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Line-1: Implications in the etiology of cancer, clinical applications, and pharmacologic targets.

Khalid M, Bojang P Jr, Hassanin AAI, Bowers EC, Reyes-Reyes EM, Ramos IN, Ramos KS.

Mutat Res. 2018 Oct - Dec;778:51-60. doi: 10.1016/j.mrrev.2018.09.003. Epub 2018 Sep 19. Review.


MEK5 promotes lung adenocarcinoma.

Sánchez-Fdez A, Ortiz-Ruiz MJ, Re-Louhau MF, Ramos I, Blanco-Múñez Ó, Ludeña D, Abad M, Sánchez-Martín M, Pandiella A, Esparís-Ogando A.

Eur Respir J. 2018 Nov 15. pii: 1801327. doi: 10.1183/13993003.01327-2018. [Epub ahead of print] No abstract available.


Combination cancer immunotherapy targeting PD-1 and GITR can rescue CD8+ T cell dysfunction and maintain memory phenotype.

Wang B, Zhang W, Jankovic V, Golubov J, Poon P, Oswald EM, Gurer C, Wei J, Ramos I, Wu Q, Waite J, Ni M, Adler C, Wei Y, Macdonald L, Rowlands T, Brydges S, Siao J, Poueymirou W, MacDonald D, Yancopoulos GD, Sleeman MA, Murphy AJ, Skokos D.

Sci Immunol. 2018 Nov 2;3(29). pii: eaat7061. doi: 10.1126/sciimmunol.aat7061.


Influenza A virus utilizes low affinity, high avidity interactions with the nuclear import machinery to ensure infection and immune evasion.

Tome-Amat J, Ramos I, Amanor F, Fernández-Sesma A, Ashour J.

J Virol. 2018 Oct 10. pii: JVI.01046-18. doi: 10.1128/JVI.01046-18. [Epub ahead of print]


Pregnancy anxiety predicts shorter gestation in Latina and non-Latina white women: The role of placental corticotrophin-releasing hormone.

Ramos IF, Guardino CM, Mansolf M, Glynn LM, Sandman CA, Hobel CJ, Dunkel Schetter C.

Psychoneuroendocrinology. 2019 Jan;99:166-173. doi: 10.1016/j.psyneuen.2018.09.008. Epub 2018 Sep 9.


Toll-Like Receptor 4 and NLRP3 Caspase 1- Interleukin-1β-Axis are Not Involved in Colon Ascendens Stent Peritonitis-Associated Heart Disease.

Alarcón MML, Ruocco JF, Ferreira F, Paula-Neto HA, Sepúlveda M, Vila Petroff M, Carvalho AB, Ramos IP, Branda HJ, Paiva CN, Medei E.

Shock. 2018 Oct;50(4):483-492. doi: 10.1097/SHK.0000000000001059.


Is it important to assess the ascending aorta after tetralogy of Fallot repair?

Cruz C, Pinho T, Madureira AJ, Dias CC, Ramos I, Silva Cardoso J, Maciel MJ.

Rev Port Cardiol. 2018 Sep;37(9):773-779. doi: 10.1016/j.repc.2017.11.014. Epub 2018 Aug 25. English, Portuguese.


Predictive factors for disseminated histoplasmosis in AIDS patients with fever admitted to a reference hospital in Brazil.

Ramos IC, Soares YC, Damasceno LS, Libório MP, Farias LABG, Heukelbach J, Alencar CHM, Leitão TDMJS.

Rev Soc Bras Med Trop. 2018 Jul-Aug;51(4):479-484. doi: 10.1590/0037-8682-0425-2017.


Epigenetic prediction of response to anti-PD-1 treatment in non-small-cell lung cancer: a multicentre, retrospective analysis.

Duruisseaux M, Martínez-Cardús A, Calleja-Cervantes ME, Moran S, Castro de Moura M, Davalos V, Piñeyro D, Sanchez-Cespedes M, Girard N, Brevet M, Giroux-Leprieur E, Dumenil C, Pradotto M, Bironzo P, Capelletto E, Novello S, Cortot A, Copin MC, Karachaliou N, Gonzalez-Cao M, Peralta S, Montuenga LM, Gil-Bazo I, Baraibar I, Lozano MD, Varela M, Ruffinelli JC, Palmero R, Nadal E, Moran T, Perez L, Ramos I, Xiao Q, Fernandez AF, Fraga MF, Gut M, Gut I, Teixidó C, Vilariño N, Prat A, Reguart N, Benito A, Garrido P, Barragan I, Emile JF, Rosell R, Brambilla E, Esteller M.

Lancet Respir Med. 2018 Oct;6(10):771-781. doi: 10.1016/S2213-2600(18)30284-4. Epub 2018 Aug 9.


Enhanced Tomographic Assessment to Detect Corneal Ectasia Based on Artificial Intelligence.

Lopes BT, Ramos IC, Salomão MQ, Guerra FP, Schallhorn SC, Schallhorn JM, Vinciguerra R, Vinciguerra P, Price FW Jr, Price MO, Reinstein DZ, Archer TJ, Belin MW, Machado AP, Ambrósio R Jr.

Am J Ophthalmol. 2018 Nov;195:223-232. doi: 10.1016/j.ajo.2018.08.005. Epub 2018 Aug 9.


Genetics and epigenetics of pediatric leukemia in the era of precision medicine.

Ramos KN, Ramos IN, Zeng Y, Ramos KS.

F1000Res. 2018 Jul 18;7. pii: F1000 Faculty Rev-1104. doi: 10.12688/f1000research.14634.1. eCollection 2018. Review.


LRP5 gene polymorphisms and radiographic joint damage in rheumatoid arthritis patients.

Bernardes M, Durães C, Oliveira A, Martins MJ, Lucas R, Costa L, Pereira JG, Ramos I, Machado JC, Simões-Ventura F.

Osteoporos Int. 2018 Oct;29(10):2355-2368. doi: 10.1007/s00198-018-4625-3. Epub 2018 Jul 17.


Radiation exposure in very low birth weight infants.

Pinto F, Rocha G, Flor-De-Lima F, Soares H, Ramos I, Guimarães H.

Minerva Pediatr. 2018 Jul 2. doi: 10.23736/S0026-4946.18.04900-9. [Epub ahead of print]


The combination of compost or biochar with urea and NBPT can improve nitrogen-use efficiency in maize.

Coelho MA, Fusconi R, Pinheiro L, Ramos IC, Ferreira AS.

An Acad Bras Cienc. 2018 Apr-Jun;90(2):1695-1703. doi: 10.1590/0001-3765201820170416.


Yolk accumulation in an insect oocyte.

Ramos I.

Mol Reprod Dev. 2018 Jul;85(7):562. doi: 10.1002/mrd.22997. Epub 2018 Jul 16. No abstract available.


Silencing of RpATG6 impaired the yolk accumulation and the biogenesis of the yolk organelles in the insect vector R. prolixus.

Vieira PH, Bomfim L, Atella GC, Masuda H, Ramos I.

PLoS Negl Trop Dis. 2018 May 16;12(5):e0006507. doi: 10.1371/journal.pntd.0006507. eCollection 2018 May.


Monitoring Crohn's disease activity: endoscopy, fecal markers and computed tomography enterography.

Lopes S, Andrade P, Afonso J, Cunha R, Rodrigues-Pinto E, Ramos I, Macedo G, Magro F.

Therap Adv Gastroenterol. 2018 Apr 19;11:1756284818769075. doi: 10.1177/1756284818769075. eCollection 2018.


Validation of analytical method for rhynchophorol quantification and stability in inorganic matrix for the controlled release of this pheromone.

Viana AC, Ramos IG, Dos Santos EL, Mascarenhas AJS, Lima MDS, Sant'Ana AEG, Druzian JI.

Chem Cent J. 2018 May 10;12(1):54. doi: 10.1186/s13065-018-0426-1.


Brucella vertebral osteomyelitis misidentified as an Ochrobactrum anthropi infection.

Trêpa J, Mendes P, Gonçalves R, Chaves C, Brás AM, Mesa A, Ramos I, Sá R, da Cunha JGS.

IDCases. 2018 Feb 1;11:74-76. doi: 10.1016/j.idcr.2018.01.010. eCollection 2018.


Prenatal and Postnatal Mother-to-Child Transmission of Acculturation's Health Effects in Hispanic Americans.

Fox M, Thayer ZM, Ramos IF, Meskal SJ, Wadhwa PD.

J Womens Health (Larchmt). 2018 Aug;27(8):1054-1063. doi: 10.1089/jwh.2017.6526. Epub 2018 Apr 2.


Congestive cirrhosis in Osler-Weber-Rendu syndrome: A rare case report.

Leitão P, Carvalho A, Guerra C, Gonçalves J, Ramos I.

Radiol Case Rep. 2017 Nov 6;13(1):51-54. doi: 10.1016/j.radcr.2017.10.011. eCollection 2018 Feb.


Is Low-Dose Radiation Exposure a Risk Factor for Atherosclerotic Disease?

Boaventura P, Durães C, Mendes A, Costa NR, Chora I, Ferreira S, Araújo E, Lopes P, Rosa G, Marques P, Tavares S, Chaves V, Bettencourt P, Oliveira I, Costa F, Ramos I, Teles MJ, Guimarães JT, Sobrinho-Simões M, Soares P.

Radiat Res. 2018 Apr;189(4):418-424. doi: 10.1667/RR14942.1. Epub 2018 Feb 20.


Embryonic stem cell-derived cardiomyocytes for the treatment of doxorubicin-induced cardiomyopathy.

Silva Dos Santos D, Brasil GV, Ramos IPR, Mesquita FCP, Kasai-Brunswick TH, Christie MLA, Cahli GM, Barbosa RAQ, da Cunha ST, Pereira JX, Medei E, Campos de Carvalho AC, Carvalho AB, Goldenberg RCDS.

Stem Cell Res Ther. 2018 Feb 5;9(1):30. doi: 10.1186/s13287-018-0788-2.


Effects of nerve stimulation on amphibian oviductal activity.

Cisint S, Fernández SN, Crespo CA, Villagra LI, Ramos I.

Micron. 2018 Apr;107:9-19. doi: 10.1016/j.micron.2018.01.005. Epub 2018 Jan 10.


Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease.

Gaspar L, Coron RP, KongThoo Lin P, Costa DM, Perez-Cabezas B, Tavares J, Roura-Ferrer M, Ramos I, Ronin C, Major LL, Ciesielski F, Pemberton IK, MacDougall J, Ciapetti P, Smith TK, Cordeiro-da-Silva A.

PLoS Negl Trop Dis. 2018 Jan 22;12(1):e0006180. doi: 10.1371/journal.pntd.0006180. eCollection 2018 Jan.


Applicability of FLOTAC® technique in recovering equine strongyle larvae in the pasture: A comparison study.

Ramos ICDN, Ramos RADN, Lima VFS, Giannelli A, López IYT, Alves LC.

Vet Parasitol. 2018 Jan 30;250:68-70. doi: 10.1016/j.vetpar.2017.12.014. Epub 2017 Dec 19.


LINE-1 couples EMT programming with acquisition of oncogenic phenotypes in human bronchial epithelial cells.

Reyes-Reyes EM, Aispuro I, Tavera-Garcia MA, Field M, Moore S, Ramos I, Ramos KS.

Oncotarget. 2017 Oct 23;8(61):103828-103842. doi: 10.18632/oncotarget.21953. eCollection 2017 Nov 28.


Cost Effectiveness of the Angiotensin Receptor Neprilysin Inhibitor Sacubitril/Valsartan for Patients with Chronic Heart Failure and Reduced Ejection Fraction in the Netherlands: A Country Adaptation Analysis Under the Former and Current Dutch Pharmacoeconomic Guidelines.

Ramos IC, Versteegh MM, de Boer RA, Koenders JMA, Linssen GCM, Meeder JG, Rutten-van Mölken MPMH.

Value Health. 2017 Dec;20(10):1260-1269. doi: 10.1016/j.jval.2017.05.013. Epub 2017 Jun 20.


A study of hormonal effects in cervical smear samples using Raman spectroscopy.

Traynor D, Kearney P, Ramos I, Martin CM, O'Leary JJ, Lyng FM.

J Biophotonics. 2018 Jun;11(6):e201700240. doi: 10.1002/jbio.201700240. Epub 2018 Jan 17.


Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death.

Hartmann BM, Albrecht RA, Zaslavsky E, Nudelman G, Pincas H, Marjanovic N, Schotsaert M, Martínez-Romero C, Fenutria R, Ingram JP, Ramos I, Fernandez-Sesma A, Balachandran S, García-Sastre A, Sealfon SC.

Nat Commun. 2017 Dec 5;8(1):1931. doi: 10.1038/s41467-017-02035-9.


Abediterol (LAS100977), an inhaled long-acting β2-adrenoceptor agonist, has a fast association rate and long residence time at receptor.

Ramos I, Aparici M, Letosa M, Puig C, Gavaldà A, Huerta JM, Espinosa S, Vilella D, Miralpeix M.

Eur J Pharmacol. 2018 Jan 15;819:89-97. doi: 10.1016/j.ejphar.2017.11.043. Epub 2017 Nov 26.


Electron microscopy observations on testis and spermatozoa of Leptodactylus chaquensis (Anura, Leptodactylidae).

Iruzubieta Villagra L, Ramos I, Cisint S, Crespo CA, Fernández SN.

Micron. 2018 Feb;105:35-46. doi: 10.1016/j.micron.2017.11.007. Epub 2017 Nov 21.


TLR4 and NLRP3 Caspase 1- IL-1β- Axis are not Involved in Colon Ascendens Stent Peritonitis (Casp)-Associated Heart Disease.

Alarcón MML, Ruocco JF, Ferreira F, Paula-Neto HA, Sepúlveda M, Petroff MV, Carvalho AB, Ramos IP, Branda HJ, Paiva CN, Medei E.

Shock. 2017 Nov 15. doi: 10.1097/SHK.0000000000001059. [Epub ahead of print]


Improved segmented modified Look-Locker inversion recovery T1 mapping sequence in mice.

Nezafat M, Ramos IT, Henningsson M, Protti A, Basha T, Botnar RM.

PLoS One. 2017 Nov 9;12(11):e0187621. doi: 10.1371/journal.pone.0187621. eCollection 2017.


Faecal immunochemical tests (FIT) can help to rule out colorectal cancer in patients presenting in primary care with lower abdominal symptoms: a systematic review conducted to inform new NICE DG30 diagnostic guidance.

Westwood M, Lang S, Armstrong N, van Turenhout S, Cubiella J, Stirk L, Ramos IC, Luyendijk M, Zaim R, Kleijnen J, Fraser CG.

BMC Med. 2017 Oct 24;15(1):189. doi: 10.1186/s12916-017-0944-z. Review.


Eggshell ultrastructure and delivery of pharmacological inhibitors to the early embryo of R. prolixus by ethanol permeabilization of the extraembryonic layers.

Bomfim L, Vieira P, Fonseca A, Ramos I.

PLoS One. 2017 Sep 29;12(9):e0185770. doi: 10.1371/journal.pone.0185770. eCollection 2017.


Micro-bead injection spectroscopy for label-free automated determination of immunoglobulin G in human serum.

Ramos II, Magalhães LM, Barreiros L, Reis S, Lima JLFC, Segundo MA.

Anal Bioanal Chem. 2018 Jan;410(3):981-988. doi: 10.1007/s00216-017-0601-6. Epub 2017 Sep 9.


Diethylcarbamazine: A potential treatment drug for pulmonary hypertension?

Ribeiro EL, Fragoso IT, Gomes FODS, Oliveira AC, Silva AKSE, Silva PME, Ciambarella BT, Ramos IPR, Peixoto CA.

Toxicol Appl Pharmacol. 2017 Oct 15;333:92-99. doi: 10.1016/j.taap.2017.08.015. Epub 2017 Aug 26.


Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei and appendix tumours in elderly patients: Is it justified?

López-López V, Cascales-Campos PA, Gil E, Arevalo J, Gonzalez A, Gil J, Muñoz-Casares FC, Melero JT, Barrios P, Morales R, Ramos I, Ortega G, Camps B, González-Bayón L, Bretcha-Boix P, Farré-Alegre J, González-Moreno S, Parrilla P.

Clin Transl Oncol. 2017 Nov;19(11):1388-1392. doi: 10.1007/s12094-017-1728-9. Epub 2017 Aug 10.


A Quadrupole Dalton-based multi-attribute method for product characterization, process development, and quality control of therapeutic proteins.

Xu W, Jimenez RB, Mowery R, Luo H, Cao M, Agarwal N, Ramos I, Wang X, Wang J.

MAbs. 2017 Oct;9(7):1186-1196. doi: 10.1080/19420862.2017.1364326. Epub 2017 Aug 14.


Spotlight on ramucirumab in the treatment of nonsmall cell lung cancer: design, development, and clinical activity.

Cobo M, Gutiérrez V, Villatoro R, Trigo JM, Ramos I, López O, Ruiz M, Godoy A, López I, Arroyo M.

Lung Cancer (Auckl). 2017 Jul 12;8:57-66. doi: 10.2147/LCTT.S118996. eCollection 2017. Review.


Pharmacological preclinical characterization of LAS190792, a novel inhaled bifunctional muscarinic receptor antagonist /β2-adrenoceptor agonist (MABA) molecule.

Aparici M, Carcasona C, Ramos I, Montero JL, Ortiz JL, Cortijo J, Puig C, Vilella D, Doe C, Gavaldà A, Miralpeix M.

Pulm Pharmacol Ther. 2017 Oct;46:1-10. doi: 10.1016/j.pupt.2017.07.003. Epub 2017 Jul 17.


High-dimensional CyTOF analysis of dengue virus-infected human DCs reveals distinct viral signatures.

Hamlin RE, Rahman A, Pak TR, Maringer K, Mena I, Bernal-Rubio D, Potla U, Maestre AM, Fredericks AC, Amir ED, Kasarskis A, Ramos I, Merad M, Fernandez-Sesma A.

JCI Insight. 2017 Jul 6;2(13). pii: 92424. doi: 10.1172/jci.insight.92424. [Epub ahead of print]


Hepatic microvascular dysfunction and increased advanced glycation end products are components of non-alcoholic fatty liver disease.

Pereira ENGDS, Silvares RR, Flores EEI, Rodrigues KL, Ramos IP, da Silva IJ, Machado MP, Miranda RA, Pazos-Moura CC, Gonçalves-de-Albuquerque CF, Faria-Neto HCC, Tibiriça E, Daliry A.

PLoS One. 2017 Jun 19;12(6):e0179654. doi: 10.1371/journal.pone.0179654. eCollection 2017.


Safety of Allogeneic Canine Adipose Tissue-Derived Mesenchymal Stem Cell Intraspinal Transplantation in Dogs with Chronic Spinal Cord Injury.

Escalhão CCM, Ramos IP, Hochman-Mendez C, Brunswick THK, Souza SAL, Gutfilen B, Dos Santos Goldenberg RC, Coelho-Sampaio T.

Stem Cells Int. 2017;2017:3053759. doi: 10.1155/2017/3053759. Epub 2017 May 15.


Chiral Derivatives of Xanthones: Investigation of the Effect of Enantioselectivity on Inhibition of Cyclooxygenases (COX-1 and COX-2) and Binding Interaction with Human Serum Albumin.

Fernandes C, Palmeira A, Ramos II, Carneiro C, Afonso C, Tiritan ME, Cidade H, Pinto PCAG, Saraiva MLMFS, Reis S, Pinto MMM.

Pharmaceuticals (Basel). 2017 May 31;10(2). pii: E50. doi: 10.3390/ph10020050.


Miliary tuberculosis with cerebral, liver, prostate and retroesophageal involvement.

Goncalves R, Lopes P, Mendes P, Trêpa J, Rua J, Sá R, Ramos I, da Cunha JS.

IDCases. 2017 Apr 25;9:25-27. doi: 10.1016/j.idcr.2017.03.011. eCollection 2017.


Physico-chemical properties, rheology and degree of esterification of passion fruit (Passiflora edulis f. flavicarpa) peel flour.

Coelho EM, de Azevêdo LC, Viana AC, Ramos IG, Gomes RG, Lima MDS, Umsza-Guez MA.

J Sci Food Agric. 2018 Jan;98(1):166-173. doi: 10.1002/jsfa.8451. Epub 2017 Aug 4.


Radiotherapy-Induced Skin Reactions Induce Fibrosis Mediated by TGF-β1 Cytokine.

de Andrade CBV, Ramos IPR, de Moraes ACN, do Nascimento ALR, Salata C, Goldenberg RCDS, de Carvalho JJ, de Almeida CEV.

Dose Response. 2017 Apr 28;15(2):1559325817705019. doi: 10.1177/1559325817705019. eCollection 2017 Apr-Jun.


Computer-assisted cognitive remediation therapy in schizophrenia: Durability of the effects and cost-utility analysis.

Garrido G, Penadés R, Barrios M, Aragay N, Ramos I, Vallès V, Faixa C, Vendrell JM.

Psychiatry Res. 2017 Aug;254:198-204. doi: 10.1016/j.psychres.2017.04.065. Epub 2017 Apr 27.


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