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A novel CRISPR/Cas9 associated technology for sequence-specific nucleic acid enrichment.

Stevens RC, Steele JL, Glover WR, Sanchez-Garcia JF, Simpson SD, O'Rourke D, Ramsdell JS, MacManes MD, Thomas WK, Shuber AP.

PLoS One. 2019 Apr 18;14(4):e0215441. doi: 10.1371/journal.pone.0215441. eCollection 2019.


Test Performance Characteristics of the AIR, GAD-7 and HADS-Anxiety Screening Questionnaires for Anxiety in Chronic Obstructive Pulmonary Disease.

Baker AM, Holbrook JT, Yohannes AM, Eakin MN, Sugar EA, Henderson RJ, Casper AS, Kaminsky DA, Rea AL, Mathews AM, Que LG, Ramsdell JW, Gerald LB, Wise RA, Hanania NA; for American Lung Association Airways Clinical Research Centers.

Ann Am Thorac Soc. 2018 Jul 9. doi: 10.1513/AnnalsATS.201708-631OC. [Epub ahead of print]


Validity of the Asthma Control Test Questionnaire Among Smoking Asthmatics.

Soler X, Holbrook JT, Gerald LB, Berry CE, Saams J, Henderson RJ, Sugar E, Wise RA, Ramsdell JW.

J Allergy Clin Immunol Pract. 2018 Jan - Feb;6(1):151-158. doi: 10.1016/j.jaip.2017.05.010. Epub 2017 Jun 29.


The Draft Genome and Transcriptome of the Atlantic Horseshoe Crab, Limulus polyphemus.

Simpson SD, Ramsdell JS, Watson Iii WH, Chabot CC.

Int J Genomics. 2017;2017:7636513. doi: 10.1155/2017/7636513. Epub 2017 Feb 6.


A New Reference Genome Assembly for the Microcrustacean Daphnia pulex.

Ye Z, Xu S, Spitze K, Asselman J, Jiang X, Ackerman MS, Lopez J, Harker B, Raborn RT, Thomas WK, Ramsdell J, Pfrender ME, Lynch M.

G3 (Bethesda). 2017 May 5;7(5):1405-1416. doi: 10.1534/g3.116.038638.


PALADIN: protein alignment for functional profiling whole metagenome shotgun data.

Westbrook A, Ramsdell J, Schuelke T, Normington L, Bergeron RD, Thomas WK, MacManes MD.

Bioinformatics. 2017 May 15;33(10):1473-1478. doi: 10.1093/bioinformatics/btx021.


iCONCUR: informed consent for clinical data and bio-sample use for research.

Kim H, Bell E, Kim J, Sitapati A, Ramsdell J, Farcas C, Friedman D, Feupe SF, Ohno-Machado L.

J Am Med Inform Assoc. 2017 Mar 1;24(2):380-387. doi: 10.1093/jamia/ocw115.


Persistent and Newly Developed Chronic Bronchitis Are Associated with Worse Outcomes in Chronic Obstructive Pulmonary Disease.

Kim V, Zhao H, Boriek AM, Anzueto A, Soler X, Bhatt SP, Rennard SI, Wise R, Comellas A, Ramsdell JW, Kinney GL, Han MK, Martinez CH, Yen A, Black-Shinn J, Porszasz J, Criner GJ, Hanania NA, Sharafkhaneh A, Crapo JD, Make BJ, Silverman EK, Curtis JL; COPDGene Investigators.

Ann Am Thorac Soc. 2016 Jul;13(7):1016-25. doi: 10.1513/AnnalsATS.201512-800OC.


Segmental allergen challenge increases levels of airway follistatin-like 1 in patients with asthma.

Miller M, Esnault S, Kurten RC, Kelly EA, Beppu A, Das S, Rosenthal P, Ramsdell J, Croft M, Zuraw B, Jarjour N, Hamid Q, Broide DH.

J Allergy Clin Immunol. 2016 Aug;138(2):596-599.e4. doi: 10.1016/j.jaci.2016.01.019. Epub 2016 Apr 20. No abstract available.


Association between Functional Small Airway Disease and FEV1 Decline in Chronic Obstructive Pulmonary Disease.

Bhatt SP, Soler X, Wang X, Murray S, Anzueto AR, Beaty TH, Boriek AM, Casaburi R, Criner GJ, Diaz AA, Dransfield MT, Curran-Everett D, Galbán CJ, Hoffman EA, Hogg JC, Kazerooni EA, Kim V, Kinney GL, Lagstein A, Lynch DA, Make BJ, Martinez FJ, Ramsdell JW, Reddy R, Ross BD, Rossiter HB, Steiner RM, Strand MJ, van Beek EJ, Wan ES, Washko GR, Wells JM, Wendt CH, Wise RA, Silverman EK, Crapo JD, Bowler RP, Han MK; COPDGene Investigators.

Am J Respir Crit Care Med. 2016 Jul 15;194(2):178-84. doi: 10.1164/rccm.201511-2219OC.


Sex-specific features of emphysema among current and former smokers with COPD.

Hardin M, Foreman M, Dransfield MT, Hansel N, Han MK, Cho MH, Bhatt SP, Ramsdell J, Lynch D, Curtis JL, Silverman EK, Washko G, DeMeo D; COPDGene Investigators.

Eur Respir J. 2016 Jan;47(1):104-12. doi: 10.1183/13993003.00996-2015. Epub 2015 Nov 5.


A genome-wide analysis of the response to inhaled β2-agonists in chronic obstructive pulmonary disease.

Hardin M, Cho MH, McDonald ML, Wan E, Lomas DA, Coxson HO, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard S, Wouters E, Bakke P, Bhatt SP, Kim V, Ramsdell J, Regan EA, Make BJ, Hokanson JE, Crapo JD, Beaty TH, Hersh CP; ECLIPSE and COPDGene Investigators; COPDGene Investigators—clinical centers.

Pharmacogenomics J. 2016 Aug;16(4):326-35. doi: 10.1038/tpj.2015.65. Epub 2015 Oct 27.


Analysis of diarrhetic shellfish poisoning toxins and pectenotoxin-2 in the bottlenose dolphin (Tursiops truncatus) by liquid chromatography-tandem mass spectrometry.

Wang Z, Broadwater MH, Ramsdell JS.

J Chromatogr A. 2015 Oct 16;1416:22-30. doi: 10.1016/j.chroma.2015.08.066. Epub 2015 Sep 2.


Are Asthma and COPD a Continuum of the Same Disease?

Soler X, Ramsdell JW.

J Allergy Clin Immunol Pract. 2015 Jul-Aug;3(4):489-95; quiz 496-7. doi: 10.1016/j.jaip.2015.05.030. Review.


A Male-Specific Genetic Map of the Microcrustacean Daphnia pulex Based on Single-Sperm Whole-Genome Sequencing.

Xu S, Ackerman MS, Long H, Bright L, Spitze K, Ramsdell JS, Thomas WK, Lynch M.

Genetics. 2015 Sep;201(1):31-8. doi: 10.1534/genetics.115.179028. Epub 2015 Jun 26.


Development of diagnostic microsatellite markers from whole-genome sequences of Ammodramus sparrows for assessing admixture in a hybrid zone.

Kovach AI, Walsh J, Ramsdell J, Kelley Thomas W.

Ecol Evol. 2015 Jun;5(11):2267-83. doi: 10.1002/ece3.1514. Epub 2015 May 13.


The Mitochondrial Genomes of the Nudibranch Mollusks, Melibe leonina and Tritonia diomedea, and Their Impact on Gastropod Phylogeny.

Sevigny JL, Kirouac LE, Thomas WK, Ramsdell JS, Lawlor KE, Sharifi O, Grewal S, Baysdorfer C, Curr K, Naimie AA, Okamoto K, Murray JA, Newcomb JM.

PLoS One. 2015 May 21;10(5):e0127519. doi: 10.1371/journal.pone.0127519. eCollection 2015. Erratum in: PLoS One. 2015;10(7):e0132861.


High Prevalence of Obstructive Sleep Apnea in Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease.

Soler X, Gaio E, Powell FL, Ramsdell JW, Loredo JS, Malhotra A, Ries AL.

Ann Am Thorac Soc. 2015 Aug;12(8):1219-25. doi: 10.1513/AnnalsATS.201407-336OC.


Oligotyping reveals stronger relationship of organic soil bacterial community structure with N-amendments and soil chemistry in comparison to that of mineral soil at Harvard Forest, MA, USA.

Turlapati SA, Minocha R, Long S, Ramsdell J, Minocha SC.

Front Microbiol. 2015 Feb 16;6:49. doi: 10.3389/fmicb.2015.00049. eCollection 2015.


Comorbidities of COPD have a major impact on clinical outcomes, particularly in African Americans.

Putcha N, Han MK, Martinez CH, Foreman MG, Anzueto AR, Casaburi R, Cho MH, Hanania NA, Hersh CP, Kinney GL, Make BJ, Steiner RM, Lutz SM, Thomashow BM, Williams AA, Bhatt SP, Beaty TH, Bowler RP, Ramsdell JW, Curtis JL, Everett D, Hokanson JE, Lynch DA, Sutherland ER, Silverman EK, Crapo JD, Wise RA, Regan EA, Hansel NN; the COPDGene® Investigators.

Chronic Obstr Pulm Dis. 2014;1(1):105-114.


A simplified score to quantify comorbidity in COPD.

Putcha N, Puhan MA, Drummond MB, Han MK, Regan EA, Hanania NA, Martinez CH, Foreman M, Bhatt SP, Make B, Ramsdell J, DeMeo DL, Barr RG, Rennard SI, Martinez F, Silverman EK, Crapo J, Wise RA, Hansel NN.

PLoS One. 2014 Dec 16;9(12):e114438. doi: 10.1371/journal.pone.0114438. eCollection 2014.


Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus.

Hersh CP, Make BJ, Lynch DA, Barr RG, Bowler RP, Calverley PM, Castaldi PJ, Cho MH, Coxson HO, DeMeo DL, Foreman MG, Han MK, Harshfield BJ, Hokanson JE, Lutz S, Ramsdell JW, Regan EA, Rennard SI, Schroeder JD, Sciurba FC, Steiner RM, Tal-Singer R, van Beek E Jr, Silverman EK, Crapo JD; COPDGene and ECLIPSE Investigators.

BMC Pulm Med. 2014 Oct 24;14:164. doi: 10.1186/1471-2466-14-164.


Childhood-onset asthma in smokers. association between CT measures of airway size, lung function, and chronic airflow obstruction.

Diaz AA, Hardin ME, Come CE, San José Estépar R, Ross JC, Kurugol S, Okajima Y, Han MK, Kim V, Ramsdell J, Silverman EK, Crapo JD, Lynch DA, Make B, Barr RG, Hersh CP, Washko GR; COPDGene Investigators.

Ann Am Thorac Soc. 2014 Nov;11(9):1371-8. doi: 10.1513/AnnalsATS.201403-095OC.


Anticholinergics/antimuscarinic drugs in asthma.

Soler X, Ramsdell J.

Curr Allergy Asthma Rep. 2014 Dec;14(12):484. doi: 10.1007/s11882-014-0484-y. Review.


Tissue distribution of amino acid- and lipid-brevetoxins after intravenous administration to C57BL/6 mice.

Leighfield TA, Muha N, Ramsdell JS.

Chem Res Toxicol. 2014 Jul 21;27(7):1166-75. doi: 10.1021/tx500053f. Epub 2014 Jul 7.


Prediction of acute respiratory disease in current and former smokers with and without COPD.

Bowler RP, Kim V, Regan E, Williams AAA, Santorico SA, Make BJ, Lynch DA, Hokanson JE, Washko GR, Bercz P, Soler X, Marchetti N, Criner GJ, Ramsdell J, Han MK, Demeo D, Anzueto A, Comellas A, Crapo JD, Dransfield M, Wells JM, Hersh CP, MacIntyre N, Martinez F, Nath HP, Niewoehner D, Sciurba F, Sharafkhaneh A, Silverman EK, van Beek EJR, Wilson C, Wendt C, Wise RA.

Chest. 2014 Oct;146(4):941-950. doi: 10.1378/chest.13-2946.


Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D.

Garland CF, Kim JJ, Mohr SB, Gorham ED, Grant WB, Giovannucci EL, Baggerly L, Hofflich H, Ramsdell JW, Zeng K, Heaney RP.

Am J Public Health. 2014 Aug;104(8):e43-50. doi: 10.2105/AJPH.2014.302034. Epub 2014 Jun 12.


The clinical and genetic features of COPD-asthma overlap syndrome.

Hardin M, Cho M, McDonald ML, Beaty T, Ramsdell J, Bhatt S, van Beek EJ, Make BJ, Crapo JD, Silverman EK, Hersh CP.

Eur Respir J. 2014 Aug;44(2):341-50. doi: 10.1183/09031936.00216013. Epub 2014 May 29.


Domoic acid epileptic disease.

Ramsdell JS, Gulland FM.

Mar Drugs. 2014 Mar 6;12(3):1185-207. doi: 10.3390/md12031185. Review.


Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema.

Castaldi PJ, Dy J, Ross J, Chang Y, Washko GR, Curran-Everett D, Williams A, Lynch DA, Make BJ, Crapo JD, Bowler RP, Regan EA, Hokanson JE, Kinney GL, Han MK, Soler X, Ramsdell JW, Barr RG, Foreman M, van Beek E, Casaburi R, Criner GJ, Lutz SM, Rennard SI, Santorico S, Sciurba FC, DeMeo DL, Hersh CP, Silverman EK, Cho MH.

Thorax. 2014 May;69(5):415-22. doi: 10.1136/thoraxjnl-2013-203601. Epub 2014 Feb 21.


Effects of inhaled fluticasone on upper airway during sleep and wakefulness in asthma: a pilot study.

Teodorescu M, Xie A, Sorkness CA, Robbins J, Reeder S, Gong Y, Fedie JE, Sexton A, Miller B, Huard T, Hind J, Bioty N, Peterson E, Kunselman SJ, Chinchilli VM, Soler X, Ramsdell J, Loredo J, Israel E, Eckert DJ, Malhotra A.

J Clin Sleep Med. 2014 Feb 15;10(2):183-93. doi: 10.5664/jcsm.3450.


FEV(1)/FEV(6) to diagnose airflow obstruction. Comparisons with computed tomography and morbidity indices.

Bhatt SP, Kim YI, Wells JM, Bailey WC, Ramsdell JW, Foreman MG, Jensen RL, Stinson DS, Wilson CG, Lynch DA, Make BJ, Dransfield MT.

Ann Am Thorac Soc. 2014 Mar;11(3):335-41. doi: 10.1513/AnnalsATS.201308-251OC.


Computed tomographic measures of airway morphology in smokers and never-smoking normals.

Washko GR, Diaz AA, Kim V, Barr RG, Dransfield MT, Schroeder J, Reilly JJ, Ramsdell JW, McKenzie A, Van Beek EJ, Lynch DA, Butler JP, Han MK.

J Appl Physiol (1985). 2014 Mar 15;116(6):668-73. doi: 10.1152/japplphysiol.00004.2013. Epub 2014 Jan 16.


Predictors of response to tiotropium versus salmeterol in asthmatic adults.

Peters SP, Bleecker ER, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Craig T, Denlinger LC, Engle LL, Dimango EA, Israel E, Kraft M, Lazarus SC, Lemanske RF Jr, Lugogo N, Martin RJ, Meyers DA, Ramsdell J, Sorkness CA, Sutherland ER, Wasserman SI, Walter MJ, Wechsler ME, Chinchilli VM, Szefler SJ; National Heart, Lung, and Blood Institute's Asthma Clinical Research Network.

J Allergy Clin Immunol. 2013 Nov;132(5):1068-1074.e1. doi: 10.1016/j.jaci.2013.08.003. Epub 2013 Sep 29.


Brevetoxin in blood, biological fluids, and tissues of sea turtles naturally exposed to Karenia brevis blooms in central west Florida.

Fauquier DA, Flewelling LJ, Maucher J, Manire CA, Socha V, Kinsel MJ, Stacy BA, Henry M, Gannon J, Ramsdell JS, Landsberg JH.

J Zoo Wildl Med. 2013 Jun;44(2):364-75.


Semisynthesis of radiolabeled amino acid and lipid brevetoxin metabolites and their blood elimination kinetics in C57BL/6 mice.

Leighfield TA, Muha N, Miles CO, Ramsdell JS.

Chem Res Toxicol. 2013 Jun 17;26(6):868-77. doi: 10.1021/tx4000057. Epub 2013 May 30.


Brevetoxicosis in seabirds naturally exposed to Karenia brevis blooms along the central west coast of Florida.

Fauquier DA, Flewelling LJ, Maucher JM, Keller M, Kinsel MJ, Johnson CK, Henry M, Gannon JG, Ramsdell JS, Landsberg JH.

J Wildl Dis. 2013 Apr;49(2):246-60. doi: 10.7589/2011-09-270.


Safety and efficacy of the once-daily anticholinergic BEA2180 compared with tiotropium in patients with COPD.

Abrahams R, Moroni-Zentgraf P, Ramsdell J, Schmidt H, Joseph E, Karpel J.

Respir Med. 2013 Jun;107(6):854-62. doi: 10.1016/j.rmed.2013.02.005. Epub 2013 Mar 13.


Persistent neurological damage associated with spontaneous recurrent seizures and atypical aggressive behavior of domoic acid epileptic disease.

Tiedeken JA, Ramsdell JS.

Toxicol Sci. 2013 May;133(1):133-43. doi: 10.1093/toxsci/kft037. Epub 2013 Mar 1.


Bioavailability and intravenous toxicokinetic parameters for Pacific ciguatoxin P-CTX-1 in rats.

Ledreux A, Ramsdell JS.

Toxicon. 2013 Mar 15;64:81-6. doi: 10.1016/j.toxicon.2012.12.026. Epub 2013 Jan 11.


Elimination kinetics of domoic acid from the brain and cerebrospinal fluid of the pregnant rat.

Maucher Fuquay J, Muha N, Wang Z, Ramsdell JS.

Chem Res Toxicol. 2012 Dec 17;25(12):2805-9. doi: 10.1021/tx300434s. Epub 2012 Nov 15.


Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial.

Calhoun WJ, Ameredes BT, King TS, Icitovic N, Bleecker ER, Castro M, Cherniack RM, Chinchilli VM, Craig T, Denlinger L, DiMango EA, Engle LL, Fahy JV, Grant JA, Israel E, Jarjour N, Kazani SD, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Moore WC, Pascual R, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Walter MJ, Wechsler ME, Boushey HA; Asthma Clinical Research Network of the National Heart, Lung, and Blood Institute.

JAMA. 2012 Sep 12;308(10):987-97. doi: 10.1001/2012.jama.10893.


Linking ciguatera poisoning to spatial ecology of fish: a novel approach to examining the distribution of biotoxin levels in the great barracuda by combining non-lethal blood sampling and biotelemetry.

O'Toole AC, Dechraoui Bottein MY, Danylchuk AJ, Ramsdell JS, Cooke SJ.

Sci Total Environ. 2012 Jun 15;427-428:98-105. doi: 10.1016/j.scitotenv.2011.11.053. Epub 2012 May 3.


Toxicokinetics of domoic acid in the fetal rat.

Maucher Fuquay J, Muha N, Wang Z, Ramsdell JS.

Toxicology. 2012 Mar 29;294(1):36-41. doi: 10.1016/j.tox.2012.01.012. Epub 2012 Jan 28.


Optimization of solid-phase extraction and liquid chromatography-tandem mass spectrometry for the determination of domoic acid in seawater, phytoplankton, and mammalian fluids and tissues.

Wang Z, Maucher-Fuquay J, Fire SE, Mikulski CM, Haynes B, Doucette GJ, Ramsdell JS.

Anal Chim Acta. 2012 Feb 17;715:71-9. doi: 10.1016/j.aca.2011.12.013. Epub 2011 Dec 19.


Asthma in the elderly: Current understanding and future research needs--a report of a National Institute on Aging (NIA) workshop.

Hanania NA, King MJ, Braman SS, Saltoun C, Wise RA, Enright P, Falsey AR, Mathur SK, Ramsdell JW, Rogers L, Stempel DA, Lima JJ, Fish JE, Wilson SR, Boyd C, Patel KV, Irvin CG, Yawn BP, Halm EA, Wasserman SI, Sands MF, Ershler WB, Ledford DK; Asthma in Elderly workshop participants.

J Allergy Clin Immunol. 2011 Sep;128(3 Suppl):S4-24. doi: 10.1016/j.jaci.2011.06.048.


Domoic acid induced status epilepticus promotes aggressive behavior in rats.

Fuquay JM, Muha N, Pennington PL, Ramsdell JS.

Physiol Behav. 2012 Jan 18;105(2):315-20. doi: 10.1016/j.physbeh.2011.08.013. Epub 2011 Aug 22.


Identification of ciguatoxins in Hawaiian monk seals Monachus schauinslandi from the Northwestern and Main Hawaiian Islands.

Bottein MY, Kashinsky L, Wang Z, Littnan C, Ramsdell JS.

Environ Sci Technol. 2011 Jun 15;45(12):5403-9. doi: 10.1021/es2002887. Epub 2011 May 17.


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