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Items: 23

1.

Diminished responses to monoaminergic antidepressants but not ketamine in a mouse model for neuropsychiatric lupus.

Srikumar BN, Naidu PS, Kalidindi N, Paschapur M, Adepu B, Subramani S, Nagar J, Srivastava R, Sreedhara MV, Prasad DS, Das ML, Louis JV, Kuchibhotla VK, Dudhgaonkar S, Pieschl RL, Li YW, Bristow LJ, Ramarao M, Vikramadithyan RK.

J Psychopharmacol. 2019 Jan;33(1):25-36. doi: 10.1177/0269881118812102. Epub 2018 Nov 28.

PMID:
30484737
2.

BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder.

Marcin LR, Warrier J, Thangathirupathy S, Shi J, Karageorge GN, Pearce BC, Ng A, Park H, Kempson J, Li J, Zhang H, Mathur A, Reddy AB, Nagaraju G, Tonukunuru G, Gupta GVRKM, Kamble M, Mannoori R, Cheruku S, Jogi S, Gulia J, Bastia T, Sanmathi C, Aher J, Kallem R, Srikumar BN, Vijaya KK, Naidu PS, Paschapur M, Kalidindi N, Vikramadithyan R, Ramarao M, Denton R, Molski T, Shields E, Subramanian M, Zhuo X, Nophsker M, Simmermacher J, Sinz M, Albright C, Bristow LJ, Islam I, Bronson JJ, Olson RE, King D, Thompson LA, Macor JE.

ACS Med Chem Lett. 2018 Apr 13;9(5):472-477. doi: 10.1021/acsmedchemlett.8b00080. eCollection 2018 May 10.

3.

Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder.

Bristow LJ, Gulia J, Weed MR, Srikumar BN, Li YW, Graef JD, Naidu PS, Sanmathi C, Aher J, Bastia T, Paschapur M, Kalidindi N, Kumar KV, Molski T, Pieschl R, Fernandes A, Brown JM, Sivarao DV, Newberry K, Bookbinder M, Polino J, Keavy D, Newton A, Shields E, Simmermacher J, Kempson J, Li J, Zhang H, Mathur A, Kallem RR, Sinha M, Ramarao M, Vikramadithyan RK, Thangathirupathy S, Warrier J, Islam I, Bronson JJ, Olson RE, Macor JE, Albright CF, King D, Thompson LA, Marcin LR, Sinz M.

J Pharmacol Exp Ther. 2017 Dec;363(3):377-393. doi: 10.1124/jpet.117.242784. Epub 2017 Sep 27.

PMID:
28954811
4.

Characterization of the adrenocorticotrophic hormone - induced mouse model of resistance to antidepressant drug treatment.

Srikumar BN, Paschapur M, Kalidindi N, Adepu B, Das ML, Sreedhara MV, Kuchibhotla VK, Pieschl RL, Li YW, Ega DSP, Louis JV, Murugesan S, Naidu PS, Ramarao M, Bristow LJ, Vikramadithyan RK.

Pharmacol Biochem Behav. 2017 Oct;161:53-61. doi: 10.1016/j.pbb.2017.09.003. Epub 2017 Sep 11.

PMID:
28911960
5.

Modulation of Kv 11.1 (hERG) channels by 5-(((1H-indazol-5-yl)oxy)methyl)-N-(4-(trifluoromethoxy)phenyl)pyrimidin-2-amine (ITP-2), a novel small molecule activator.

Sale H, Roy S, Warrier J, Thangathirupathy S, Vadari Y, Gopal SK, Krishnamurthy P, Ramarao M.

Br J Pharmacol. 2017 Aug;174(15):2484-2500. doi: 10.1111/bph.13859. Epub 2017 Jun 18.

6.

Expression and characterization of cynomolgus monkey cytochrome CYP3A4 in a novel human embryonic kidney cell-based mammalian system.

Selvakumar S, Bhutani P, Ghosh K, Krishnamurthy P, Kallipatti S, Selvam S, Ramarao M, Mandlekar S, Sinz MW, Rodrigues AD, Subramanian M.

Drug Metab Dispos. 2014 Mar;42(3):369-76. doi: 10.1124/dmd.113.055491. Epub 2013 Dec 13.

PMID:
24335510
7.

Crystal structure of rat intestinal alkaline phosphatase--role of crown domain in mammalian alkaline phosphatases.

Ghosh K, Mazumder Tagore D, Anumula R, Lakshmaiah B, Kumar PP, Singaram S, Matan T, Kallipatti S, Selvam S, Krishnamurthy P, Ramarao M.

J Struct Biol. 2013 Nov;184(2):182-92. doi: 10.1016/j.jsb.2013.09.017. Epub 2013 Sep 27.

PMID:
24076154
8.

Thermodynamic characterization of cytosolic phospholipase A2 alpha inhibitors.

Ramarao MK, Shen MW, Murphy EA, Duan W, Zhao Y, McKew J, Lee KL, Thakker P, Behnke ML, Clark JD.

Anal Biochem. 2008 Dec 15;383(2):217-25. doi: 10.1016/j.ab.2008.08.025. Epub 2008 Aug 30.

PMID:
18801329
9.

In vitro allergen challenge of peripheral blood induces differential gene expression in mononuclear cells of asthmatic patients: inhibition of cytosolic phospholipase A2alpha overcomes the asthma-associated response.

Whalen KA, Legault H, Hang C, Hill A, Kasaian M, Donaldson D, Bensch GW, Bensch G, Baker J, Reddy PS, Wood N, Ramarao MK, Ellis DK, Csimma C, McKee C, Clark JD, Ryan J, Dorner AJ, O'Toole M.

Clin Exp Allergy. 2008 Oct;38(10):1590-605. doi: 10.1111/j.1365-2222.2008.03059.x. Epub 2008 Jul 28.

10.

Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib.

McKew JC, Lee KL, Shen MW, Thakker P, Foley MA, Behnke ML, Hu B, Sum FW, Tam S, Hu Y, Chen L, Kirincich SJ, Michalak R, Thomason J, Ipek M, Wu K, Wooder L, Ramarao MK, Murphy EA, Goodwin DG, Albert L, Xu X, Donahue F, Ku MS, Keith J, Nickerson-Nutter CL, Abraham WM, Williams C, Hegen M, Clark JD.

J Med Chem. 2008 Jun 26;51(12):3388-413. doi: 10.1021/jm701467e. Epub 2008 May 23.

PMID:
18498150
11.

Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy.

Lee KL, Behnke ML, Foley MA, Chen L, Wang W, Vargas R, Nunez J, Tam S, Mollova N, Xu X, Shen MW, Ramarao MK, Goodwin DG, Nickerson-Nutter CL, Abraham WM, Williams C, Clark JD, McKew JC.

Bioorg Med Chem. 2008 Feb 1;16(3):1345-58. Epub 2007 Oct 22.

PMID:
17998165
12.

Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha.

Lee KL, Foley MA, Chen L, Behnke ML, Lovering FE, Kirincich SJ, Wang W, Shim J, Tam S, Shen MW, Khor S, Xu X, Goodwin DG, Ramarao MK, Nickerson-Nutter C, Donahue F, Ku MS, Clark JD, McKew JC.

J Med Chem. 2007 Mar 22;50(6):1380-400. Epub 2007 Feb 17.

PMID:
17305324
13.

High-throughput screening for the discovery of inhibitors of fatty acid amide hydrolase using a microsome-based fluorescent assay.

Wang Y, Ramirez F, Krishnamurthy G, Gilbert A, Kadakia N, Xu J, Kalgaonkar G, Ramarao MK, Edris W, Rogers KE, Jones PG.

J Biomol Screen. 2006 Aug;11(5):519-27. Epub 2006 Jun 7.

PMID:
16760367
14.

A novel scintillation proximity assay for fatty acid amide hydrolase compatible with inhibitor screening.

Wang Y, Xu J, Uveges A, Ramarao MK, Rogers KE, Jones PG.

Anal Biochem. 2006 Jul 1;354(1):35-42. Epub 2006 May 2.

PMID:
16707086
15.

A fluorescence-based assay for fatty acid amide hydrolase compatible with high-throughput screening.

Ramarao MK, Murphy EA, Shen MW, Wang Y, Bushell KN, Huang N, Pan N, Williams C, Clark JD.

Anal Biochem. 2005 Aug 1;343(1):143-51.

PMID:
16018870
16.

Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis.

Xue L, Chu F, Cheng Y, Sun X, Borthakur A, Ramarao M, Pandey P, Wu M, Schlossman SF, Prasad KV.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6925-30.

17.

Interactions of the rapsyn RING-H2 domain with dystroglycan.

Bartoli M, Ramarao MK, Cohen JB.

J Biol Chem. 2001 Jul 6;276(27):24911-7. Epub 2001 May 7.

18.

Role of rapsyn tetratricopeptide repeat and coiled-coil domains in self-association and nicotinic acetylcholine receptor clustering.

Ramarao MK, Bianchetta MJ, Lanken J, Cohen JB.

J Biol Chem. 2001 Mar 9;276(10):7475-83. Epub 2000 Nov 21.

19.

Mechanism of nicotinic acetylcholine receptor cluster formation by rapsyn.

Ramarao MK, Cohen JB.

Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):4007-12.

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Trichloroethylene: a suitable general anaesthetic in rural and private practice.

RAMARAO MV.

J Indian Med Assoc. 1954 Oct 16;24(2):60-1. No abstract available.

PMID:
13212083

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