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Suspected cancer symptoms and blood test results in primary care before a diagnosis of lung cancer: a case-control study.

McDonald L, Carroll R, Harish A, Tanna N, Mehmud F, Alikhan R, Ramagopalan SV.

Future Oncol. 2019 Oct 31. doi: 10.2217/fon-2019-0442. [Epub ahead of print]


Incidence of seroconversion and sero-reversion in patients with multiple sclerosis (MS) who had been treated with natalizumab: A systematic review and meta-analysis.

Azimi A, Hanaei S, Sahraian MA, Mohammadifar M, Ramagopalan SV, Ghajarzadeh M.

J Clin Neurosci. 2019 Sep 23. pii: S0967-5868(19)31406-7. doi: 10.1016/j.jocn.2019.08.103. [Epub ahead of print] Review.


Automated extraction of treatment patterns from social media posts: an exploratory analysis in renal cell carcinoma.

Ramagopalan SV, Malcolm B, Merinopoulou E, McDonald L, Cox A.

Future Oncol. 2019 Nov;15(31):3587-3596. doi: 10.2217/fon-2019-0406. Epub 2019 Sep 4.


Costs of gastrointestinal bleeding events in atrial fibrillation: a UK Clinical Practice Research Datalink study.

Ramagopalan SV, Samnaliev M, Weir S, Sammon CJ, Carroll R, Alikhan R.

Future Cardiol. 2019 Sep;15(5):367-375. doi: 10.2217/fca-2019-0033. Epub 2019 Jul 26.


Patient characteristics and stroke and bleeding events in nonvalvular atrial fibrillation patients treated with apixaban and vitamin K antagonists: a Spanish real-world study.

Ramagopalan SV, Sicras-Mainar A, Polanco-Sanchez C, Carroll R, de Bobadilla JF.

J Comp Eff Res. 2019 Oct;8(14):1201-1212. doi: 10.2217/cer-2019-0079. Epub 2019 Jul 23.


Commonly used definitions in real-world studies may underestimate the prevalence of renal disease among nonvalvular atrial fibrillation patients.

Schultze A, Graham S, Nordstrom BL, Mehmud F, Ramagopalan SV.

J Comp Eff Res. 2019 Sep;8(12):961-968. doi: 10.2217/cer-2019-0070. Epub 2019 Jul 18.


Google searches do not correlate with melanoma incidence in majority English speaking countries.

McDonald L, Simpson A, Graham S, Schultze A, Nordstrom B, Durani P, Mehmud F, Ramagopalan SV.

NPJ Digit Med. 2018 Sep 5;1:44. doi: 10.1038/s41746-018-0050-4. eCollection 2018.


Impact of atrial fibrillation awareness campaigns: interrupted time series using the Clinical Practice Research Datalink.

Allan V, Sammon CJ, McDonald L, Mehmud F, Alikhan R, Ramagopalan SV.

Future Cardiol. 2019 Jul;15(4):311-318. doi: 10.2217/fca-2019-0025. Epub 2019 Jun 26.


Renal function and oral anticoagulant treatment of incident non-valvular atrial fibrillation: a retrospective study.

Ramagopalan SV, Stamp E, Sammon CJ, Besford M, Carroll R, Mehmud F, Alikhan R.

Future Cardiol. 2019 Jul;15(4):301-309. doi: 10.2217/fca-2019-0012. Epub 2019 May 29.


The Effect of Vitamin D Supplements on Clinical and Para-Clinical Outcomes in Patients With Multiple Sclerosis: Protocol for a Systematic Review.

Ghajarzadeh M, Keshtkar AA, Azimi A, Sahraian MA, Mohammadifar M, Ramagopalan SV.

JMIR Res Protoc. 2019 Apr 22;8(4):e12045. doi: 10.2196/12045.


The changing face of venous thromboembolism management in England.

Ramagopalan SV, Carroll R, Ulvestad M, Mehmud F, Alikhan R.

Future Cardiol. 2019 May;15(3):183-185. doi: 10.2217/fca-2019-0003. Epub 2019 Mar 25.


Discontinuation and primary care visits in nonvalvular atrial fibrillation patients treated with apixaban or warfarin.

Ramagopalan SV, Graham S, Carroll R, Raluy-Callado M, Nordstrom BL, Donaldson R, Colby C, Mehmud F, Alikhan R.

J Comp Eff Res. 2019 Apr;8(6):371-379. doi: 10.2217/cer-2019-0005. Epub 2019 Feb 8.


Sleep and BMI: Do (Fitbit) bands aid?

McDonald L, Mehmud F, Ramagopalan SV.

Version 2. F1000Res. 2018 Apr 27 [revised 2018 Jan 1];7:511. doi: 10.12688/f1000research.14774.2. eCollection 2018.


Prodromal symptoms of multiple sclerosis in primary care.

Disanto G, Zecca C, MacLachlan S, Sacco R, Handunnetthi L, Meier UC, Simpson A, McDonald L, Rossi A, Benkert P, Kuhle J, Ramagopalan SV, Gobbi C.

Ann Neurol. 2018 Jun;83(6):1162-1173. doi: 10.1002/ana.25247. Epub 2018 May 30.


Performing studies using the UK Clinical Practice Research Datalink: to link or not to link?

McDonald L, Schultze A, Carroll R, Ramagopalan SV.

Eur J Epidemiol. 2018 Jun;33(6):601-605. doi: 10.1007/s10654-018-0389-5. Epub 2018 Apr 4.


Evaluation of comparative effectiveness research: a practical tool.

Schaumberg DA, McDonald L, Shah S, Stokes M, Nordstrom BL, Ramagopalan SV.

J Comp Eff Res. 2018 May;7(5):503-515. doi: 10.2217/cer-2018-0007. Epub 2018 Feb 21.


Unintended consequences of machine learning in medicine?

McDonald L, Ramagopalan SV, Cox AP, Oguz M.

F1000Res. 2017 Sep 19;6:1707. doi: 10.12688/f1000research.12693.1. eCollection 2017.


An analysis of characteristics of post-authorisation studies registered on the ENCePP EU PAS Register.

Carroll R, Ramagopalan SV, Cid-Ruzafa J, Lambrelli D, McDonald L.

Version 2. F1000Res. 2017 Aug 14 [revised 2017 Jan 1];6:1447. doi: 10.12688/f1000research.12198.2. eCollection 2017.


A review of data sharing statements in observational studies published in the BMJ: A cross-sectional study.

McDonald L, Schultze A, Simpson A, Graham S, Wasiak R, Ramagopalan SV.

Version 2. F1000Res. 2017 Sep 19 [revised 2017 Jan 1];6:1708. doi: 10.12688/f1000research.12673.2. eCollection 2017.


Lack of data sharing in observational studies.

McDonald L, Schultze A, Simpson A, Graham S, Wasiak R, Ramagopalan SV.

BMJ. 2017 Oct 24;359:j4866. doi: 10.1136/bmj.j4866. No abstract available.


Real-world data really matter.

McDonald L, Ramagopalan SV, Lees M.

CMAJ. 2017 Oct 16;189(41):E1293. doi: 10.1503/cmaj.733383. No abstract available.


Identification of genetic variants affecting vitamin D receptor binding and associations with autoimmune disease.

Gallone G, Haerty W, Disanto G, Ramagopalan SV, Ponting CP, Berlanga-Taylor AJ.

Hum Mol Genet. 2017 Jun 1;26(11):2164-2176. doi: 10.1093/hmg/ddx092.


Soil heavy metals are associated with the distribution of multiple sclerosis in Isfahan, Iran.

Etemadifar M, Mehrabi B, Kiani-Peykani R, Abtahi SH, Nekouie-Isfahani K, Ramagopalan SV, Fereidan-Esfahani M.

Acta Neurol Scand. 2016 Oct;134(4):292-9. doi: 10.1111/ane.12543. Epub 2015 Dec 21.


Decrease in rate of multiple sclerosis-related hospitalizations in Portugal.

Pereira M, Lambrelli D, Ramagopalan SV.

F1000Res. 2016 Jun 13;5:1353. doi: 10.12688/f1000research.8787.1. eCollection 2016.


Real-world data in the United Kingdom: opportunities and challenges.

McDonald L, Lambrelli D, Wasiak R, Ramagopalan SV.

BMC Med. 2016 Jun 24;14(1):97. doi: 10.1186/s12916-016-0647-x.


Seasonality of tweets related to multiple sclerosis.

Simpson A, Pereira M, Cooper S, Ramagopalan SV.

J Neurol Neurosurg Psychiatry. 2016 Sep;87(9):1030-1. doi: 10.1136/jnnp-2016-313941. Epub 2016 Jun 8. No abstract available.


The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans.

Lowe R, Overhoff MG, Ramagopalan SV, Garbe JC, Koh J, Stampfer MR, Beach DH, Rakyan VK, Bishop CL.

Genome Biol. 2015 Sep 17;16:194. doi: 10.1186/s13059-015-0748-4.


Funding source and primary outcome changes in clinical trials registered on are associated with the reporting of a statistically significant primary outcome: a cross-sectional study.

Ramagopalan SV, Skingsley AP, Handunnetthi L, Magnus D, Klingel M, Pakpoor J, Goldacre B.

Version 2. F1000Res. 2015 Mar 26 [revised 2015 Jan 1];4:80. doi: 10.12688/f1000research.6312.2. eCollection 2015.


Clinical associations between gout and multiple sclerosis, Parkinson's disease and motor neuron disease: record-linkage studies.

Pakpoor J, Seminog OO, Ramagopalan SV, Goldacre MJ.

BMC Neurol. 2015 Feb 28;15:16. doi: 10.1186/s12883-015-0273-9.


Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study.

Kuhle J, Disanto G, Dobson R, Adiutori R, Bianchi L, Topping J, Bestwick JP, Meier UC, Marta M, Dalla Costa G, Runia T, Evdoshenko E, Lazareva N, Thouvenot E, Iaffaldano P, Direnzo V, Khademi M, Piehl F, Comabella M, Sombekke M, Killestein J, Hegen H, Rauch S, D'Alfonso S, Alvarez-Cermeño JC, Kleinová P, Horáková D, Roesler R, Lauda F, Llufriu S, Avsar T, Uygunoglu U, Altintas A, Saip S, Menge T, Rajda C, Bergamaschi R, Moll N, Khalil M, Marignier R, Dujmovic I, Larsson H, Malmestrom C, Scarpini E, Fenoglio C, Wergeland S, Laroni A, Annibali V, Romano S, Martínez AD, Carra A, Salvetti M, Uccelli A, Torkildsen Ø, Myhr KM, Galimberti D, Rejdak K, Lycke J, Frederiksen JL, Drulovic J, Confavreux C, Brassat D, Enzinger C, Fuchs S, Bosca I, Pelletier J, Picard C, Colombo E, Franciotta D, Derfuss T, Lindberg R, Yaldizli Ö, Vécsei L, Kieseier BC, Hartung HP, Villoslada P, Siva A, Saiz A, Tumani H, Havrdová E, Villar LM, Leone M, Barizzone N, Deisenhammer F, Teunissen C, Montalban X, Tintoré M, Olsson T, Trojano M, Lehmann S, Castelnovo G, Lapin S, Hintzen R, Kappos L, Furlan R, Martinelli V, Comi G, Ramagopalan SV, Giovannoni G.

Mult Scler. 2015 Jul;21(8):1013-24. doi: 10.1177/1352458514568827. Epub 2015 Feb 13.


National survey of UK medical students on the perception of neurology.

Pakpoor J, Handel AE, Disanto G, Davenport RJ, Giovannoni G, Ramagopalan SV; Association of British Neurologists.

BMC Med Educ. 2014 Oct 21;14:225. doi: 10.1186/1472-6920-14-225.


An epidemiological study of neuromyelitis optica in Isfahan.

Etemadifar M, Dashti M, Vosoughi R, Abtahi SH, Ramagopalan SV, Nasr Z.

Mult Scler. 2014 Dec;20(14):1920-2. doi: 10.1177/1352458514537699. Epub 2014 Jun 2. No abstract available.


Impact of month of birth on the development of autoimmune thyroid disease in the United Kingdom and Europe.

Hamilton A, Newby PR, Carr-Smith JD, Disanto G, Allahabadia A, Armitage M, Brix TH, Chatterjee K, Connell JM, Hegedüs L, Hunt PJ, Lazarus JH, Pearce SH, Robinson BG, Taylor JC, Vaidya B, Wass JA, Wiersinga WM, Weetman AP, Ramagopalan SV, Franklyn JA, Gough SC, Simmonds MJ.

J Clin Endocrinol Metab. 2014 Aug;99(8):E1459-65. doi: 10.1210/jc.2014-1270. Epub 2014 May 19.


Regulatory genomic regions active in immune cell types explain a large proportion of the genetic risk of multiple sclerosis.

Elangovan RI, Disanto G, Berlanga-Taylor AJ, Ramagopalan SV, Handunnetthi L.

J Hum Genet. 2014 Apr;59(4):211-5. doi: 10.1038/jhg.2014.3. Epub 2014 Feb 13.


Russell W Brain and the aetiology of multiple sclerosis--a historical perspective.

Pakpoor J, Ramagopalan SV.

QJM. 2014 Jun;107(6):423-7. doi: 10.1093/qjmed/hcu001. Epub 2014 Jan 18.


Multiple sclerosis in the Iranian immigrant population of BC, Canada: prevalence and risk factors.

Guimond C, Lee JD, Ramagopalan SV, Dyment DA, Hanwell H, Giovannoni G, Criscuoli M, Yee IM, Vorobeychik G, Ebers GC, Sadovnick AD.

Mult Scler. 2014 Aug;20(9):1182-8. doi: 10.1177/1352458513519179. Epub 2014 Jan 10.


Multiple sclerosis in Isfahan, Iran: an update.

Etemadifar M, Abtahi SH, Akbari M, Murray RT, Ramagopalan SV, Fereidan-Esfahani M.

Mult Scler. 2014 Jul;20(8):1145-7. doi: 10.1177/1352458513516531. Epub 2013 Dec 10. No abstract available.


Risk of subarachnoid haemorrhage in people admitted to hospital with selected immune-mediated diseases: record-linkage studies.

Ramagopalan SV, Pakpoor J, Seminog O, Goldacre R, Graham L, Goldacre MJ.

BMC Neurol. 2013 Nov 14;13:176. doi: 10.1186/1471-2377-13-176.


Epstein-Barr virus is a necessary causative agent in the pathogenesis of multiple sclerosis: yes.

Pakpoor J, Ramagopalan SV.

Mult Scler. 2013 Nov;19(13):1690-1. doi: 10.1177/1352458513506505. No abstract available.


Similar genetics of adult and pediatric MS: age is just a number.

Disanto G, Ramagopalan SV.

Neurology. 2013 Dec 3;81(23):1974-5. doi: 10.1212/01.wnl.0000436947.85775.5c. Epub 2013 Nov 6.


Hypovitaminosis-D and EBV: no interdependence between two MS risk factors in a healthy young UK autumn cohort.

Ramien C, Pachnio A, Sisay S, Begum J, Leese A, Disanto G, Kuhle J, Giovannoni G, Rickinson A, Ramagopalan SV, Moss P, Meier UC.

Mult Scler. 2014 May;20(6):751-3. doi: 10.1177/1352458513509507. Epub 2013 Nov 5.


Integrating multiple oestrogen receptor alpha ChIP studies: overlap with disease susceptibility regions, DNase I hypersensitivity peaks and gene expression.

Handel AE, Sandve GK, Disanto G, Handunnetthi L, Giovannoni G, Ramagopalan SV.

BMC Med Genomics. 2013 Oct 30;6:45. doi: 10.1186/1755-8794-6-45.


Safety and efficacy of mitoxantrone in pediatric patients with aggressive multiple sclerosis.

Etemadifar M, Afzali P, Abtahi SH, Ramagopalan SV, Nourian SM, Murray RT, Fereidan-Esfahani M.

Eur J Paediatr Neurol. 2014 Mar;18(2):119-25. doi: 10.1016/j.ejpn.2013.09.001. Epub 2013 Oct 7.


Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists.

Pryce G, Visintin C, Ramagopalan SV, Al-Izki S, De Faveri LE, Nuamah RA, Mein CA, Montpetit A, Hardcastle AJ, Kooij G, de Vries HE, Amor S, Thomas SA, Ledent C, Marsicano G, Lutz B, Thompson AJ, Selwood DL, Giovannoni G, Baker D.

FASEB J. 2014 Jan;28(1):117-30. doi: 10.1096/fj.13-239442. Epub 2013 Oct 11.


DNase hypersensitive sites and association with multiple sclerosis.

Disanto G, Kjetil Sandve G, Ricigliano VA, Pakpoor J, Berlanga-Taylor AJ, Handel AE, Kuhle J, Holden L, Watson CT, Giovannoni G, Handunnetthi L, Ramagopalan SV.

Hum Mol Genet. 2014 Feb 15;23(4):942-8. doi: 10.1093/hmg/ddt489. Epub 2013 Oct 2.


Vitamin d: shining a light on clinical and sex specific effects in multiple sclerosis?

Fereidan-Esfahani M, Ramagopalan SV, Etemadifar M, Sadri S, Abtahi SH.

Int J Prev Med. 2013 May;4(5):499-500. No abstract available.


Hospital admissions for vitamin D related conditions and subsequent immune-mediated disease: record-linkage studies.

Ramagopalan SV, Goldacre R, Disanto G, Giovannoni G, Goldacre MJ.

BMC Med. 2013 Jul 25;11:171. doi: 10.1186/1741-7015-11-171.


The promise and challenges of blood spot methylomics.

Ramagopalan SV, Rakyan VK.

Epigenetics. 2013 Aug;8(8):775-7. doi: 10.4161/epi.25357. Epub 2013 Jun 19. Review.


Vitamin D receptor ChIP-seq in primary CD4+ cells: relationship to serum 25-hydroxyvitamin D levels and autoimmune disease.

Handel AE, Sandve GK, Disanto G, Berlanga-Taylor AJ, Gallone G, Hanwell H, Drabløs F, Giovannoni G, Ebers GC, Ramagopalan SV.

BMC Med. 2013 Jul 12;11:163. doi: 10.1186/1741-7015-11-163.


Lesion-to-ventricle distance and other risk factors for the persistence of newly formed black holes in relapsing-remitting multiple sclerosis.

Papadopoulou A, Menegola M, Kuhle J, Ramagopalan SV, D'Souza M, Sprenger T, Radue EW, Kappos L, Yaldizli Ö.

Mult Scler. 2014 Mar;20(3):322-30. doi: 10.1177/1352458513495583. Epub 2013 Jul 11.


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