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Items: 1 to 50 of 92

1.
2.

Gelatinase A (MMP-2), collagenase-2 (MMP-8), and laminin-5 gamma2-chain expression in murine inflammatory bowel disease (ulcerative colitis).

Pirilä E, Ramamurthy NS, Sorsa T, Salo T, Hietanen J, Maisi P.

Dig Dis Sci. 2003 Jan;48(1):93-8.

PMID:
12645796
3.

Inhibition of matrix metalloproteinase-mediated periodontal bone loss in rats: a comparison of 6 chemically modified tetracyclines.

Ramamurthy NS, Rifkin BR, Greenwald RA, Xu JW, Liu Y, Turner G, Golub LM, Vernillo AT.

J Periodontol. 2002 Jul;73(7):726-34.

PMID:
12146531
4.

Chemically modified tetracycline (CMT-8) and estrogen promote wound healing in ovariectomized rats: effects on matrix metalloproteinase-2, membrane type 1 matrix metalloproteinase, and laminin-5 gamma2-chain.

Pirilä E, Parikka M, Ramamurthy NS, Maisi P, McClain S, Kucine A, Tervahartiala T, Prikk K, Golub LM, Salo T, Sorsa T.

Wound Repair Regen. 2002 Jan-Feb;10(1):38-51.

PMID:
11983005
5.

Inhibition of proteolytic, serpinolytic, and progelatinase-b activation activities of periodontopathogens by doxycycline and the non-antimicrobial chemically modified tetracycline derivatives.

Grenier D, Plamondon P, Sorsa T, Lee HM, McNamara T, Ramamurthy NS, Golub LM, Teronen O, Mayrand D.

J Periodontol. 2002 Jan;73(1):79-85.

PMID:
11846203
6.

Inhibition of alveolar bone loss by matrix metalloproteinase inhibitors in experimental periodontal disease.

Ramamurthy NS, Xu JW, Bird J, Baxter A, Bhogal R, Wills R, Watson B, Owen D, Wolff M, Greenwald RA.

J Periodontal Res. 2002 Feb;37(1):1-7.

PMID:
11842933
7.

A combination of a chemically modified doxycycline and a bisphosphonate synergistically inhibits endotoxin-induced periodontal breakdown in rats.

Llavaneras A, Ramamurthy NS, Heikkilä P, Teronen O, Salo T, Rifkin BR, Ryan ME, Golub LM, Sorsa T.

J Periodontol. 2001 Aug;72(8):1069-77.

PMID:
11525440
8.

Excessive matrix metalloproteinase activity in diabetes: inhibition by tetracycline analogues with zinc reactivity.

Ryan ME, Usman A, Ramamurthy NS, Golub LM, Greenwald RA.

Curr Med Chem. 2001 Feb;8(3):305-16.

PMID:
11172685
9.

Biodistribution of radiolabeled [(3)H] CMT-3 in rats.

Chen J, Bookbinder M, Ryan ME, Golub LM, Ashley R, Ramamurthy NS.

Curr Med Chem. 2001 Feb;8(3):253-6.

PMID:
11172679
10.

Effects of ovariectomy on bone morphology in maxillae of mature rats.

Ishihara A, Sasaki T, Debari K, Furuya R, Kawawa T, Ramamurthy NS, Golub LM.

J Electron Microsc (Tokyo). 1999;48(4):465-9.

PMID:
10510861
11.

Matrix metalloproteinase inhibitor prevents acute lung injury after cardiopulmonary bypass.

Carney DE, Lutz CJ, Picone AL, Gatto LA, Ramamurthy NS, Golub LM, Simon SR, Searles B, Paskanik A, Snyder K, Finck C, Schiller HJ, Nieman GF.

Circulation. 1999 Jul 27;100(4):400-6.

PMID:
10421601
12.

Wound healing in aged normal and ovariectomized rats: effects of chemically modified doxycycline (CMT-8) on MMP expression and collagen synthesis.

Ramamurthy NS, McClain SA, Pirila E, Maisi P, Salo T, Kucine A, Sorsa T, Vishram F, Golub LM.

Ann N Y Acad Sci. 1999 Jun 30;878:720-3. No abstract available.

PMID:
10415818
13.

CMT-8/clodronate combination therapy synergistically inhibits alveolar bone loss in LPS-induced periodontitis.

Llavaneras A, Golub LM, Rifkin BR, Heikkilä P, Sorsa T, Teronen O, Salo T, Liu Y, Ryan ME, Ramamurthy NS.

Ann N Y Acad Sci. 1999 Jun 30;878:671-4. No abstract available.

PMID:
10415804
14.

Effects of chemically modified tetracycline, CMT-8, on bone loss and osteoclast structure and function in osteoporotic states.

Sasaki T, Ohyori N, Debari K, Ramamurthy NS, Golub LM.

Ann N Y Acad Sci. 1999 Jun 30;878:347-60.

PMID:
10415740
15.

MMP-mediated events in diabetes.

Ryan ME, Ramamurthy NS, Sorsa T, Golub LM.

Ann N Y Acad Sci. 1999 Jun 30;878:311-34.

PMID:
10415738
16.

A chemically modified nonantimicrobial tetracycline (CMT-8) inhibits gingival matrix metalloproteinases, periodontal breakdown, and extra-oral bone loss in ovariectomized rats.

Golub LM, Ramamurthy NS, Llavaneras A, Ryan ME, Lee HM, Liu Y, Bain S, Sorsa T.

Ann N Y Acad Sci. 1999 Jun 30;878:290-310.

PMID:
10415737
17.

Tetracyclines inhibit protein glycation in experimental diabetes.

Ryan ME, Ramamurthy NS, Golub LM.

Adv Dent Res. 1998 Nov;12(2):152-8.

PMID:
9972141
18.

Topically applied CMT-2 enhances wound healing in streptozotocin diabetic rat skin.

Ramamurthy NS, Kucine AJ, McClain SA, McNamara TF, Golub LM.

Adv Dent Res. 1998 Nov;12(2):144-8.

PMID:
9972139
19.
20.

The potential role of doxycycline in the treatment of osteoarthritis of the temporomandibular joint.

Israel HA, Ramamurthy NS, Greenwald R, Golub L.

Adv Dent Res. 1998 Nov;12(2):51-5.

PMID:
9972122
21.

Root-surface caries in rats and humans: inhibition by a non-antimicrobial property of tetracyclines.

Ramamurthy NS, Schroeder KL, McNamara TF, Gwinnett AJ, Evans RT, Bosko C, Golub LM.

Adv Dent Res. 1998 Nov;12(2):43-50.

PMID:
9972121
22.

Functional sites of chemically modified tetracyclines: inhibition of the oxidative activation of human neutrophil and chicken osteoclast pro-matrix metalloproteinases.

Sorsa T, Ramamurthy NS, Vernillo AT, Zhang X, Konttinen YT, Rifkin BR, Golub LM.

J Rheumatol. 1998 May;25(5):975-82.

PMID:
9598901
23.
24.

In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: relationship to bone and cartilage degradation.

Greenwald RA, Golub LM, Ramamurthy NS, Chowdhury M, Moak SA, Sorsa T.

Bone. 1998 Jan;22(1):33-8.

PMID:
9437511
25.

Tetracycline prevents cancellous bone loss and maintains near-normal rates of bone formation in streptozotocin diabetic rats.

Bain S, Ramamurthy NS, Impeduglia T, Scolman S, Golub LM, Rubin C.

Bone. 1997 Aug;21(2):147-53.

PMID:
9267690
26.
27.
28.

The "cyclic" regimen of low-dose doxycycline for adult periodontitis: a preliminary study.

Crout RJ, Lee HM, Schroeder K, Crout H, Ramamurthy NS, Wiener M, Golub LM.

J Periodontol. 1996 May;67(5):506-14.

PMID:
8724709
29.

Local and systemic factors in periodontal disease increase matrix-degrading enzyme activities in rat gingiva: effect of micocycline therapy.

Chang KM, Ryan ME, Golub LM, Ramamurthy NS, McNamara TF.

Res Commun Mol Pathol Pharmacol. 1996 Mar;91(3):303-18.

PMID:
8829770
30.

Tenidap and flurbiprofen enhance uptake of matrix metalloproteinase inhibitor 4-dedimethylaminotetracycline in inflamed joints of adjuvant arthritic rats.

Leung MK, Greenwald RA, Ramamurthy NS, Moak SA, Koszulinski R, Dieudonne D, Golub LM.

J Rheumatol. 1995 Sep;22(9):1726-31.

PMID:
8523353
31.

Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva.

Golub LM, Sorsa T, Lee HM, Ciancio S, Sorbi D, Ramamurthy NS, Gruber B, Salo T, Konttinen YT.

J Clin Periodontol. 1995 Feb;22(2):100-9.

PMID:
7775665
32.

Identification and characterization of gelatinases/type IV collagenases in jaw cysts.

Teronen O, Salo T, Konttinen YT, Rifkin B, Vernillo A, Ramamurthy NS, Kjeldsen L, Borregaard N, Hietanen J, Sorsa T.

J Oral Pathol Med. 1995 Feb;24(2):78-84.

PMID:
7745546
33.

A non-antimicrobial tetracycline inhibits gingival matrix metalloproteinases and bone loss in Porphyromonas gingivalis-induced periodontitis in rats.

Golub LM, Evans RT, McNamara TF, Lee HM, Ramamurthy NS.

Ann N Y Acad Sci. 1994 Sep 6;732:96-111. No abstract available.

PMID:
7978855
34.

Gelatinases/type IV collagenases in jaw cyst expansion.

Teronen O, Salo T, Konttinen YT, Rifkin B, Vernillo A, Ramamurthy NS, Kjeldsen L, Borregaard N, Sommerhoff CP, Sorsa T.

Ann N Y Acad Sci. 1994 Sep 6;732:486-8. No abstract available.

PMID:
7978847
35.

Tissue healing with doxycycline and chemically modified tetracycline treatments in rats with Porphyromonas gingivalis-induced periodontitis.

Karimbux NY, Ramamurthy NS, Golub LM, Nishimura I.

Ann N Y Acad Sci. 1994 Sep 6;732:433-5. No abstract available.

PMID:
7978831
36.

Modulation of bone resorption by tetracyclines.

Rifkin BR, Vernillo AT, Golub LM, Ramamurthy NS.

Ann N Y Acad Sci. 1994 Sep 6;732:165-80. Review. No abstract available.

PMID:
7978789
37.

Tetracyclines inhibit Porphyromonas gingivalis-induced alveolar bone loss in rats by a non-antimicrobial mechanism.

Chang KM, Ramamurthy NS, McNamara TF, Evans RT, Klausen B, Murray PA, Golub LM.

J Periodontal Res. 1994 Jul;29(4):242-9.

PMID:
7932017
38.

Bone cells and matrix bind chemically modified non-antimicrobial tetracycline.

Sasaki T, Ramamurthy NS, Golub LM.

Bone. 1994 May-Jun;15(3):373-5.

PMID:
8068461
39.

The nonantimicrobial properties of tetracycline for the treatment of periodontal disease.

Vernillo AT, Ramamurthy NS, Golub LM, Rifkin BR.

Curr Opin Periodontol. 1994:111-8. Review.

PMID:
8032451
40.

Chemically-modified tetracycline normalizes collagen metabolism in diabetic rats: a dose-response study.

Yu Z, Ramamurthy NS, Leung M, Chang KM, McNamara TF, Golub LM.

J Periodontal Res. 1993 Nov;28(6 Pt 1):420-8.

PMID:
8254459
41.

Reactive oxygen species activate and tetracyclines inhibit rat osteoblast collagenase.

Ramamurthy NS, Vernillo AT, Greenwald RA, Lee HM, Sorsa T, Golub LM, Rifkin BR.

J Bone Miner Res. 1993 Oct;8(10):1247-53.

PMID:
8256662
43.

Tetracyclines inhibit intracellular muscle proteolysis in vitro.

Schneider BS, Maimon J, Golub LM, Ramamurthy NS, Greenwald RA.

Biochem Biophys Res Commun. 1992 Oct 30;188(2):767-72.

PMID:
1445321
44.

Periodontopathic potential of two strains of Porphyromonas gingivalis in gnotobiotic rats.

Evans RT, Klausen B, Ramamurthy NS, Golub LM, Sfintescu C, Genco RJ.

Arch Oral Biol. 1992 Oct;37(10):813-9.

PMID:
1359858
45.

Immunization with Porphyromonas (Bacteroides) gingivalis fimbriae protects against periodontal destruction.

Evans RT, Klausen B, Sojar HT, Bedi GS, Sfintescu C, Ramamurthy NS, Golub LM, Genco RJ.

Infect Immun. 1992 Jul;60(7):2926-35.

46.
48.

Parathyroid hormone regulation of matrix degrading enzymes in rat osteoblastic osteosarcoma 17/2.8 cells.

Vernillo AT, Ramamurthy NS, Lee HM, Rifkin BR.

Res Commun Chem Pathol Pharmacol. 1992 Mar;75(3):323-39.

PMID:
1324516
49.

HPLC determination of a chemically modified nonantimicrobial tetracycline: biological implications.

Yu Z, Leung MK, Ramamurthy NS, McNamara TF, Golub LM.

Biochem Med Metab Biol. 1992 Feb;47(1):10-20.

PMID:
1314064
50.

Tetracycline administration restores osteoblast structure and function during experimental diabetes.

Sasaki T, Kaneko H, Ramamurthy NS, Golub LM.

Anat Rec. 1991 Sep;231(1):25-34.

PMID:
1836318

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