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Items: 1 to 50 of 54

1.

Temporal induction of intestinal epithelial hypoxia-inducible factor-2α is sufficient to drive colitis.

Solanki S, Devenport SN, Ramakrishnan SK, Shah YM.

Am J Physiol Gastrointest Liver Physiol. 2019 Aug 1;317(2):G98-G107. doi: 10.1152/ajpgi.00081.2019. Epub 2019 Jun 26.

PMID:
31241981
2.

A model of uric acid transport in the rat proximal tubule.

Edwards A, Auberson M, Ramakrishnan SK, Bonny O.

Am J Physiol Renal Physiol. 2019 May 1;316(5):F934-F947. doi: 10.1152/ajprenal.00603.2018. Epub 2019 Feb 20.

PMID:
30785349
3.

Intestinal non-canonical NFκB signaling shapes the local and systemic immune response.

Ramakrishnan SK, Zhang H, Ma X, Jung I, Schwartz AJ, Triner D, Devenport SN, Das NK, Xue X, Zeng MY, Hu Y, Mortensen RM, Greenson JK, Cascalho M, Wobus CE, Colacino JA, Nunez G, Rui L, Shah YM.

Nat Commun. 2019 Feb 8;10(1):660. doi: 10.1038/s41467-019-08581-8.

4.

Hypoxia-Inducible Factor (HIF)-1α Promotes Inflammation and Injury Following Aspiration-Induced Lung Injury in Mice.

Suresh MV, Balijepalli S, Zhang B, Singh VV, Swamy S, Panicker S, Dolgachev VA, Subramanian C, Ramakrishnan SK, Thomas B, Rao TC, Delano MJ, Machado-Aranda D, Shah YM, Raghavendran K.

Shock. 2019 Dec;52(6):612-621. doi: 10.1097/SHK.0000000000001312.

PMID:
30601332
5.

Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice.

Triner D, Devenport SN, Ramakrishnan SK, Ma X, Frieler RA, Greenson JK, Inohara N, Nunez G, Colacino JA, Mortensen RM, Shah YM.

Gastroenterology. 2019 Apr;156(5):1467-1482. doi: 10.1053/j.gastro.2018.12.003. Epub 2018 Dec 11.

PMID:
30550822
6.

Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload.

Schwartz AJ, Das NK, Ramakrishnan SK, Jain C, Jurkovic MT, Wu J, Nemeth E, Lakhal-Littleton S, Colacino JA, Shah YM.

J Clin Invest. 2019 Jan 2;129(1):336-348. doi: 10.1172/JCI122359. Epub 2018 Dec 10.

7.

Natural Secretory Immunoglobulins Promote Enteric Viral Infections.

Turula H, Bragazzi Cunha J, Mainou BA, Ramakrishnan SK, Wilke CA, Gonzalez-Hernandez MB, Pry A, Fava J, Bassis CM, Edelman J, Shah YM, Corthesy B, Moore BB, Wobus CE.

J Virol. 2018 Nov 12;92(23). pii: e00826-18. doi: 10.1128/JVI.00826-18. Print 2018 Dec 1.

8.

Redox-Dependent Bone Alkaline Phosphatase Dysfunction Drives Part of the Complex Bone Phenotype in Mice Deficient for Memo1.

Moor MB, Ramakrishnan SK, Legrand F, Dolder S, Siegrist M, Durussel F, Centeno G, Firsov D, Hynes NE, Hofstetter W, Bonny O.

JBMR Plus. 2018 Jul;2(4):195-205. doi: 10.1002/jbm4.10034. Epub 2018 Jan 17.

9.

Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm.

Schofield HK, Tandon M, Park MJ, Halbrook CJ, Ramakrishnan SK, Kim EC, Shi J, Omary MB, Shah YM, Esni F, Pasca di Magliano M.

Cell Mol Gastroenterol Hepatol. 2017 Nov 10;5(2):169-185.e2. doi: 10.1016/j.jcmgh.2017.10.008. eCollection 2018.

10.

An OLTAM system for analysis of brown/beige fat thermogenic activity.

Kim DI, Liao J, Emont MP, Park MJ, Jun H, Ramakrishnan SK, Lin JD, Shah YM, Omary MB, Wu J.

Int J Obes (Lond). 2018 Apr;42(4):939-945. doi: 10.1038/ijo.2017.308. Epub 2018 Jan 23.

11.

PRRT2 Regulates Synaptic Fusion by Directly Modulating SNARE Complex Assembly.

Coleman J, Jouannot O, Ramakrishnan SK, Zanetti MN, Wang J, Salpietro V, Houlden H, Rothman JE, Krishnakumar SS.

Cell Rep. 2018 Jan 16;22(3):820-831. doi: 10.1016/j.celrep.2017.12.056.

12.

A central role for hypoxia-inducible factor (HIF)-2α in hepatic glucose homeostasis.

Ramakrishnan SK, Shah YM.

Nutr Healthy Aging. 2017 Dec 7;4(3):207-216. doi: 10.3233/NHA-170022. Review.

13.

Dual modulation of human hepatic zonation via canonical and non-canonical Wnt pathways.

McEnerney L, Duncan K, Bang BR, Elmasry S, Li M, Miki T, Ramakrishnan SK, Shah YM, Saito T.

Exp Mol Med. 2017 Dec 15;49(12):e413. doi: 10.1038/emm.2017.226.

14.

Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis.

Xie C, Yagai T, Luo Y, Liang X, Chen T, Wang Q, Sun D, Zhao J, Ramakrishnan SK, Sun L, Jiang C, Xue X, Tian Y, Krausz KW, Patterson AD, Shah YM, Wu Y, Jiang C, Gonzalez FJ.

Nat Med. 2017 Nov;23(11):1298-1308. doi: 10.1038/nm.4412. Epub 2017 Oct 9.

15.

Fenofibrate Decreases Insulin Clearance and Insulin Secretion to Maintain Insulin Sensitivity.

Ramakrishnan SK, Russo L, Ghanem SS, Patel PR, Oyarce AM, Heinrich G, Najjar SM.

J Biol Chem. 2016 Nov 11;291(46):23915-23924. Epub 2016 Sep 23.

16.

Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis.

Xue X, Ramakrishnan SK, Weisz K, Triner D, Xie L, Attili D, Pant A, Győrffy B, Zhan M, Carter-Su C, Hardiman KM, Wang TD, Dame MK, Varani J, Brenner D, Fearon ER, Shah YM.

Cell Metab. 2016 Sep 13;24(3):447-461. doi: 10.1016/j.cmet.2016.07.015. Epub 2016 Aug 18.

17.

Interactions at the Peptide/Silicon Surfaces: Evidence of Peptide Multilayer Assembly.

Pápa Z, Ramakrishnan SK, Martin M, Cloitre T, Zimányi L, Márquez J, Budai J, Tóth Z, Gergely C.

Langmuir. 2016 Jul 19;32(28):7250-8. doi: 10.1021/acs.langmuir.6b00916. Epub 2016 Jul 7.

PMID:
27315212
18.

mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells.

Grahammer F, Ramakrishnan SK, Rinschen MM, Larionov AA, Syed M, Khatib H, Roerden M, Sass JO, Helmstaedter M, Osenberg D, Kühne L, Kretz O, Wanner N, Jouret F, Benzing T, Artunc F, Huber TB, Theilig F.

J Am Soc Nephrol. 2017 Jan;28(1):230-241. doi: 10.1681/ASN.2015111224. Epub 2016 Jun 13.

19.

Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis.

Ro SH, Xue X, Ramakrishnan SK, Cho CS, Namkoong S, Jang I, Semple IA, Ho A, Park HW, Shah YM, Lee JH.

Elife. 2016 Feb 25;5:e12204. doi: 10.7554/eLife.12204.

20.

Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion.

Mori H, Yao Y, Learman BS, Kurozumi K, Ishida J, Ramakrishnan SK, Overmyer KA, Xue X, Cawthorn WP, Reid MA, Taylor M, Ning X, Shah YM, MacDougald OA.

Sci Rep. 2016 Feb 10;6:21520. doi: 10.1038/srep21520.

21.

HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling.

Ramakrishnan SK, Zhang H, Takahashi S, Centofanti B, Periyasamy S, Weisz K, Chen Z, Uhler MD, Rui L, Gonzalez FJ, Shah YM.

Cell Metab. 2016 Mar 8;23(3):505-16. doi: 10.1016/j.cmet.2016.01.004. Epub 2016 Feb 4.

22.

PPARα (Peroxisome Proliferator-activated Receptor α) Activation Reduces Hepatic CEACAM1 Protein Expression to Regulate Fatty Acid Oxidation during Fasting-refeeding Transition.

Ramakrishnan SK, Khuder SS, Al-Share QY, Russo L, Abdallah SL, Patel PR, Heinrich G, Muturi HT, Mopidevi BR, Oyarce AM, Shah YM, Sanchez ER, Najjar SM.

J Biol Chem. 2016 Apr 8;291(15):8121-9. doi: 10.1074/jbc.M116.714014. Epub 2016 Feb 4.

23.

Role of Intestinal HIF-2α in Health and Disease.

Ramakrishnan SK, Shah YM.

Annu Rev Physiol. 2016;78:301-25. doi: 10.1146/annurev-physiol-021115-105202. Epub 2015 Nov 19. Review.

24.

Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion Molecule 2 (CEACAM2).

Ghanem SS, Heinrich G, Lester SG, Pfeiffer V, Bhattacharya S, Patel PR, DeAngelis AM, Dai T, Ramakrishnan SK, Smiley ZN, Jung DY, Lee Y, Kitamura T, Ergun S, Kulkarni RN, Kim JK, Giovannucci DR, Najjar SM.

J Biol Chem. 2016 Jan 8;291(2):980-8. doi: 10.1074/jbc.M115.692582. Epub 2015 Nov 19.

25.

Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1.

Zhang H, Ramakrishnan SK, Triner D, Centofanti B, Maitra D, Győrffy B, Sebolt-Leopold JS, Dame MK, Varani J, Brenner DE, Fearon ER, Omary MB, Shah YM.

Sci Signal. 2015 Oct 6;8(397):ra98. doi: 10.1126/scisignal.aac5418.

26.

Engineered Adhesion Peptides for Improved Silicon Adsorption.

Ramakrishnan SK, Jebors S, Martin M, Cloitre T, Agarwal V, Mehdi A, Martinez J, Subra G, Gergely C.

Langmuir. 2015 Nov 3;31(43):11868-74. doi: 10.1021/acs.langmuir.5b02857. Epub 2015 Oct 22.

PMID:
26440047
27.

Intestine-specific Disruption of Hypoxia-inducible Factor (HIF)-2α Improves Anemia in Sickle Cell Disease.

Das N, Xie L, Ramakrishnan SK, Campbell A, Rivella S, Shah YM.

J Biol Chem. 2015 Sep 25;290(39):23523-7. doi: 10.1074/jbc.C115.681643. Epub 2015 Aug 19.

28.

Maternal intestinal HIF-2α is necessary for sensing iron demands of lactation in mice.

Ramakrishnan SK, Anderson ER, Martin A, Centofanti B, Shah YM.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):E3738-47. doi: 10.1073/pnas.1504891112. Epub 2015 Jun 29.

29.

Fatty acid binding protein-4 (FABP4) is a hypoxia inducible gene that sensitizes mice to liver ischemia/reperfusion injury.

Hu B, Guo Y, Garbacz WG, Jiang M, Xu M, Huang H, Tsung A, Billiar TR, Ramakrishnan SK, Shah YM, Lam KS, Huang M, Xie W.

J Hepatol. 2015 Oct;63(4):855-62. doi: 10.1016/j.jhep.2015.05.030. Epub 2015 Jun 10.

30.

Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin Resistance.

Al-Share QY, DeAngelis AM, Lester SG, Bowman TA, Ramakrishnan SK, Abdallah SL, Russo L, Patel PR, Kaw MK, Raphael CK, Kim AJ, Heinrich G, Lee AD, Kim JK, Kulkarni RN, Philbrick WM, Najjar SM.

Diabetes. 2015 Aug;64(8):2780-90. doi: 10.2337/db14-1772. Epub 2015 May 13.

31.

High-calorie diet exacerbates prostate neoplasia in mice with haploinsufficiency of Pten tumor suppressor gene.

Liu J, Ramakrishnan SK, Khuder SS, Kaw MK, Muturi HT, Lester SG, Lee SJ, Fedorova LV, Kim AJ, Mohamed IE, Gatto-Weis C, Eisenmann KM, Conran PB, Najjar SM.

Mol Metab. 2015 Jan 2;4(3):186-98. doi: 10.1016/j.molmet.2014.12.011. eCollection 2015 Mar.

32.

Design rules for metal binding biomolecules: understanding of amino acid adsorption on platinum crystallographic facets from density functional calculations.

Ramakrishnan SK, Martin M, Cloitre T, Firlej L, Gergely C.

Phys Chem Chem Phys. 2015 Feb 14;17(6):4193-8. doi: 10.1039/c4cp05112b.

PMID:
25566851
33.

Activation of hypoxia-inducible factor-1α in type 2 alveolar epithelial cell is a major driver of acute inflammation following lung contusion.

Suresh MV, Ramakrishnan SK, Thomas B, Machado-Aranda D, Bi Y, Talarico N, Anderson E, Yatrik SM, Raghavendran K.

Crit Care Med. 2014 Oct;42(10):e642-53. doi: 10.1097/CCM.0000000000000488.

34.

Bacterial siderophores that evade or overwhelm lipocalin 2 induce hypoxia inducible factor 1α and proinflammatory cytokine secretion in cultured respiratory epithelial cells.

Holden VI, Lenio S, Kuick R, Ramakrishnan SK, Shah YM, Bachman MA.

Infect Immun. 2014 Sep;82(9):3826-36. doi: 10.1128/IAI.01849-14. Epub 2014 Jun 30.

35.

Molecular mechanism of selective binding of peptides to silicon surface.

Ramakrishnan SK, Martin M, Cloitre T, Firlej L, Gergely C.

J Chem Inf Model. 2014 Jul 28;54(7):2117-26. doi: 10.1021/ci500260v. Epub 2014 Jun 17.

PMID:
24936969
36.

Global expression profile of telomerase-associated genes in HeLa cells.

Varshney A, Ramakrishnan SK, Sharma A, Santosh B, Bala J, Yadava PK, Jaiswal RK.

Gene. 2014 Sep 1;547(2):211-7. doi: 10.1016/j.gene.2014.06.018. Epub 2014 Jun 11.

PMID:
24929127
37.

Hypoxia-inducible factor/MAZ-dependent induction of caveolin-1 regulates colon permeability through suppression of occludin, leading to hypoxia-induced inflammation.

Xie L, Xue X, Taylor M, Ramakrishnan SK, Nagaoka K, Hao C, Gonzalez FJ, Shah YM.

Mol Cell Biol. 2014 Aug;34(16):3013-23. doi: 10.1128/MCB.00324-14. Epub 2014 Jun 2.

38.

Activation of HIF-1α does not increase intestinal tumorigenesis.

Xue X, Ramakrishnan SK, Shah YM.

Am J Physiol Gastrointest Liver Physiol. 2014 Jul 15;307(2):G187-95. doi: 10.1152/ajpgi.00112.2014. Epub 2014 May 29.

39.

Expression of targeted ribozyme against telomerase RNA causes altered expression of several other genes in tumor cells.

Ramakrishnan SK, Varshney A, Sharma A, Das BC, Yadava PK.

Tumour Biol. 2014 Jun;35(6):5539-50. doi: 10.1007/s13277-014-1729-z. Epub 2014 Mar 25.

PMID:
24664581
40.

Loss of von Hippel-Lindau protein (VHL) increases systemic cholesterol levels through targeting hypoxia-inducible factor 2α and regulation of bile acid homeostasis.

Ramakrishnan SK, Taylor M, Qu A, Ahn SH, Suresh MV, Raghavendran K, Gonzalez FJ, Shah YM.

Mol Cell Biol. 2014 Apr;34(7):1208-20. doi: 10.1128/MCB.01441-13. Epub 2014 Jan 13.

41.

Insights on the facet specific adsorption of amino acids and peptides toward platinum.

Ramakrishnan SK, Martin M, Cloitre T, Firlej L, Cuisinier FJ, Gergely C.

J Chem Inf Model. 2013 Dec 23;53(12):3273-9. doi: 10.1021/ci400630d. Epub 2013 Dec 6.

PMID:
24289530
42.

Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia.

Anderson ER, Taylor M, Xue X, Ramakrishnan SK, Martin A, Xie L, Bredell BX, Gardenghi S, Rivella S, Shah YM.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4922-30. doi: 10.1073/pnas.1314197110. Epub 2013 Nov 26.

43.

α-Ketoglutarate regulates acid-base balance through an intrarenal paracrine mechanism.

Tokonami N, Morla L, Centeno G, Mordasini D, Ramakrishnan SK, Nikolaeva S, Wagner CA, Bonny O, Houillier P, Doucet A, Firsov D.

J Clin Invest. 2013 Jul;123(7):3166-71. doi: 10.1172/JCI67562. Epub 2013 Jun 24.

44.

Ceacam1 deletion causes vascular alterations in large vessels.

Najjar SM, Ledford KJ, Abdallah SL, Paus A, Russo L, Kaw MK, Ramakrishnan SK, Muturi HT, Raphael CK, Lester SG, Heinrich G, Pierre SV, Benndorf R, Kleff V, Jaffa AA, Lévy E, Vazquez G, Goldberg IJ, Beauchemin N, Scalia R, Ergün S.

Am J Physiol Endocrinol Metab. 2013 Aug 15;305(4):E519-29. doi: 10.1152/ajpendo.00266.2013. Epub 2013 Jun 25.

45.

Overexpression of pendrin in intercalated cells produces chloride-sensitive hypertension.

Jacques T, Picard N, Miller RL, Riemondy KA, Houillier P, Sohet F, Ramakrishnan SK, Büsst CJ, Jayat M, Cornière N, Hassan H, Aronson PS, Hennings JC, Hübner CA, Nelson RD, Chambrey R, Eladari D.

J Am Soc Nephrol. 2013 Jun;24(7):1104-13. doi: 10.1681/ASN.2012080787. Epub 2013 Jun 13.

46.

Haploinsufficiency of the ammonia transporter Rhcg predisposes to chronic acidosis: Rhcg is critical for apical and basolateral ammonia transport in the mouse collecting duct.

Bourgeois S, Bounoure L, Christensen EI, Ramakrishnan SK, Houillier P, Devuyst O, Wagner CA.

J Biol Chem. 2013 Feb 22;288(8):5518-29. doi: 10.1074/jbc.M112.441782. Epub 2012 Dec 31.

47.

Hesperidin-mediated expression of Nrf2 and upregulation of antioxidant status in senescent rat heart.

Elavarasan J, Velusamy P, Ganesan T, Ramakrishnan SK, Rajasekaran D, Periandavan K.

J Pharm Pharmacol. 2012 Oct;64(10):1472-82. doi: 10.1111/j.2042-7158.2012.01512.x. Epub 2012 May 9.

PMID:
22943178
48.

PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor.

Loupy A, Ramakrishnan SK, Wootla B, Chambrey R, de la Faille R, Bourgeois S, Bruneval P, Mandet C, Christensen EI, Faure H, Cheval L, Laghmani K, Collet C, Eladari D, Dodd RH, Ruat M, Houillier P.

J Clin Invest. 2012 Sep;122(9):3355-67. doi: 10.1172/JCI57407. Epub 2012 Aug 13.

49.

Evidence for kidney rejection after combined bone marrow and renal transplantation despite ongoing whole-blood chimerism in rhesus macaques.

Ramakrishnan SK, Page A, Farris AB 3rd, Singh K, Leopardi F, Hamby K, Sen S, Polnett A, Deane T, Song M, Stempora L, Strobert E, Kirk AD, Larsen CP, Kean LS.

Am J Transplant. 2012 Jul;12(7):1755-64. doi: 10.1111/j.1600-6143.2012.04045.x. Epub 2012 May 29.

50.

Adaptation cost of diarrhea and malaria in 2030 for India.

Ramakrishnan SK.

Indian J Occup Environ Med. 2011 May;15(2):64-7. doi: 10.4103/0019-5278.90376.

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