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Items: 15


A novel immunogenic mouse model of melanoma for the preclinical assessment of combination targeted and immune-based therapy.

Lelliott EJ, Cullinane C, Martin CA, Walker R, Ramsbottom KM, Souza-Fonseca-Guimaraes F, Abuhammad S, Michie J, Kirby L, Young RJ, Slater A, Lau P, Meeth K, Oliaro J, Haynes N, McArthur GA, Sheppard KE.

Sci Rep. 2019 Feb 4;9(1):1225. doi: 10.1038/s41598-018-37883-y.


Antagonism of IAPs Enhances CAR T-cell Efficacy.

Michie J, Beavis PA, Freeman AJ, Vervoort SJ, Ramsbottom KM, Narasimhan V, Lelliott EJ, Lalaoui N, Ramsay RG, Johnstone RW, Silke J, Darcy PK, Voskoboinik I, Kearney CJ, Oliaro J.

Cancer Immunol Res. 2019 Feb;7(2):183-192. doi: 10.1158/2326-6066.CIR-18-0428. Epub 2019 Jan 16.


Tumor immune evasion arises through loss of TNF sensitivity.

Kearney CJ, Vervoort SJ, Hogg SJ, Ramsbottom KM, Freeman AJ, Lalaoui N, Pijpers L, Michie J, Brown KK, Knight DA, Sutton V, Beavis PA, Voskoboinik I, Darcy PK, Silke J, Trapani JA, Johnstone RW, Oliaro J.

Sci Immunol. 2018 May 18;3(23). pii: eaar3451. doi: 10.1126/sciimmunol.aar3451.


Epigenetic targeting of Notch1-driven transcription using the HDACi panobinostat is a potential therapy against T-cell acute lymphoblastic leukemia.

Waibel M, Vervoort SJ, Kong IY, Heinzel S, Ramsbottom KM, Martin BP, Hawkins ED, Johnstone RW.

Leukemia. 2018 Jan;32(1):237-241. doi: 10.1038/leu.2017.282. Epub 2017 Sep 15. No abstract available.


DOCK8 Drives Src-Dependent NK Cell Effector Function.

Kearney CJ, Vervoort SJ, Ramsbottom KM, Freeman AJ, Michie J, Peake J, Casanova JL, Picard C, Tangye SG, Ma CS, Johnstone RW, Randall KL, Oliaro J.

J Immunol. 2017 Aug 9. pii: ji1700751. doi: 10.4049/jimmunol.1700751. [Epub ahead of print]


PD-L1 and IAPs co-operate to protect tumors from cytotoxic lymphocyte-derived TNF.

Kearney CJ, Lalaoui N, Freeman AJ, Ramsbottom KM, Silke J, Oliaro J.

Cell Death Differ. 2017 Oct;24(10):1705-1716. doi: 10.1038/cdd.2017.94. Epub 2017 Jun 30.


HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2+ Tumors.

Medon M, Vidacs E, Vervoort SJ, Li J, Jenkins MR, Ramsbottom KM, Trapani JA, Smyth MJ, Darcy PK, Atadja PW, Henderson MA, Johnstone RW, Haynes NM.

Cancer Res. 2017 May 15;77(10):2594-2606. doi: 10.1158/0008-5472.CAN-16-2247. Epub 2017 Mar 1.


Loss of DNAM-1 ligand expression by acute myeloid leukemia cells renders them resistant to NK cell killing.

Kearney CJ, Ramsbottom KM, Voskoboinik I, Darcy PK, Oliaro J.

Oncoimmunology. 2016 Jun 27;5(8):e1196308. doi: 10.1080/2162402X.2016.1196308. eCollection 2016 Aug.


Lethal giant larvae-1 deficiency enhances the CD8(+) effector T-cell response to antigen challenge in vivo.

Ramsbottom KM, Sacirbegovic F, Hawkins ED, Kallies A, Belz GT, Van Ham V, Haynes NM, Durrant MJ, Humbert PO, Russell SM, Oliaro J.

Immunol Cell Biol. 2016 Mar;94(3):306-11. doi: 10.1038/icb.2015.82. Epub 2015 Sep 22.


Scribble acts as an oncogene in Eμ-myc-driven lymphoma.

Hawkins ED, Oliaro J, Ramsbottom KM, Newbold A, Humbert PO, Johnstone RW, Russell SM.

Oncogene. 2016 Mar 3;35(9):1193-7. doi: 10.1038/onc.2015.167. Epub 2015 May 18.


Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time.

Jenkins MR, Rudd-Schmidt JA, Lopez JA, Ramsbottom KM, Mannering SI, Andrews DM, Voskoboinik I, Trapani JA.

J Exp Med. 2015 Mar 9;212(3):307-17. doi: 10.1084/jem.20140964. Epub 2015 Mar 2.


A method for detecting intracellular perforin in mouse lymphocytes.

Brennan AJ, House IG, Oliaro J, Ramsbottom KM, Hagn M, Yagita H, Trapani JA, Voskoboinik I.

J Immunol. 2014 Dec 1;193(11):5744-50. doi: 10.4049/jimmunol.1402207. Epub 2014 Oct 27.


Lethal giant larvae 1 tumour suppressor activity is not conserved in models of mammalian T and B cell leukaemia.

Hawkins ED, Oliaro J, Ramsbottom KM, Ting SB, Sacirbegovic F, Harvey M, Kinwell T, Ghysdael J, Johnstone RW, Humbert PO, Russell SM.

PLoS One. 2014 Jan 27;9(1):e87376. doi: 10.1371/journal.pone.0087376. eCollection 2014.


Cutting edge: DNAX accessory molecule 1-deficient CD8+ T cells display immunological synapse defects that impair antitumor immunity.

Ramsbottom KM, Hawkins ED, Shimoni R, McGrath M, Chan CJ, Russell SM, Smyth MJ, Oliaro J.

J Immunol. 2014 Jan 15;192(2):553-7. doi: 10.4049/jimmunol.1302197. Epub 2013 Dec 13.


Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity.

Hawkins ED, Oliaro J, Kallies A, Belz GT, Filby A, Hogan T, Haynes N, Ramsbottom KM, Van Ham V, Kinwell T, Seddon B, Davies D, Tarlinton D, Lew AM, Humbert PO, Russell SM.

Nat Commun. 2013;4:1801. doi: 10.1038/ncomms2796.


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