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Items: 1 to 50 of 328

1.

Corrigendum: Bioinspired, Size-Tunable Self-Assembly of Polymer-Lipid Bilayer Nanodiscs.

Ravula T, Ramadugu SK, Di Mauro G, Ramamoorthy A.

Angew Chem Int Ed Engl. 2019 Sep 16;58(38):13184. doi: 10.1002/anie.201906502. No abstract available.

PMID:
31532905
2.

Corrigendum: Formation of pH-Resistant Monodispersed Polymer-Lipid Bilayer Nanodiscs.

Ravula T, Hardin NZ, Ramadugu SK, Cox SJ, Ramamoorthy A.

Angew Chem Int Ed Engl. 2019 Sep 16;58(38):13185. doi: 10.1002/anie.201906504. No abstract available.

PMID:
31532904
3.

Metal-Chelated Polymer Nanodiscs for NMR Studies.

Hardin N, Kocman V, Di Mauro G, Ravula T, Ramamoorthy A.

Angew Chem Int Ed Engl. 2019 Sep 17. doi: 10.1002/anie.201910118. [Epub ahead of print]

PMID:
31529579
4.

Evolution of Next Generation Therapeutics: Past, Present, and Future of Precision Medicines.

Ramamoorthy A, Karnes JH, Finkel R, Blanchard R, Pacanowski M.

Clin Transl Sci. 2019 Aug 23. doi: 10.1111/cts.12675. [Epub ahead of print] No abstract available.

PMID:
31444855
5.

Use of paramagnetic systems to speed-up NMR data acquisition and for structural and dynamic studies.

Kocman V, Di Mauro GM, Veglia G, Ramamoorthy A.

Solid State Nucl Magn Reson. 2019 Oct;102:36-46. doi: 10.1016/j.ssnmr.2019.07.002. Epub 2019 Jul 12. Review.

PMID:
31325686
6.

Magnetic Alignment of Polymer Macro-Nanodiscs Enables Residual-Dipolar-Coupling-Based High-Resolution Structural Studies by NMR Spectroscopy.

Ravula T, Ramamoorthy A.

Angew Chem Int Ed Engl. 2019 Oct 14;58(42):14925-14928. doi: 10.1002/anie.201907655. Epub 2019 Sep 11.

PMID:
31310700
7.

Diverse Structural Conversion and Aggregation Pathways of Alzheimer's Amyloid-β (1-40).

Lin Y, Sahoo BR, Ozawa D, Kinoshita M, Kang J, Lim MH, Okumura M, Huh YH, Moon E, Jang JH, Lee HJ, Ryu KY, Ham S, Won HS, Ryu KS, Sugiki T, Bang JK, Hoe HS, Fujiwara T, Ramamoorthy A, Lee YH.

ACS Nano. 2019 Aug 27;13(8):8766-8783. doi: 10.1021/acsnano.9b01578. Epub 2019 Jul 24.

PMID:
31310506
8.

What Does It Take to Transform Real-World Data Into Real-World Evidence?

Ramamoorthy A, Huang SM.

Clin Pharmacol Ther. 2019 Jul;106(1):10-18. doi: 10.1002/cpt.1486. No abstract available.

PMID:
31273768
9.

Styrene maleic acid derivates to enhance the applications of bio-inspired polymer based lipid-nanodiscs.

Ravula T, Hardin NZ, Di Mauro GM, Ramamoorthy A.

Eur Polym J. 2018 Nov;108:597-602. doi: 10.1016/j.eurpolymj.2018.09.048. Epub 2018 Sep 25.

PMID:
31105326
10.

Self-Assembly of Polymer-Encased Lipid Nanodiscs and Membrane Protein Reconstitution.

Sahoo BR, Genjo T, Moharana KC, Ramamoorthy A.

J Phys Chem B. 2019 May 30;123(21):4562-4570. doi: 10.1021/acs.jpcb.9b03681. Epub 2019 May 16.

PMID:
31050900
11.

Probing membrane enhanced protein-protein interactions in a minimal redox complex of cytochrome-P450 and P450-reductase.

Mahajan M, Ravula T, Prade E, Anantharamaiah GM, Ramamoorthy A.

Chem Commun (Camb). 2019 May 16;55(41):5777-5780. doi: 10.1039/c9cc01630a.

PMID:
31041432
12.

A cationic polymethacrylate-copolymer acts as an agonist for β-amyloid and an antagonist for amylin fibrillation.

Sahoo BR, Genjo T, Nakayama TW, Stoddard AK, Ando T, Yasuhara K, Fierke CA, Ramamoorthy A.

Chem Sci. 2019 Feb 27;10(14):3976-3986. doi: 10.1039/c8sc05771k. eCollection 2019 Apr 14.

13.

An Overview of Genomic Biomarker Use in Cardiovascular Disease Clinical Trials.

Adeniyi O, Ramamoorthy A, Schuck R, Sun J, Wilson J, Zineh I, Pacanowski M.

Clin Pharmacol Ther. 2019 Oct;106(4):841-846. doi: 10.1002/cpt.1473. Epub 2019 Jun 20.

PMID:
31002380
14.

Real-World Data and Clinical Pharmacology: A Regulatory Science Perspective.

Liu Q, Ramamoorthy A, Huang SM.

Clin Pharmacol Ther. 2019 Jul;106(1):67-71. doi: 10.1002/cpt.1413. Epub 2019 Apr 9. No abstract available.

PMID:
30964944
15.

Probing transient non-native states in amyloid beta fiber elongation by NMR.

Brender JR, Ghosh A, Kotler SA, Krishnamoorthy J, Bera S, Morris V, Sil TB, Garai K, Reif B, Bhunia A, Ramamoorthy A.

Chem Commun (Camb). 2019 Apr 11;55(31):4483-4486. doi: 10.1039/c9cc01067j.

PMID:
30917192
16.

Polymer nanodiscs: Advantages and limitations.

Ravula T, Hardin NZ, Ramamoorthy A.

Chem Phys Lipids. 2019 Mar;219:45-49. doi: 10.1016/j.chemphyslip.2019.01.010. Epub 2019 Jan 29. Review.

PMID:
30707909
17.

Hydrophobic Functionalization of Polyacrylic Acid as a Versatile Platform for the Development of Polymer Lipid Nanodisks.

Hardin NZ, Ravula T, Mauro GD, Ramamoorthy A.

Small. 2019 Mar;15(9):e1804813. doi: 10.1002/smll.201804813. Epub 2019 Jan 22.

PMID:
30667600
18.

Proton-detected 3D 1H anisotropic/14N/1H isotropic chemical shifts correlation NMR under fast magic angle spinning on solid samples without isotopic enrichment.

Pandey MK, Damron JT, Ramamoorthy A, Nishiyama Y.

Solid State Nucl Magn Reson. 2019 Feb;97:40-45. doi: 10.1016/j.ssnmr.2018.12.002. Epub 2018 Dec 28.

PMID:
30623800
19.

PathFX provides mechanistic insights into drug efficacy and safety for regulatory review and therapeutic development.

Wilson JL, Racz R, Liu T, Adeniyi O, Sun J, Ramamoorthy A, Pacanowski M, Altman R.

PLoS Comput Biol. 2018 Dec 7;14(12):e1006614. doi: 10.1371/journal.pcbi.1006614. eCollection 2018 Dec.

20.

Retraction: Polymer nanodiscs and macro-nanodiscs of a varying lipid composition.

Ramadugu VSK, Di Mauro GM, Ravula T, Ramamoorthy A.

Chem Commun (Camb). 2018 Dec 11;54(99):14033. doi: 10.1039/c8cc90544d.

21.

Unveiling the Genetic Architecture of Human Disease for Precision Medicine.

Ramamoorthy A, Yee SW, Karnes J.

Clin Transl Sci. 2019 Jan;12(1):3-5. doi: 10.1111/cts.12593. Epub 2018 Nov 26. No abstract available.

22.

Zinc boosts EGCG's hIAPP amyloid Inhibition both in solution and membrane.

Lee YH, Lin Y, Cox SJ, Kinoshita M, Sahoo BR, Ivanova M, Ramamoorthy A.

Biochim Biophys Acta Proteins Proteom. 2019 May;1867(5):529-536. doi: 10.1016/j.bbapap.2018.11.006. Epub 2018 Nov 22.

PMID:
30468883
23.

Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs.

Sahoo BR, Genjo T, Bekier M, Cox SJ, Stoddard AK, Ivanova M, Yasuhara K, Fierke CA, Wang Y, Ramamoorthy A.

Chem Commun (Camb). 2018 Nov 13;54(91):12883-12886. doi: 10.1039/c8cc07921h.

PMID:
30379172
24.

Demographic Composition of Select Oncologic New Molecular Entities Approved by the FDA Between 2008 and 2017.

Ramamoorthy A, Knepper TC, Merenda C, Mendoza M, McLeod HL, Bull J, Zhang L, Pacanowski M.

Clin Pharmacol Ther. 2018 Nov;104(5):940-948. doi: 10.1002/cpt.1180. Epub 2018 Sep 14.

25.

Nanodisc-Forming Scaffold Protein Promoted Retardation of Amyloid-Beta Aggregation.

Sahoo BR, Genjo T, Cox SJ, Stoddard AK, Anantharamaiah GM, Fierke C, Ramamoorthy A.

J Mol Biol. 2018 Oct 19;430(21):4230-4244. doi: 10.1016/j.jmb.2018.08.018. Epub 2018 Aug 28.

PMID:
30170005
26.

Effect of polymer charge on functional reconstitution of membrane proteins in polymer nanodiscs.

Ravula T, Hardin NZ, Bai J, Im SC, Waskell L, Ramamoorthy A.

Chem Commun (Camb). 2018 Aug 23;54(69):9615-9618. doi: 10.1039/c8cc04184a.

27.

Picturing the Membrane-assisted Choreography of Cytochrome P450 with Lipid Nanodiscs.

Barnaba C, Ramamoorthy A.

Chemphyschem. 2018 Oct 19;19(20):2603-2613. doi: 10.1002/cphc.201800444. Epub 2018 Jul 31. Review.

PMID:
29995333
28.

Lipid-exchange in nanodiscs discloses membrane boundaries of cytochrome-P450 reductase.

Barnaba C, Ravula T, Medina-Meza IG, Im SC, Anantharamaiah GM, Waskell L, Ramamoorthy A.

Chem Commun (Camb). 2018 Jun 14;54(49):6336-6339. doi: 10.1039/c8cc02003e.

29.

Protein aggregation and amyloidosis.

Ramamoorthy A.

Biochim Biophys Acta Biomembr. 2018 Jun 1. pii: S0005-2736(18)30159-7. doi: 10.1016/j.bbamem.2018.05.017. [Epub ahead of print] No abstract available.

30.

The Influence of Chemical Modification on Linker Rotational Dynamics in Metal-Organic Frameworks.

Damron JT, Ma J, Kurz R, Saalwächter K, Matzger AJ, Ramamoorthy A.

Angew Chem Int Ed Engl. 2018 Jul 9;57(28):8678-8681. doi: 10.1002/anie.201805004. Epub 2018 Jun 12.

31.

Substrate mediated redox partner selectivity of cytochrome P450.

Gentry KA, Zhang M, Im SC, Waskell L, Ramamoorthy A.

Chem Commun (Camb). 2018 May 31;54(45):5780-5783. doi: 10.1039/c8cc02525h.

32.

hIAPP forms toxic oligomers in plasma.

Rodriguez Camargo DC, Garg D, Buday K, Franko A, Rodriguez Camargo A, Schmidt F, Cox SJ, Suladze S, Haslbeck M, Mideksa YG, Gemmecker G, Aichler M, Mettenleiter G, Schulz M, Walch AK, Hrabě de Angelis M, Feige MJ, Sierra CA, Conrad M, Tripsianes K, Ramamoorthy A, Reif B.

Chem Commun (Camb). 2018 May 24;54(43):5426-5429. doi: 10.1039/c8cc03097a.

33.

Preparation of Stable Amyloid-β Oligomers Without Perturbative Methods.

Kotler SA, Ramamoorthy A.

Methods Mol Biol. 2018;1777:331-338. doi: 10.1007/978-1-4939-7811-3_21.

PMID:
29744846
34.

A Minimal Functional Complex of Cytochrome P450 and FBD of Cytochrome P450 Reductase in Nanodiscs.

Prade E, Mahajan M, Im SC, Zhang M, Gentry KA, Anantharamaiah GM, Waskell L, Ramamoorthy A.

Angew Chem Int Ed Engl. 2018 Jul 9;57(28):8458-8462. doi: 10.1002/anie.201802210. Epub 2018 Jun 14.

35.

Impact of membrane curvature on amyloid aggregation.

Terakawa MS, Lin Y, Kinoshita M, Kanemura S, Itoh D, Sugiki T, Okumura M, Ramamoorthy A, Lee YH.

Biochim Biophys Acta Biomembr. 2018 Apr 28. pii: S0005-2736(18)30130-5. doi: 10.1016/j.bbamem.2018.04.012. [Epub ahead of print] Review.

36.

Engineering l-asparaginase for spontaneous formation of calcium phosphate bioinspired microreactors.

Louka A, Matlahov I, Giuntini S, Cerofolini L, Cavallo A, Pillozzi S, Ravera E, Fragai M, Arcangeli A, Ramamoorthy A, Goobes G, Luchinat C.

Phys Chem Chem Phys. 2018 May 9;20(18):12719-12726. doi: 10.1039/c8cp00419f.

PMID:
29697113
37.

FDA Approval Summary: Niraparib for the Maintenance Treatment of Patients with Recurrent Ovarian Cancer in Response to Platinum-Based Chemotherapy.

Ison G, Howie LJ, Amiri-Kordestani L, Zhang L, Tang S, Sridhara R, Pierre V, Charlab R, Ramamoorthy A, Song P, Li F, Yu J, Manheng W, Palmby TR, Ghosh S, Horne HN, Lee EY, Philip R, Dave K, Chen XH, Kelly SL, Janoria KG, Banerjee A, Eradiri O, Dinin J, Goldberg KB, Pierce WF, Ibrahim A, Kluetz PG, Blumenthal GM, Beaver JA, Pazdur R.

Clin Cancer Res. 2018 Sep 1;24(17):4066-4071. doi: 10.1158/1078-0432.CCR-18-0042. Epub 2018 Apr 12.

38.

A blend of two resveratrol derivatives abolishes hIAPP amyloid growth and membrane damage.

Sciacca MFM, Chillemi R, Sciuto S, Greco V, Messineo C, Kotler SA, Lee DK, Brender JR, Ramamoorthy A, La Rosa C, Milardi D.

Biochim Biophys Acta Biomembr. 2018 Mar 17. pii: S0005-2736(18)30092-0. doi: 10.1016/j.bbamem.2018.03.012. [Epub ahead of print]

39.

Semen-derived amyloidogenic peptides-Key players of HIV infection.

Lee YH, Ramamoorthy A.

Protein Sci. 2018 Jul;27(7):1151-1165. doi: 10.1002/pro.3395. Epub 2018 Mar 14. Review.

40.

Real-time monitoring of the aggregation of Alzheimer's amyloid-β via1H magic angle spinning NMR spectroscopy.

Wang J, Yamamoto T, Bai J, Cox SJ, Korshavn KJ, Monette M, Ramamoorthy A.

Chem Commun (Camb). 2018 Feb 20;54(16):2000-2003. doi: 10.1039/c8cc00167g.

41.

Cytochrome-P450-Induced Ordering of Microsomal Membranes Modulates Affinity for Drugs.

Barnaba C, Sahoo BR, Ravula T, Medina-Meza IG, Im SC, Anantharamaiah GM, Waskell L, Ramamoorthy A.

Angew Chem Int Ed Engl. 2018 Mar 19;57(13):3391-3395. doi: 10.1002/anie.201713167. Epub 2018 Feb 22.

42.

Unusual multiscale mechanics of biomimetic nanoparticle hydrogels.

Zhou Y, Damasceno PF, Somashekar BS, Engel M, Tian F, Zhu J, Huang R, Johnson K, McIntyre C, Sun K, Yang M, Green PF, Ramamoorthy A, Glotzer SC, Kotov NA.

Nat Commun. 2018 Jan 12;9(1):181. doi: 10.1038/s41467-017-02579-w.

43.

Crowdsourced Asparagus Urinary Odor Population Kinetics.

Ramamoorthy A, Sadler BM, van Hasselt JGC, Elassaiss-Schaap J, Kasichayanula S, Edwards AY, van der Graaf PH, Zhang L, Wagner JA.

CPT Pharmacometrics Syst Pharmacol. 2018 Jan;7(1):34-41. doi: 10.1002/psp4.12264. Epub 2017 Dec 14.

44.

Formation of pH-Resistant Monodispersed Polymer-Lipid Nanodiscs.

Ravula T, Hardin NZ, Ramadugu SK, Cox SJ, Ramamoorthy A.

Angew Chem Int Ed Engl. 2018 Jan 26;57(5):1342-1345. doi: 10.1002/anie.201712017. Epub 2018 Jan 8. Erratum in: Angew Chem Int Ed Engl. 2019 Sep 16;58(38):13185.

45.

Spontaneous Lipid Nanodisc Fomation by Amphiphilic Polymethacrylate Copolymers.

Yasuhara K, Arakida J, Ravula T, Ramadugu SK, Sahoo B, Kikuchi JI, Ramamoorthy A.

J Am Chem Soc. 2017 Dec 27;139(51):18657-18663. doi: 10.1021/jacs.7b10591. Epub 2017 Dec 5.

46.

Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate.

Rodriguez Camargo DC, Korshavn KJ, Jussupow A, Raltchev K, Goricanec D, Fleisch M, Sarkar R, Xue K, Aichler M, Mettenleiter G, Walch AK, Camilloni C, Hagn F, Reif B, Ramamoorthy A.

Elife. 2017 Nov 17;6. pii: e31226. doi: 10.7554/eLife.31226.

47.

Membrane environment drives cytochrome P450's spin transition and its interaction with cytochrome b5.

Ravula T, Barnaba C, Mahajan M, Anantharamaiah GM, Im SC, Waskell L, Ramamoorthy A.

Chem Commun (Camb). 2017 Nov 28;53(95):12798-12801. doi: 10.1039/c7cc07520k.

48.

Why do we fall into sync with others? Interpersonal synchronization and the brain's optimization principle.

Koban L, Ramamoorthy A, Konvalinka I.

Soc Neurosci. 2019 Feb;14(1):1-9. doi: 10.1080/17470919.2017.1400463. Epub 2017 Nov 8.

PMID:
29091537
49.

Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease.

Beck MW, Derrick JS, Suh JM, Kim M, Korshavn KJ, Kerr RA, Cho WJ, Larsen SD, Ruotolo BT, Ramamoorthy A, Lim MH.

ChemMedChem. 2017 Nov 22;12(22):1828-1838. doi: 10.1002/cmdc.201700456. Epub 2017 Oct 9.

50.

Multi-target-directed phenol-triazole ligands as therapeutic agents for Alzheimer's disease.

Jones MR, Mathieu E, Dyrager C, Faissner S, Vaillancourt Z, Korshavn KJ, Lim MH, Ramamoorthy A, Wee Yong V, Tsutsui S, Stys PK, Storr T.

Chem Sci. 2017 Aug 1;8(8):5636-5643. doi: 10.1039/c7sc01269a. Epub 2017 Jun 5.

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