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Items: 40

1.

A novel method for evaluating the effect of pollution on the human skin under controlled conditions.

Curpen S, Francois-Newton V, Moga A, Hosenally M, Petkar G, Soobramaney V, Ruchaia B, Lutchmanen Kolanthan V, Roheemun N, Sokeechand BN, Aumeeruddy Z, Ramracheya RD.

Skin Res Technol. 2019 Aug 1. doi: 10.1111/srt.12763. [Epub ahead of print]

PMID:
31373064
2.

Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular Ca2+ release.

Denwood G, Tarasov A, Salehi A, Vergari E, Ramracheya R, Takahashi H, Nikolaev VO, Seino S, Gribble F, Reimann F, Rorsman P, Zhang Q.

J Gen Physiol. 2019 Jul 29. pii: jgp.201912351. doi: 10.1085/jgp.201912351. [Epub ahead of print]

PMID:
31358556
3.

PYY plays a key role in the resolution of diabetes following bariatric surgery in humans.

Guida C, Stephen SD, Watson M, Dempster N, Larraufie P, Marjot T, Cargill T, Rickers L, Pavlides M, Tomlinson J, Cobbold JFL, Zhao CM, Chen D, Gribble F, Reimann F, Gillies R, Sgromo B, Rorsman P, Ryan JD, Ramracheya RD.

EBioMedicine. 2019 Feb;40:67-76. doi: 10.1016/j.ebiom.2018.12.040. Epub 2019 Jan 11.

4.

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion.

Vergari E, Knudsen JG, Ramracheya R, Salehi A, Zhang Q, Adam J, Asterholm IW, Benrick A, Briant LJB, Chibalina MV, Gribble FM, Hamilton A, Hastoy B, Reimann F, Rorsman NJG, Spiliotis II, Tarasov A, Wu Y, Ashcroft FM, Rorsman P.

Nat Commun. 2019 Jan 11;10(1):139. doi: 10.1038/s41467-018-08193-8.

5.

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production.

Knudsen JG, Hamilton A, Ramracheya R, Tarasov AI, Brereton M, Haythorne E, Chibalina MV, Spégel P, Mulder H, Zhang Q, Ashcroft FM, Adam J, Rorsman P.

Cell Metab. 2019 Feb 5;29(2):430-442.e4. doi: 10.1016/j.cmet.2018.10.003. Epub 2018 Nov 8.

6.

GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca2+ channels.

Ramracheya R, Chapman C, Chibalina M, Dou H, Miranda C, González A, Moritoh Y, Shigeto M, Zhang Q, Braun M, Clark A, Johnson PR, Rorsman P, Briant LJB.

Physiol Rep. 2018 Sep;6(17):e13852. doi: 10.14814/phy2.13852.

7.

New Approaches for Weight Loss: Experiments Using Animal Models.

Olsen MK, Johannessen H, Ramracheya R, Zhao CM, Chen D.

Curr Pharm Des. 2018;24(18):1926-1935. doi: 10.2174/1381612824666180614075412.

PMID:
29898650
8.

Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells.

Hamilton A, Zhang Q, Salehi A, Willems M, Knudsen JG, Ringgaard AK, Chapman CE, Gonzalez-Alvarez A, Surdo NC, Zaccolo M, Basco D, Johnson PRV, Ramracheya R, Rutter GA, Galione A, Rorsman P, Tarasov AI.

Diabetes. 2018 Jun;67(6):1128-1139. doi: 10.2337/db17-1102. Epub 2018 Mar 21.

9.

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes.

Adam J, Ramracheya R, Chibalina MV, Ternette N, Hamilton A, Tarasov AI, Zhang Q, Rebelato E, Rorsman NJG, Martín-Del-Río R, Lewis A, Özkan G, Do HW, Spégel P, Saitoh K, Kato K, Igarashi K, Kessler BM, Pugh CW, Tamarit-Rodriguez J, Mulder H, Clark A, Frizzell N, Soga T, Ashcroft FM, Silver A, Pollard PJ, Rorsman P.

Cell Rep. 2017 Sep 26;20(13):3135-3148. doi: 10.1016/j.celrep.2017.08.093.

10.

Sitagliptin and Roux-en-Y gastric bypass modulate insulin secretion via regulation of intra-islet PYY.

Guida C, McCulloch LJ, Godazgar M, Stephen SD, Baker C, Basco D, Dong J, Chen D, Clark A, Ramracheya RD.

Diabetes Obes Metab. 2018 Mar;20(3):571-581. doi: 10.1111/dom.13113. Epub 2017 Oct 10.

11.

Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy.

Babinsky VN, Hannan FM, Ramracheya RD, Zhang Q, Nesbit MA, Hugill A, Bentley L, Hough TA, Joynson E, Stewart M, Aggarwal A, Prinz-Wohlgenannt M, Gorvin CM, Kallay E, Wells S, Cox RD, Richards D, Rorsman P, Thakker RV.

Endocrinology. 2017 Aug 1;158(8):2486-2502. doi: 10.1210/en.2017-00111.

12.

The Role of PYY in Pancreatic Islet Physiology and Surgical Control of Diabetes.

Guida C, Stephen S, Guitton R, Ramracheya RD.

Trends Endocrinol Metab. 2017 Aug;28(8):626-636. doi: 10.1016/j.tem.2017.04.005. Epub 2017 May 19. Review.

PMID:
28533020
13.

Key Matrix Proteins Within the Pancreatic Islet Basement Membrane Are Differentially Digested During Human Islet Isolation.

Cross SE, Vaughan RH, Willcox AJ, McBride AJ, Abraham AA, Han B, Johnson JD, Maillard E, Bateman PA, Ramracheya RD, Rorsman P, Kadler KE, Dunne MJ, Hughes SJ, Johnson PR.

Am J Transplant. 2017 Feb;17(2):451-461. doi: 10.1111/ajt.13975. Epub 2016 Sep 6.

14.

PYY-Dependent Restoration of Impaired Insulin and Glucagon Secretion in Type 2 Diabetes following Roux-En-Y Gastric Bypass Surgery.

Ramracheya RD, McCulloch LJ, Clark A, Wiggins D, Johannessen H, Olsen MK, Cai X, Zhao CM, Chen D, Rorsman P.

Cell Rep. 2016 May 3;15(5):944-950. doi: 10.1016/j.celrep.2016.03.091. Epub 2016 Apr 21.

15.

High-content screening identifies a role for Na(+) channels in insulin production.

Szabat M, Modi H, Ramracheya R, Girbinger V, Chan F, Lee JT, Piske M, Kamal S, Carol Yang YH, Welling A, Rorsman P, Johnson JD.

R Soc Open Sci. 2015 Dec 2;2(12):150306. doi: 10.1098/rsos.150306. eCollection 2015 Dec.

16.

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.

Shigeto M, Ramracheya R, Tarasov AI, Cha CY, Chibalina MV, Hastoy B, Philippaert K, Reinbothe T, Rorsman N, Salehi A, Sones WR, Vergari E, Weston C, Gorelik J, Katsura M, Nikolaev VO, Vennekens R, Zaccolo M, Galione A, Johnson PR, Kaku K, Ladds G, Rorsman P.

J Clin Invest. 2015 Dec;125(12):4714-28. doi: 10.1172/JCI81975. Epub 2015 Nov 16.

17.

Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.

Zhang Q, Chibalina MV, Bengtsson M, Groschner LN, Ramracheya R, Rorsman NJ, Leiss V, Nassar MA, Welling A, Gribble FM, Reimann F, Hofmann F, Wood JN, Ashcroft FM, Rorsman P.

J Physiol. 2014 Nov 1;592(21):4677-96. doi: 10.1113/jphysiol.2014.274209. Epub 2014 Aug 28.

18.

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose.

Brereton MF, Iberl M, Shimomura K, Zhang Q, Adriaenssens AE, Proks P, Spiliotis II, Dace W, Mattis KK, Ramracheya R, Gribble FM, Reimann F, Clark A, Rorsman P, Ashcroft FM.

Nat Commun. 2014 Aug 22;5:4639. doi: 10.1038/ncomms5639.

19.

ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on secretion.

Rorsman P, Ramracheya R, Rorsman NJ, Zhang Q.

Diabetologia. 2014 Sep;57(9):1749-61. doi: 10.1007/s00125-014-3279-8. Epub 2014 Jun 7. Review.

PMID:
24906950
20.

Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes.

Zhang Q, Ramracheya R, Lahmann C, Tarasov A, Bengtsson M, Braha O, Braun M, Brereton M, Collins S, Galvanovskis J, Gonzalez A, Groschner LN, Rorsman NJ, Salehi A, Travers ME, Walker JN, Gloyn AL, Gribble F, Johnson PR, Reimann F, Ashcroft FM, Rorsman P.

Cell Metab. 2013 Dec 3;18(6):871-82. doi: 10.1016/j.cmet.2013.10.014.

21.

Autocrine regulation of insulin secretion.

Braun M, Ramracheya R, Rorsman P.

Diabetes Obes Metab. 2012 Oct;14 Suppl 3:143-51. doi: 10.1111/j.1463-1326.2012.01642.x. Review.

PMID:
22928575
22.

Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes.

Rosengren AH, Braun M, Mahdi T, Andersson SA, Travers ME, Shigeto M, Zhang E, Almgren P, Ladenvall C, Axelsson AS, Edlund A, Pedersen MG, Jonsson A, Ramracheya R, Tang Y, Walker JN, Barrett A, Johnson PR, Lyssenko V, McCarthy MI, Groop L, Salehi A, Gloyn AL, Renström E, Rorsman P, Eliasson L.

Diabetes. 2012 Jul;61(7):1726-33. doi: 10.2337/db11-1516. Epub 2012 Apr 9.

23.

Multivesicular exocytosis in rat pancreatic beta cells.

Hoppa MB, Jones E, Karanauskaite J, Ramracheya R, Braun M, Collins SC, Zhang Q, Clark A, Eliasson L, Genoud C, Macdonald PE, Monteith AG, Barg S, Galvanovskis J, Rorsman P.

Diabetologia. 2012 Apr;55(4):1001-12. doi: 10.1007/s00125-011-2400-5. Epub 2011 Dec 22.

24.

Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?

Walker JN, Ramracheya R, Zhang Q, Johnson PR, Braun M, Rorsman P.

Diabetes Obes Metab. 2011 Oct;13 Suppl 1:95-105. doi: 10.1111/j.1463-1326.2011.01450.x. Review.

PMID:
21824262
25.

Chronic Palmitate Exposure Inhibits Insulin Secretion by Dissociation of Ca2+ Channels from Secretory Granules.

Hoppa MB, Collins S, Ramracheya R, Hodson L, Amisten S, Zhang Q, Johnson P, Ashcroft FM, Rorsman P.

Cell Metab. 2011 Apr 6;13(4):487. doi: 10.1016/j.cmet.2011.03.002. Epub 2011 Apr 5. No abstract available.

26.

Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets.

Ramracheya R, Ward C, Shigeto M, Walker JN, Amisten S, Zhang Q, Johnson PR, Rorsman P, Braun M.

Diabetes. 2010 Sep;59(9):2198-208. doi: 10.2337/db09-1505. Epub 2010 Jun 14.

27.

GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.

De Marinis YZ, Salehi A, Ward CE, Zhang Q, Abdulkader F, Bengtsson M, Braha O, Braun M, Ramracheya R, Amisten S, Habib AM, Moritoh Y, Zhang E, Reimann F, Rosengren A, Shibasaki T, Gribble F, Renström E, Seino S, Eliasson L, Rorsman P.

Cell Metab. 2010 Jun 9;11(6):543-553. doi: 10.1016/j.cmet.2010.04.007.

28.

Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells.

Braun M, Ramracheya R, Bengtsson M, Clark A, Walker JN, Johnson PR, Rorsman P.

Diabetes. 2010 Jul;59(7):1694-701. doi: 10.2337/db09-0797. Epub 2010 Apr 22.

29.

Progression of diet-induced diabetes in C57BL6J mice involves functional dissociation of Ca2(+) channels from secretory vesicles.

Collins SC, Hoppa MB, Walker JN, Amisten S, Abdulkader F, Bengtsson M, Fearnside J, Ramracheya R, Toye AA, Zhang Q, Clark A, Gauguier D, Rorsman P.

Diabetes. 2010 May;59(5):1192-201. doi: 10.2337/db09-0791. Epub 2010 Feb 11.

30.

Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules.

Hoppa MB, Collins S, Ramracheya R, Hodson L, Amisten S, Zhang Q, Johnson P, Ashcroft FM, Rorsman P.

Cell Metab. 2009 Dec;10(6):455-65. doi: 10.1016/j.cmet.2009.09.011.

31.

Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells.

Braun M, Ramracheya R, Amisten S, Bengtsson M, Moritoh Y, Zhang Q, Johnson PR, Rorsman P.

Diabetologia. 2009 Aug;52(8):1566-78. doi: 10.1007/s00125-009-1382-z. Epub 2009 May 14.

PMID:
19440689
32.

Exocytotic properties of human pancreatic beta-cells.

Braun M, Ramracheya R, Johnson PR, Rorsman P.

Ann N Y Acad Sci. 2009 Jan;1152:187-93. doi: 10.1111/j.1749-6632.2008.03992.x.

PMID:
19161389
33.

Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis.

Sumara G, Formentini I, Collins S, Sumara I, Windak R, Bodenmiller B, Ramracheya R, Caille D, Jiang H, Platt KA, Meda P, Aebersold R, Rorsman P, Ricci R.

Cell. 2009 Jan 23;136(2):235-48. doi: 10.1016/j.cell.2008.11.018. Epub 2009 Jan 8.

34.

Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion.

Braun M, Ramracheya R, Bengtsson M, Zhang Q, Karanauskaite J, Partridge C, Johnson PR, Rorsman P.

Diabetes. 2008 Jun;57(6):1618-28. doi: 10.2337/db07-0991. Epub 2008 Apr 4.

35.

Function and expression of melatonin receptors on human pancreatic islets.

Ramracheya RD, Muller DS, Squires PE, Brereton H, Sugden D, Huang GC, Amiel SA, Jones PM, Persaud SJ.

J Pineal Res. 2008 Apr;44(3):273-9. doi: 10.1111/j.1600-079X.2007.00523.x. Epub 2008 Jan 9.

PMID:
18194202
36.

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.

MacDonald PE, De Marinis YZ, Ramracheya R, Salehi A, Ma X, Johnson PR, Cox R, Eliasson L, Rorsman P.

PLoS Biol. 2007 Jun;5(6):e143.

37.

Direct regulation of insulin secretion by angiotensin II in human islets of Langerhans.

Ramracheya RD, Muller DS, Wu Y, Whitehouse BJ, Huang GC, Amiel SA, Karalliedde J, Viberti G, Jones PM, Persaud SJ.

Diabetologia. 2006 Feb;49(2):321-31. Epub 2006 Jan 17.

PMID:
16416272
38.

The in vitro differentiation of rat neural stem cells into an insulin-expressing phenotype.

Burns CJ, Minger SL, Hall S, Milne H, Ramracheya RD, Evans ND, Persaud SJ, Jones PM.

Biochem Biophys Res Commun. 2005 Jan 21;326(3):570-7.

PMID:
15596137
39.

The development of new density gradient media for purifying human islets and islet-quality assessments.

Huang GC, Zhao M, Jones P, Persaud S, Ramracheya R, Löbner K, Christie MR, Banga JP, Peakman M, Sirinivsan P, Rela M, Heaton N, Amiel S.

Transplantation. 2004 Jan 15;77(1):143-5.

PMID:
14724452
40.

Role of adenine nucleotides in insulin secretion from MIN6 pseudoislets.

Hauge-Evans AC, Squires PE, Belin VD, Roderigo-Milne H, Ramracheya RD, Persaud SJ, Jones PM.

Mol Cell Endocrinol. 2002 Jun 14;191(2):167-76.

PMID:
12062900

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