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Items: 1 to 50 of 428

1.

SOX17 expression and its downregulation by promoter methylation in cervical adenocarcinoma in situ and adenocarcinoma.

Hopman ANH, Moshi JM, Hoogduin KJ, Ummelen M, Henfling MER, van Engeland M, Wouters KAD, Stoop H, Looijenga LHJ, Ramaekers FCS.

Histopathology. 2019 Aug 23. doi: 10.1111/his.13980. [Epub ahead of print]

PMID:
31444787
2.

Assessment of fibroblast nuclear morphology aids interpretation of LMNA variants.

van Tienen FHJ, Lindsey PJ, Kamps MAF, Krapels IP, Ramaekers FCS, Brunner HG, van den Wijngaard A, Broers JLV.

Eur J Hum Genet. 2019 Mar;27(3):389-399. doi: 10.1038/s41431-018-0294-0. Epub 2018 Nov 12.

PMID:
30420677
3.

Upregulation of AKR1C1 and AKR1C3 expression in OPSCC with integrated HPV16 and HPV-negative tumors is an indicator of poor prognosis.

Huebbers CU, Verhees F, Poluschkin L, Olthof NC, Kolligs J, Siefer OG, Henfling M, Ramaekers FCS, Preuss SF, Beutner D, Seehawer J, Drebber U, Korkmaz Y, Lam WL, Vucic EA, Kremer B, Klussmann JP, Speel EM.

Int J Cancer. 2019 May 15;144(10):2465-2477. doi: 10.1002/ijc.31954. Epub 2019 Jan 30.

PMID:
30367463
4.

Determination of the proliferative fractions in differentiating hematopoietic cell lineages of normal bone marrow.

Nies KPH, Kraaijvanger R, Lindelauf KHK, Drent RJMR, Rutten RMJ, Ramaekers FCS, Leers MPG.

Cytometry A. 2018 Nov;93(11):1097-1105. doi: 10.1002/cyto.a.23564. Epub 2018 Sep 3.

PMID:
30176186
5.

The IGF pathway is activated in insulinomas but downregulated in metastatic disease.

Henfling M, Perren A, Schmitt AM, Saddig CM, Starke AA, Riedl RG, Versleijen-Jonkers YMH, Sprij-Mooij DM, Ramaekers FCS, Hofland L, Speel EM.

Endocr Relat Cancer. 2018 Jul 18. pii: ERC-18-0222. doi: 10.1530/ERC-18-0222. [Epub ahead of print]

6.

Investigating the race for the surface and skin integration in clinically retrieved abutments with two-photon microscopy.

Kapsokalyvas D, van Hoof M, Wigren S, Chimhanda T, Kuijpers HJ, Ramaekers FCS, Stokroos RJ, van Zandvoort MAMJ.

Colloids Surf B Biointerfaces. 2017 Nov 1;159:97-107. doi: 10.1016/j.colsurfb.2017.07.072. Epub 2017 Jul 27.

7.

Limited additive value of the Ki-67 proliferative index on patient survival in World Health Organization-classified pulmonary carcinoids.

Swarts DR, Rudelius M, Claessen SM, Cleutjens JP, Seidl S, Volante M, Ramaekers FC, Speel EJ.

Histopathology. 2017 Feb;70(3):412-422. doi: 10.1111/his.13096. Epub 2016 Nov 23.

PMID:
27701763
8.

Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates.

Sieprath T, Corne TD, Nooteboom M, Grootaert C, Rajkovic A, Buysschaert B, Robijns J, Broers JL, Ramaekers FC, Koopman WJ, Willems PH, De Vos WH.

Nucleus. 2015;6(3):236-46. doi: 10.1080/19491034.2015.1050568. Epub 2015 May 21.

9.

Human papillomavirus typing by single tube multiplex amplification in real time (SMART): the PapillomaFinder® SMART 20 assay.

Ossel J, Litjens RJ, Reijans M, Brink AA, Ummelen M, Ramaekers FC, Hopman AH, Simons G.

J Clin Virol. 2014 Dec;61(4):540-7. doi: 10.1016/j.jcv.2014.10.005. Epub 2014 Oct 22.

PMID:
25453331
10.

Viral load, gene expression and mapping of viral integration sites in HPV16-associated HNSCC cell lines.

Olthof NC, Huebbers CU, Kolligs J, Henfling M, Ramaekers FC, Cornet I, van Lent-Albrechts JA, Stegmann AP, Silling S, Wieland U, Carey TE, Walline HM, Gollin SM, Hoffmann TK, de Winter J, Kremer B, Klussmann JP, Speel EJ.

Int J Cancer. 2015 Mar 1;136(5):E207-18. doi: 10.1002/ijc.29112. Epub 2014 Aug 14.

11.

Interobserver variability for the WHO classification of pulmonary carcinoids.

Swarts DR, van Suylen RJ, den Bakker MA, van Oosterhout MF, Thunnissen FB, Volante M, Dingemans AM, Scheltinga MR, Bootsma GP, Pouwels HM, van den Borne BE, Ramaekers FC, Speel EJ.

Am J Surg Pathol. 2014 Oct;38(10):1429-36. doi: 10.1097/PAS.0000000000000300.

PMID:
25046341
12.

Chromosome instability predicts progression of premalignant lesions of the larynx.

Bergshoeff VE, Van der Heijden SJ, Haesevoets A, Litjens SG, Bot FJ, Voogd AC, Chenault MN, Hopman AH, Schuuring E, Van der Wal JM, Manni JJ, Ramaekers FC, Kremer B, Speel EJ.

Pathology. 2014 Apr;46(3):216-24. doi: 10.1097/PAT.0000000000000068.

PMID:
24614717
13.

Comprehensive analysis of HPV16 integration in OSCC reveals no significant impact of physical status on viral oncogene and virally disrupted human gene expression.

Olthof NC, Speel EJ, Kolligs J, Haesevoets A, Henfling M, Ramaekers FC, Preuss SF, Drebber U, Wieland U, Silling S, Lam WL, Vucic EA, Kremer B, Klussmann JP, Huebbers CU.

PLoS One. 2014 Feb 24;9(2):e88718. doi: 10.1371/journal.pone.0088718. eCollection 2014.

14.

The role of the nuclear lamina in cancer and apoptosis.

Broers JL, Ramaekers FC.

Adv Exp Med Biol. 2014;773:27-48. doi: 10.1007/978-1-4899-8032-8_2. Review.

PMID:
24563342
15.

MEN1 gene mutation and reduced expression are associated with poor prognosis in pulmonary carcinoids.

Swarts DR, Scarpa A, Corbo V, Van Criekinge W, van Engeland M, Gatti G, Henfling ME, Papotti M, Perren A, Ramaekers FC, Speel EJ, Volante M.

J Clin Endocrinol Metab. 2014 Feb;99(2):E374-8. doi: 10.1210/jc.2013-2782. Epub 2013 Nov 25.

16.

P16(INK4A) immunostaining is a strong indicator for high-risk-HPV-associated oropharyngeal carcinomas and dysplasias, but is unreliable to predict low-risk-HPV-infection in head and neck papillomas and laryngeal dysplasias.

Mooren JJ, Gültekin SE, Straetmans JM, Haesevoets A, Peutz-Kootstra CJ, Huebbers CU, Dienes HP, Wieland U, Ramaekers FC, Kremer B, Speel EJ, Klussmann JP.

Int J Cancer. 2014 May 1;134(9):2108-17. doi: 10.1002/ijc.28534. Epub 2013 Oct 21.

17.

Human papillomavirus multiplex ligation-dependent probe amplification assay for the assessment of viral load, integration, and gain of telomerase-related genes in cervical malignancies.

Theelen W, Litjens RJ, Vinokurova S, Haesevoets A, Reijans M, Simons G, Smedts F, Herrington CS, Ramaekers FC, von Knebel Doeberitz M, Speel EJ, Hopman AH.

Hum Pathol. 2013 Nov;44(11):2410-8. doi: 10.1016/j.humpath.2013.04.026. Epub 2013 Aug 19.

18.

An exploration of pathways involved in lung carcinoid progression using gene expression profiling.

Swarts DR, Van Neste L, Henfling ME, Eijkenboom I, Eijk PP, van Velthuysen ML, Vink A, Volante M, Ylstra B, Van Criekinge W, van Engeland M, Ramaekers FC, Speel EJ.

Carcinogenesis. 2013 Dec;34(12):2726-37. doi: 10.1093/carcin/bgt271. Epub 2013 Aug 8.

19.

Serum markers in small cell lung cancer: opportunities for improvement.

Harmsma M, Schutte B, Ramaekers FC.

Biochim Biophys Acta. 2013 Dec;1836(2):255-72. doi: 10.1016/j.bbcan.2013.06.002. Epub 2013 Jun 21. Review.

PMID:
23796706
20.

Molecular biomarkers in cervical cancer diagnosis: a critical appraisal.

Litjens RJ, Hopman AH, van de Vijver KK, Ramaekers FC, Kruitwagen RF, Kruse AJ.

Expert Opin Med Diagn. 2013 Jul;7(4):365-77. doi: 10.1517/17530059.2013.808621. Epub 2013 Jun 19. Review.

PMID:
23777477
21.

Use of the HPV MLPA assay in cervical cytology for the prediction of high grade lesions.

Litjens RJ, Theelen W, van de Pas Y, Ossel J, Reijans M, Simons G, Speel EJ, Slangen BF, Ramaekers FC, Kruitwagen RF, Hopman AH.

J Med Virol. 2013 Aug;85(8):1386-93. doi: 10.1002/jmv.23629.

PMID:
23765775
22.

A combination of two electrophoretical approaches for detailed proteome-based characterization of SCLC subtypes.

Poschmann G, Lendzian A, Uszkoreit J, Eisenacher M, Borght AV, Ramaekers FC, Meyer HE, Stühler K.

Arch Physiol Biochem. 2013 Jul;119(3):114-25. doi: 10.3109/13813455.2013.789529. Epub 2013 May 8.

PMID:
23651173
23.

CD44 and OTP are strong prognostic markers for pulmonary carcinoids.

Swarts DR, Henfling ME, Van Neste L, van Suylen RJ, Dingemans AM, Dinjens WN, Haesevoets A, Rudelius M, Thunnissen E, Volante M, Van Criekinge W, van Engeland M, Ramaekers FC, Speel EJ.

Clin Cancer Res. 2013 Apr 15;19(8):2197-207. doi: 10.1158/1078-0432.CCR-12-3078. Epub 2013 Feb 26.

24.

BCL2 and keratin 5 define the uterine-cervix-isthmus junction, a transition between endocervical and tubal-like epithelium.

Hoogduin KJ, Hopman AN, Ramaekers FC, McCluggage WG, Smedts F.

Int J Gynecol Pathol. 2013 Jan;32(1):122-30. doi: 10.1097/PGP.0b013e318253c6f6.

PMID:
23202780
25.

Chromosome stability in tonsillar squamous cell carcinoma is associated with HPV16 integration and indicates a favorable prognosis.

Mooren JJ, Kremer B, Claessen SM, Voogd AC, Bot FJ, Peter Klussmann J, Huebbers CU, Hopman AH, Ramaekers FC, Speel EJ.

Int J Cancer. 2013 Apr 15;132(8):1781-9. doi: 10.1002/ijc.27846. Epub 2012 Oct 11.

26.

Cytoplasmic localization of PML particles in laminopathies.

Houben F, De Vos WH, Krapels IP, Coorens M, Kierkels GJ, Kamps MA, Verstraeten VL, Marcelis CL, van den Wijngaard A, Ramaekers FC, Broers JL.

Histochem Cell Biol. 2013 Jan;139(1):119-34. doi: 10.1007/s00418-012-1005-5. Epub 2012 Aug 25.

PMID:
22918509
27.

Molecular and cellular biology of neuroendocrine lung tumors: evidence for separate biological entities.

Swarts DR, Ramaekers FC, Speel EJ.

Biochim Biophys Acta. 2012 Dec;1826(2):255-71. doi: 10.1016/j.bbcan.2012.05.001. Epub 2012 May 10. Review.

PMID:
22579738
28.

Next-generation treatment strategies for human papillomavirus-related head and neck squamous cell carcinoma: where do we go?

Olthof NC, Straetmans JM, Snoeck R, Ramaekers FC, Kremer B, Speel EJ.

Rev Med Virol. 2012 Mar;22(2):88-105. doi: 10.1002/rmv.714. Epub 2011 Oct 7. Review.

PMID:
21984561
29.

Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies.

De Vos WH, Houben F, Kamps M, Malhas A, Verheyen F, Cox J, Manders EM, Verstraeten VL, van Steensel MA, Marcelis CL, van den Wijngaard A, Vaux DJ, Ramaekers FC, Broers JL.

Hum Mol Genet. 2011 Nov 1;20(21):4175-86. doi: 10.1093/hmg/ddr344. Epub 2011 Aug 10.

PMID:
21831885
30.

Deletions of 11q22.3-q25 are associated with atypical lung carcinoids and poor clinical outcome.

Swarts DR, Claessen SM, Jonkers YM, van Suylen RJ, Dingemans AM, de Herder WW, de Krijger RR, Smit EF, Thunnissen FB, Seldenrijk CA, Vink A, Perren A, Ramaekers FC, Speel EJ.

Am J Pathol. 2011 Sep;179(3):1129-37. doi: 10.1016/j.ajpath.2011.05.028. Epub 2011 Jul 16.

31.

Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice.

Vanmierlo T, Rutten K, van Vark-van der Zee LC, Friedrichs S, Bloks VW, Blokland A, Ramaekers FC, Sijbrands E, Steinbusch H, Prickaerts J, Kuipers F, Lütjohann D, Mulder M.

Plant Foods Hum Nutr. 2011 Jun;66(2):149-56. doi: 10.1007/s11130-011-0219-3.

32.

Reorganization of the nuclear lamina and cytoskeleton in adipogenesis.

Verstraeten VL, Renes J, Ramaekers FC, Kamps M, Kuijpers HJ, Verheyen F, Wabitsch M, Steijlen PM, van Steensel MA, Broers JL.

Histochem Cell Biol. 2011 Mar;135(3):251-61. doi: 10.1007/s00418-011-0792-4. Epub 2011 Feb 25.

33.

Apolipoprotein CI knock-out mice display impaired memory functions.

Berbée JF, Vanmierlo T, Abildayeva K, Blokland A, Jansen PJ, Lütjohann D, Gautier T, Sijbrands E, Prickaerts J, Hadfoune M, Ramaekers FC, Kuipers F, Rensen PC, Mulder M.

J Alzheimers Dis. 2011;23(4):737-47. doi: 10.3233/JAD-2010-100576.

PMID:
21157034
34.

Increase in viral load, viral integration, and gain of telomerase genes during uterine cervical carcinogenesis can be simultaneously assessed by the HPV 16/18 MLPA-assay.

Theelen W, Speel EJ, Herfs M, Reijans M, Simons G, Meulemans EV, Baldewijns MM, Ramaekers FC, Somja J, Delvenne P, Hopman AH.

Am J Pathol. 2010 Oct;177(4):2022-33. doi: 10.2353/ajpath.2010.090901. Epub 2010 Sep 2.

35.

The two faces of cervical adenocarcinoma in situ.

Smedts F, Ramaekers FC, Hopman AH.

Int J Gynecol Pathol. 2010 Jul;29(4):378-85. doi: 10.1097/PGP.0b013e3181cd3175.

PMID:
20567153
36.

Increased plasticity of the nuclear envelope and hypermobility of telomeres due to the loss of A-type lamins.

De Vos WH, Houben F, Hoebe RA, Hennekam R, van Engelen B, Manders EM, Ramaekers FC, Broers JL, Van Oostveldt P.

Biochim Biophys Acta. 2010 Apr;1800(4):448-58. doi: 10.1016/j.bbagen.2010.01.002. Epub 2010 Jan 14.

PMID:
20079404
37.

Autophosphorylation of polo-like kinase 4 and its role in centriole duplication.

Sillibourne JE, Tack F, Vloemans N, Boeckx A, Thambirajah S, Bonnet P, Ramaekers FC, Bornens M, Grand-Perret T.

Mol Biol Cell. 2010 Feb 15;21(4):547-61. doi: 10.1091/mbc.E09-06-0505. Epub 2009 Dec 23.

38.

A new multiparameter assay to assess HPV 16/18, viral load and physical status together with gain of telomerase genes in HPV-related cancers.

Theelen W, Reijans M, Simons G, Ramaekers FC, Speel EJ, Hopman AH.

Int J Cancer. 2010 Feb 15;126(4):959-75. doi: 10.1002/ijc.24844.

39.

The caspase-9 derived C-terminal fragment of cytokeratin 18 modulates topoisomerase action.

Schutte B, Henfling ME, Verheyen FK, Li G, Tolstonog GV, Ramaekers FC.

Int J Oncol. 2009 Sep;35(3):625-30.

PMID:
19639183
40.

Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levels.

Jansen PJ, Lütjohann D, Thelen KM, von Bergmann K, van Leuven F, Ramaekers FC, Monique M.

J Alzheimers Dis. 2009;18(2):319-29. doi: 10.3233/JAD-2009-1150.

PMID:
19584433
41.

Re-expression of alpha skeletal actin as a marker for dedifferentiation in cardiac pathologies.

Driesen RB, Verheyen FK, Debie W, Blaauw E, Babiker FA, Cornelussen RN, Ausma J, Lenders MH, Borgers M, Chaponnier C, Ramaekers FC.

J Cell Mol Med. 2009 May;13(5):896-908. doi: 10.1111/j.1582-4934.2008.00523.x.

42.

Distribution pattern and marker profile show two subpopulations of reserve cells in the endocervical canal.

Martens JE, Smedts FM, Ploeger D, Helmerhorst TJ, Ramaekers FC, Arends JW, Hopman AH.

Int J Gynecol Pathol. 2009 Jul;28(4):381-8. doi: 10.1097/PGP.0b013e31819932f8.

PMID:
19483623
43.

P21 Cip1/WAF1 expression is strongly associated with HPV-positive tonsillar carcinoma and a favorable prognosis.

Hafkamp HC, Mooren JJ, Claessen SM, Klingenberg B, Voogd AC, Bot FJ, Klussmann JP, Hopman AH, Manni JJ, Kremer B, Ramaekers FC, Speel EJ.

Mod Pathol. 2009 May;22(5):686-98. doi: 10.1038/modpathol.2009.23. Epub 2009 Mar 20.

44.

The R439C mutation in LMNA causes lamin oligomerization and susceptibility to oxidative stress.

Verstraeten VL, Caputo S, van Steensel MA, Duband-Goulet I, Zinn-Justin S, Kamps M, Kuijpers HJ, Ostlund C, Worman HJ, Briedé JJ, Le Dour C, Marcelis CL, van Geel M, Steijlen PM, van den Wijngaard A, Ramaekers FC, Broers JL.

J Cell Mol Med. 2009 May;13(5):959-71. doi: 10.1111/j.1582-4934.2009.00690.x. Epub 2009 Feb 11.

45.

Identification of proteomic differences between squamous cell carcinoma of the lung and bronchial epithelium.

Poschmann G, Sitek B, Sipos B, Ulrich A, Wiese S, Stephan C, Warscheid B, Klöppel G, Vander Borght A, Ramaekers FC, Meyer HE, Stühler K.

Mol Cell Proteomics. 2009 May;8(5):1105-16. doi: 10.1074/mcp.M800422-MCP200. Epub 2009 Jan 27.

46.

Disturbed nuclear orientation and cellular migration in A-type lamin deficient cells.

Houben F, Willems CH, Declercq IL, Hochstenbach K, Kamps MA, Snoeckx LH, Ramaekers FC, Broers JL.

Biochim Biophys Acta. 2009 Feb;1793(2):312-24. doi: 10.1016/j.bbamcr.2008.10.003. Epub 2008 Oct 25.

47.

Processing and staining of cell and tissue material for interphase cytogenetics.

Hopman AH, Ramaekers FC.

Curr Protoc Cytom. 2001 May;Chapter 8:Unit 8.5. doi: 10.1002/0471142956.cy0805s05.

PMID:
18770743
48.

Molecular evidence for a clonal relationship between multiple lesions in patients with unknown primary adenocarcinoma.

Speel EJ, van de Wouw AJ, Claessen SM, Haesevoets A, Hopman AH, van der Wurff AA, Osieka R, Buettner R, Hillen HF, Ramaekers FC.

Int J Cancer. 2008 Sep 15;123(6):1292-300. doi: 10.1002/ijc.23616.

49.

Chromosome instability in resection margins predicts recurrence of oral squamous cell carcinoma.

Bergshoeff VE, Hopman AH, Zwijnenberg IR, Ramaekers FC, Bot FJ, Kremer B, Manni JJ, Speel EJ.

J Pathol. 2008 Jul;215(3):347-8. doi: 10.1002/path.2349. No abstract available.

PMID:
18421698
50.

Cardiotin localization in mitochondria of cardiomyocytes in vivo and in vitro and its down-regulation during dedifferentiation.

Driesen RB, Verheyen FK, Schaart G, de Mazière A, Viebahn C, Prinzen FW, Lenders MH, Debie W, Totzeck A, Borgers M, Ramaekers FC.

Cardiovasc Pathol. 2009 Jan-Feb;18(1):19-27. doi: 10.1016/j.carpath.2007.12.008. Epub 2008 Feb 20.

PMID:
18402829

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