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Items: 39

1.

Anti-IL-13Rα2 therapy promotes recovery in a murine model of inflammatory bowel disease.

Karmele EP, Pasricha TS, Ramalingam TR, Thompson RW, Gieseck RL 3rd, Knilans KJ, Hegen M, Farmer M, Jin F, Kleinman A, Hinds DA; 23andMe Research Team, Almeida Pereira T, de Queiroz Prado R, Bing N, Tchistiakova L, Kasaian MT, Wynn TA, Vannella KM.

Mucosal Immunol. 2019 Sep;12(5):1174-1186. doi: 10.1038/s41385-019-0189-6. Epub 2019 Jul 15.

PMID:
31308480
2.

TAZ is required for lung alveolar epithelial cell differentiation after injury.

Sun T, Huang Z, Zhang H, Posner C, Jia G, Ramalingam TR, Xu M, Brightbill H, Egen JG, Dey A, Arron JR.

JCI Insight. 2019 Jun 18;5. pii: 128674. doi: 10.1172/jci.insight.128674.

3.

Prognostic and predictive biomarkers for patients with idiopathic pulmonary fibrosis treated with pirfenidone: post-hoc assessment of the CAPACITY and ASCEND trials.

Neighbors M, Cabanski CR, Ramalingam TR, Sheng XR, Tew GW, Gu C, Jia G, Peng K, Ray JM, Ley B, Wolters PJ, Collard HR, Arron JR.

Lancet Respir Med. 2018 Aug;6(8):615-626. doi: 10.1016/S2213-2600(18)30185-1. Epub 2018 Jun 29.

PMID:
30072107
4.

Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a candidate gene sequencing study.

Dressen A, Abbas AR, Cabanski C, Reeder J, Ramalingam TR, Neighbors M, Bhangale TR, Brauer MJ, Hunkapiller J, Reeder J, Mukhyala K, Cuenco K, Tom J, Cowgill A, Vogel J, Forrest WF, Collard HR, Wolters PJ, Kropski JA, Lancaster LH, Blackwell TS, Arron JR, Yaspan BL.

Lancet Respir Med. 2018 Aug;6(8):603-614. doi: 10.1016/S2213-2600(18)30135-8. Epub 2018 Jun 18.

5.

Type 2 immunity is protective in metabolic disease but exacerbates NAFLD collaboratively with TGF-β.

Hart KM, Fabre T, Sciurba JC, Gieseck RL 3rd, Borthwick LA, Vannella KM, Acciani TH, de Queiroz Prado R, Thompson RW, White S, Soucy G, Bilodeau M, Ramalingam TR, Arron JR, Shoukry NH, Wynn TA.

Sci Transl Med. 2017 Jun 28;9(396). pii: eaal3694. doi: 10.1126/scitranslmed.aal3694.

PMID:
28659437
6.

Cutting Edge: Eosinophils Undergo Caspase-1-Mediated Pyroptosis in Response to Necrotic Liver Cells.

Palacios-Macapagal D, Connor J, Mustelin T, Ramalingam TR, Wynn TA, Davidson TS.

J Immunol. 2017 Aug 1;199(3):847-853. doi: 10.4049/jimmunol.1601162. Epub 2017 Jun 26.

7.

IL-13 is a therapeutic target in radiation lung injury.

Chung SI, Horton JA, Ramalingam TR, White AO, Chung EJ, Hudak KE, Scroggins BT, Arron JR, Wynn TA, Citrin DE.

Sci Rep. 2016 Dec 22;6:39714. doi: 10.1038/srep39714.

8.

Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection.

Wilhelm C, Harrison OJ, Schmitt V, Pelletier M, Spencer SP, Urban JF Jr, Ploch M, Ramalingam TR, Siegel RM, Belkaid Y.

J Exp Med. 2016 Jul 25;213(8):1409-18. doi: 10.1084/jem.20151448. Epub 2016 Jul 18.

9.

Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis.

Gieseck RL 3rd, Ramalingam TR, Hart KM, Vannella KM, Cantu DA, Lu WY, Ferreira-González S, Forbes SJ, Vallier L, Wynn TA.

Immunity. 2016 Jul 19;45(1):145-58. doi: 10.1016/j.immuni.2016.06.009. Epub 2016 Jul 12.

10.

Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine-driven inflammation and fibrosis.

Vannella KM, Ramalingam TR, Borthwick LA, Barron L, Hart KM, Thompson RW, Kindrachuk KN, Cheever AW, White S, Budelsky AL, Comeau MR, Smith DE, Wynn TA.

Sci Transl Med. 2016 May 4;8(337):337ra65. doi: 10.1126/scitranslmed.aaf1938.

PMID:
27147589
11.

Enhanced protection from fibrosis and inflammation in the combined absence of IL-13 and IFN-γ.

Ramalingam TR, Gieseck RL, Acciani TH, M Hart K, Cheever AW, Mentink-Kane MM, Vannella KM, Wynn TA.

J Pathol. 2016 Jul;239(3):344-54. doi: 10.1002/path.4733. Epub 2016 Jun 10.

12.

Acidic chitinase primes the protective immune response to gastrointestinal nematodes.

Vannella KM, Ramalingam TR, Hart KM, de Queiroz Prado R, Sciurba J, Barron L, Borthwick LA, Smith AD, Mentink-Kane M, White S, Thompson RW, Cheever AW, Bock K, Moore I, Fitz LJ, Urban JF Jr, Wynn TA.

Nat Immunol. 2016 May;17(5):538-44. doi: 10.1038/ni.3417. Epub 2016 Apr 4.

13.

Interleukin-13 Receptor α1-Dependent Responses in the Intestine Are Critical to Parasite Clearance.

Sun R, Urban JF Jr, Notari L, Vanuytsel T, Madden KB, Bohl JA, Ramalingam TR, Wynn TA, Zhao A, Shea-Donohue T.

Infect Immun. 2016 Mar 24;84(4):1032-1044. doi: 10.1128/IAI.00990-15. Print 2016 Apr.

14.

IL-25 or IL-17E Protects against High-Fat Diet-Induced Hepatic Steatosis in Mice Dependent upon IL-13 Activation of STAT6.

Wang AJ, Yang Z, Grinchuk V, Smith A, Qin B, Lu N, Wang D, Wang H, Ramalingam TR, Wynn TA, Urban JF Jr, Shea-Donohue T, Zhao A.

J Immunol. 2015 Nov 15;195(10):4771-80. doi: 10.4049/jimmunol.1500337. Epub 2015 Sep 30.

15.

TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma.

Choy DF, Hart KM, Borthwick LA, Shikotra A, Nagarkar DR, Siddiqui S, Jia G, Ohri CM, Doran E, Vannella KM, Butler CA, Hargadon B, Sciurba JC, Gieseck RL, Thompson RW, White S, Abbas AR, Jackman J, Wu LC, Egen JG, Heaney LG, Ramalingam TR, Arron JR, Wynn TA, Bradding P.

Sci Transl Med. 2015 Aug 19;7(301):301ra129. doi: 10.1126/scitranslmed.aab3142.

PMID:
26290411
16.

Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis.

Borthwick LA, Barron L, Hart KM, Vannella KM, Thompson RW, Oland S, Cheever A, Sciurba J, Ramalingam TR, Fisher AJ, Wynn TA.

Mucosal Immunol. 2016 Jan;9(1):38-55. doi: 10.1038/mi.2015.34. Epub 2015 Apr 29.

17.

Incomplete deletion of IL-4Rα by LysM(Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis.

Vannella KM, Barron L, Borthwick LA, Kindrachuk KN, Narasimhan PB, Hart KM, Thompson RW, White S, Cheever AW, Ramalingam TR, Wynn TA.

PLoS Pathog. 2014 Sep 11;10(9):e1004372. doi: 10.1371/journal.ppat.1004372. eCollection 2014 Sep.

18.

TNF-α/IL-17 synergy inhibits IL-13 bioactivity via IL-13Rα2 induction.

Badalyan V, Thompson R, Addo K, Borthwick LA, Fisher AJ, Ort T, Myers TG, Wynn TA, Ramalingam TR.

J Allergy Clin Immunol. 2014 Oct;134(4):975-8.e5. doi: 10.1016/j.jaci.2014.05.019. Epub 2014 Jun 20. No abstract available.

19.

Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity.

Spencer SP, Wilhelm C, Yang Q, Hall JA, Bouladoux N, Boyd A, Nutman TB, Urban JF Jr, Wang J, Ramalingam TR, Bhandoola A, Wynn TA, Belkaid Y.

Science. 2014 Jan 24;343(6169):432-7. doi: 10.1126/science.1247606.

20.

Genetic deletion of IL-25 (IL-17E) confers resistance to dextran sulfate sodium-induced colitis in mice.

Wang AJ, Smith A, Li Y, Urban JF Jr, Ramalingam TR, Wynn TA, Lu N, Shea-Donohue T, Yang Z, Zhao A.

Cell Biosci. 2014 Nov 26;4:72. doi: 10.1186/2045-3701-4-72. eCollection 2014.

21.

IL-33-induced alterations in murine intestinal function and cytokine responses are MyD88, STAT6, and IL-13 dependent.

Yang Z, Sun R, Grinchuk V, Fernández-Blanco JA, Notari L, Bohl JA, McLean LP, Ramalingam TR, Wynn TA, Urban JF Jr, Vogel SN, Shea-Donohue T, Zhao A.

Am J Physiol Gastrointest Liver Physiol. 2013 Feb 15;304(4):G381-9. doi: 10.1152/ajpgi.00357.2012. Epub 2012 Dec 20. Erratum in: Am J Physiol Gastrointest Liver Physiol. 2013 Jun 15;304(12):G1137. Blanco, Joan Antoni Fernandez [corrected to Fernández-Blanco, Joan Antoni].

22.

Mechanisms of fibrosis: therapeutic translation for fibrotic disease.

Wynn TA, Ramalingam TR.

Nat Med. 2012 Jul 6;18(7):1028-40. doi: 10.1038/nm.2807. Review.

23.

Accelerated and progressive and lethal liver fibrosis in mice that lack interleukin (IL)-10, IL-12p40, and IL-13Rα2.

Mentink-Kane MM, Cheever AW, Wilson MS, Madala SK, Beers LM, Ramalingam TR, Wynn TA.

Gastroenterology. 2011 Dec;141(6):2200-9. doi: 10.1053/j.gastro.2011.08.008. Epub 2011 Aug 22.

24.

Shedding LIGHT on severe asthma.

Wynn TA, Ramalingam TR.

Nat Med. 2011 May;17(5):547-8. doi: 10.1038/nm0511-547. No abstract available.

25.

Mapping mouse IL-13 binding regions using structure modeling, molecular docking, and high-density peptide microarray analysis.

Madala SK, Dolan MA, Sharma D, Ramalingam TR, Wilson MS, Mentink-Kane MM, Masison DC, Wynn TA.

Proteins. 2011 Jan;79(1):282-93. doi: 10.1002/prot.22881.

26.

Critical role of IL-25 in nematode infection-induced alterations in intestinal function.

Zhao A, Urban JF Jr, Sun R, Stiltz J, Morimoto M, Notari L, Madden KB, Yang Z, Grinchuk V, Ramalingam TR, Wynn TA, Shea-Donohue T.

J Immunol. 2010 Dec 1;185(11):6921-9. doi: 10.4049/jimmunol.1000450. Epub 2010 Oct 25.

27.

Colitis and intestinal inflammation in IL10-/- mice results from IL-13Rα2-mediated attenuation of IL-13 activity.

Wilson MS, Ramalingam TR, Rivollier A, Shenderov K, Mentink-Kane MM, Madala SK, Cheever AW, Artis D, Kelsall BL, Wynn TA.

Gastroenterology. 2011 Jan;140(1):254-64. doi: 10.1053/j.gastro.2010.09.047. Epub 2010 Oct 14.

28.

Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13-dependent fibrosis.

Madala SK, Pesce JT, Ramalingam TR, Wilson MS, Minnicozzi S, Cheever AW, Thompson RW, Mentink-Kane MM, Wynn TA.

J Immunol. 2010 Apr 1;184(7):3955-63. doi: 10.4049/jimmunol.0903008. Epub 2010 Feb 24.

29.

Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent.

Wilson MS, Madala SK, Ramalingam TR, Gochuico BR, Rosas IO, Cheever AW, Wynn TA.

J Exp Med. 2010 Mar 15;207(3):535-52. doi: 10.1084/jem.20092121. Epub 2010 Feb 22.

30.

Regulation of helminth-induced Th2 responses by thymic stromal lymphopoietin.

Ramalingam TR, Pesce JT, Mentink-Kane MM, Madala S, Cheever AW, Comeau MR, Ziegler SF, Wynn TA.

J Immunol. 2009 May 15;182(10):6452-9. doi: 10.4049/jimmunol.0900181.

31.

Retnla (relmalpha/fizz1) suppresses helminth-induced Th2-type immunity.

Pesce JT, Ramalingam TR, Wilson MS, Mentink-Kane MM, Thompson RW, Cheever AW, Urban JF Jr, Wynn TA.

PLoS Pathog. 2009 Apr;5(4):e1000393. doi: 10.1371/journal.ppat.1000393. Epub 2009 Apr 17.

32.

Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis.

Pesce JT, Ramalingam TR, Mentink-Kane MM, Wilson MS, El Kasmi KC, Smith AM, Thompson RW, Cheever AW, Murray PJ, Wynn TA.

PLoS Pathog. 2009 Apr;5(4):e1000371. doi: 10.1371/journal.ppat.1000371. Epub 2009 Apr 10.

33.

The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation.

Claudio E, Sønder SU, Saret S, Carvalho G, Ramalingam TR, Wynn TA, Chariot A, Garcia-Perganeda A, Leonardi A, Paun A, Chen A, Ren NY, Wang H, Siebenlist U.

J Immunol. 2009 Feb 1;182(3):1617-30.

34.

Suppression of murine allergic airway disease by IL-2:anti-IL-2 monoclonal antibody-induced regulatory T cells.

Wilson MS, Pesce JT, Ramalingam TR, Thompson RW, Cheever A, Wynn TA.

J Immunol. 2008 Nov 15;181(10):6942-54.

35.

Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain.

Ramalingam TR, Pesce JT, Sheikh F, Cheever AW, Mentink-Kane MM, Wilson MS, Stevens S, Valenzuela DM, Murphy AJ, Yancopoulos GD, Urban JF Jr, Donnelly RP, Wynn TA.

Nat Immunol. 2008 Jan;9(1):25-33. Epub 2007 Dec 9.

36.

IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice.

Wilson MS, Elnekave E, Mentink-Kane MM, Hodges MG, Pesce JT, Ramalingam TR, Thompson RW, Kamanaka M, Flavell RA, Keane-Myers A, Cheever AW, Wynn TA.

J Clin Invest. 2007 Oct;117(10):2941-51.

37.

Immunopathology of schistosomiasis.

Wilson MS, Mentink-Kane MM, Pesce JT, Ramalingam TR, Thompson R, Wynn TA.

Immunol Cell Biol. 2007 Feb-Mar;85(2):148-54. Epub 2006 Dec 12. Review.

38.

The IL-21 receptor augments Th2 effector function and alternative macrophage activation.

Pesce J, Kaviratne M, Ramalingam TR, Thompson RW, Urban JF Jr, Cheever AW, Young DA, Collins M, Grusby MJ, Wynn TA.

J Clin Invest. 2006 Jul;116(7):2044-55. Epub 2006 Jun 15.

39.

Exploiting worm and allergy models to understand Th2 cytokine biology.

Ramalingam TR, Reiman RM, Wynn TA.

Curr Opin Allergy Clin Immunol. 2005 Oct;5(5):392-8. Review.

PMID:
16131912

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