doi: 10.1016/j.dnarep.2009.07.009. Epub 2009 Aug 26.

34.

Template strand scrunching during DNA gap repair synthesis by human polymerase lambda.

Garcia-Diaz M, Bebenek K, Larrea AA, Havener JM, Perera L, Krahn JM, Pedersen LC, Ramsden DA, Kunkel TA.

Nat Struct Mol Biol. 2009 Sep;16(9):967-72. doi: 10.1038/nsmb.1654. Epub 2009 Aug 23.

35.

Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.

Zhou T, Akopiants K, Mohapatra S, Lin PS, Valerie K, Ramsden DA, Lees-Miller SP, Povirk LF.

DNA Repair (Amst). 2009 Aug 6;8(8):901-11. doi: 10.1016/j.dnarep.2009.05.003. Epub 2009 Jun 7.

36.

WRN Exonuclease activity is blocked by specific oxidatively induced base lesions positioned in either DNA strand.

Bukowy Z, Harrigan JA, Ramsden DA, Tudek B, Bohr VA, Stevnsner T.

Nucleic Acids Res. 2008 Sep;36(15):4975-87. doi: 10.1093/nar/gkn468. Epub 2008 Jul 25.

37.

A comparison of BRCT domains involved in nonhomologous end-joining: introducing the solution structure of the BRCT domain of polymerase lambda.

Mueller GA, Moon AF, Derose EF, Havener JM, Ramsden DA, Pedersen LC, London RE.

DNA Repair (Amst). 2008 Aug 2;7(8):1340-51. doi: 10.1016/j.dnarep.2008.04.018. Epub 2008 Jun 26.

38.

End-bridging is required for pol mu to efficiently promote repair of noncomplementary ends by nonhomologous end joining.

Davis BJ, Havener JM, Ramsden DA.

Nucleic Acids Res. 2008 May;36(9):3085-94. doi: 10.1093/nar/gkn164. Epub 2008 Apr 8.

39.

Solution structure of polymerase mu's BRCT Domain reveals an element essential for its role in nonhomologous end joining.

DeRose EF, Clarkson MW, Gilmore SA, Galban CJ, Tripathy A, Havener JM, Mueller GA, Ramsden DA, London RE, Lee AL.

Biochemistry. 2007 Oct 30;46(43):12100-10. Epub 2007 Oct 4.

40.
41.

Loading of the nonhomologous end joining factor, Ku, on protein-occluded DNA ends.

Roberts SA, Ramsden DA.

J Biol Chem. 2007 Apr 6;282(14):10605-13. Epub 2007 Feb 8.

42.

Structural insight into the substrate specificity of DNA Polymerase mu.

Moon AF, Garcia-Diaz M, Bebenek K, Davis BJ, Zhong X, Ramsden DA, Kunkel TA, Pedersen LC.

Nat Struct Mol Biol. 2007 Jan;14(1):45-53. Epub 2006 Dec 10. Erratum in: Nat Struct Mol Biol. 2007 Jul;14(7):680.

PMID:
17159995
43.

Genomic instability due to V(D)J recombination-associated transposition.

Reddy YV, Perkins EJ, Ramsden DA.

Genes Dev. 2006 Jun 15;20(12):1575-82.

44.

A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining.

Nick McElhinny SA, Havener JM, Garcia-Diaz M, Juárez R, Bebenek K, Kee BL, Blanco L, Kunkel TA, Ramsden DA.

Mol Cell. 2005 Aug 5;19(3):357-66.

45.

Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends.

Reddy YV, Ding Q, Lees-Miller SP, Meek K, Ramsden DA.

J Biol Chem. 2004 Sep 17;279(38):39408-13. Epub 2004 Jul 15.

46.
47.

The DNA-dependent protein kinase: the director at the end.

Meek K, Gupta S, Ramsden DA, Lees-Miller SP.

Immunol Rev. 2004 Aug;200:132-41. Review.

PMID:
15242401
48.

Histone 3 lysine 4 methylation during the pre-B to immature B-cell transition.

Perkins EJ, Kee BL, Ramsden DA.

Nucleic Acids Res. 2004 Mar 29;32(6):1942-7. Print 2004.

49.

Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.

Ding Q, Reddy YV, Wang W, Woods T, Douglas P, Ramsden DA, Lees-Miller SP, Meek K.

Mol Cell Biol. 2003 Aug;23(16):5836-48.

50.

Polymerase mu is a DNA-directed DNA/RNA polymerase.

Nick McElhinny SA, Ramsden DA.

Mol Cell Biol. 2003 Apr;23(7):2309-15.

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