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Items: 1 to 50 of 62

1.

Aggregatibacter actinomycetemcomitans colonization and persistence in a primate model.

Velusamy SK, Sampathkumar V, Ramasubbu N, Paster BJ, Fine DH.

Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22307-22313. doi: 10.1073/pnas.1905238116. Epub 2019 Oct 14.

PMID:
31611409
2.

The Role of Exopolysaccharides in Oral Biofilms.

Cugini C, Shanmugam M, Landge N, Ramasubbu N.

J Dent Res. 2019 Jul;98(7):739-745. doi: 10.1177/0022034519845001. Epub 2019 Apr 22.

PMID:
31009580
3.

Utilization of Variant and Fusion Proteins To Functionally Map the Aggregatibacter actinomycetemcomitans Trimeric Autotransporter Protein ApiA.

Cugini C, Mei Y, Furgang D, George N, Ramasubbu N, Fine DH.

Infect Immun. 2018 Feb 20;86(3). pii: e00697-17. doi: 10.1128/IAI.00697-17. Print 2018 Mar.

4.

Dispersion Risk Associated With Surgical Debridement Devices.

Granick M, Rubinsky L, Parthiban C, Shanmugam M, Ramasubbu N.

Wounds. 2017 Oct;29(10):E88-E91.

5.

Role of de-N-acetylase PgaB from Aggregatibacter actinomycetemcomitans in exopolysaccharide export in biofilm mode of growth.

Shanmugam M, Oyeniyi AO, Parthiban C, Gujjarlapudi SK, Pier GB, Ramasubbu N.

Mol Oral Microbiol. 2017 Dec;32(6):500-510. doi: 10.1111/omi.12188. Epub 2017 Jul 3.

6.

Direct-Contact Low-Frequency Ultrasound Clearance of Biofilm From Metallic Implant Materials.

Granick MS, Paribathan C, Shanmugam M, Ramasubbu N.

Eplasty. 2017 Mar 29;17:e13. eCollection 2017.

7.

Complete Genome Sequence of Aggregatibacter actinomycetemcomitans Strain IDH781.

May AC, Ehrlich RL, Balashov S, Ehrlich GD, Shanmugam M, Fine DH, Ramasubbu N, Mell JC, Cugini C.

Genome Announc. 2016 Nov 10;4(6). pii: e01285-16. doi: 10.1128/genomeA.01285-16.

8.

Structural and functional analysis of de-N-acetylase PgaB from periodontopathogen Aggregatibacter actinomycetemcomitans.

Parthiban C, Varudharasu D, Shanmugam M, Gopal P, Ragunath C, Thomas L, Nitz M, Ramasubbu N.

Mol Oral Microbiol. 2017 Aug;32(4):324-340. doi: 10.1111/omi.12175. Epub 2016 Nov 24.

PMID:
27706922
9.

Surface display of Aggregatibacter actinomycetemcomitans autotransporter Aae and dispersin B hybrid act as antibiofilm agents.

Ragunath C, DiFranco K, Shanmugam M, Gopal P, Vyas V, Fine DH, Cugini C, Ramasubbu N.

Mol Oral Microbiol. 2016 Aug;31(4):329-39. doi: 10.1111/omi.12126. Epub 2015 Sep 22.

10.

Transcriptome Profiling of Wild-Type and pga-Knockout Mutant Strains Reveal the Role of Exopolysaccharide in Aggregatibacter actinomycetemcomitans.

Shanmugam M, El Abbar F, Ramasubbu N.

PLoS One. 2015 Jul 29;10(7):e0134285. doi: 10.1371/journal.pone.0134285. eCollection 2015.

11.

Structure of amylase-binding protein A of Streptococcus gordonii: a potential receptor for human salivary α-amylase enzyme.

Sethi A, Mohanty B, Ramasubbu N, Gooley PR.

Protein Sci. 2015 Jun;24(6):1013-8. doi: 10.1002/pro.2671. Epub 2015 Apr 2.

12.

Role of exopolysaccharide in Aggregatibacter actinomycetemcomitans-induced bone resorption in a rat model for periodontal disease.

Shanmugam M, Gopal P, El Abbar F, Schreiner HC, Kaplan JB, Fine DH, Ramasubbu N.

PLoS One. 2015 Feb 23;10(2):e0117487. doi: 10.1371/journal.pone.0117487. eCollection 2015.

13.

Synthesis of β-(1→6)-linked N-acetyl-D-glucosamine oligosaccharide substrates and their hydrolysis by Dispersin B.

Fekete A, Borbás A, Gyémánt G, Kandra L, Fazekas E, Ramasubbu N, Antus S.

Carbohydr Res. 2011 Sep 6;346(12):1445-53. doi: 10.1016/j.carres.2011.03.029. Epub 2011 Mar 23.

14.

Modeling and biochemical analysis of the activity of antibiofilm agent Dispersin B.

Kerrigan JE, Ragunath C, Kandra L, Gyémánt G, Lipták A, Jánossy L, Kaplan JB, Ramasubbu N.

Acta Biol Hung. 2008 Dec;59(4):439-51. doi: 10.1556/ABiol.59.2008.4.5.

15.

Evidence for pentagalloyl glucose binding to human salivary alpha-amylase through aromatic amino acid residues.

Gyémánt G, Zajácz A, Bécsi B, Ragunath C, Ramasubbu N, Erdodi F, Batta G, Kandra L.

Biochim Biophys Acta. 2009 Feb;1794(2):291-6. doi: 10.1016/j.bbapap.2008.10.012. Epub 2008 Nov 6.

PMID:
19038368
16.

Probing the role of aromatic residues at the secondary saccharide-binding sites of human salivary alpha-amylase in substrate hydrolysis and bacterial binding.

Ragunath C, Manuel SG, Venkataraman V, Sait HB, Kasinathan C, Ramasubbu N.

J Mol Biol. 2008 Dec 31;384(5):1232-48. doi: 10.1016/j.jmb.2008.09.089. Epub 2008 Oct 14.

17.

Role of active-site residues of dispersin B, a biofilm-releasing beta-hexosaminidase from a periodontal pathogen, in substrate hydrolysis.

Manuel SG, Ragunath C, Sait HB, Izano EA, Kaplan JB, Ramasubbu N.

FEBS J. 2007 Nov;274(22):5987-99. Epub 2007 Oct 19.

18.

Poly-N-acetylglucosamine mediates biofilm formation and detergent resistance in Aggregatibacter actinomycetemcomitans.

Izano EA, Sadovskaya I, Wang H, Vinogradov E, Ragunath C, Ramasubbu N, Jabbouri S, Perry MB, Kaplan JB.

Microb Pathog. 2008 Jan;44(1):52-60. Epub 2007 Aug 12.

19.

Detachment and killing of Aggregatibacter actinomycetemcomitans biofilms by dispersin B and SDS.

Izano EA, Wang H, Ragunath C, Ramasubbu N, Kaplan JB.

J Dent Res. 2007 Jul;86(7):618-22.

PMID:
17586707
20.

Poly-N-acetylglucosamine mediates biofilm formation and antibiotic resistance in Actinobacillus pleuropneumoniae.

Izano EA, Sadovskaya I, Vinogradov E, Mulks MH, Velliyagounder K, Ragunath C, Kher WB, Ramasubbu N, Jabbouri S, Perry MB, Kaplan JB.

Microb Pathog. 2007 Jul;43(1):1-9. Epub 2007 Mar 4.

21.

Tyrosine sulfation of statherin.

Kasinathan C, Gandhi N, Ramaprasad P, Sundaram P, Ramasubbu N.

Int J Biol Sci. 2007 Mar 2;3(4):237-41.

22.

Susceptibility of staphylococcal biofilms to enzymatic treatments depends on their chemical composition.

Chaignon P, Sadovskaya I, Ragunah Ch, Ramasubbu N, Kaplan JB, Jabbouri S.

Appl Microbiol Biotechnol. 2007 May;75(1):125-32. Epub 2007 Jan 13.

PMID:
17221196
23.

Structural analysis of dispersin B, a biofilm-releasing glycoside hydrolase from the periodontopathogen Actinobacillus actinomycetemcomitans.

Ramasubbu N, Thomas LM, Ragunath C, Kaplan JB.

J Mol Biol. 2005 Jun 10;349(3):475-86. Epub 2005 Apr 14.

PMID:
15878175
24.

Genes involved in the synthesis and degradation of matrix polysaccharide in Actinobacillus actinomycetemcomitans and Actinobacillus pleuropneumoniae biofilms.

Kaplan JB, Velliyagounder K, Ragunath C, Rohde H, Mack D, Knobloch JK, Ramasubbu N.

J Bacteriol. 2004 Dec;186(24):8213-20.

25.

Enzymatic detachment of Staphylococcus epidermidis biofilms.

Kaplan JB, Ragunath C, Velliyagounder K, Fine DH, Ramasubbu N.

Antimicrob Agents Chemother. 2004 Jul;48(7):2633-6.

26.

Human salivary alpha-amylase Trp58 situated at subsite -2 is critical for enzyme activity.

Ramasubbu N, Ragunath C, Mishra PJ, Thomas LM, Gyémánt G, Kandra L.

Eur J Biochem. 2004 Jun;271(12):2517-29.

27.
28.

Introducing transglycosylation activity into human salivary alpha-amylase (HSA).

Remenyik J, Ragunath C, Ramasubbu N, Gyémánt G, Lipták A, Kandra L.

Org Lett. 2003 Dec 11;5(25):4895-8.

PMID:
14653701
29.

Detachment of Actinobacillus actinomycetemcomitans biofilm cells by an endogenous beta-hexosaminidase activity.

Kaplan JB, Ragunath C, Ramasubbu N, Fine DH.

J Bacteriol. 2003 Aug;185(16):4693-8.

30.

Subsite mapping of human salivary alpha-amylase and the mutant Y151M.

Kandra L, Gyémánt G, Remenyik J, Ragunath C, Ramasubbu N.

FEBS Lett. 2003 Jun 5;544(1-3):194-8.

31.

Probing the role of a mobile loop in substrate binding and enzyme activity of human salivary amylase.

Ramasubbu N, Ragunath C, Mishra PJ.

J Mol Biol. 2003 Jan 31;325(5):1061-76.

PMID:
12527308
32.

The mechanism of salivary amylase hydrolysis: role of residues at subsite S2'.

Mishra PJ, Ragunath C, Ramasubbu N.

Biochem Biophys Res Commun. 2002 Mar 29;292(2):468-73.

PMID:
11906186
33.

Expression, characterization, and biochemical properties of recombinant human salivary amylase.

Ragunath C, Sundar K, Ramasubbu N.

Protein Expr Purif. 2002 Mar;24(2):202-11.

PMID:
11858714
34.

Candidacidal activity prompted by N-terminus histatin-like domain of human salivary mucin (MUC7)1.

Gururaja TL, Levine JH, Tran DT, Naganagowda GA, Ramalingam K, Ramasubbu N, Levine MJ.

Biochim Biophys Acta. 1999 Apr 12;1431(1):107-19.

PMID:
10209284
35.

The roles of histidine residues at the starch-binding site in streptococcal-binding activities of human salivary amylase.

Tseng CC, Miyamoto M, Ramalingam K, Hemavathy KC, Levine MJ, Ramasubbu N.

Arch Oral Biol. 1999 Feb;44(2):119-27.

PMID:
10206330
36.

Structural features of the human salivary mucin, MUC7.

Gururaja TL, Ramasubbu N, Venugopalan P, Reddy MS, Ramalingam K, Levine MJ.

Glycoconj J. 1998 May;15(5):457-67.

PMID:
9881747
37.
38.
39.

Crystal structure of a dipeptide Boc-Aib-Phe-OMe.

Balakrishnan R, Parthasarathy R, Ramasubbu N.

J Pept Res. 1997 May;49(5):371-4.

PMID:
9211217
40.

Stabilization of helix by side-chain interactions in histatin-derived peptides: role in candidacidal activity.

Ramalingam K, Gururaja TL, Ramasubbu N, Levine MJ.

Biochem Biophys Res Commun. 1996 Aug 5;225(1):47-53.

PMID:
8769093
41.

Preliminary X-ray crystallographic analysis of human salivary cystatin.

Ramasubbu N, Weaver T, Tseng CC, Bobek LA, Levine MJ.

Acta Crystallogr D Biol Crystallogr. 1996 Jul 1;52(Pt 4):869-70.

PMID:
15299654
42.

Structure of human salivary alpha-amylase at 1.6 A resolution: implications for its role in the oral cavity.

Ramasubbu N, Paloth V, Luo Y, Brayer GD, Levine MJ.

Acta Crystallogr D Biol Crystallogr. 1996 May 1;52(Pt 3):435-46.

PMID:
15299664
43.

Biological activities and secondary structures of variant forms of human salivary cystatin SN produced in Escherichia coli.

Bobek LA, Ramasubbu N, Wang X, Weaver TR, Levine MJ.

Gene. 1994 Dec 30;151(1-2):303-8.

PMID:
7828895
44.

A new class of substituted 1,2,4-triazolo-1,3,4-thiadiazepines.

Thomas LM, Ramasubbu N, Bhandary KK, Shridhara K, Holla BS.

Acta Crystallogr C. 1994 Oct 15;50 ( Pt 10):1608-12.

PMID:
7986428
45.

Structural characteristics of diproline: a new crystal form of tBoc-Pro-Pro-OH.

Thomas LM, Ramasubbu N, Bhandary KK.

Int J Pept Protein Res. 1994 Sep;44(3):207-14.

PMID:
7822096
46.

Crystal structure of cyclo(Pro-Gly)3:Li complex: a model for ion transport by cyclo(Pro-Gly)3.

Thomas LM, Ramasubbu N, Bhandary KK.

Biopolymers. 1994 Aug;34(8):1007-13.

PMID:
8075383
47.
48.

Structural characteristics of human salivary statherin: a model for boundary lubrication at the enamel surface.

Ramasubbu N, Thomas LM, Bhandary KK, Levine MJ.

Crit Rev Oral Biol Med. 1993;4(3-4):363-70.

PMID:
8373992
49.

Formation of salivary-mucosal pellicle: the role of transglutaminase.

Bradway SD, Bergey EJ, Scannapieco FA, Ramasubbu N, Zawacki S, Levine MJ.

Biochem J. 1992 Jun 1;284 ( Pt 2):557-64.

50.

Large-scale purification and characterization of the major phosphoproteins and mucins of human submandibular-sublingual saliva.

Ramasubbu N, Reddy MS, Bergey EJ, Haraszthy GG, Soni SD, Levine MJ.

Biochem J. 1991 Dec 1;280 ( Pt 2):341-52.

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