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Modeling open surgery in mice to explore peritoneal damage, carbon dioxide humidification and desmoidogenesis.

Chittleborough T, Sampurno S, Carpinteri S, Lynch AC, Heriot AG, Ramsay RG.

Pleura Peritoneum. 2019 Nov 2;4(4):20190023. doi: 10.1515/pp-2019-0023. eCollection 2019 Dec 1.


Modes of carbon dioxide delivery during laparoscopy generate distinct differences in peritoneal damage and hypoxia in a porcine model.

Sampurno S, Chittleborough TJ, Carpinteri S, Hiller J, Heriot A, Lynch AC, Ramsay RG.

Surg Endosc. 2019 Oct 17. doi: 10.1007/s00464-019-07213-y. [Epub ahead of print]


Prognostic Impact of Tumor-Infiltrating Lymphocytes in Primary and Metastatic Colorectal Cancer: A Systematic Review and Meta-analysis.

Kong JC, Guerra GR, Pham T, Mitchell C, Lynch AC, Warrier SK, Ramsay RG, Heriot AG.

Dis Colon Rectum. 2019 Apr;62(4):498-508. doi: 10.1097/DCR.0000000000001332.


Antagonism of IAPs Enhances CAR T-cell Efficacy.

Michie J, Beavis PA, Freeman AJ, Vervoort SJ, Ramsbottom KM, Narasimhan V, Lelliott EJ, Lalaoui N, Ramsay RG, Johnstone RW, Silke J, Darcy PK, Voskoboinik I, Kearney CJ, Oliaro J.

Cancer Immunol Res. 2019 Feb;7(2):183-192. doi: 10.1158/2326-6066.CIR-18-0428. Epub 2019 Jan 16.


Novel Vaccine Targeting Colonic Adenoma: a Pre-clinical Model.

Pham T, Carpinteri S, Sampurno S, Pereira L, Roth S, Narasimhan V, Darcy P, Desai J, Heriot AG, Ramsay RG.

J Gastrointest Surg. 2019 Mar;23(3):626-633. doi: 10.1007/s11605-018-4060-y. Epub 2019 Jan 8.


A Roberts Syndrome Individual With Differential Genotoxin Sensitivity and a DNA Damage Response Defect.

McKay MJ, Craig J, Kalitsis P, Kozlov S, Verschoor S, Chen P, Lobachevsky P, Vasireddy R, Yan Y, Ryan J, McGillivray G, Savarirayan R, Lavin MF, Ramsay RG, Xu H.

Int J Radiat Oncol Biol Phys. 2019 Apr 1;103(5):1194-1202. doi: 10.1016/j.ijrobp.2018.11.047. Epub 2018 Nov 30.


Intratumor MAPK and PI3K signaling pathway heterogeneity in glioblastoma tissue correlates with CREB signaling and distinct target gene signatures.

Daniel PM, Filiz G, Tymms MJ, Ramsay RG, Kaye AH, Stylli SS, Mantamadiotis T.

Exp Mol Pathol. 2018 Aug;105(1):23-31. doi: 10.1016/j.yexmp.2018.05.009. Epub 2018 May 28.


Risk Factors Associated With Circumferential Resection Margin Positivity in Rectal Cancer: A Binational Registry Study.

Warrier SK, Kong JC, Guerra GR, Chittleborough TJ, Naik A, Ramsay RG, Lynch AC, Heriot AG.

Dis Colon Rectum. 2018 Apr;61(4):433-440. doi: 10.1097/DCR.0000000000001026.


Salvage Surgery for Locoregional Failure in Anal Squamous Cell Carcinoma.

Guerra GR, Kong JC, Bernardi MP, Ramsay RG, Phillips WA, Warrier SK, Lynch AC, Ngan SY, Heriot AG.

Dis Colon Rectum. 2018 Feb;61(2):179-186. doi: 10.1097/DCR.0000000000001010.


Experimental study of delivery of humidified-warm carbon dioxide during open abdominal surgery.

Carpinteri S, Sampurno S, Malaterre J, Millen R, Dean M, Kong J, Chittleborough T, Heriot A, Lynch AC, Ramsay RG.

Br J Surg. 2018 Apr;105(5):597-605. doi: 10.1002/bjs.10685. Epub 2017 Nov 28.


Exploiting induced senescence in intestinal organoids to drive enteroendocrine cell expansion.

Ramsay RG, Abud HE.

Stem Cell Investig. 2017 May 9;4:36. doi: 10.21037/sci.2017.04.06. eCollection 2017. No abstract available.


Improving trial design in cancer anesthesia (onco-anesthesia) research.

Hiller JG, Myles PS, Ramsay RG, Riedel BJ.

Can J Anaesth. 2017 Aug;64(8):872-873. doi: 10.1007/s12630-017-0873-5. Epub 2017 Mar 30. No abstract available.


Outcome and Salvage Surgery Following "Watch and Wait" for Rectal Cancer after Neoadjuvant Therapy: A Systematic Review.

Kong JC, Guerra GR, Warrier SK, Ramsay RG, Heriot AG.

Dis Colon Rectum. 2017 Mar;60(3):335-345. doi: 10.1097/DCR.0000000000000754. Review.


SCA-1 Labels a Subset of Estrogen-Responsive Bipotential Repopulating Cells within the CD24+ CD49fhi Mammary Stem Cell-Enriched Compartment.

Dall GV, Vieusseux JL, Korach KS, Arao Y, Hewitt SC, Hamilton KJ, Dzierzak E, Boon WC, Simpson ER, Ramsay RG, Stein T, Morris JS, Anderson RL, Risbridger GP, Britt KL.

Stem Cell Reports. 2017 Feb 14;8(2):417-431. doi: 10.1016/j.stemcr.2016.12.022. Epub 2017 Jan 26.


Immunomodulation by MYB is associated with tumor relapse in patients with early stage colorectal cancer.

Millen R, Malaterre J, Cross RS, Carpinteri S, Desai J, Tran B, Darcy P, Gibbs P, Sieber O, Zeps N, Waring P, Fox S, Pereira L, Ramsay RG.

Oncoimmunology. 2016 Jun 29;5(7):e1149667. doi: 10.1080/2162402X.2016.1149667. eCollection 2016 Jul.


Adenoid Cystic Carcinoma Can Be Driven by MYB or MYBL1 Rearrangements: New Insights into MYB and Tumor Biology.

Gonda TJ, Ramsay RG.

Cancer Discov. 2016 Feb;6(2):125-7. doi: 10.1158/2159-8290.CD-15-1470.


CDK9 inhibitors selectively target estrogen receptor-positive breast cancer cells through combined inhibition of MYB and MCL-1 expression.

Mitra P, Yang RM, Sutton J, Ramsay RG, Gonda TJ.

Oncotarget. 2016 Feb 23;7(8):9069-83. doi: 10.18632/oncotarget.6997.


Molecular biology of anal squamous cell carcinoma: implications for future research and clinical intervention.

Bernardi MP, Ngan SY, Michael M, Lynch AC, Heriot AG, Ramsay RG, Phillips WA.

Lancet Oncol. 2015 Dec;16(16):e611-21. doi: 10.1016/S1470-2045(15)00292-2. Review.


Predicting pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a systematic review.

Ryan JE, Warrier SK, Lynch AC, Ramsay RG, Phillips WA, Heriot AG.

Colorectal Dis. 2016 Mar;18(3):234-46. doi: 10.1111/codi.13207. Review.


Directly targeting transcriptional dysregulation in cancer.

Gonda TJ, Ramsay RG.

Nat Rev Cancer. 2015 Nov;15(11):686-94. doi: 10.1038/nrc4018. Review.


BET inhibitor resistance emerges from leukaemia stem cells.

Fong CY, Gilan O, Lam EY, Rubin AF, Ftouni S, Tyler D, Stanley K, Sinha D, Yeh P, Morison J, Giotopoulos G, Lugo D, Jeffrey P, Lee SC, Carpenter C, Gregory R, Ramsay RG, Lane SW, Abdel-Wahab O, Kouzarides T, Johnstone RW, Dawson SJ, Huntly BJ, Prinjha RK, Papenfuss AT, Dawson MA.

Nature. 2015 Sep 24;525(7570):538-42. doi: 10.1038/nature14888. Epub 2015 Sep 14.


Intestinal-specific activatable Myb initiates colon tumorigenesis in mice.

Malaterre J, Pereira L, Putoczki T, Millen R, Paquet-Fifield S, Germann M, Liu J, Cheasley D, Sampurno S, Stacker SA, Achen MG, Ward RL, Waring P, Mantamadiotis T, Ernst M, Ramsay RG.

Oncogene. 2016 May 12;35(19):2475-84. doi: 10.1038/onc.2015.305. Epub 2015 Aug 24.


New Insights on COX-2 in Chronic Inflammation Driving Breast Cancer Growth and Metastasis.

Hugo HJ, Saunders C, Ramsay RG, Thompson EW.

J Mammary Gland Biol Neoplasia. 2015 Dec;20(3-4):109-19. doi: 10.1007/s10911-015-9333-4. Epub 2015 Jul 21. Review.


Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis.

Cheasley D, Pereira L, Sampurno S, Sieber O, Jorissen R, Xu H, Germann M, Yuqian Y, Ramsay RG, Malaterre J.

Mol Cancer Res. 2015 Aug;13(8):1185-96. doi: 10.1158/1541-7786.MCR-15-0014. Epub 2015 May 1.


Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells.

Flanagan DJ, Phesse TJ, Barker N, Schwab RH, Amin N, Malaterre J, Stange DE, Nowell CJ, Currie SA, Saw JT, Beuchert E, Ramsay RG, Sansom OJ, Ernst M, Clevers H, Vincan E.

Stem Cell Reports. 2015 May 12;4(5):759-67. doi: 10.1016/j.stemcr.2015.03.003. Epub 2015 Apr 16.


MYB elongation is regulated by the nucleic acid binding of NFκB p50 to the intronic stem-loop region.

Pereira LA, Hugo HJ, Malaterre J, Huiling X, Sonza S, Cures A, Purcell DF, Ramsland PA, Gerondakis S, Gonda TJ, Ramsay RG.

PLoS One. 2015 Apr 8;10(4):e0122919. doi: 10.1371/journal.pone.0122919. eCollection 2015.


Myb via TGFβ is required for collagen type 1 production and skin integrity.

Sampurno S, Cross R, Pearson H, Kaur P, Malaterre J, Ramsay RG.

Growth Factors. 2015 Apr;33(2):102-12. doi: 10.3109/08977194.2015.1016222. Epub 2015 Mar 25.


Peritoneal Tumorigenesis and Inflammation are Ameliorated by Humidified-Warm Carbon Dioxide Insufflation in the Mouse.

Carpinteri S, Sampurno S, Bernardi MP, Germann M, Malaterre J, Heriot A, Chambers BA, Mutsaers SE, Lynch AC, Ramsay RG.

Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1540-7. doi: 10.1245/s10434-015-4508-1. Epub 2015 Mar 21.


Therapeutic DNA vaccination against colorectal cancer by targeting the MYB oncoprotein.

Cross RS, Malaterre J, Davenport AJ, Carpinteri S, Anderson RL, Darcy PK, Ramsay RG.

Clin Transl Immunology. 2015 Jan 9;4(1):e30. doi: 10.1038/cti.2014.29. eCollection 2015 Jan.


Cohesin Rad21 mediates loss of heterozygosity and is upregulated via Wnt promoting transcriptional dysregulation in gastrointestinal tumors.

Xu H, Yan Y, Deb S, Rangasamy D, Germann M, Malaterre J, Eder NC, Ward RL, Hawkins NJ, Tothill RW, Chen L, Mortensen NJ, Fox SB, McKay MJ, Ramsay RG.

Cell Rep. 2014 Dec 11;9(5):1781-1797. doi: 10.1016/j.celrep.2014.10.059. Epub 2014 Nov 20.


Tripartite interactions between Wnt signaling, Notch and Myb for stem/progenitor cell functions during intestinal tumorigenesis.

Germann M, Xu H, Malaterre J, Sampurno S, Huyghe M, Cheasley D, Fre S, Ramsay RG.

Stem Cell Res. 2014 Nov;13(3 Pt A):355-66. doi: 10.1016/j.scr.2014.08.002. Epub 2014 Sep 28.


Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

Phesse TJ, Buchert M, Stuart E, Flanagan DJ, Faux M, Afshar-Sterle S, Walker F, Zhang HH, Nowell CJ, Jorissen R, Tan CW, Hirokawa Y, Eissmann MF, Poh AR, Malaterre J, Pearson HB, Kirsch DG, Provero P, Poli V, Ramsay RG, Sieber O, Burgess AW, Huszar D, Vincan E, Ernst M.

Sci Signal. 2014 Sep 30;7(345):ra92. doi: 10.1126/scisignal.2005411.


Marker genes identify three somatic cell types in the fetal mouse ovary.

Rastetter RH, Bernard P, Palmer JS, Chassot AA, Chen H, Western PS, Ramsay RG, Chaboissier MC, Wilhelm D.

Dev Biol. 2014 Oct 15;394(2):242-52. doi: 10.1016/j.ydbio.2014.08.013. Epub 2014 Aug 23.


Selective CREB-dependent cyclin expression mediated by the PI3K and MAPK pathways supports glioma cell proliferation.

Daniel P, Filiz G, Brown DV, Hollande F, Gonzales M, D'Abaco G, Papalexis N, Phillips WA, Malaterre J, Ramsay RG, Mantamadiotis T.

Oncogenesis. 2014 Jun 30;3:e108. doi: 10.1038/oncsis.2014.21.


RAD21 cohesin overexpression is a prognostic and predictive marker exacerbating poor prognosis in KRAS mutant colorectal carcinomas.

Deb S, Xu H, Tuynman J, George J, Yan Y, Li J, Ward RL, Mortensen N, Hawkins NJ, McKay MJ, Ramsay RG, Fox SB.

Br J Cancer. 2014 Mar 18;110(6):1606-13. doi: 10.1038/bjc.2014.31. Epub 2014 Feb 18.


Physiological expression of the PI3K-activating mutation Pik3ca(H1047R) combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice.

Hare LM, Phesse TJ, Waring PM, Montgomery KG, Kinross KM, Mills K, Roh V, Heath JK, Ramsay RG, Ernst M, Phillips WA.

Biochem J. 2014 Mar 1;458(2):251-8. doi: 10.1042/BJ20131412.


Direct repression of MYB by ZEB1 suppresses proliferation and epithelial gene expression during epithelial-to-mesenchymal transition of breast cancer cells.

Hugo HJ, Pereira L, Suryadinata R, Drabsch Y, Gonda TJ, Gunasinghe NP, Pinto C, Soo ET, van Denderen BJ, Hill P, Ramsay RG, Sarcevic B, Newgreen DF, Thompson EW.

Breast Cancer Res. 2013 Nov 27;15(6):R113. doi: 10.1186/bcr3580.


Myb and the regulation of stem cells in the intestine and brain: a tale of two niches.

Malaterre J, Pereira L, Ramsay RG.

Adv Exp Med Biol. 2013;786:353-68. doi: 10.1007/978-94-007-6621-1_19.


The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis.

Sampurno S, Bijenhof A, Cheasley D, Xu H, Robine S, Hilton D, Alexander WS, Pereira L, Mantamadiotis T, Malaterre J, Ramsay RG.

Cell Death Dis. 2013 Apr 25;4:e605. doi: 10.1038/cddis.2013.119.


Inhibition of established micrometastases by targeted drug delivery via cell surface-associated GRP78.

Miao YR, Eckhardt BL, Cao Y, Pasqualini R, Argani P, Arap W, Ramsay RG, Anderson RL.

Clin Cancer Res. 2013 Apr 15;19(8):2107-16. doi: 10.1158/1078-0432.CCR-12-2991. Epub 2013 Mar 7.


CSF-1 receptor-dependent colon development, homeostasis and inflammatory stress response.

Huynh D, Akçora D, Malaterre J, Chan CK, Dai XM, Bertoncello I, Stanley ER, Ramsay RG.

PLoS One. 2013;8(2):e56951. doi: 10.1371/journal.pone.0056951. Epub 2013 Feb 22.


The CSF-1 receptor fashions the intestinal stem cell niche.

Akcora D, Huynh D, Lightowler S, Germann M, Robine S, de May JR, Pollard JW, Stanley ER, Malaterre J, Ramsay RG.

Stem Cell Res. 2013 Mar;10(2):203-12. doi: 10.1016/j.scr.2012.12.001. Epub 2012 Dec 9.


Enhanced lithium-induced brain recovery following cranial irradiation is not impeded by inflammation.

Malaterre J, McPherson CS, Denoyer D, Lai E, Hagekyriakou J, Lightowler S, Shudo K, Ernst M, Ashley DM, Short JL, Wheeler G, Ramsay RG.

Stem Cells Transl Med. 2012 Jun;1(6):469-79. doi: 10.5966/sctm.2011-0046. Epub 2012 May 30.


Delayed development of specific thyroid hormone-regulated events in transthyretin null mice.

Monk JA, Sims NA, Dziegielewska KM, Weiss RE, Ramsay RG, Richardson SJ.

Am J Physiol Endocrinol Metab. 2013 Jan 1;304(1):E23-31. doi: 10.1152/ajpendo.00216.2012. Epub 2012 Oct 23.


The tumor suppressor Apc controls planar cell polarities central to gut homeostasis.

Bellis J, Duluc I, Romagnolo B, Perret C, Faux MC, Dujardin D, Formstone C, Lightowler S, Ramsay RG, Freund JN, De Mey JR.

J Cell Biol. 2012 Aug 6;198(3):331-41. doi: 10.1083/jcb.201204086. Epub 2012 Jul 30.


Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules.

Faure AJ, Schmidt D, Watt S, Schwalie PC, Wilson MD, Xu H, Ramsay RG, Odom DT, Flicek P.

Genome Res. 2012 Nov;22(11):2163-75. doi: 10.1101/gr.136507.111. Epub 2012 Jul 10.


RAD21 mutations cause a human cohesinopathy.

Deardorff MA, Wilde JJ, Albrecht M, Dickinson E, Tennstedt S, Braunholz D, Mönnich M, Yan Y, Xu W, Gil-Rodríguez MC, Clark D, Hakonarson H, Halbach S, Michelis LD, Rampuria A, Rossier E, Spranger S, Van Maldergem L, Lynch SA, Gillessen-Kaesbach G, Lüdecke HJ, Ramsay RG, McKay MJ, Krantz ID, Xu H, Horsfield JA, Kaiser FJ.

Am J Hum Genet. 2012 Jun 8;90(6):1014-27. doi: 10.1016/j.ajhg.2012.04.019. Epub 2012 May 24.


Estrogen receptor-α recruits P-TEFb to overcome transcriptional pausing in intron 1 of the MYB gene.

Mitra P, Pereira LA, Drabsch Y, Ramsay RG, Gonda TJ.

Nucleic Acids Res. 2012 Jul;40(13):5988-6000. doi: 10.1093/nar/gks286. Epub 2012 Apr 5.


Colorectal cancer mouse models: integrating inflammation and the stroma.

Ernst M, Ramsay RG.

J Gastroenterol Hepatol. 2012 Jan;27(1):39-50. doi: 10.1111/j.1440-1746.2011.06883.x.


Myb controls intestinal stem cell genes and self-renewal.

Cheasley D, Pereira L, Lightowler S, Vincan E, Malaterre J, Ramsay RG.

Stem Cells. 2011 Dec;29(12):2042-50. doi: 10.1002/stem.761.

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