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Oxidative DNA-protein crosslinks formed in mammalian cells by abasic site lyases involved in DNA repair.

Quiñones JL, Thapar U, Wilson SH, Ramsden DA, Demple B.

DNA Repair (Amst). 2020 Mar;87:102773. doi: 10.1016/j.dnarep.2019.102773. Epub 2020 Jan 9.


Nicotinamide N-methyltransferase expression in SH-SY5Y human neuroblastoma cells decreases oxidative stress.

Mistry RJ, Klamt F, Ramsden DB, Parsons RB.

J Biochem Mol Toxicol. 2020 Jan 7:e22439. doi: 10.1002/jbt.22439. [Epub ahead of print]


The Drosophila melanogaster Ortholog of RFWD3 Functions Independently of RAD51 During DNA Repair.

Carvajal-Garcia J, Gales ER, Ramsden DA, Sekelsky J.

G3 (Bethesda). 2020 Jan 3. pii: g3.400903.2019. doi: 10.1534/g3.119.400903. [Epub ahead of print]


Genetic determinants of cellular addiction to DNA polymerase theta.

Feng W, Simpson DA, Carvajal-Garcia J, Price BA, Kumar RJ, Mose LE, Wood RD, Rashid N, Purvis JE, Parker JS, Ramsden DA, Gupta GP.

Nat Commun. 2019 Sep 19;10(1):4286. doi: 10.1038/s41467-019-12234-1.


Perspectives from the Innovation and Quality Consortium Induction Working Group on Factors Impacting Clinical Drug-Drug Interactions Resulting from Induction: Focus on Cytochrome 3A Substrates.

Ramsden D, Fung C, Hariparsad N, Kenny JR, Mohutsky M, Parrott NJ, Robertson S, Tweedie DJ.

Drug Metab Dispos. 2019 Oct;47(10):1206-1221. doi: 10.1124/dmd.119.087270. Epub 2019 Aug 22.


Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine.

Kaminski AM, Chiruvella KK, Ramsden DA, Kunkel TA, Bebenek K, Pedersen LC.

Nucleic Acids Res. 2019 Sep 26;47(17):9410-9422. doi: 10.1093/nar/gkz680.


The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson's disease.

Pang SY, Ho PW, Liu HF, Leung CT, Li L, Chang EES, Ramsden DB, Ho SL.

Transl Neurodegener. 2019 Aug 16;8:23. doi: 10.1186/s40035-019-0165-9. eCollection 2019. Review.


In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters.

Ramsden D, Wu JT, Zerler B, Iqbal S, Jiang J, Clausen V, Aluri K, Gu Y, Dennin S, Kim J, Chong S.

Drug Metab Dispos. 2019 Oct;47(10):1183-1194. doi: 10.1124/dmd.119.087098. Epub 2019 Jul 3.


Songbird feathers as indicators of mercury exposure: high variability and low predictive power suggest limitations.

Low KE, Ramsden DK, Jackson AK, Emery C, Robinson WD, Randolph J, Eagles-Smith CA.

Ecotoxicology. 2019 May 21. doi: 10.1007/s10646-019-02052-y. [Epub ahead of print]


Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA).

Ho PW, Leung CT, Liu H, Pang SY, Lam CS, Xian J, Li L, Kung MH, Ramsden DB, Ho SL.

Autophagy. 2020 Feb;16(2):347-370. doi: 10.1080/15548627.2019.1603545. Epub 2019 Apr 14.


Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining.

Pryor JM, Conlin MP, Carvajal-Garcia J, Luedeman ME, Luthman AJ, Small GW, Ramsden DA.

Science. 2018 Sep 14;361(6407):1126-1129. doi: 10.1126/science.aat2477.


Identification and Characterization of a Selective Human Carbonyl Reductase 1 Substrate.

Ramsden D, Smith D, Arenas R, Frederick K, Cerny MA.

Drug Metab Dispos. 2018 Oct;46(10):1434-1440. doi: 10.1124/dmd.118.082487. Epub 2018 Aug 1.


Human amylase gene copy number variation as a determinant of metabolic state.

Elder PJD, Ramsden DB, Burnett D, Weickert MO, Barber TM.

Expert Rev Endocrinol Metab. 2018 Jul;13(4):193-205. doi: 10.1080/17446651.2018.1499466. Review.


Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA In Vitro Response Thresholds, Variability, and Clinical Relevance.

Kenny JR, Ramsden D, Buckley DB, Dallas S, Fung C, Mohutsky M, Einolf HJ, Chen L, Dekeyser JG, Fitzgerald M, Goosen TC, Siu YA, Walsky RL, Zhang G, Tweedie D, Hariparsad N.

Drug Metab Dispos. 2018 Sep;46(9):1285-1303. doi: 10.1124/dmd.118.081927. Epub 2018 Jun 29.


The kinetic analysis of the N-methylation of 4-phenylpyridine by nicotinamide N-methyltransferase: Evidence for a novel mechanism of substrate inhibition.

van Haren MJ, Thomas MG, Sartini D, Barlow DJ, Ramsden DB, Emanuelli M, Klamt F, Martin NI, Parsons RB.

Int J Biochem Cell Biol. 2018 May;98:127-136. doi: 10.1016/j.biocel.2018.03.010. Epub 2018 Mar 13.


High-Throughput Analysis of DNA Break-Induced Chromosome Rearrangements by Amplicon Sequencing.

Brown AJ, Al-Soodani AT, Saul M, Her S, Garcia JC, Ramsden DA, Her C, Roberts SA.

Methods Enzymol. 2018;601:111-144. doi: 10.1016/bs.mie.2017.11.028. Epub 2018 Feb 21.


The Clinical Utility of Measuring IgG Subclass Immunoglobulins During Immunological Investigation for Suspected Primary Antibody Deficiencies.

Parker AR, Skold M, Ramsden DB, Ocejo-Vinyals JG, López-Hoyos M, Harding S.

Lab Med. 2017 Nov 8;48(4):314-325. doi: 10.1093/labmed/lmx058. Review.


Polμ tumor variants decrease the efficiency and accuracy of NHEJ.

Sastre-Moreno G, Pryor JM, Díaz-Talavera A, Ruiz JF, Ramsden DA, Blanco L.

Nucleic Acids Res. 2017 Sep 29;45(17):10018-10031. doi: 10.1093/nar/gkx625.


DNA Ligase IV Guides End-Processing Choice during Nonhomologous End Joining.

Conlin MP, Reid DA, Small GW, Chang HH, Watanabe G, Lieber MR, Ramsden DA, Rothenberg E.

Cell Rep. 2017 Sep 19;20(12):2810-2819. doi: 10.1016/j.celrep.2017.08.091.


Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu.

Moon AF, Pryor JM, Ramsden DA, Kunkel TA, Bebenek K, Pedersen LC.

Nucleic Acids Res. 2017 Sep 6;45(15):9138-9148. doi: 10.1093/nar/gkx527.


Serum IgG4 Concentration in IgG4-Related Disease.

Kawa S, Skold M, Ramsden DB, Parker A, Harding SJ.

Clin Lab. 2017 Sep 1;63(9):1323-1337. doi: 10.7754/Clin.Lab.2017.170403. Review.


DNA repair factor RAD18 and DNA polymerase Polκ confer tolerance of oncogenic DNA replication stress.

Yang Y, Gao Y, Mutter-Rottmayer L, Zlatanou A, Durando M, Ding W, Wyatt D, Ramsden D, Tanoue Y, Tateishi S, Vaziri C.

J Cell Biol. 2017 Oct 2;216(10):3097-3115. doi: 10.1083/jcb.201702006. Epub 2017 Aug 23.


Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Focus on Downregulation, CYP2C Induction, and CYP2B6 Positive Control.

Hariparsad N, Ramsden D, Palamanda J, Dekeyser JG, Fahmi OA, Kenny JR, Einolf H, Mohutsky M, Pardon M, Siu YA, Chen L, Sinz M, Jones B, Walsky R, Dallas S, Balani SK, Zhang G, Buckley D, Tweedie D.

Drug Metab Dispos. 2017 Oct;45(10):1049-1059. doi: 10.1124/dmd.116.074567. Epub 2017 Jun 23.


Substrate preference of Gen endonucleases highlights the importance of branched structures as DNA damage repair intermediates.

Bellendir SP, Rognstad DJ, Morris LP, Zapotoczny G, Walton WG, Redinbo MR, Ramsden DA, Sekelsky J, Erie DA.

Nucleic Acids Res. 2017 May 19;45(9):5333-5348. doi: 10.1093/nar/gkx214.


Regulation of human polλ by ATM-mediated phosphorylation during non-homologous end joining.

Sastre-Moreno G, Pryor JM, Moreno-Oñate M, Herrero-Ruiz AM, Cortés-Ledesma F, Blanco L, Ramsden DA, Ruiz JF.

DNA Repair (Amst). 2017 Mar;51:31-45. doi: 10.1016/j.dnarep.2017.01.004. Epub 2017 Jan 17.


Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson's disease.

Liu HF, Ho PW, Leung GC, Lam CS, Pang SY, Li L, Kung MH, Ramsden DB, Ho SL.

Sci Rep. 2017 Jan 18;7:40887. doi: 10.1038/srep40887.


Bridging of double-stranded breaks by the nonhomologous end-joining ligation complex is modulated by DNA end chemistry.

Reid DA, Conlin MP, Yin Y, Chang HH, Watanabe G, Lieber MR, Ramsden DA, Rothenberg E.

Nucleic Acids Res. 2017 Feb 28;45(4):1872-1878. doi: 10.1093/nar/gkw1221.


Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks.

Wyatt DW, Feng W, Conlin MP, Yousefzadeh MJ, Roberts SA, Mieczkowski P, Wood RD, Gupta GP, Ramsden DA.

Mol Cell. 2016 Aug 18;63(4):662-673. doi: 10.1016/j.molcel.2016.06.020. Epub 2016 Jul 21.


Evaluation of CYP2B6 Induction and Prediction of Clinical Drug-Drug Interactions: Considerations from the IQ Consortium Induction Working Group-An Industry Perspective.

Fahmi OA, Shebley M, Palamanda J, Sinz MW, Ramsden D, Einolf HJ, Chen L, Wang H.

Drug Metab Dispos. 2016 Oct;44(10):1720-30. doi: 10.1124/dmd.116.071076. Epub 2016 Jul 15.


Nicotinamide N-methyltransferase catalyses the N-methylation of the endogenous β-carboline norharman: evidence for a novel detoxification pathway.

Thomas MG, Sartini D, Emanuelli M, van Haren MJ, Martin NI, Mountford DM, Barlow DJ, Klamt F, Ramsden DB, Reza M, Parsons RB.

Biochem J. 2016 Oct 1;473(19):3253-67. doi: 10.1042/BCJ20160219. Epub 2016 Jul 7.


Multiple sclerosis: assay of free immunoglobulin light chains.

Ramsden DB.

Ann Clin Biochem. 2017 Jan;54(1):5-13. doi: 10.1177/0004563216652175. Epub 2016 Sep 28. Review.


Enteral feeding reduces metabolic activity of the intestinal microbiome in Crohn's disease: an observational study.

Walton C, Montoya MP, Fowler DP, Turner C, Jia W, Whitehead RN, Griffiths L, Waring RH, Ramsden DB, Cole JA, Cauchi M, Bessant C, Naylor SJ, Hunter JO.

Eur J Clin Nutr. 2016 Sep;70(9):1052-6. doi: 10.1038/ejcn.2016.74. Epub 2016 May 11.


Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.

Schellenberg MJ, Perera L, Strom CN, Waters CA, Monian B, Appel CD, Vilas CK, Williams JG, Ramsden DA, Williams RS.

Nucleic Acids Res. 2016 May 5;44(8):3829-44. doi: 10.1093/nar/gkw228. Epub 2016 Apr 8.


Nonhomologous end joining of complex DNA double-strand breaks with proximal thymine glycol and interplay with base excision repair.

Almohaini M, Chalasani SL, Bafail D, Akopiants K, Zhou T, Yannone SM, Ramsden DA, Hartman MCT, Povirk LF.

DNA Repair (Amst). 2016 May;41:16-26. doi: 10.1016/j.dnarep.2016.03.003. Epub 2016 Mar 24.


Contribution of Major Metabolites toward Complex Drug-Drug Interactions of Deleobuvir: In Vitro Predictions and In Vivo Outcomes.

Sane RS, Ramsden D, Sabo JP, Cooper C, Rowland L, Ting N, Whitcher-Johnstone A, Tweedie DJ.

Drug Metab Dispos. 2016 Mar;44(3):466-75. doi: 10.1124/dmd.115.066985. Epub 2015 Dec 18.


Nicotinamide N-methyltransferase increases complex I activity in SH-SY5Y cells via sirtuin 3.

Liu KY, Mistry RJ, Aguirre CA, Fasouli ES, Thomas MG, Klamt F, Ramsden DB, Parsons RB.

Biochem Biophys Res Commun. 2015 Nov 20;467(3):491-6. doi: 10.1016/j.bbrc.2015.10.023. Epub 2015 Oct 8.


Essential role for polymerase specialization in cellular nonhomologous end joining.

Pryor JM, Waters CA, Aza A, Asagoshi K, Strom C, Mieczkowski PA, Blanco L, Ramsden DA.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4537-45. doi: 10.1073/pnas.1505805112. Epub 2015 Aug 3.


Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.

Wilson JE, Petrucelli AS, Chen L, Koblansky AA, Truax AD, Oyama Y, Rogers AB, Brickey WJ, Wang Y, Schneider M, Mühlbauer M, Chou WC, Barker BR, Jobin C, Allbritton NL, Ramsden DA, Davis BK, Ting JP.

Nat Med. 2015 Aug;21(8):906-13. doi: 10.1038/nm.3908. Epub 2015 Jun 24.


Determination of a Degradation Constant for CYP3A4 by Direct Suppression of mRNA in a Novel Human Hepatocyte Model, HepatoPac.

Ramsden D, Zhou J, Tweedie DJ.

Drug Metab Dispos. 2015 Sep;43(9):1307-15. doi: 10.1124/dmd.115.065326. Epub 2015 Jun 15.


Prognostic Value of the Radiologic Appearance of the Navicular Ossification Center in Congenital Talipes Equinovarus.

Atanda AA, Oni JK, Ramsden DM, Yoon RS, Ahmad AA, Otsuka NY.

J Foot Ankle Surg. 2015 Sep-Oct;54(5):844-7. doi: 10.1053/j.jfas.2015.01.007. Epub 2015 Jun 3.


Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair.

Reid DA, Keegan S, Leo-Macias A, Watanabe G, Strande NT, Chang HH, Oksuz BA, Fenyo D, Lieber MR, Ramsden DA, Rothenberg E.

Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2575-84. doi: 10.1073/pnas.1420115112. Epub 2015 May 4.


LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity.

Liu HF, Lu S, Ho PW, Tse HM, Pang SY, Kung MH, Ho JW, Ramsden DB, Zhou ZJ, Ho SL.

Ann Clin Transl Neurol. 2014 Mar;1(3):199-208. doi: 10.1002/acn3.45. Epub 2014 Mar 4.


Mass balance, metabolite profile, and in vitro-in vivo comparison of clearance pathways of deleobuvir, a hepatitis C virus polymerase inhibitor.

Chen LZ, Sabo JP, Philip E, Rowland L, Mao Y, Latli B, Ramsden D, Mandarino DA, Sane RS.

Antimicrob Agents Chemother. 2015 Jan;59(1):25-37. doi: 10.1128/AAC.03861-14. Epub 2014 Oct 13.


Mechanism of suppression of chromosomal instability by DNA polymerase POLQ.

Yousefzadeh MJ, Wyatt DW, Takata K, Mu Y, Hensley SC, Tomida J, Bylund GO, Doublié S, Johansson E, Ramsden DA, McBride KM, Wood RD.

PLoS Genet. 2014 Oct 2;10(10):e1004654. doi: 10.1371/journal.pgen.1004654. eCollection 2014 Oct.


Requirements for 5'dRP/AP lyase activity in Ku.

Strande NT, Carvajal-Garcia J, Hallett RA, Waters CA, Roberts SA, Strom C, Kuhlman B, Ramsden DA.

Nucleic Acids Res. 2014;42(17):11136-43. doi: 10.1093/nar/gku796. Epub 2014 Sep 8.


Altered CYP2C9 activity following modulation of CYP3A4 levels in human hepatocytes: an example of protein-protein interactions.

Ramsden D, Tweedie DJ, Chan TS, Tracy TS.

Drug Metab Dispos. 2014 Nov;42(11):1940-6. doi: 10.1124/dmd.114.057901. Epub 2014 Aug 25.


The fidelity of the ligation step determines how ends are resolved during nonhomologous end joining.

Waters CA, Strande NT, Pryor JM, Strom CN, Mieczkowski P, Burkhalter MD, Oh S, Qaqish BF, Moore DT, Hendrickson EA, Ramsden DA.

Nat Commun. 2014 Jul 3;5:4286. doi: 10.1038/ncomms5286.


Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time.

Williams GJ, Hammel M, Radhakrishnan SK, Ramsden D, Lees-Miller SP, Tainer JA.

DNA Repair (Amst). 2014 May;17:110-20. doi: 10.1016/j.dnarep.2014.02.009. Epub 2014 Mar 20. Review.


Nonhomologous end joining: a good solution for bad ends.

Waters CA, Strande NT, Wyatt DW, Pryor JM, Ramsden DA.

DNA Repair (Amst). 2014 May;17:39-51. doi: 10.1016/j.dnarep.2014.02.008. Epub 2014 Mar 14. Review.


Sustained active site rigidity during synthesis by human DNA polymerase μ.

Moon AF, Pryor JM, Ramsden DA, Kunkel TA, Bebenek K, Pedersen LC.

Nat Struct Mol Biol. 2014 Mar;21(3):253-60. doi: 10.1038/nsmb.2766. Epub 2014 Feb 2.

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