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Items: 43

1.

Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway.

Ando K, Shah AK, Sachdev V, Kleinstiver BP, Taylor-Parker J, Welch MM, Hu Y, Salgia R, White FM, Parvin JD, Ozonoff A, Rameh LE, Joung JK, Bharti AK.

Oncotarget. 2017 Jul 4;8(27):43733-43751. doi: 10.18632/oncotarget.16376.

2.

IQGAP1 makes PI(3)K signalling as easy as PIP, PIP2, PIP3.

Rameh LE, Mackey AM.

Nat Cell Biol. 2016 Nov 29;18(12):1263-1265. doi: 10.1038/ncb3440.

PMID:
27897158
3.

Phosphoinositide signalling in type 2 diabetes: a β-cell perspective.

Rameh LE, Deeney JT.

Biochem Soc Trans. 2016 Feb;44(1):293-8. doi: 10.1042/BST20150229. Review.

PMID:
26862218
4.

Analysis of the Phosphoinositide Composition of Subcellular Membrane Fractions.

Sarkes DA, Rameh LE.

Methods Mol Biol. 2016;1376:213-27. doi: 10.1007/978-1-4939-3170-5_18.

PMID:
26552687
5.

PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K?

Toker A, Rameh L.

Cancer Cell. 2015 Aug 10;28(2):143-5. doi: 10.1016/j.ccell.2015.07.010.

6.

PIP4kγ is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation.

Mackey AM, Sarkes DA, Bettencourt I, Asara JM, Rameh LE.

Sci Signal. 2014 Nov 4;7(350):ra104. doi: 10.1126/scisignal.2005191.

7.

Targeting Plasmodium PI(4)K to eliminate malaria.

McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ, Zeeman AM, Dechering KJ, Kumar TS, Henrich PP, Gagaring K, Ibanez M, Kato N, Kuhen KL, Fischli C, Nagle A, Rottmann M, Plouffe DM, Bursulaya B, Meister S, Rameh L, Trappe J, Haasen D, Timmerman M, Sauerwein RW, Suwanarusk R, Russell B, Renia L, Nosten F, Tully DC, Kocken CH, Glynne RJ, Bodenreider C, Fidock DA, Diagana TT, Winzeler EA.

Nature. 2013 Dec 12;504(7479):248-253. doi: 10.1038/nature12782. Epub 2013 Nov 27.

8.

Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.

Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC.

Cell. 2013 Nov 7;155(4):844-57. doi: 10.1016/j.cell.2013.09.057.

9.

AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve.

Er EE, Mendoza MC, Mackey AM, Rameh LE, Blenis J.

Sci Signal. 2013 Jun 11;6(279):ra45. doi: 10.1126/scisignal.2004015.

10.

Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration.

Oppelt A, Lobert VH, Haglund K, Mackey AM, Rameh LE, Liestøl K, Schink KO, Pedersen NM, Wenzel EM, Haugsten EM, Brech A, Rusten TE, Stenmark H, Wesche J.

EMBO Rep. 2013 Jan;14(1):57-64. doi: 10.1038/embor.2012.183. Epub 2012 Nov 16.

11.

Systemic elevation of PTEN induces a tumor-suppressive metabolic state.

Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP.

Cell. 2012 Mar 30;149(1):49-62. doi: 10.1016/j.cell.2012.02.030. Epub 2012 Mar 6.

12.

SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages.

Berger SB, Romero X, Ma C, Wang G, Faubion WA, Liao G, Compeer E, Keszei M, Rameh L, Wang N, Boes M, Regueiro JR, Reinecker HC, Terhorst C.

Nat Immunol. 2010 Oct;11(10):920-7. doi: 10.1038/ni.1931. Epub 2010 Sep 5.

13.

Negative regulation of Vps34 by Cdk mediated phosphorylation.

Furuya T, Kim M, Lipinski M, Li J, Kim D, Lu T, Shen Y, Rameh L, Yankner B, Tsai LH, Yuan J.

Mol Cell. 2010 May 28;38(4):500-11. doi: 10.1016/j.molcel.2010.05.009.

14.

Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation.

Poliseno L, Salmena L, Riccardi L, Fornari A, Song MS, Hobbs RM, Sportoletti P, Varmeh S, Egia A, Fedele G, Rameh L, Loda M, Pandolfi PP.

Sci Signal. 2010 Apr 13;3(117):ra29. doi: 10.1126/scisignal.2000594. Erratum in: Sci Signal. 2010;3(123):er6.

15.
16.

Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling.

Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC.

Cancer Cell. 2009 Aug 4;16(2):115-25. doi: 10.1016/j.ccr.2009.06.006.

17.

High-throughput, cell-free, liposome-based approach for assessing in vitro activity of lipid kinases.

Demian DJ, Clugston SL, Foster MM, Rameh L, Sarkes D, Townson SA, Yang L, Zhang M, Charlton ME.

J Biomol Screen. 2009 Aug;14(7):838-44. doi: 10.1177/1087057109339205. Epub 2009 Jul 29.

PMID:
19641220
18.

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.

Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, Gupta PB, Boehm JS, Reiling JH, Silver S, Lu Y, Stemke-Hale K, Dutta B, Joy C, Sahin AA, Gonzalez-Angulo AM, Lluch A, Rameh LE, Jacks T, Root DE, Lander ES, Mills GB, Hahn WC, Sellers WR, Garraway LA.

Cancer Cell. 2009 Jul 7;16(1):21-32. doi: 10.1016/j.ccr.2009.04.012.

19.

SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34.

Mallo GV, Espina M, Smith AC, Terebiznik MR, Alemán A, Finlay BB, Rameh LE, Grinstein S, Brumell JH.

J Cell Biol. 2008 Aug 25;182(4):741-52. doi: 10.1083/jcb.200804131.

20.

Serum withdrawal-induced accumulation of phosphoinositide 3-kinase lipids in differentiating 3T3-L6 myoblasts: distinct roles for Ship2 and PTEN.

Mandl A, Sarkes D, Carricaburu V, Jung V, Rameh L.

Mol Cell Biol. 2007 Dec;27(23):8098-112. Epub 2007 Sep 24.

21.

Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase.

Mason D, Mallo GV, Terebiznik MR, Payrastre B, Finlay BB, Brumell JH, Rameh L, Grinstein S.

J Gen Physiol. 2007 Apr;129(4):267-83.

22.

A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast.

Mitra P, Zhang Y, Rameh LE, Ivshina MP, McCollum D, Nunnari JJ, Hendricks GM, Kerr ML, Field SJ, Cantley LC, Ross AH.

J Cell Biol. 2004 Jul 19;166(2):205-11. Epub 2004 Jul 12.

23.

Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice.

Lamia KA, Peroni OD, Kim YB, Rameh LE, Kahn BB, Cantley LC.

Mol Cell Biol. 2004 Jun;24(11):5080-7.

24.

Diarrhea-associated HIV-1 APIs potentiate muscarinic activation of Cl- secretion by T84 cells via prolongation of cytosolic Ca2+ signaling.

Rufo PA, Lin PW, Andrade A, Jiang L, Rameh L, Flexner C, Alper SL, Lencer WI.

Am J Physiol Cell Physiol. 2004 May;286(5):C998-C1008. Epub 2003 Dec 30.

25.

Identification and characterization of a phosphoinositide phosphate kinase homolog.

Chang JD, Field SJ, Rameh LE, Carpenter CL, Cantley LC.

J Biol Chem. 2004 Mar 19;279(12):11672-9. Epub 2003 Dec 30.

26.

The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation.

Carricaburu V, Lamia KA, Lo E, Favereaux L, Payrastre B, Cantley LC, Rameh LE.

Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9867-72. Epub 2003 Aug 1.

27.

Lipid research picks up speed on the slopes of Taos.

Field SJ, Lamia KA, Rameh LE, Cantley LC.

Dev Cell. 2002 Apr;2(4):407-10.

28.

Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation.

Vieira OV, Botelho RJ, Rameh L, Brachmann SM, Matsuo T, Davidson HW, Schreiber A, Backer JM, Cantley LC, Grinstein S.

J Cell Biol. 2001 Oct 1;155(1):19-25.

29.

Phosphoinositide binding domains: embracing 3-phosphate.

Fruman DA, Rameh LE, Cantley LC.

Cell. 1999 Jun 25;97(7):817-20. Review. No abstract available.

30.

The role of phosphoinositide 3-kinase lipid products in cell function.

Rameh LE, Cantley LC.

J Biol Chem. 1999 Mar 26;274(13):8347-50. Review. No abstract available.

31.

Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling.

Rameh LE, Rhee SG, Spokes K, Kazlauskas A, Cantley LC, Cantley LG.

J Biol Chem. 1998 Sep 11;273(37):23750-7.

32.

Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate.

Tolias KF, Rameh LE, Ishihara H, Shibasaki Y, Chen J, Prestwich GD, Cantley LC, Carpenter CL.

J Biol Chem. 1998 Jul 17;273(29):18040-6.

33.

Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate.

Klarlund JK, Rameh LE, Cantley LC, Buxton JM, Holik JJ, Sakelis C, Patki V, Corvera S, Czech MP.

J Biol Chem. 1998 Jan 23;273(4):1859-62.

34.

A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.

Rameh LE, Tolias KF, Duckworth BC, Cantley LC.

Nature. 1997 Nov 13;390(6656):192-6.

PMID:
9367159
35.

A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains.

Rameh LE, Arvidsson Ak, Carraway KL 3rd, Couvillon AD, Rathbun G, Crompton A, VanRenterghem B, Czech MP, Ravichandran KS, Burakoff SJ, Wang DS, Chen CS, Cantley LC.

J Biol Chem. 1997 Aug 29;272(35):22059-66.

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40.

Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression.

Jhun BH, Rose DW, Seely BL, Rameh L, Cantley L, Saltiel AR, Olefsky JM.

Mol Cell Biol. 1994 Nov;14(11):7466-75.

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43.

Generation of cell lines to study the role played by oncogenes and anti-oncogenes in cell proliferation control.

Costanzi E, Rameh LE, Joazeiro CA, Armelin MC.

Braz J Med Biol Res. 1990;23(9):795-9.

PMID:
2101319

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