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Items: 1 to 50 of 305

1.

Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs.

Sahoo BR, Genjo T, Bekier M, Cox SJ, Stoddard AK, Ivanova M, Yasuhara K, Fierke CA, Wang Y, Ramamoorthy A.

Chem Commun (Camb). 2018 Nov 13;54(91):12883-12886. doi: 10.1039/c8cc07921h.

PMID:
30379172
2.

Demographic Composition of Select Oncologic New Molecular Entities Approved by the FDA Between 2008 and 2017.

Ramamoorthy A, Knepper TC, Merenda C, Mendoza M, McLeod HL, Bull J, Zhang L, Pacanowski M.

Clin Pharmacol Ther. 2018 Nov;104(5):940-948. doi: 10.1002/cpt.1180. Epub 2018 Sep 14.

PMID:
30218447
3.

Nanodisc-Forming Scaffold Protein Promoted Retardation of Amyloid-Beta Aggregation.

Sahoo BR, Genjo T, Cox SJ, Stoddard AK, Anantharamaiah GM, Fierke C, Ramamoorthy A.

J Mol Biol. 2018 Oct 19;430(21):4230-4244. doi: 10.1016/j.jmb.2018.08.018. Epub 2018 Aug 28.

PMID:
30170005
4.

Effect of polymer charge on functional reconstitution of membrane proteins in polymer nanodiscs.

Ravula T, Hardin NZ, Bai J, Im SC, Waskell L, Ramamoorthy A.

Chem Commun (Camb). 2018 Aug 23;54(69):9615-9618. doi: 10.1039/c8cc04184a.

PMID:
30094448
5.

Picturing the Membrane-assisted Choreography of Cytochrome P450 with Lipid Nanodiscs.

Barnaba C, Ramamoorthy A.

Chemphyschem. 2018 Oct 19;19(20):2603-2613. doi: 10.1002/cphc.201800444. Epub 2018 Jul 31. Review.

PMID:
29995333
6.

Lipid-exchange in nanodiscs discloses membrane boundaries of cytochrome-P450 reductase.

Barnaba C, Ravula T, Medina-Meza IG, Im SC, Anantharamaiah GM, Waskell L, Ramamoorthy A.

Chem Commun (Camb). 2018 Jun 14;54(49):6336-6339. doi: 10.1039/c8cc02003e.

PMID:
29863198
7.

Protein aggregation and amyloidosis.

Ramamoorthy A.

Biochim Biophys Acta Biomembr. 2018 Jun 1. pii: S0005-2736(18)30159-7. doi: 10.1016/j.bbamem.2018.05.017. [Epub ahead of print] No abstract available.

PMID:
29859784
8.

The Influence of Chemical Modification on Linker Rotational Dynamics in Metal-Organic Frameworks.

Damron JT, Ma J, Kurz R, Saalwächter K, Matzger AJ, Ramamoorthy A.

Angew Chem Int Ed Engl. 2018 Jul 9;57(28):8678-8681. doi: 10.1002/anie.201805004. Epub 2018 Jun 12.

PMID:
29782692
9.

Substrate mediated redox partner selectivity of cytochrome P450.

Gentry KA, Zhang M, Im SC, Waskell L, Ramamoorthy A.

Chem Commun (Camb). 2018 May 31;54(45):5780-5783. doi: 10.1039/c8cc02525h.

PMID:
29781479
10.

hIAPP forms toxic oligomers in plasma.

Rodriguez Camargo DC, Garg D, Buday K, Franko A, Rodriguez Camargo A, Schmidt F, Cox SJ, Suladze S, Haslbeck M, Mideksa YG, Gemmecker G, Aichler M, Mettenleiter G, Schulz M, Walch AK, Hrabě de Angelis M, Feige MJ, Sierra CA, Conrad M, Tripsianes K, Ramamoorthy A, Reif B.

Chem Commun (Camb). 2018 May 24;54(43):5426-5429. doi: 10.1039/c8cc03097a.

PMID:
29745410
11.

Preparation of Stable Amyloid-β Oligomers Without Perturbative Methods.

Kotler SA, Ramamoorthy A.

Methods Mol Biol. 2018;1777:331-338. doi: 10.1007/978-1-4939-7811-3_21.

PMID:
29744846
12.

A Minimal Functional Complex of Cytochrome P450 and FBD of Cytochrome P450 Reductase in Nanodiscs.

Prade E, Mahajan M, Im SC, Zhang M, Gentry KA, Anantharamaiah GM, Waskell L, Ramamoorthy A.

Angew Chem Int Ed Engl. 2018 Jul 9;57(28):8458-8462. doi: 10.1002/anie.201802210. Epub 2018 Jun 14.

PMID:
29722926
13.

Impact of membrane curvature on amyloid aggregation.

Terakawa MS, Lin Y, Kinoshita M, Kanemura S, Itoh D, Sugiki T, Okumura M, Ramamoorthy A, Lee YH.

Biochim Biophys Acta Biomembr. 2018 Apr 28. pii: S0005-2736(18)30130-5. doi: 10.1016/j.bbamem.2018.04.012. [Epub ahead of print] Review.

PMID:
29709613
14.

Engineering l-asparaginase for spontaneous formation of calcium phosphate bioinspired microreactors.

Louka A, Matlahov I, Giuntini S, Cerofolini L, Cavallo A, Pillozzi S, Ravera E, Fragai M, Arcangeli A, Ramamoorthy A, Goobes G, Luchinat C.

Phys Chem Chem Phys. 2018 May 9;20(18):12719-12726. doi: 10.1039/c8cp00419f.

PMID:
29697113
15.

FDA Approval Summary: Niraparib for the Maintenance Treatment of Patients with Recurrent Ovarian Cancer in Response to Platinum-Based Chemotherapy.

Ison G, Howie LJ, Amiri-Kordestani L, Zhang L, Tang S, Sridhara R, Pierre V, Charlab R, Ramamoorthy A, Song P, Li F, Yu J, Manheng W, Palmby TR, Ghosh S, Horne HN, Lee EY, Philip R, Dave K, Chen XH, Kelly SL, Janoria KG, Banerjee A, Eradiri O, Dinin J, Goldberg KB, Pierce WF, Ibrahim A, Kluetz PG, Blumenthal GM, Beaver JA, Pazdur R.

Clin Cancer Res. 2018 Sep 1;24(17):4066-4071. doi: 10.1158/1078-0432.CCR-18-0042. Epub 2018 Apr 12.

PMID:
29650751
16.

A blend of two resveratrol derivatives abolishes hIAPP amyloid growth and membrane damage.

Sciacca MFM, Chillemi R, Sciuto S, Greco V, Messineo C, Kotler SA, Lee DK, Brender JR, Ramamoorthy A, La Rosa C, Milardi D.

Biochim Biophys Acta Biomembr. 2018 Mar 17. pii: S0005-2736(18)30092-0. doi: 10.1016/j.bbamem.2018.03.012. [Epub ahead of print]

PMID:
29555190
17.

Semen-derived amyloidogenic peptides-Key players of HIV infection.

Lee YH, Ramamoorthy A.

Protein Sci. 2018 Jul;27(7):1151-1165. doi: 10.1002/pro.3395. Epub 2018 Mar 14. Review.

PMID:
29493036
18.

Real-time monitoring of the aggregation of Alzheimer's amyloid-β via1H magic angle spinning NMR spectroscopy.

Wang J, Yamamoto T, Bai J, Cox SJ, Korshavn KJ, Monette M, Ramamoorthy A.

Chem Commun (Camb). 2018 Feb 20;54(16):2000-2003. doi: 10.1039/c8cc00167g.

PMID:
29411841
19.

Cytochrome-P450-Induced Ordering of Microsomal Membranes Modulates Affinity for Drugs.

Barnaba C, Sahoo BR, Ravula T, Medina-Meza IG, Im SC, Anantharamaiah GM, Waskell L, Ramamoorthy A.

Angew Chem Int Ed Engl. 2018 Mar 19;57(13):3391-3395. doi: 10.1002/anie.201713167. Epub 2018 Feb 22.

PMID:
29385304
20.

Unusual multiscale mechanics of biomimetic nanoparticle hydrogels.

Zhou Y, Damasceno PF, Somashekar BS, Engel M, Tian F, Zhu J, Huang R, Johnson K, McIntyre C, Sun K, Yang M, Green PF, Ramamoorthy A, Glotzer SC, Kotov NA.

Nat Commun. 2018 Jan 12;9(1):181. doi: 10.1038/s41467-017-02579-w.

21.

Crowdsourced Asparagus Urinary Odor Population Kinetics.

Ramamoorthy A, Sadler BM, van Hasselt JGC, Elassaiss-Schaap J, Kasichayanula S, Edwards AY, van der Graaf PH, Zhang L, Wagner JA.

CPT Pharmacometrics Syst Pharmacol. 2018 Jan;7(1):34-41. doi: 10.1002/psp4.12264. Epub 2017 Dec 14.

22.

Formation of pH-Resistant Monodispersed Polymer-Lipid Nanodiscs.

Ravula T, Hardin NZ, Ramadugu SK, Cox SJ, Ramamoorthy A.

Angew Chem Int Ed Engl. 2018 Jan 26;57(5):1342-1345. doi: 10.1002/anie.201712017. Epub 2018 Jan 8.

PMID:
29232017
23.

Spontaneous Lipid Nanodisc Fomation by Amphiphilic Polymethacrylate Copolymers.

Yasuhara K, Arakida J, Ravula T, Ramadugu SK, Sahoo B, Kikuchi JI, Ramamoorthy A.

J Am Chem Soc. 2017 Dec 27;139(51):18657-18663. doi: 10.1021/jacs.7b10591. Epub 2017 Dec 5.

24.

Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate.

Rodriguez Camargo DC, Korshavn KJ, Jussupow A, Raltchev K, Goricanec D, Fleisch M, Sarkar R, Xue K, Aichler M, Mettenleiter G, Walch AK, Camilloni C, Hagn F, Reif B, Ramamoorthy A.

Elife. 2017 Nov 17;6. pii: e31226. doi: 10.7554/eLife.31226.

25.

Membrane environment drives cytochrome P450's spin transition and its interaction with cytochrome b5.

Ravula T, Barnaba C, Mahajan M, Anantharamaiah GM, Im SC, Waskell L, Ramamoorthy A.

Chem Commun (Camb). 2017 Nov 28;53(95):12798-12801. doi: 10.1039/c7cc07520k.

PMID:
29143058
26.

Why do we fall into sync with others? Interpersonal synchronization and the brain's optimization principle.

Koban L, Ramamoorthy A, Konvalinka I.

Soc Neurosci. 2017 Nov 8:1-9. doi: 10.1080/17470919.2017.1400463. [Epub ahead of print]

PMID:
29091537
27.

Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease.

Beck MW, Derrick JS, Suh JM, Kim M, Korshavn KJ, Kerr RA, Cho WJ, Larsen SD, Ruotolo BT, Ramamoorthy A, Lim MH.

ChemMedChem. 2017 Nov 22;12(22):1828-1838. doi: 10.1002/cmdc.201700456. Epub 2017 Oct 9.

28.

Multi-target-directed phenol-triazole ligands as therapeutic agents for Alzheimer's disease.

Jones MR, Mathieu E, Dyrager C, Faissner S, Vaillancourt Z, Korshavn KJ, Lim MH, Ramamoorthy A, Wee Yong V, Tsutsui S, Stys PK, Storr T.

Chem Sci. 2017 Aug 1;8(8):5636-5643. doi: 10.1039/c7sc01269a. Epub 2017 Jun 5.

29.

Polymer nanodiscs and macro-nanodiscs of a varying lipid composition.

Ramadugu VSK, Di Mauro GM, Ravula T, Ramamoorthy A.

Chem Commun (Camb). 2017 Sep 28;53(78):10824-10826. doi: 10.1039/c7cc06409h.

30.

pH Tunable and Divalent Metal Ion Tolerant Polymer Lipid Nanodiscs.

Ravula T, Hardin NZ, Ramadugu SK, Ramamoorthy A.

Langmuir. 2017 Oct 10;33(40):10655-10662. doi: 10.1021/acs.langmuir.7b02887. Epub 2017 Sep 26.

PMID:
28920693
31.

Electrostatic Constraints Assessed by 1H MAS NMR Illuminate Differences in Crystalline Polymorphs.

Damron JT, Kersten KM, Pandey MK, Mroue KH, Yarava JR, Nishiyama Y, Matzger AJ, Ramamoorthy A.

J Phys Chem Lett. 2017 Sep 7;8(17):4253-4257. doi: 10.1021/acs.jpclett.7b01650. Epub 2017 Aug 25.

PMID:
28825828
32.

Kinetic and Structural Characterization of the Effects of Membrane on the Complex of Cytochrome b 5 and Cytochrome c.

Gentry KA, Prade E, Barnaba C, Zhang M, Mahajan M, Im SC, Anantharamaiah GM, Nagao S, Waskell L, Ramamoorthy A.

Sci Rep. 2017 Aug 10;7(1):7793. doi: 10.1038/s41598-017-08130-7.

33.

Growth-incompetent monomers of human calcitonin lead to a noncanonical direct relationship between peptide concentration and aggregation lag time.

Kamgar-Parsi K, Hong L, Naito A, Brooks CL 3rd, Ramamoorthy A.

J Biol Chem. 2017 Sep 8;292(36):14963-14976. doi: 10.1074/jbc.M117.791236. Epub 2017 Jul 24.

34.

Bioinspired, Size-Tunable Self-Assembly of Polymer-Lipid Bilayer Nanodiscs.

Ravula T, Ramadugu SK, Di Mauro G, Ramamoorthy A.

Angew Chem Int Ed Engl. 2017 Sep 11;56(38):11466-11470. doi: 10.1002/anie.201705569. Epub 2017 Aug 10.

35.

Accelerated molecular dynamics simulation analysis of MSI-594 in a lipid bilayer.

Mukherjee S, Kar RK, Nanga RPR, Mroue KH, Ramamoorthy A, Bhunia A.

Phys Chem Chem Phys. 2017 Jul 26;19(29):19289-19299. doi: 10.1039/c7cp01941f.

36.
37.

Model membrane size-dependent amyloidogenesis of Alzheimer's amyloid-β peptides.

Kinoshita M, Kakimoto E, Terakawa MS, Lin Y, Ikenoue T, So M, Sugiki T, Ramamoorthy A, Goto Y, Lee YH.

Phys Chem Chem Phys. 2017 Jun 21;19(24):16257-16266. doi: 10.1039/c6cp07774a.

PMID:
28608875
38.

Dynamic membrane interactions of antibacterial and antifungal biomolecules, and amyloid peptides, revealed by solid-state NMR spectroscopy.

Naito A, Matsumori N, Ramamoorthy A.

Biochim Biophys Acta Gen Subj. 2018 Feb;1862(2):307-323. doi: 10.1016/j.bbagen.2017.06.004. Epub 2017 Jun 6. Review.

PMID:
28599848
39.

3D Double-Quantum/Double-Quantum Exchange Spectroscopy of Protons under 100 kHz Magic Angle Spinning.

Zhang R, Duong NT, Nishiyama Y, Ramamoorthy A.

J Phys Chem B. 2017 Jun 22;121(24):5944-5952. doi: 10.1021/acs.jpcb.7b03480. Epub 2017 Jun 9.

PMID:
28537394
40.

The catalytic function of cytochrome P450 is entwined with its membrane-bound nature.

Barnaba C, Gentry K, Sumangala N, Ramamoorthy A.

F1000Res. 2017 May 9;6:662. doi: 10.12688/f1000research.11015.1. eCollection 2017. Review.

41.

Conformations and Intermolecular Interactions in Cellulose/Silk Fibroin Blend Films: A Solid-State NMR Perspective.

Tian D, Li T, Zhang R, Wu Q, Chen T, Sun P, Ramamoorthy A.

J Phys Chem B. 2017 Jun 29;121(25):6108-6116. doi: 10.1021/acs.jpcb.7b02838. Epub 2017 May 17.

PMID:
28481526
42.

Proton-Based Ultrafast Magic Angle Spinning Solid-State NMR Spectroscopy.

Zhang R, Mroue KH, Ramamoorthy A.

Acc Chem Res. 2017 Apr 18;50(4):1105-1113. doi: 10.1021/acs.accounts.7b00082. Epub 2017 Mar 29. Review.

43.

Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β.

Korshavn KJ, Satriano C, Lin Y, Zhang R, Dulchavsky M, Bhunia A, Ivanova MI, Lee YH, La Rosa C, Lim MH, Ramamoorthy A.

J Biol Chem. 2017 Mar 17;292(11):4638-4650. doi: 10.1074/jbc.M116.764092. Epub 2017 Feb 1.

44.

Natural Alternatives for Chemicals Used in Histopathology Lab- A Literature Review.

Ramamoorthy A, Ravi S, Jeddy N, Thangavelu R, Janardhanan S.

J Clin Diagn Res. 2016 Nov;10(11):EE01-EE04. doi: 10.7860/JCDR/2016/23420.8860. Epub 2016 Nov 1. Review.

45.

Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-Related Pathological Features in Alzheimer's Disease.

Lee HJ, Korshavn KJ, Nam Y, Kang J, Paul TJ, Kerr RA, Youn IS, Ozbil M, Kim KS, Ruotolo BT, Prabhakar R, Ramamoorthy A, Lim MH.

Chemistry. 2017 Feb 21;23(11):2706-2715. doi: 10.1002/chem.201605401. Epub 2017 Jan 26.

46.

An Iridium(III) Complex as a Photoactivatable Tool for Oxidation of Amyloidogenic Peptides with Subsequent Modulation of Peptide Aggregation.

Kang J, Lee SJ, Nam JS, Lee HJ, Kang MG, Korshavn KJ, Kim HT, Cho J, Ramamoorthy A, Rhee HW, Kwon TH, Lim MH.

Chemistry. 2017 Jan 31;23(7):1645-1653. doi: 10.1002/chem.201604751. Epub 2017 Jan 3.

47.

Mode of Action of a Designed Antimicrobial Peptide: High Potency against Cryptococcus neoformans.

Datta A, Yadav V, Ghosh A, Choi J, Bhattacharyya D, Kar RK, Ilyas H, Dutta A, An E, Mukhopadhyay J, Lee D, Sanyal K, Ramamoorthy A, Bhunia A.

Biophys J. 2016 Oct 18;111(8):1724-1737. doi: 10.1016/j.bpj.2016.08.032.

48.

The Role of Cholesterol in Driving IAPP-Membrane Interactions.

Sciacca MF, Lolicato F, Di Mauro G, Milardi D, D'Urso L, Satriano C, Ramamoorthy A, La Rosa C.

Biophys J. 2016 Jul 12;111(1):140-51. doi: 10.1016/j.bpj.2016.05.050.

49.

Selective detection and complete identification of triglycerides in cortical bone by high-resolution (1)H MAS NMR spectroscopy.

Mroue KH, Xu J, Zhu P, Morris MD, Ramamoorthy A.

Phys Chem Chem Phys. 2016 Jul 28;18(28):18687-91. doi: 10.1039/c6cp03506j. Epub 2016 Jul 4.

50.

Enhancing NMR Sensitivity of Natural-Abundance Low-γ Nuclei by Ultrafast Magic-Angle-Spinning Solid-State NMR Spectroscopy.

Zhang R, Chen Y, Rodriguez-Hornedo N, Ramamoorthy A.

Chemphyschem. 2016 Oct 5;17(19):2962-2966. doi: 10.1002/cphc.201600637. Epub 2016 Jul 22.

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