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Self-Assembly, Antimicrobial Activity, and Membrane Interactions of Arginine-Capped Peptide Bola-Amphiphiles.

Edwards-Gayle CJC, Castelletto V, Hamley IW, Barrett G, Greco F, Hermida-Merino D, Rambo RP, Seitsonen J, Ruokolainen J.

ACS Appl Bio Mater. 2019 May 20;2(5):2208-2218. doi: 10.1021/acsabm.9b00172. Epub 2019 Apr 16.


Melanin production by tyrosinase activity on a tyrosine-rich peptide fragment and pH-dependent self-assembly of its lipidated analogue.

Hutchinson JA, Hamley IW, Edwards-Gayle CJC, Castelletto V, Piras C, Cramer R, Kowalczyk R, Seitsonen J, Ruokolainen J, Rambo RP.

Org Biomol Chem. 2019 May 8;17(18):4543-4553. doi: 10.1039/c9ob00550a.


Crystal structure and epitope analysis of house dust mite allergen Der f 21.

Pang SL, Ho KL, Waterman J, Rambo RP, Teh AH, Mathavan I, Harris G, Beis K, Say YH, Anusha MS, Sio YY, Chew FT, Ng CL.

Sci Rep. 2019 Mar 20;9(1):4933. doi: 10.1038/s41598-019-40879-x.


Structural insight into the human mitochondrial tRNA purine N1-methyltransferase and ribonuclease P complexes.

Oerum S, Roovers M, Rambo RP, Kopec J, Bailey HJ, Fitzpatrick F, Newman JA, Newman WG, Amberger A, Zschocke J, Droogmans L, Oppermann U, Yue WW.

J Biol Chem. 2018 Aug 17;293(33):12862-12876. doi: 10.1074/jbc.RA117.001286. Epub 2018 Jun 7.


Arginine-Containing Surfactant-Like Peptides: Interaction with Lipid Membranes and Antimicrobial Activity.

Castelletto V, Barnes RH, Karatzas KA, Edwards-Gayle CJC, Greco F, Hamley IW, Rambo R, Seitsonen J, Ruokolainen J.

Biomacromolecules. 2018 Jul 9;19(7):2782-2794. doi: 10.1021/acs.biomac.8b00391. Epub 2018 May 16.


Considerations for Sample Preparation Using Size-Exclusion Chromatography for Home and Synchrotron Sources.

Rambo RP.

Adv Exp Med Biol. 2017;1009:31-45. doi: 10.1007/978-981-10-6038-0_3.


Self-Assembly of Telechelic Tyrosine End-Capped PEO Star Polymers in Aqueous Solution.

Edwards-Gayle CJC, Greco F, Hamley IW, Rambo RP, Reza M, Ruokolainen J, Skoulas D, Iatrou H.

Biomacromolecules. 2018 Jan 8;19(1):167-177. doi: 10.1021/acs.biomac.7b01420. Epub 2017 Dec 19.


Structural basis of Smoothened regulation by its extracellular domains.

Byrne EFX, Sircar R, Miller PS, Hedger G, Luchetti G, Nachtergaele S, Tully MD, Mydock-McGrane L, Covey DF, Rambo RP, Sansom MSP, Newstead S, Rohatgi R, Siebold C.

Nature. 2016 Jul 28;535(7613):517-522. doi: 10.1038/nature18934. Epub 2016 Jul 20.


Fissure Integrity and Volume Reduction in Emphysema: A Retrospective Study.

de Oliveira HG, de Oliveira SM, Rambo RR, de Macedo Neto AV.

Respiration. 2016;91(6):471-9. doi: 10.1159/000446288. Epub 2016 Jun 1.


Self-Assembly of the Cyclic Lipopeptide Daptomycin: Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride.

Kirkham S, Castelletto V, Hamley IW, Inoue K, Rambo R, Reza M, Ruokolainen J.

Chemphyschem. 2016 Jul 18;17(14):2118-22. doi: 10.1002/cphc.201600308. Epub 2016 Apr 18.


Crystal structure of the RNA-dependent RNA polymerase from influenza C virus.

Hengrung N, El Omari K, Serna Martin I, Vreede FT, Cusack S, Rambo RP, Vonrhein C, Bricogne G, Stuart DI, Grimes JM, Fodor E.

Nature. 2015 Nov 5;527(7576):114-7. doi: 10.1038/nature15525. Epub 2015 Oct 26.


Resolving Individual Components in Protein-RNA Complexes Using Small-Angle X-ray Scattering Experiments.

Rambo RP.

Methods Enzymol. 2015;558:363-390. doi: 10.1016/bs.mie.2015.02.004. Epub 2015 Apr 3.


Structural Characterisation of Non-Deamidated Acidic Variants of Erwinia chrysanthemi L-asparaginase Using Small-Angle X-ray Scattering and Ion-Mobility Mass Spectrometry.

Gervais D, King D, Kanda P, Foote N, Elliott L, Brown P, Lee NO, Thalassinos K, Pizzey C, Rambo R, Minshull TC, Dickman MJ, Smith S.

Pharm Res. 2015 Nov;32(11):3636-48. doi: 10.1007/s11095-015-1722-2. Epub 2015 Jun 4.


Modeling macromolecular motions by x-ray-scattering-constrained molecular dynamics.

Rambo RP, Tainer JA.

Biophys J. 2015 May 19;108(10):2421-2423. doi: 10.1016/j.bpj.2015.04.023. No abstract available.


Methods for using new conceptual tools and parameters to assess RNA structure by small-angle X-ray scattering.

Reyes FE, Schwartz CR, Tainer JA, Rambo RP.

Methods Enzymol. 2014;549:235-63. doi: 10.1016/B978-0-12-801122-5.00011-8.


Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes.

Pratt AJ, Shin DS, Merz GE, Rambo RP, Lancaster WA, Dyer KN, Borbat PP, Poole FL 2nd, Adams MW, Freed JH, Crane BR, Tainer JA, Getzoff ED.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):E4568-76. doi: 10.1073/pnas.1308531111. Epub 2014 Oct 14.


Catalytic asymmetric synthesis of 4-nitropyrazolidines: an access to optically active 1,2,3-triamines.

Lykke L, Carlsen BD, Rambo RS, Jørgensen KA.

J Am Chem Soc. 2014 Aug 13;136(32):11296-9. doi: 10.1021/ja506694v. Epub 2014 Aug 1.


A structure-specific nucleic acid-binding domain conserved among DNA repair proteins.

Mason AC, Rambo RP, Greer B, Pritchett M, Tainer JA, Cortez D, Eichman BF.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7618-23. doi: 10.1073/pnas.1324143111. Epub 2014 May 12.


RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response.

Groocock LM, Nie M, Prudden J, Moiani D, Wang T, Cheltsov A, Rambo RP, Arvai AS, Hitomi C, Tainer JA, Luger K, Perry JJ, Lazzerini-Denchi E, Boddy MN.

EMBO Rep. 2014 May;15(5):601-8. doi: 10.1002/embr.201338369. Epub 2014 Apr 8.


Organocatalytic access to enantioenriched dihydropyran phosphonates via an inverse-electron-demand hetero-Diels-Alder reaction.

Weise CF, Lauridsen VH, Rambo RS, Iversen EH, Olsen ML, Jørgensen KA.

J Org Chem. 2014 Apr 18;79(8):3537-46. doi: 10.1021/jo500347a. Epub 2014 Apr 3.


High-throughput SAXS for the characterization of biomolecules in solution: a practical approach.

Dyer KN, Hammel M, Rambo RP, Tsutakawa SE, Rodic I, Classen S, Tainer JA, Hura GL.

Methods Mol Biol. 2014;1091:245-58. doi: 10.1007/978-1-62703-691-7_18.


Molecular crowding favors reactivity of a human ribozyme under physiological ionic conditions.

Strulson CA, Yennawar NH, Rambo RP, Bevilacqua PC.

Biochemistry. 2013 Nov 19;52(46):8187-97. doi: 10.1021/bi400816s. Epub 2013 Nov 4.


Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing.

Zhao W, Saro D, Hammel M, Kwon Y, Xu Y, Rambo RP, Williams GJ, Chi P, Lu L, Pezza RJ, Camerini-Otero RD, Tainer JA, Wang HW, Sung P.

Nucleic Acids Res. 2014 Jan;42(2):906-17. doi: 10.1093/nar/gkt924. Epub 2013 Oct 22.


Comprehensive macromolecular conformations mapped by quantitative SAXS analyses.

Hura GL, Budworth H, Dyer KN, Rambo RP, Hammel M, McMurray CT, Tainer JA.

Nat Methods. 2013 Jun;10(6):453-4. doi: 10.1038/nmeth.2453. No abstract available.


Accurate assessment of mass, models and resolution by small-angle scattering.

Rambo RP, Tainer JA.

Nature. 2013 Apr 25;496(7446):477-81. doi: 10.1038/nature12070.


Super-resolution in solution X-ray scattering and its applications to structural systems biology.

Rambo RP, Tainer JA.

Annu Rev Biophys. 2013;42:415-41. doi: 10.1146/annurev-biophys-083012-130301. Epub 2013 Mar 11. Review.


Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source.

Classen S, Hura GL, Holton JM, Rambo RP, Rodic I, McGuire PJ, Dyer K, Hammel M, Meigs G, Frankel KA, Tainer JA.

J Appl Crystallogr. 2013 Feb 1;46(Pt 1):1-13. Epub 2013 Jan 17.


A new structural framework for integrating replication protein A into DNA processing machinery.

Brosey CA, Yan C, Tsutakawa SE, Heller WT, Rambo RP, Tainer JA, Ivanov I, Chazin WJ.

Nucleic Acids Res. 2013 Feb 1;41(4):2313-27. doi: 10.1093/nar/gks1332. Epub 2013 Jan 8.


Preparation and characterization of the extracellular domain of human Sid-1.

Pratt AJ, Rambo RP, Lau PW, MacRae IJ.

PLoS One. 2012;7(4):e33607. doi: 10.1371/journal.pone.0033607. Epub 2012 Apr 11.


Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase.

Roberts VA, Pique ME, Hsu S, Li S, Slupphaug G, Rambo RP, Jamison JW, Liu T, Lee JH, Tainer JA, Ten Eyck LF, Woods VL Jr.

Nucleic Acids Res. 2012 Jul;40(13):6070-81. Epub 2012 Apr 6.


SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication.

Bétous R, Mason AC, Rambo RP, Bansbach CE, Badu-Nkansah A, Sirbu BM, Eichman BF, Cortez D.

Genes Dev. 2012 Jan 15;26(2):151-62. doi: 10.1101/gad.178459.111.


Small-angle X-ray scattering studies of the oligomeric state and quaternary structure of the trifunctional proline utilization A (PutA) flavoprotein from Escherichia coli.

Singh RK, Larson JD, Zhu W, Rambo RP, Hura GL, Becker DF, Tanner JJ.

J Biol Chem. 2011 Dec 16;286(50):43144-53. doi: 10.1074/jbc.M111.292474. Epub 2011 Oct 19.


Solution structure of RNase P RNA.

Kazantsev AV, Rambo RP, Karimpour S, Santalucia J Jr, Tainer JA, Pace NR.

RNA. 2011 Jun;17(6):1159-71. doi: 10.1261/rna.2563511. Epub 2011 Apr 29.


Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod-Debye law.

Rambo RP, Tainer JA.

Biopolymers. 2011 Aug;95(8):559-71. doi: 10.1002/bip.21638. Epub 2011 Apr 20.


Achieving fidelity in homologous recombination despite extreme complexity: informed decisions by molecular profiling.

Rambo RP, Williams GJ, Tainer JA.

Mol Cell. 2010 Nov 12;40(3):347-8. doi: 10.1016/j.molcel.2010.10.032.


Free state conformational sampling of the SAM-I riboswitch aptamer domain.

Stoddard CD, Montange RK, Hennelly SP, Rambo RP, Sanbonmatsu KY, Batey RT.

Structure. 2010 Jul 14;18(7):787-97. doi: 10.1016/j.str.2010.04.006.


Multi-domain packing in the aminoacylatable 3' end of a plant viral RNA.

Hammond JA, Rambo RP, Kieft JS.

J Mol Biol. 2010 Jun 11;399(3):450-63. doi: 10.1016/j.jmb.2010.04.016. Epub 2010 Apr 14.


Improving small-angle X-ray scattering data for structural analyses of the RNA world.

Rambo RP, Tainer JA.

RNA. 2010 Mar;16(3):638-46. doi: 10.1261/rna.1946310. Epub 2010 Jan 27.


Bridging the solution divide: comprehensive structural analyses of dynamic RNA, DNA, and protein assemblies by small-angle X-ray scattering.

Rambo RP, Tainer JA.

Curr Opin Struct Biol. 2010 Feb;20(1):128-37. doi: 10.1016/ Epub 2010 Jan 22. Review.


Structural mechanism of abscisic acid binding and signaling by dimeric PYR1.

Nishimura N, Hitomi K, Arvai AS, Rambo RP, Hitomi C, Cutler SR, Schroeder JI, Getzoff ED.

Science. 2009 Dec 4;326(5958):1373-9. doi: 10.1126/science.1181829. Epub 2009 Oct 22.


Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex.

Hammel M, Yu Y, Mahaney BL, Cai B, Ye R, Phipps BM, Rambo RP, Hura GL, Pelikan M, So S, Abolfath RM, Chen DJ, Lees-Miller SP, Tainer JA.

J Biol Chem. 2010 Jan 8;285(2):1414-23. doi: 10.1074/jbc.M109.065615. Epub 2009 Nov 5.


Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS).

Hura GL, Menon AL, Hammel M, Rambo RP, Poole FL 2nd, Tsutakawa SE, Jenney FE Jr, Classen S, Frankel KA, Hopkins RC, Yang SJ, Scott JW, Dillard BD, Adams MW, Tainer JA.

Nat Methods. 2009 Aug;6(8):606-12. doi: 10.1038/nmeth.1353. Epub 2009 Jul 20.


Comparison and functional implications of the 3D architectures of viral tRNA-like structures.

Hammond JA, Rambo RP, Filbin ME, Kieft JS.

RNA. 2009 Feb;15(2):294-307. doi: 10.1261/rna.1360709.


Crystal structure of the lysine riboswitch regulatory mRNA element.

Garst AD, Héroux A, Rambo RP, Batey RT.

J Biol Chem. 2008 Aug 15;283(33):22347-51. doi: 10.1074/jbc.C800120200. Epub 2008 Jul 1.


Structure of the SAM-II riboswitch bound to S-adenosylmethionine.

Gilbert SD, Rambo RP, Van Tyne D, Batey RT.

Nat Struct Mol Biol. 2008 Feb;15(2):177-82. doi: 10.1038/nsmb.1371. Epub 2008 Jan 20.


tRNA-mRNA mimicry drives translation initiation from a viral IRES.

Costantino DA, Pfingsten JS, Rambo RP, Kieft JS.

Nat Struct Mol Biol. 2008 Jan;15(1):57-64. Epub 2007 Dec 23.


A general strategy to solve the phase problem in RNA crystallography.

Keel AY, Rambo RP, Batey RT, Kieft JS.

Structure. 2007 Jul;15(7):761-72.


Assembly of an active group II intron-maturase complex by protein dimerization.

Rambo RP, Doudna JA.

Biochemistry. 2004 Jun 1;43(21):6486-97.


Crystal structure of the ribonucleoprotein core of the signal recognition particle.

Batey RT, Rambo RP, Lucast L, Rha B, Doudna JA.

Science. 2000 Feb 18;287(5456):1232-9.


Tertiary Motifs in RNA Structure and Folding.

Batey RT, Rambo RP, Doudna JA.

Angew Chem Int Ed Engl. 1999 Aug;38(16):2326-2343.


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