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Magnetic-Alignment of Polymer Nanodiscs Probed by Solid-State NMR Spectroscopy.

Ravula T, Kim J, Lee D, Ramamoorthy A.

Langmuir. 2020 Jan 21. doi: 10.1021/acs.langmuir.9b03538. [Epub ahead of print]


Expression, purification, and functional reconstitution of 19F-labeled cytochrome b5 in peptide nanodiscs for NMR studies.

Bai J, Wang J, Ravula T, Im SC, Anantharamaiah GM, Waskell L, Ramamoorthy A.

Biochim Biophys Acta Biomembr. 2020 Jan 14:183194. doi: 10.1016/j.bbamem.2020.183194. [Epub ahead of print]


Structural Interaction of Apolipoprotein A-I Mimetic Peptide with Amyloid-β Generates Toxic Hetero-oligomers.

Sahoo BR, Bekier ME 2nd, Liu Z, Kocman V, Stoddard AK, Anantharamaiah GM, Nowick J, Fierke CA, Wang Y, Ramamoorthy A.

J Mol Biol. 2019 Dec 19. pii: S0022-2836(19)30705-3. doi: 10.1016/j.jmb.2019.12.005. [Epub ahead of print]


Exploiting heterogeneous time scale of dynamics to enhance 2D HETCOR solid-state NMR sensitivity.

Zhang R, Nishiyama Y, Ramamoorthy A.

J Magn Reson. 2019 Dec;309:106615. doi: 10.1016/j.jmr.2019.106615. Epub 2019 Oct 14.


Probing protein-protein and protein-substrate interactions in the dynamic membrane-associated ternary complex of cytochromes P450, b5, and reductase.

Gentry KA, Anantharamaiah GM, Ramamoorthy A.

Chem Commun (Camb). 2019 Nov 18;55(89):13422-13425. doi: 10.1039/c9cc05904k. Epub 2019 Oct 22.


Corrigendum: Bioinspired, Size-Tunable Self-Assembly of Polymer-Lipid Bilayer Nanodiscs.

Ravula T, Ramadugu SK, Di Mauro G, Ramamoorthy A.

Angew Chem Int Ed Engl. 2019 Sep 16;58(38):13184. doi: 10.1002/anie.201906502. No abstract available.


Corrigendum: Formation of pH-Resistant Monodispersed Polymer-Lipid Bilayer Nanodiscs.

Ravula T, Hardin NZ, Ramadugu SK, Cox SJ, Ramamoorthy A.

Angew Chem Int Ed Engl. 2019 Sep 16;58(38):13185. doi: 10.1002/anie.201906504. No abstract available.


Metal-Chelated Polymer Nanodiscs for NMR Studies.

Hardin NZ, Kocman V, Di Mauro GM, Ravula T, Ramamoorthy A.

Angew Chem Int Ed Engl. 2019 Nov 25;58(48):17246-17250. doi: 10.1002/anie.201910118. Epub 2019 Oct 17.


Evolution of Next Generation Therapeutics: Past, Present, and Future of Precision Medicines.

Ramamoorthy A, Karnes JH, Finkel R, Blanchard R, Pacanowski M.

Clin Transl Sci. 2019 Nov;12(6):560-563. doi: 10.1111/cts.12675. Epub 2019 Aug 23. No abstract available.


Use of paramagnetic systems to speed-up NMR data acquisition and for structural and dynamic studies.

Kocman V, Di Mauro GM, Veglia G, Ramamoorthy A.

Solid State Nucl Magn Reson. 2019 Oct;102:36-46. doi: 10.1016/j.ssnmr.2019.07.002. Epub 2019 Jul 12. Review.


Magnetic Alignment of Polymer Macro-Nanodiscs Enables Residual-Dipolar-Coupling-Based High-Resolution Structural Studies by NMR Spectroscopy.

Ravula T, Ramamoorthy A.

Angew Chem Int Ed Engl. 2019 Oct 14;58(42):14925-14928. doi: 10.1002/anie.201907655. Epub 2019 Sep 11.


Diverse Structural Conversion and Aggregation Pathways of Alzheimer's Amyloid-β (1-40).

Lin Y, Sahoo BR, Ozawa D, Kinoshita M, Kang J, Lim MH, Okumura M, Huh YH, Moon E, Jang JH, Lee HJ, Ryu KY, Ham S, Won HS, Ryu KS, Sugiki T, Bang JK, Hoe HS, Fujiwara T, Ramamoorthy A, Lee YH.

ACS Nano. 2019 Aug 27;13(8):8766-8783. doi: 10.1021/acsnano.9b01578. Epub 2019 Jul 24.


What Does It Take to Transform Real-World Data Into Real-World Evidence?

Ramamoorthy A, Huang SM.

Clin Pharmacol Ther. 2019 Jul;106(1):10-18. doi: 10.1002/cpt.1486. No abstract available.


Styrene maleic acid derivates to enhance the applications of bio-inspired polymer based lipid-nanodiscs.

Ravula T, Hardin NZ, Di Mauro GM, Ramamoorthy A.

Eur Polym J. 2018 Nov;108:597-602. doi: 10.1016/j.eurpolymj.2018.09.048. Epub 2018 Sep 25.


Self-Assembly of Polymer-Encased Lipid Nanodiscs and Membrane Protein Reconstitution.

Sahoo BR, Genjo T, Moharana KC, Ramamoorthy A.

J Phys Chem B. 2019 May 30;123(21):4562-4570. doi: 10.1021/acs.jpcb.9b03681. Epub 2019 May 16.


Probing membrane enhanced protein-protein interactions in a minimal redox complex of cytochrome-P450 and P450-reductase.

Mahajan M, Ravula T, Prade E, Anantharamaiah GM, Ramamoorthy A.

Chem Commun (Camb). 2019 May 16;55(41):5777-5780. doi: 10.1039/c9cc01630a.


A cationic polymethacrylate-copolymer acts as an agonist for β-amyloid and an antagonist for amylin fibrillation.

Sahoo BR, Genjo T, Nakayama TW, Stoddard AK, Ando T, Yasuhara K, Fierke CA, Ramamoorthy A.

Chem Sci. 2019 Feb 27;10(14):3976-3986. doi: 10.1039/c8sc05771k. eCollection 2019 Apr 14.


An Overview of Genomic Biomarker Use in Cardiovascular Disease Clinical Trials.

Adeniyi O, Ramamoorthy A, Schuck R, Sun J, Wilson J, Zineh I, Pacanowski M.

Clin Pharmacol Ther. 2019 Oct;106(4):841-846. doi: 10.1002/cpt.1473. Epub 2019 Jun 20.


Real-World Data and Clinical Pharmacology: A Regulatory Science Perspective.

Liu Q, Ramamoorthy A, Huang SM.

Clin Pharmacol Ther. 2019 Jul;106(1):67-71. doi: 10.1002/cpt.1413. Epub 2019 Apr 9. No abstract available.


Probing transient non-native states in amyloid beta fiber elongation by NMR.

Brender JR, Ghosh A, Kotler SA, Krishnamoorthy J, Bera S, Morris V, Sil TB, Garai K, Reif B, Bhunia A, Ramamoorthy A.

Chem Commun (Camb). 2019 Apr 11;55(31):4483-4486. doi: 10.1039/c9cc01067j.


Polymer nanodiscs: Advantages and limitations.

Ravula T, Hardin NZ, Ramamoorthy A.

Chem Phys Lipids. 2019 Mar;219:45-49. doi: 10.1016/j.chemphyslip.2019.01.010. Epub 2019 Jan 29. Review.


Hydrophobic Functionalization of Polyacrylic Acid as a Versatile Platform for the Development of Polymer Lipid Nanodisks.

Hardin NZ, Ravula T, Mauro GD, Ramamoorthy A.

Small. 2019 Mar;15(9):e1804813. doi: 10.1002/smll.201804813. Epub 2019 Jan 22.


Proton-detected 3D 1H anisotropic/14N/1H isotropic chemical shifts correlation NMR under fast magic angle spinning on solid samples without isotopic enrichment.

Pandey MK, Damron JT, Ramamoorthy A, Nishiyama Y.

Solid State Nucl Magn Reson. 2019 Feb;97:40-45. doi: 10.1016/j.ssnmr.2018.12.002. Epub 2018 Dec 28.


PathFX provides mechanistic insights into drug efficacy and safety for regulatory review and therapeutic development.

Wilson JL, Racz R, Liu T, Adeniyi O, Sun J, Ramamoorthy A, Pacanowski M, Altman R.

PLoS Comput Biol. 2018 Dec 7;14(12):e1006614. doi: 10.1371/journal.pcbi.1006614. eCollection 2018 Dec.


Retraction: Polymer nanodiscs and macro-nanodiscs of a varying lipid composition.

Ramadugu VSK, Di Mauro GM, Ravula T, Ramamoorthy A.

Chem Commun (Camb). 2018 Dec 11;54(99):14033. doi: 10.1039/c8cc90544d.


Unveiling the Genetic Architecture of Human Disease for Precision Medicine.

Ramamoorthy A, Yee SW, Karnes J.

Clin Transl Sci. 2019 Jan;12(1):3-5. doi: 10.1111/cts.12593. Epub 2018 Nov 26. No abstract available.


Zinc boosts EGCG's hIAPP amyloid Inhibition both in solution and membrane.

Lee YH, Lin Y, Cox SJ, Kinoshita M, Sahoo BR, Ivanova M, Ramamoorthy A.

Biochim Biophys Acta Proteins Proteom. 2019 May;1867(5):529-536. doi: 10.1016/j.bbapap.2018.11.006. Epub 2018 Nov 22.


Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs.

Sahoo BR, Genjo T, Bekier M, Cox SJ, Stoddard AK, Ivanova M, Yasuhara K, Fierke CA, Wang Y, Ramamoorthy A.

Chem Commun (Camb). 2018 Nov 13;54(91):12883-12886. doi: 10.1039/c8cc07921h.


Demographic Composition of Select Oncologic New Molecular Entities Approved by the FDA Between 2008 and 2017.

Ramamoorthy A, Knepper TC, Merenda C, Mendoza M, McLeod HL, Bull J, Zhang L, Pacanowski M.

Clin Pharmacol Ther. 2018 Nov;104(5):940-948. doi: 10.1002/cpt.1180. Epub 2018 Sep 14.


Nanodisc-Forming Scaffold Protein Promoted Retardation of Amyloid-Beta Aggregation.

Sahoo BR, Genjo T, Cox SJ, Stoddard AK, Anantharamaiah GM, Fierke C, Ramamoorthy A.

J Mol Biol. 2018 Oct 19;430(21):4230-4244. doi: 10.1016/j.jmb.2018.08.018. Epub 2018 Aug 28.


Effect of polymer charge on functional reconstitution of membrane proteins in polymer nanodiscs.

Ravula T, Hardin NZ, Bai J, Im SC, Waskell L, Ramamoorthy A.

Chem Commun (Camb). 2018 Aug 23;54(69):9615-9618. doi: 10.1039/c8cc04184a.


Picturing the Membrane-assisted Choreography of Cytochrome P450 with Lipid Nanodiscs.

Barnaba C, Ramamoorthy A.

Chemphyschem. 2018 Oct 19;19(20):2603-2613. doi: 10.1002/cphc.201800444. Epub 2018 Jul 31. Review.


Lipid-exchange in nanodiscs discloses membrane boundaries of cytochrome-P450 reductase.

Barnaba C, Ravula T, Medina-Meza IG, Im SC, Anantharamaiah GM, Waskell L, Ramamoorthy A.

Chem Commun (Camb). 2018 Jun 14;54(49):6336-6339. doi: 10.1039/c8cc02003e.


Protein aggregation and amyloidosis.

Ramamoorthy A.

Biochim Biophys Acta Biomembr. 2018 Jun 1. pii: S0005-2736(18)30159-7. doi: 10.1016/j.bbamem.2018.05.017. [Epub ahead of print] No abstract available.


The Influence of Chemical Modification on Linker Rotational Dynamics in Metal-Organic Frameworks.

Damron JT, Ma J, Kurz R, Saalwächter K, Matzger AJ, Ramamoorthy A.

Angew Chem Int Ed Engl. 2018 Jul 9;57(28):8678-8681. doi: 10.1002/anie.201805004. Epub 2018 Jun 12.


Substrate mediated redox partner selectivity of cytochrome P450.

Gentry KA, Zhang M, Im SC, Waskell L, Ramamoorthy A.

Chem Commun (Camb). 2018 May 31;54(45):5780-5783. doi: 10.1039/c8cc02525h.


hIAPP forms toxic oligomers in plasma.

Rodriguez Camargo DC, Garg D, Buday K, Franko A, Rodriguez Camargo A, Schmidt F, Cox SJ, Suladze S, Haslbeck M, Mideksa YG, Gemmecker G, Aichler M, Mettenleiter G, Schulz M, Walch AK, Hrabě de Angelis M, Feige MJ, Sierra CA, Conrad M, Tripsianes K, Ramamoorthy A, Reif B.

Chem Commun (Camb). 2018 May 24;54(43):5426-5429. doi: 10.1039/c8cc03097a.


Preparation of Stable Amyloid-β Oligomers Without Perturbative Methods.

Kotler SA, Ramamoorthy A.

Methods Mol Biol. 2018;1777:331-338. doi: 10.1007/978-1-4939-7811-3_21.


A Minimal Functional Complex of Cytochrome P450 and FBD of Cytochrome P450 Reductase in Nanodiscs.

Prade E, Mahajan M, Im SC, Zhang M, Gentry KA, Anantharamaiah GM, Waskell L, Ramamoorthy A.

Angew Chem Int Ed Engl. 2018 Jul 9;57(28):8458-8462. doi: 10.1002/anie.201802210. Epub 2018 Jun 14.


Impact of membrane curvature on amyloid aggregation.

Terakawa MS, Lin Y, Kinoshita M, Kanemura S, Itoh D, Sugiki T, Okumura M, Ramamoorthy A, Lee YH.

Biochim Biophys Acta Biomembr. 2018 Apr 28. pii: S0005-2736(18)30130-5. doi: 10.1016/j.bbamem.2018.04.012. [Epub ahead of print] Review.


Engineering l-asparaginase for spontaneous formation of calcium phosphate bioinspired microreactors.

Louka A, Matlahov I, Giuntini S, Cerofolini L, Cavallo A, Pillozzi S, Ravera E, Fragai M, Arcangeli A, Ramamoorthy A, Goobes G, Luchinat C.

Phys Chem Chem Phys. 2018 May 9;20(18):12719-12726. doi: 10.1039/c8cp00419f.


FDA Approval Summary: Niraparib for the Maintenance Treatment of Patients with Recurrent Ovarian Cancer in Response to Platinum-Based Chemotherapy.

Ison G, Howie LJ, Amiri-Kordestani L, Zhang L, Tang S, Sridhara R, Pierre V, Charlab R, Ramamoorthy A, Song P, Li F, Yu J, Manheng W, Palmby TR, Ghosh S, Horne HN, Lee EY, Philip R, Dave K, Chen XH, Kelly SL, Janoria KG, Banerjee A, Eradiri O, Dinin J, Goldberg KB, Pierce WF, Ibrahim A, Kluetz PG, Blumenthal GM, Beaver JA, Pazdur R.

Clin Cancer Res. 2018 Sep 1;24(17):4066-4071. doi: 10.1158/1078-0432.CCR-18-0042. Epub 2018 Apr 12.


A blend of two resveratrol derivatives abolishes hIAPP amyloid growth and membrane damage.

Sciacca MFM, Chillemi R, Sciuto S, Greco V, Messineo C, Kotler SA, Lee DK, Brender JR, Ramamoorthy A, La Rosa C, Milardi D.

Biochim Biophys Acta Biomembr. 2018 Mar 17. pii: S0005-2736(18)30092-0. doi: 10.1016/j.bbamem.2018.03.012. [Epub ahead of print]


Semen-derived amyloidogenic peptides-Key players of HIV infection.

Lee YH, Ramamoorthy A.

Protein Sci. 2018 Jul;27(7):1151-1165. doi: 10.1002/pro.3395. Epub 2018 Mar 14. Review.


Real-time monitoring of the aggregation of Alzheimer's amyloid-β via1H magic angle spinning NMR spectroscopy.

Wang J, Yamamoto T, Bai J, Cox SJ, Korshavn KJ, Monette M, Ramamoorthy A.

Chem Commun (Camb). 2018 Feb 20;54(16):2000-2003. doi: 10.1039/c8cc00167g.


Cytochrome-P450-Induced Ordering of Microsomal Membranes Modulates Affinity for Drugs.

Barnaba C, Sahoo BR, Ravula T, Medina-Meza IG, Im SC, Anantharamaiah GM, Waskell L, Ramamoorthy A.

Angew Chem Int Ed Engl. 2018 Mar 19;57(13):3391-3395. doi: 10.1002/anie.201713167. Epub 2018 Feb 22.


Unusual multiscale mechanics of biomimetic nanoparticle hydrogels.

Zhou Y, Damasceno PF, Somashekar BS, Engel M, Tian F, Zhu J, Huang R, Johnson K, McIntyre C, Sun K, Yang M, Green PF, Ramamoorthy A, Glotzer SC, Kotov NA.

Nat Commun. 2018 Jan 12;9(1):181. doi: 10.1038/s41467-017-02579-w.


Crowdsourced Asparagus Urinary Odor Population Kinetics.

Ramamoorthy A, Sadler BM, van Hasselt JGC, Elassaiss-Schaap J, Kasichayanula S, Edwards AY, van der Graaf PH, Zhang L, Wagner JA.

CPT Pharmacometrics Syst Pharmacol. 2018 Jan;7(1):34-41. doi: 10.1002/psp4.12264. Epub 2017 Dec 14.


Formation of pH-Resistant Monodispersed Polymer-Lipid Nanodiscs.

Ravula T, Hardin NZ, Ramadugu SK, Cox SJ, Ramamoorthy A.

Angew Chem Int Ed Engl. 2018 Jan 26;57(5):1342-1345. doi: 10.1002/anie.201712017. Epub 2018 Jan 8. Erratum in: Angew Chem Int Ed Engl. 2019 Sep 16;58(38):13185.


Spontaneous Lipid Nanodisc Fomation by Amphiphilic Polymethacrylate Copolymers.

Yasuhara K, Arakida J, Ravula T, Ramadugu SK, Sahoo B, Kikuchi JI, Ramamoorthy A.

J Am Chem Soc. 2017 Dec 27;139(51):18657-18663. doi: 10.1021/jacs.7b10591. Epub 2017 Dec 5.

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