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Items: 33

1.

Selectfluor as a nucleofuge in the reactions of azabicyclo[n.2.1]alkane beta-halocarbamic acid esters (n = 2,3).

Krow GR, Gandla D, Guo W, Centafont RA, Lin G, Debrosse C, Sonnet PE, Ross CW III, Ramjit HG, Cannon KC.

J Org Chem. 2008 Mar 21;73(6):2122-9. doi: 10.1021/jo702155v. Epub 2008 Feb 22.

PMID:
18290657
2.

Neighboring group participation in the additions of iodonium and bromonium ions to N-alkoxycarbonyl-2-azabicyclo[2.2.n]alk-5-enes (n = 1,2).

Krow GR, Gandla D, Guo W, Centafont RA, Lin G, DeBrosse C, Sonnet PE, Ross CW III, Ramjit HG, Carroll PJ, Cannon KC.

J Org Chem. 2008 Mar 21;73(6):2114-21. doi: 10.1021/jo702153q. Epub 2008 Feb 22.

PMID:
18290656
3.
4.

Acetonitrile/water gas-phase reaction products observed by use of atmospheric pressure chemical ionization: adducts formed with sulfonamides.

Ross CW 3rd, Coddington AB, Murphy JS, Wisnoski DD, Zartman CB, Ramjit HG.

Rapid Commun Mass Spectrom. 2005;19(5):667-73.

PMID:
15700234
5.

Novel selectfluor and deoxo-fluor-mediated rearrangements. New 5(6)-methyl and phenyl methanopyrrolidine alcohols and fluorides.

Krow GR, Lin G, Moore KP, Thomas AM, DeBrosse C, Ross CW 3rd, Ramjit HG.

Org Lett. 2004 May 13;6(10):1669-72.

PMID:
15128263
6.

The synthesis of a prodrug of doxorubicin designed to provide reduced systemic toxicity and greater target efficacy.

Garsky VM, Lumma PK, Feng DM, Wai J, Ramjit HG, Sardana MK, Oliff A, Jones RE, DeFeo-Jones D, Freidinger RM.

J Med Chem. 2001 Nov 22;44(24):4216-24.

PMID:
11708923
8.

In vitro and in vivo studies on the metabolism of tirofiban.

Vickers S, Theoharides AD, Arison B, Balani SK, Cui D, Duncan CA, Ellis JD, Gorham LM, Polsky SL, Prueksaritanont T, Ramjit HG, Slaughter DE, Vyas KP.

Drug Metab Dispos. 1999 Nov;27(11):1360-6.

PMID:
10534322
9.

Antibacterial activity of lonchocarpol A.

Salvatore MJ, King AB, Graham AC, Onishi HR, Bartizal KF, Abruzzo GK, Gill CJ, Ramjit HG, Pitzenberger SM, Witherup KM.

J Nat Prod. 1998 May;61(5):640-2.

PMID:
9599265
10.

Discovery and development of the novel potent orally active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): coapplication of structure-based design and rapid multiple analogue synthesis on solid support.

Brady SF, Stauffer KJ, Lumma WC, Smith GM, Ramjit HG, Lewis SD, Lucas BJ, Gardell SJ, Lyle EA, Appleby SD, Cook JJ, Holahan MA, Stranieri MT, Lynch JJ Jr, Lin JH, Chen IW, Vastag K, Naylor-Olsen AM, Vacca JP.

J Med Chem. 1998 Jan 29;41(3):401-6.

PMID:
9464370
11.

Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position.

Feng DM, Gardell SJ, Lewis SD, Bock MG, Chen Z, Freidinger RM, Naylor-Olsen AM, Ramjit HG, Woltmann R, Baskin EP, Lynch JJ, Lucas R, Shafer JA, Dancheck KB, Chen IW, Mao SS, Krueger JA, Hare TR, Mulichak AM, Vacca JP.

J Med Chem. 1997 Nov 7;40(23):3726-33.

PMID:
9371237
13.

Metabolism of L-689,502 by rat liver slices to potent HIV-1 protease inhibitors.

Balani SK, Pitzenberger SM, Schwartz MS, Ramjit HG, Thompson WJ.

Drug Metab Dispos. 1995 Feb;23(2):185-9.

PMID:
7736909
14.

Hepatic metabolism of spironolactone. Production of 3-hydroxy-thiomethyl metabolites.

Los LE, Pitzenberger SM, Ramjit HG, Coddington AB, Colby HD.

Drug Metab Dispos. 1994 Nov-Dec;22(6):903-8.

PMID:
7895608
15.

Metabolism of 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2 (1H)-one (L-696,229), an HIV-1 reverse transcriptase inhibitor, by rat liver slices and in humans.

Balani SK, Kauffman LR, Arison BH, Olah TV, Goldman ME, Varga SL, O'Brien JA, Ramjit HG, Rooney CS, Hoffman JM, et al.

Drug Metab Dispos. 1994 Mar-Apr;22(2):200-5.

PMID:
7516852
16.

Identification of spironolactone metabolites in plasma and target organs of guinea pigs.

Los LE, Coddington AB, Ramjit HG, Colby HD.

Drug Metab Dispos. 1993 Nov-Dec;21(6):1086-90.

PMID:
7905388
17.

Biotransformation of 5-chloro-3-phenylthioindole-2-carboxamide (L-734,005) in rhesus monkeys and rat liver microsomes to a potent HIV-1 reverse transcriptase inhibitor.

Balani SK, Goldman ME, Kauffman LR, Varga SL, O'Brien JA, Smith SJ, Olah TV, Ramjit HG, Schorn TW, Pitzenberger SM, et al.

Drug Metab Dispos. 1993 Jul-Aug;21(4):598-604.

PMID:
7690697
18.

Determination of the HMG-CoA reductase inhibitors simvastatin, lovastatin, and pravastatin in plasma by gas chromatography/chemical ionization mass spectrometry.

Morris MJ, Gilbert JD, Hsieh JY, Matuszewski BK, Ramjit HG, Bayne WF.

Biol Mass Spectrom. 1993 Jan;22(1):1-8.

PMID:
8431499
19.

Metabolism of a new HIV-1 reverse transcriptase inhibitor, 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one (L-696,229), in rat and liver slices.

Balani SK, Pitzenberger SM, Kauffman LR, Arison BH, Ramjit HG, Goldman ME, O'Brien JA, King JD, Hoffman JM, Rooney CS, et al.

Drug Metab Dispos. 1992 Nov-Dec;20(6):869-76.

PMID:
1283569
20.

Physiological disposition and metabolism of L-365,260, a potent antagonist of brain cholecystokinin receptor, in laboratory animals.

Chen IW, Dorley JM, Ramjit HG, Pitzenberger SM, Lin JH.

Drug Metab Dispos. 1992 May-Jun;20(3):390-5.

PMID:
1355713
21.

Large-scale purification and characterization of recombinant tick anticoagulant peptide.

Lehman ED, Schaefer TF, Przysiecki CT, Joyce JG, Bailey FJ, Schulman CA, Burke CJ, Ramjit HG, Miller WJ.

J Chromatogr. 1992 Feb 14;574(2):225-35.

PMID:
1618954
22.

Determination of mevalonolactone in capsules by capillary gas-liquid chromatography.

Lindemann CJ, Singh MM, Ramjit HG, Bell C, Ip DP.

J Pharm Biomed Anal. 1991;9(4):311-6.

PMID:
1911983
23.

Metabolism of antiparkinson agent dopazinol by rat liver microsomes.

Vyas KP, Kari PH, Ramjit HG, Pitzenberger SM, Hichens M.

Drug Metab Dispos. 1990 Nov-Dec;18(6):1025-30.

PMID:
1981508
24.

In vitro and in vivo biotransformation of simvastatin, an inhibitor of HMG CoA reductase.

Vickers S, Duncan CA, Vyas KP, Kari PH, Arison B, Prakash SR, Ramjit HG, Pitzenberger SM, Stokker G, Duggan DE.

Drug Metab Dispos. 1990 Jul-Aug;18(4):476-83.

PMID:
1976071
25.

Biotransformation of lovastatin. I. Structure elucidation of in vitro and in vivo metabolites in the rat and mouse.

Vyas KP, Kari PH, Pitzenberger SM, Halpin RA, Ramjit HG, Arison B, Murphy JS, Hoffman WF, Schwartz MS, Ulm EH, et al.

Drug Metab Dispos. 1990 Mar-Apr;18(2):203-11.

PMID:
1971574
26.

Origin of monacolin L from Aspergillus terreus cultures.

Treiber LR, Reamer RA, Rooney CS, Ramjit HG.

J Antibiot (Tokyo). 1989 Jan;42(1):30-6.

27.
28.

Disposition and metabolism of sodium 4-[(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)sulfonyl]-gamma -oxobenzenebutanoate in rats and dogs.

Tocco DJ, deLuna FA, Duncan AE, Ramjit HG, Pitzenberger SM, Hsieh JY.

Drug Metab Dispos. 1988 Sep-Oct;16(5):690-6.

PMID:
2906591
29.

Occurrence of beta-hydroxylated asparagine residues in non-vitamin K-dependent proteins containing epidermal growth factor-like domains.

Przysiecki CT, Staggers JE, Ramjit HG, Musson DG, Stern AM, Bennett CD, Friedman PA.

Proc Natl Acad Sci U S A. 1987 Nov;84(22):7856-60.

30.

Carnitine and glucuronic acid conjugates of pivalic acid.

Vickers S, Duncan CA, White SD, Ramjit HG, Smith JL, Walker RW, Flynn H, Arison BH.

Xenobiotica. 1985 Jun;15(6):453-8.

PMID:
4036169
31.
32.

Metabolism of methyldopa in man after oral administration of the pivaloyloxyethyl ester.

Vickers S, Duncan CA, Ramjit HG, Dobrinska MR, Dollery CT, Gomez HJ, Leidy HL, Vincek WC.

Drug Metab Dispos. 1984 Mar-Apr;12(2):242-6.

PMID:
6144491
33.

Metabolism of the TRH analog L-pyro-2-aminoadipyl-L-histidyl-[3H]-L-thiazolidine-4-carboxamide (MK-771) in gut and brain tissue of rats: the implications for its bioavailability.

Vickers S, Duncan CA, Arison BH, Ramjit HG, Rosegay A, Nutt RF, Veber DF.

Drug Metab Dispos. 1983 Mar-Apr;11(2):147-51.

PMID:
6133720

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